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| 1 | Neonatal ketamine exposure-induced hippocampal neuroapoptosis in the developing brain impairs adult spatial learning ability显示文摘Ketamine exposure can lead to selective neuroapoptosis in the developing brain.p66ShcA,the cellular adapter protein expressed selectively in immature neurons,is a known pro-apoptotic molecule that triggers neuroapoptosis when activated.Sprague-Dawley rats at postnatal day 7 were subcutaneously injected in the neck with ketamine 20 mg/kg,six times at 2-hour intervals.At 0,1,3,and 6 hours after final injection,western blot assay was used to detect the expression of cleaved caspase-3,p66ShcA,and phosphorylated p66ShcA.We found that the expression of activated p66ShcA and caspase-3 increased after ketamine exposure and peaked at 3 hours.The same procedure was performed on a different group of rats.At the age of 4 weeks,spatial learning and memory abilities were tested with the Morris water maze.Latency to find the hidden platform for these rats was longer than it was for control rats,although the residence time in the target quadrant was similar.These findings indicate that ketamine exposure resulted in p66ShcA being activated in the course of an apoptotic cascade during the neonatal period.This may have contributed to the deficit in spatial learning and memory that persisted into adulthood.The experimental protocol was approved by the Institutional Animal Care and Use Committee at the University of Texas at Arlington,USA (approval No.A13.008) on January 22,2013. | Dan Lyu Ning Tang Andrew W. Womack Yong-Jin He Qing Lin | 2020 | Neural Regeneration Research2020，15，5： | 7 |
| 2 | Pharmacokinetic and Pharmacodynamic Efficacies of Continuous versus Intermittent Administration of Meropenem in Patients with Severe Sepsis and Septic Shock: A Prospective Randomized Pilot Study显示文摘 | Hui-Ying Zhao Jian Gu Jie Lyu Dan Liu Yi-Tong Wang Fang Liu Feng-Xue Zhu You-Zhong An | 2017 | Chinese Medical Journal2017，，10： | 6 |
| 3 | Transport of Asian surface pollutants to the global stratosphere from the Tibetan Plateau region during the Asian summer monsoon显示文摘Due to its surrounding strong and deep Asian summer monsoon(ASM)circulation and active surface pollutant emissions,surface pollutants are transported to the stratosphere from the Tibetan Plateau region,which may have critical impacts on global climate through chemical,microphysical and radiative processes.This article reviews major recent advances in research regarding troposphere-stratosphere transport from the region of the Tibetan Plateau.Since the discovery of the total ozone valley over the Tibetan Plateau in summer from satellite observations in the early 1990s,new satellite-borne instruments have become operational and have provided significant new information on atmospheric composition.In addition,in situ measurements and model simulations are used to investigate deep convection and the ASM anticyclone,surface sources and pathways,atmospheric chemical transformations and the impact on global climate.Also challenges are discussed for further understanding critical questions on microphysics and microchemistry in clouds during the pathway to the global stratosphere over the Tibetan Plateau. | Jianchun Bian Dan Li Zhixuan Bai Qian Li Daren Lyu Xiuji Zhou | 2020 | National Science Review2020，7，3： | 5 |
| 4 | Hierarchical carbon nanocages as high-rate anodes for Li-and Na-ion batteries显示文摘新奇的层次碳 nanocages (hCNCs ) 为 Li 离子和 Na 离子电池作为高率的阳极被建议。为 hCNCs 的多孔的网络的唯一的结构极大地赞成电解质穿入,离子散开,电子传导,和结构的稳定性,导致高率能力和优秀 cyclability。为锂存储,相应电极存储 970 mAh 的一个稳定的可逆能力吗? | Zhiyang Lyu Lijun Yang Dan Xu Jin Zhao Hongwei Lai Yufei Jiang Qiang Wu Yi Li Xizhang Wang Zheng Hu | 2015 | Nano Research2015，8，11： | 3 |
