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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Inflammation and atherosclerosis: signaling pathways and therapeutic intervention显示文摘Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors.Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses can promote or quell atherosclerosis.Several signaling pathways,that are associated with the inflammatory response,have been implicated within atherosclerosis such as NLRP3 inflammasome,toll-like receptors,proprotein convertase subtilisin/kexin type 9. | Peng Kong Zi-Yang Cui Xiao-Fu Huang Dan-Dan Zhang Rui-Juan Guo Mei Han | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 20 |
| 3 | Left atrial appendage morphology in patients with atrial fibrillation in China: implications for stroke risk assessment from a single center study显示文摘 | Kong Bin Liu Yu Hu He Wang Lei Fan Yang Mei Yang Liu Wanli Liao Jiafen Liu Dan Xing Dong Huang He | 2014 | Chinese Medical Journal2014，，24： | 12 |
| 4 | Dyslipidemia and Outcome in Patients with Acute Ischemic Stroke显示文摘Objective To study the relationship between dyslipidemia and outcome in patients with acute ischemic stroke. Methods Data about 1 568 patients with acute ischemic stroke were collected from 4 hospitals in Shandong Province from January 2006 to December 2008. National Institute of Health Stroke Scale(NIHSS) >10 at discharge or death was defined as the outcome. Effect of dyslipidemia on outcome in patients with acute ischemic stroke was analyzed by multivariate logistic regression analysis and propensity score-adjusted analysis, respectively. Results The serum levels of TC, LDL-C, and HDL-C were significantly associated with the outcome in patients with acute ischemic stroke. Multivariate logistic regression analysis and propensity score-adjusted analysis showed that the ORs and 95% CIs were 3.013(1.259, 7.214)/2.655(1.298, 5.43), 3.157(1.306, 7.631)/3.405(1.621, 7.154), and 0.482(0.245, 0.946)/0.51(0.282, 0.921), respectively, for patients with acute ischemic stroke. Hosmer-Lemeshow goodness-of-fit test showed no significant difference in observed and predicted risk in patients with acute ischemic stroke(chi-square=8.235, P=0.411). Conclusion Serum levels of TC, LDL-C, and HDL-C are positively related with the outcome in patients with acute ischemic stroke. | XU Tian ZHANG Jin Tao YANG Mei ZHANG Huan LIU Wen Qing KONG Yan XU Tan ZHANG Yong Hong | 2014 | Biomedical and Environmental Sciences2014，27，2： | 12 |
| 5 | Cobalt and manganese stress in the microalga Pavlova viridis (Prymnesiophyceae):Effects on lipid peroxidation and antioxidant enzymes显示文摘海洋环境的污染在最近的年里成为了主要担心的一个问题。由从他们在工业过程的增加的利用的重金属结果的严肃的公害并且因为大多数重金属被搬运进海洋环境并且没有分解,积累了。现在的学习的目的是在生长上调查效果,颜料,类脂化合物每氧化,和海洋的微水藻 Pavlova 的一些抗氧化剂酶活动青绿色的响应钴(公司)和锰( Mn )的提高的集中,特别关于对重导致金属的氧化应力的抗氧化的防卫的参与。响应 Co2+ ,类脂化合物与控制相比每氧化被提高,作为在微海藻的房间然而并非 Mn2+ 的金属集中 assayed 引起的氧化损坏的一个指示。Pavlova 的暴露青绿色的到以一种不同方式在酶活动引起变化的二金属,取决于金属 assayed:在 Co2+ 处理以后,全部的超级氧化物 dismutase (草皮) 活动是不规则的,尽管它没被 Mn2+ 暴露显著地影响。,Co2+和Mn2+刺激了过氧化氢酶(猫)和谷胱甘肽( GSH )的活动谷胱甘肽过氧化物酶( GPX )响应Co2+处理在活动显示出显著增加并且与Mn2+集中逐渐地减少了,然后很快升起了,直到 50 μm ol/L ,在 200 μm ol/L Mn2+到达到大约38.98%。这些结果建议一些抗氧化剂酶的激活被提高,到抵抗二金属在更高的集中导致的氧化压力。 | LI Mei ZHU Qin HU Chang-wei CHEN Li LIU Zhi-li KONG Zhi-ming | 2007 | Journal of Environmental Sciences2007，19，11： | 9 |
| 6 | Psychological status and diabetes-related distress of Chinese type 1 diabetes patients in Jiangsu province, China显示文摘We sought to assess the psychological status and diabetes-related distress of Chinese type 1 diabetes patients in Jiangsu province,China.According to the World Health Organization criteria,42 patients with type 1 diabetes were enrolled in the study and assessed with the Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS)and Diabetes Distress Scale(DDS).All data were tabulated and statistical analyses were performed.The study summarized cases of 42 patients with type 1 diabetes,including 17 males and 25 females with a mean age of 23±12 years and a mean duration of diabetes of 7±6 years.Compared to the Chinese normative data,the SAS standard score was significantly higher,whereas SDS standard score had no statistical significance.The SAS standard score was most highly correlated with diabetes