| 5 | Circulating Current Suppression for MMC-HVDC Systems with Asymmetric Arm Impedance显示文摘The modular multilevel converter(MMC)has been a highly promising topology in the high-voltage direct-current(HVDC)transmission area,where each arm of the MMC may consist of hundreds of series-connected submodules and an inductor.Due to its parameter inaccuracy,component aging,and so on,the component parameter in different arms of the MMC may be different,which may cause circulating current in the MMC-HVDC transmission system,and result in current deterioration,power losses,and electromagnetic interference,etc.In this paper,the circulating current suppressing(CCS)in the MMC-HVDC system,due to asymmetric arm impedance,is analyzed.Based on the mathematical analysis,a method of using an auxiliary circuit is proposed for the MMC to realize the CCS and improve the performance of the MMC-HVDC system.Simulation studies are conducted with PSCAD/EMTDC in the HVDC system,which confirms the feasibility of the proposed method. | Fujin Deng Qian Heng Chengkai Liu Yongqing Lyu Qingsong Wang Dan Liu Rongwu Zhu | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 3 |
| 6 | Modulation of bone remodeling by the gut microbiota:a new therapy for osteoporosis显示文摘The gut microbiota(GM)plays a crucial role in maintaining the overall health and well-being of the host.Recent studies have demonstrated that the GM may significantly influence bone metabolism and degenerative skeletal diseases,such as osteoporosis(OP).Interventions targeting GM modification,including probiotics or antibiotics,have been found to affect bone remodeling.This review provides a comprehensive summary of recent research on the role of GM in regulating bone remodeling and seeks to elucidate the regulatory mechanism from various perspectives,such as the interaction with the immune system,interplay with estrogen or parathyroid hormone(PTH),the impact of GM metabolites,and the effect of extracellular vesicles(EVs).Moreover,this review explores the potential of probiotics as a therapeutic approach for OP.The insights presented may contribute to the development of innovative GM-targeted therapies for OP. | Zhengtian Lyu Yongfei Hu Yuming Guo Dan Liu | 2023 | Bone Research2023，11，3： | 3 |
| 7 | Iron-Imprinted Single-Atomic Site Catalyst-Based Nanoprobe for Detection of Hydrogen Peroxide in Living Cells显示文摘Fe-based single-atomic site catalysts(SASCs),with the natural metalloproteases-like active site structure,have attracted widespread attention in biocatalysis and biosensing.Precisely,controlling the isolated single-atom Fe-N-C active site structure is crucial to improve the SASCs’performance.In this work,we use a facile ion-imprinting method(IIM)to synthesize isolated Fe-N-C single-atomic site catalysts(IIM-Fe-SASC).With this method,the ion-imprinting process can precisely control ion at the atomic level and form numerous well-defined single-atomic Fe-N-C sites.The IIM-Fe-SASC shows better peroxidase-like activities than that of non-imprinted references.Due to its excellent properties,IIM-Fe-SASC is an ideal nanoprobe used in the colorimetric biosensing of hydrogen peroxide(H_(2)O_(2)).Using IIM-Fe-SASC as the nanoprobe,in situ detection of H_(2)O_(2)generated from MDA-MB-231 cells has been successfully demonstrated with satisfactory sensitivity and specificity.This work opens a novel and easy route in designing advanced SASC and provides a sensitive tool for intracellular H_(2)O_(2)detection. | Zhaoyuan Lyu Shichao Ding Maoyu Wang Xiaoqing Pan Zhenxing Feng Hangyu Tian Chengzhou Zhu Dan Du Yuehe Lin | 2021 | Nano-Micro Letters2021，13，9： | 2 |
| 8 | Environmental Monitoring of A Laboratory for New Coronavirus Nucleic Acid Testing显示文摘The coronavirus disease 2019(COVID-19) is an infection of the respiratory tract which first broke out in Wuhan, China, in December 2019. The etiologic agent of this disease was identified as a betacoronavirus related to severe acute respiratory syndrome coronavirus(SARS-CoV). Thus, the International Committee on Virus Classification named the new coronavirus severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)[1]. | NING Pei Yong YU Ai Ping WANG Yuan GUO Li Ru SHAN Dan KONG Mei YU Ling Qi LYU Li Kun ZOU Ming SU Xu FEI Chun Nan ZHOU Yu Hui WANG Bai Qi | 2020 | Biomedical and Environmental Sciences2020，33，10： | 2 |