duration(γ=0.547,P=0.011).Additionally,19.5%of the patients had moderate or even severe diabetes-related distress and 21.4%had moderate or even severe emotional burden while 26.2%had regimen-related distress.Multiple stepwise regression analysis showed that the mean correlation between DDS and the four domains was high,particularly the emotional burden domain(estimatedβ=0.363,P<0.001)and regimen-related distress domain(estimatedβ=0.356,P<0.001).The correlation between SAS and DDS was positive(estimatedβ=0.039,P=0.027).In conclusion,the results showed the importance of psychological aspects in Chinese individuals with type 1 diabetes.Screening and treatment of psychological aspects may result in better adherence and increased quality of life for patients with diabetes. | Lulu Kong Yun Cai Gang Mei Rong Gu Xiaojiao Zhang Yao Qin Ya Cai Yan Li Hongwen Zhou Mei Zhang Tao Yang | 2013 | The Journal of Biomedical Research2013，27，5： | 9 |
| 7 | Correlation of the temporal and spatial expression patterns of HQT with the biosynthesis and accumulation of chlorogenic acid in Lonicera japonica flowers显示文摘Hydroxycinnamoyl-CoA quinate transferase(HQT)is one of the key enzymes in the biosynthesis of chlorogenic acid(CGA)in the flowers of Lonicera japonica.However,the spatiotemporal expression patterns of HQT and its relationship to the dynamics of CGA biosynthesis,transport,and storage remain largely unknown.In this study,we collected L.japonica flower samples at different growth stages(S1–S6)and examined the spatiotemporal expression pattern of HQT and the dynamic accumulation patterns of CGA using a combination of molecular and cytological techniques.Our results suggest that the spatiotemporal expression pattern of HQT is directly correlated with dynamic changes in CGA accumulation and distribution in L.japonica flowers.We further show that CGA is synthesized primarily in the cytoplasm and chloroplasts.CGA synthesized in the cytoplasm first accumulates in specialized vesicles and is then transferred to large central vacuoles for storage by fusion of CGA-containing vesicles with vacuoles.Furthermore,CGA synthesized in the chloroplasts appears to be transferred into the vacuoles for storage by direct membrane fusion between the tonoplast and the disrupted chloroplast membranes.Collectively,our results suggest that CGA is synthesized in chloroplasts and cytoplasm and finally transferred to the vacuole for long-term storage. | Yanqun Li Dexin Kong Mei Bai Hanjun He Haiyang Wang Hong Wu | 2019 | Horticulture Research2019，6，1： | 7 |
| 8 | Small interference RNA targeting vascular endothelial growth factor gene effectively attenuates retinal neovascularization in mice model显示文摘 | KONG Yi-chun SUN Bei ZHAO Kan-xing HAN Mei WANG Yu-chuan | 2013 | Chinese Medical Journal2013，，8： | 7 |
| 9 | Damage patterns of retinal nerve fiber layer in acute and chronic intraocular pressure elevation in primary angle closure glaucoma显示文摘AIM:To observe the differences of damage patterns of retinal nerve fiber layer(RNFL)between acute and chronic intraocular pressure(IOP)elevation in primary angle closure glaucoma(PACG)using optical coherence tomography(OCT). METHODS:Twenty-four patients(48 eyes)with unilateral acute PACG(APACG)attack in the 6 months after admission and 36 patients(64 eyes)with chronic PACG(CPACG)were included in this prospective study.For all cases,IOP has been controlled under 21mmHg after treatment.Using stratus OCT, the RNFL thickness was assessed in eyes with PACG within 3 days,2 weeks,1,3 and 6 months after IOP was controlled. Repeated measures ANOVA was used to examine the changes of RNFL thickness at different time after IOP being controlled in both acute attack eyes and unaffected fellow eyes of APACG and eyes with CPACG. RESULTS:The mean RNFL thickness for the APACG-attacked eyes increased significantly within 3 days(121.49±23.84)μm after acute onset and then became thinner along with time[(107.22±24.72)μm at 2 weeks,(93.58±18.37)μm at 1 month,(84.10±19.89)μm at 3 months and(78.98±19.17)μm at 6 months].In APACG-attacked eyes,there were significant differences of average RNFL thickness at 5 different times after IOP was controlled(P<0.001).In the APACG unaffected fellow eyes and CPACG eyes,there were no significant