| 9 | Extensively Drug-Resistant(XDR)Salmonella Typhi Outbreak by Waterborne Infection——Beijing Municipality,China,January-February 2022显示文摘Summary What is already known about this topic?Typhoid fever remains a major public health problem in developing countries.Waterborne typhoid fever affects an estimated 27 million people worldwide each year.Decades of indiscriminate antibiotic usage has driven the emergence and spread of multidrug-resistant(MDR)and even extensively drug-resistant(XDR)Salmonella Typhi(S.Typhi)strains. | Yu Wang Dan Lu Yingying Jin Huanxin Wang Bing Lyu Xin Zhang Ying Huang Gaolin Shu Baiwei Liu Changying Lin Hao Zhao Mingqiang Zhao Lingyu Shen Zhiyong Gao Daitao Zhang Quanyi Wang Mei Qu Lei Jia | 2022 | China CDC weekly2022，4，12： | 1 |
| 10 | Analysis of cyclin E co-expression genes reveals nuclear transcription factor Y subunit alpha is an oncogene in gastric cancer显示文摘Objective: To explore genes potentially co-expressed with cyclin E in gastric cancer and discover possible targets for gastric cancer treatment. Methods: The Cancer Genome Atlas (TCGA) stomach adenocarcinoma sequencing data were used to predict genes co-expressed with cyclin E. Co-expression genes predicted by cBioPortal online analysis with Pearson correlation coefficient ≥0.4 were analyzed by gene ontology (GO) enrichment annotation using the PANTHER online platform (Ver. 7). Interactions between proteins encoded by these genes were analyzed using the STRING online platform (Ver. 10.5) and Cytoscape software (Ver. 3.5.1). Genes displaying a high degree of connection were analyzed by transcription factor enrichment prediction using FunRich software (Ver. 3). The significant transcription factor and cyclin E expression levels and their impact on gastric cancer progression were analyzed by Western blotting and Kaplan-Meier survival curve analysis. Results: After filtering the co-expression gene prediction results, 78 predicted genes that included 73 protein coding genes and 5 non-coding genes with Pearson correlation coefficient ≥0.4 were selected. The expressions of the genes were considered to be correlated with cyclin E expression. Among the 78 genes co-expressed with cyclin E, 19 genes at the central of the regulatory network associated with cyclin E were discovered. Nuclear transcription factor Y subunit alpha (NF-YA) was identified as a significant transcription factor associated with cyclin E co-expressing genes. Analysis of specimen donors’ clinical records revealed that high expression of NF-YA tended to be associated with increased cyclin E expression. The expression of both was associated with progression of gastric cancer. Western blotting results showed that compared with normal tissues, NF-YA and cyclin E were highly expressed in tumor tissues (P < 0.001). Survival curve analysis clearly demonstrated relatively poor overall survival of gastric cancer patients with high cyclin E or high NF-YA expression level, compared to patients with low cyclin E or NF-YA expression (P < 0.05). Conclusions: NF-YA may promote gastric cancer progression by increasing the transcription of cyclin E and other cell cycle regulatory genes. NF-YA might be a potential therapeutically useful prognostic factor for gastric cancer. | Liang-Yu Bie Dan Li Yu Mu Sheng Wang Bei-Bei Chen Hui-Fang Lyu Li-Li Han Cai-Yun Nie Chang-Cheng Yang Lin Wang Chuan-Chuan Ren Wei-Jie Zhang Ping Guo Feng Shi Qing-Xia Fan Liu-Xing Wang Xiao-Bing Chen Su-Xia Luo | 2019 | Chronic Diseases and Translational Medicine2019，5，1： | 1 |
| 11 | Enhanced thermal conductivity of epoxy composites with core-shell SiC@SiO_(2) nanowires显示文摘Electronic packaging materials and thermal interface materials(TIMs)are widely used in thermal management.In this study,the epoxy composites with core-shell structure SiC@SiO_(2) nanowires(SiC@SiO_(2) NWs)as fillers could effectively enhance the thermal conductivity of epoxy composites.The unique structure of fillers results in a high thermal conductivity of epoxy composites,which is attributed to good interfacial compatibility epoxy matrix and bridging connections of SiC@SiO_(2) NWs.From neat epoxy to 2.5 wt%loading of SiC@SiO_(2) NWs,the thermal conductivity is significantly increased from 0.218 to 0.391 W m^(−1) K^(−1),increased by 79.4%.In addition,the composite with 2.5 wt%filler possess lower coefficient of thermal expansion and better thermal stability than that of neat epoxy.All these outstanding properties imply that epoxy/SiC@SiO_(2) NWs composites could be the ideal candidate for TIM. | Dianyu Shen Mengjie Wang Yuming Wu Zhiduo Liu Yong Cao Ting Wang Xinfeng Wu Qingtang Shi Kuan W.A.Chee Wen Dai Hua Bai Dan Dai Jilei Lyu Nan Jiang Cheng-Te Lin Jinhong Yu | 2017 | High Voltage2017，2，3： | 1 |
| 12 | Recent advances in carbon-supported non-precious metal singleatom catalysts for energy conversion electrocatalysis显示文摘Non-precious metal single-atom catalysts(NPM-SACs)with unique electronic structures and coordination environments have gained much attention in electrocatalysis owing to their low cost,high atomic utilization,and high performance.NPM-SACs on carbon support(NPM-SACs/CS)are promising because of the carbon substrate with a large surface area,excellent electrical conductivity,and high chemical stability.This review provides an overview of recent developments in NPM-SACs/CS for the electrocatalytic field.First,the state-of-the-art synthesis methods and advanced characterization techniques of NPM-SACs/CS are discussed in detail.Then,the structural adjustment strategy of NPM-SACs/CS for optimizing electrocatalytic performance is introduced concisely.Furthermore,we provide a comprehensive summary of recent advances in developing NPM-SACs/CS for important electrochemical reactions,including carbon dioxide reduction reaction,hydrogen evolution reaction,oxygen evolution reaction,oxygen reduction reaction,and nitrogen reduction reaction.In the end,the existing challenges and future opportunities of NPM-SACs/CS in the electrocatalytic field are highlighted. | Li-Xia Liu Yangyang Ding Linan Zhu Jin-Cheng Li Huitong Du Xiang Li Zhaoyuan Lyu Dan Du Fuqiang Liu Yuanyuan Wang Wenlei Zhu Yuehe Lin | 2023 | National Science Open2023，2，2： | 1 |
| 13 | Preoperative Diagnosis in 46 Cases of Pulmonary Sclerosing Hemangioma显示文摘Pulmonary sclerosing hemangioma (PSH),a thoracic tumor,was first described by Liebow and Hubbell[1] in 1956.Recently,immunohistochemical evidence and characterization of antibodies have clarified that PSHs are true tumors.They are mainly composed of epithelial cells (Type Ⅱ pneumocytes) aligned in different directions and accompanied by proliferation and reaction of other components.Because these tumors,especially when multiple,are rare,there is little published information about their clinical manifestations and imaging data.Thus,they can easily be misdiagnosed as malignant disease of the lungs.The presence of a solitary,well-defined,round or oval mass on computed tomography (CT) scanning suggests,however,that pathological examination is necessary to make a definite diagnosis. | Ai-Min Hu Dan Zhao Hua Zheng Qun-Hui Wang Yan Lyu Bao-Lan Li | 2016 | Chinese Medical Journal2016，，11： | 1 |
| 14 | Association between angiotensin-converting enzyme gene polymorphisms and vitiligo risk: a meta-analysis显示文摘 | Dong-Yun Lei Xing-Qiang Wang Le-Chun Lyu Wen-Juan Wu Dan Xu Ying Tu Li He | 2018 | International Journal of Dermatology and Venereology2018，1，1： | 1 |
| 15 | Taxonomic revision of Amolops chunganensis(Pope,1929)(Amphibia: Anura) and description of a new species from southwestern China, with discussion on Amolops monticola group and assignment of species groups of the genus Amolops显示文摘Amolops chunganensis is a species complex and reported widely from eastern,southern,and southwestern China.Based on molecular data of 19 populations of A.chunganensis sensu lato from China,including the population from Mt.Wuyi(type locality),we recognize A.chunganensis sensu stricto and provide an expanded description based on the topotypic specimens.Combining morphological and molecular data,we describe a new species,Amolops chaochin sp.nov.,from southwestern China,which was previously identified