differences in mean RNFL thickness at 5 different times(F=0.450,P=0.104 in APACG unaffected fellow eyes and F=1.558,P=0.200 in CPACG eyes).There was significant difference for interaction between time periods and groups(F=1.912,P=0.003). CONCLUSION:RNFL damage patterns are different under different IOP elevated courses.In APACG,RNFL was found to be swollen and thickening right after acute attack and then becomes thinning and atrophy along with the time,while RNFL was found to be diffused thinness in CPACG. | Xing Liu Mei Li Yi-Min Zhong Hui Xiao Jing-Jing Huang and Xiang-Yun Kong | 2010 | International Journal of Ophthalmology(English edition)2010，3，2： | 4 |
| 10 | RESEARCH ON ADAPTIVE COMPRESSION CODING FOR NETWORK CODING IN WIRELESS SENSOR NETWORK显示文摘Based on the sequence entropy of Shannon information theory, we work on the network coding technology in Wireless Sensor Network (WSN). In this paper, we take into account the similarity of the transmission sequences at the network coding node in the multi-sources and multi-receivers network in order to compress the data redundancy. Theoretical analysis and computer simulation results show that this proposed scheme not only further improves the efficiency of network transmission and enhances the throughput of the network, but also reduces the energy consumption of sensor nodes and extends the network life cycle. | Liu Ying Yang Zhen Mei Zhonghui Kong Yuanyuan | 2012 | Journal of Electronics(China)2012，29，5： | 4 |
| 11 | A Case of New Variant COVID-19 First Emerging in South Africa Detected in a Security Guard at the Isolation Point—Shenzhen,China,January 23,2021显示文摘On January 22,2021,a 34-year-old male,who served as a security guard at the isolation point in Shenzhen,tested positive for coronavirus disease 2019(COVID-19)during the every-three-day routine test.After the nasopharyngeal swab was further confirmed as positive for COVID-19 by Shenzhen CDC,the patient was transferred to the Third People’s Hospital of Shenzhen and was diagnosed as a COVID-19 asymptomatic infection.On January 25,2021,Shenzhen CDC identified the 20H/501.Y.V2(B.1.351)variant,which was a variant of COVID-19 virus first emerging in the South Africa. | Jun Meng Shujiang Mei Long Chen Chunli Wu Shisong Fang Bo Peng Dongfeng Kong Xiaomin Zhang Linghong Xiong Yalan Huang Qiongcheng Chen Renli Zhang Yaqing He | 2021 | China CDC weekly2021，3，10： | 3 |
| 12 | Two new tremulane sesquiterpenes from a mangrove endophytic fungus,Coriolopsis sp.J5显示文摘Two new tremulane sesquiterpenes coriolopsin A(1) and coriolopsin B(2),together with two known ones conocenol C(3) and ceriponol E(4),were isolated from the fermentation extract of endophytic fungus Coriolopsis sp.J5 from Ceriops tagal.The structures and absolute configuration of compounds 1 and 2 were determined based on HR-ESI-MS and spectroscopic data(IR,UV,1D,2D NMR and X-ray crystallographic analysis). | Liang-Liang Chen Fan-Dong Kong Pei Wang Jing-Zhe Yuan Zhi-Kai Guo Hao Wang Hao-Fu Dai Wen-Li Mei | 2017 | Chinese Chemical Letters2017，28，2： | 3 |
| 13 | Atomic layer deposition-induced integration of N-doped carbon particles on carbon foam for flexible supercapacitor显示文摘Flexible devices have attracted abundant attention in energy storage systems.In this paper,we presented a novel approach for fabricating flexible supercapacitor based on metal organic frameworks-derived material.In this approach,a uniform zeolitic imidazolate frameworks-8 layer with a high mass loading was deposited on a flexible carbon foam(CF)skeleton efficiently by the induction of a uniform ZnO nanomembrane prepared via an atomic layer deposition technique.A flexible N-doped carbon particle-carbon foam(N-CP-CF)composite with a hierarchically porous structure and a large specific surface area(i.e.,538 m^(2) g^(-1))was obtained in a subsequent pyrolysis process.The resultant materials have the excellent electrochemical performance(i.e.,a high specific capacitance of 300 F g^(-1) and a high energy density of 20.8 W h kg^(-1)).The N-CP-CF composite can provide a stable capacitance(i.e.,250 F g^(-1))and an energy density(i.e.,17.36 W h kg^(-1))under large deformation(25% of original thickness).This work could propose a promising strategy in fabrication of flexible electrode with a large potential towards energy storage applications in the future. | Zhe Zhao Ye Kong Chang Liu Jinrun Liu Zhijie Wang Gengfeng Zheng Gaoshan Huang Yongfeng Mei | 2020 | Journal of Materiomics2020，6，1： | 3 |