as A.chunganensis.The new species is distinguished from all other species in the A.monticola group by:(1)moderate body size,SVL 35.3-39.2 mm in males(n=7),and 50.5-54.4 mm in females(n=7);(2)distinct tympanum,larger than half of eye diameter;(3)small tooth-like projection on anteromedial edge of mandible;(4)circummarginal groove on all fingers;(5)white tubercles on dorsal side of posterior body in both sexes;(6)distinct tubercles on dorsal thigh and white spinose tubercles on dorsal tibia in both sexes;(7)white tubercles on posterior region of tympanum in males;(8)toe webbing reaching disk by dermal fringe on inner side of toe II;(9)vomerine teeth present;(10)transverse bands on dorsal limbs;(11)external vocal sacs present in males.We further reviewed the assignment of Amolops groups,with an overall revision of membership and diagnosis of all species groups. | Ke Jiang Jin-Long Ren Zhi-Tong Lyu Dan Wang Zeng Wang Ke Lv Jia-Wei Wu Jia-Tang Li | 2021 | Zoological Research2021，42，5： | 1 |
| 16 | Analysing the effects of the mesoscopic characteristics of mineral powder fillers on the cohesive strength of asphalt mortars at low temperatures显示文摘 | Lyu Dan Zheng Chuan-feng Qin Yong | 2014 | Construction and Building Materials2014，65，： | 1 |
| 17 | Environmentally persistent free radicals in PM_(2.5):a review显示文摘Environmentally persistent free radicals(EPFRs)are a new class of pollutants that are long-lived in fine particles(PM_(2.5)),i.e.,their 1/e lifetime ranges from days to months(or even infinite).They are capable of producing harmful reactive oxygen species such as hydroxyl radicals.The redox cycling of EPFRs is considered as an important pathway for PM_(2.5) to induce oxidative stress inside the humans,causing adverse health effects such as respiratory and cardiovascular diseases.Conse-quently,research regarding their toxicity,formation and environmental occurrences in PM_(2.5) has attracted increasing atten-tions globally during the past two decades.However,literature data in this field remain quite limited and discrete.Hence,an extensive review is urgently needed to summarize the current understanding of this topic.In this work,we systematically reviewed the analytical methods and environmental occurrences,e.g.,types,concentrations,and decay behaviors,as well as possible sources of EPFRs in PM_(2.5).The types of pretreatment methods,g-values of common EPFRs and categories of decay processes were discussed in detail.Moreover,great efforts were made to revisit the original data of the published works of EPFRs in airborne particulate matter and provided additional useful information for comparison where possible,e.g.,their mean and standard deviation of g-values,line widths(ΔHp-p),and concentrations.Finally,possible research opportunities were highlighted to further advance our knowledge of this emerging issue. | Mengxia Xu Tao Wu Yu-Ting Tang Tong Chen Lavrent Khachatryan Poornima Ramesh Iyer Dengting Guo Anran Chen Miao Lyu Jinhu Li Jiaqi Liu Dan Li Yuxin Zuo Shihan Zhang Yiran Wang Yining Meng Fei Qi | 2019 | Waste Disposal and Sustainable Energy2019，1，3： | 0 |
| 18 | Unconventional energetics of small vacancy clusters in BCC high-entropy alloy Nb_(0.75)ZrTiV_(0.5)显示文摘The stability of small vacancy clusters including divacancy,trivacancy and tetravacancy has been studied in body-centered cubic high-entropy alloy Nb_(0.75)ZrTiV_(0.5) in structures of random solid solution and short-range order by first-principles calculations and molecular dynamics simulations.Different from conventional body-centered cubic metals,the tightly bound configurations have a lower structural stability and are not preferred energetically in the studied high-entropy alloy.Instability of vacancy configurations leads to vacancy-atom exchanges that favor less compact configurations.The formation energy of small vacancy clusters is much smaller than its constituent elements of Nb and V due to the large structural adjustment induced by severe local lattice distortion.The difference in local lattice distortion and elemental arrangement in the vacancy neighborhood leads to significant site-to-site variation in vacancy cluster energy and configuration.The formation energy has a strong correlation with the local energy state of the vacancy configuration and the extent of structural relaxation.Compared to random solid solution,the structure of short-range order has a higher stability for the most compact cluster configurations and tends to have higher vacancy cluster formation energy.According to classical molecular dynamics simulations of cluster diffusion at high temperature,the studied high-entropy alloy has a higher probability of cluster dissociation compared to Nb and V.The unconventional energetics of small vacancy clusters is expected to have a profound impact on their generation,diffusion,dissociation,coalescence,as well as the defect microstructure evolution during irradiation. | Tan Shi Xi Qiu Yundi Zhou Sixin Lyu Jing Li Dan Sun Qing Peng Yong Xin Chenyang Lu | 2023 | Journal of Materials Science & Technology2023，，15： | 0 |
| 19 | Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus—China,2011–2021显示文摘Summary What is already known about this topic?Joint effects of gestational weight gain(GWG)and hyperglycemia on adverse pregnancy outcomes suggest that lower optimal GWG is optimal for women with gestational diabetes mellitus(GDM).However,there is still a lack of guidelines.What is added by this report?Optimal weekly GWG range after diagnosis of GDM for underweight,normal-weight,overweight,and obese women was 0.37–0.56 kg/week,0.26–0.48 kg/week,0.19–0.32 kg/week,and 0.12–0.23 kg/week,respectively.What are the implications for public health practice?The findings may be used to inform prenatal counseling regarding optimal gestational weight gain for women with gestational diabetes mellitus,and suggest the need for weight gain management. | Jinlang Lyu Yin Sun Yuelong Ji Nana Liu Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Liangkun Ma Haijun Wang | 2023 | China CDC weekly2023，5，9： | 0 |
| 20 | Tracking Cryptosporidium in urban wastewater treatment plants in a cold region:Occurrence,species and infectivity显示文摘This study investigated the occurrence,species,infectivity and removal efficiency of Cryptosporidium spp.across typical wastewater treatment train.Samples from different process units were collected seasonally and synchronously from four wastewater treatment plants(WWTPs)in Northeastern China.Live Cryptosporidium oocysts were identified in most samples from both influent(97.50%)and effluent(90.00%)wastewaters of the four WWTPs,at an average density of 26.34 and 4.15 oocysts/L,respectively.The overall removal efficiency was 84.25%,and oocysts were mainly removed(62.01%)by the modified secondary sedimentation process.Ten Cryptosporidium species were identified in the effluent samples.C.andersoni,C.bovis,and C.ryanae were the three most prevalent species.Oocyst viability assays indicated no reduction of excystation rate during the primary and secondary wastewater treatments(varied in the range of 63.08%–68.50%),but the excystation rate declined to 52.21%in the effluent after disinfection.Notably,the Cryptosporidium oocysts showed higher infection intensity in the cold season(winter and spring)than that in summer and autumn.The influences of environmental temperature on virulence factors of Cryptosporidium were further examined.It was observed that more extracellular secretory proteins were bound on the oocyst surface and several virulence genes were expressed relatively strongly at low temperatures,both of which could facilitate oocyst adhesion,invasion,and host immune evasion.This research is of considerable interest since it serves as an important step towards more accurate panoramic recognition of Cryptosporidium risk reduction in WWTPs,and especially highlights the potential health risk associated with Cryptosporidium in cold regions/seasons. | Dan Xiao Zhaofeng Lyu Shiheng Chen Yang Huo Wei Fan Mingxin Huo | 2022 | Frontiers of Environmental Science & Engineering2022，16，9： | 0 |
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