| 14 | Stimulus responsive fluorescent hyperbranched polymers and their applications显示文摘Fluorescent hyperbranched polymers (FHBPs),which combine the versatile fluorescent property with unique characteristics of hyperbranched architecture,are desirable candidates for stimulus responsive materials.This review demonstrates the structure and environment-dependent emission behaviors of a series of FHBPs.AEE active FHBPs showing opposite performance to ACQ effect are used to sensitively detect explosives and a superamplification effect is found.Specially designed FHBPs can complex with metal ions,leading to fluorescence turn-off due to complex quenching effect.The protonation of amino-containing FHBPs exhibits pH-dependent fluorescence responses to solution acidity.Some FHBPs containing responsive moieties are photo-and thermo-sensitive,and show potential applications as smart materials. | WANG Jian 1,MEI Ju 1,QIN AnJun 1,SUN JingZhi 1 & TANG Ben Zhong 1,2 1 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering,Institute of Biomedical Macromolecules,Zhejiang University,Hangzhou 310027,China 2 Department of Chemistry,The Hong Kong University of Science & Technology,Hong Kong,China | 2010 | Science China Chemistry2010，53，12： | 3 |
| 15 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021，3，50： | 3 |
| 16 | A novel terbium complex using oxadiazole derivative as a neutral ligand:Synthesis and properties显示文摘A novel terbium complex using 1,3,4-oxadiazole derivative as a neutral ligand was synthesized and characterized. Its thermal stability and photoluminescent properties were studied. The strong emission peaked at 546 nm with a full width at half maximum of 5 nm was observed in the pure terbium complex film under excitation of 328 nm light, which is attributed to the characteristic emission of terbium ion. The good thermal stability and intense sharp emission of this terbium complex display its potential application in electroluminescence devices. | Yu Liu Kong Qiang Xing Ji Yong Deng Mei Xiang Zhu Xia Yu Wang Wei Guo Zhu | 2007 | Chinese Chemical Letters2007，18，5： | 3 |
| 17 | Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis显示文摘 | Julian J. Lum Daniel E. Bauer Mei Kong Marian H. Harris Chi Li Tullia Lindsten Craig B. Thompson | 2005 | Cell2005，，2： | 3 |
| 18 | Comparative WGBS identifies genes that influence non-ripe phenotype in tomato epimutant Colourless non-ripening显示文摘Whole-genome bisulfite sequencing(WGBS)allows single-base resolution and genome-wide profiling of DNA methylation in plants and animals.This technology provides a powerful tool to identify genes that are potentially controlled by dynamic changes of DNA methylation and demethylation.However,naturally occurring epimutants are rare and genes under epigenetic regulation as well as their biological relevances are often difficult to define.In tomato,fruit development and ripening are a complex process that involves epigenetic control.We have taken the advantage of the tomato epimutant Colourless non-ripening(Cnr)and performed comparative mining of the WGBS datasets for the Cnr and Sl CMT3-silenced Cnr fruits.We compared DNA methylation profiles for the promoter sequences of approximately 5,000 bp immediately upstream of the coding region of a list of20 genes.Differentially methylated regions were found for some of these genes.Virus-induced gene silencing(VIGS)of differentially methylated gene Sl DET1 or Sl PDS resulted in unusual brown pigmentation in Cnr fruits.These results suggest that comparative WGBS coupled with VIGS can be used to identify genes that may contribute to the colourless unripe phenotype of fruit in the Cnr epimutant. | Weiwei Chen Zhiming Yu Junhua Kong Hui Wang Yichen Li Mei Zhao Xiaohong Wang Qianqian Zheng Nongnong Shi Pengcheng Zhang Silin Zhong Paul Hunter Mahmut Tor Yiguo Hong | 2018 | Science China(Life Sciences)2018，61，2： | 3 |
| 19 | Angiographic embolization in the treatment of intrahepatic arterial bleeding in patients with blunt abdominal trauma显示文摘BACKGROUND: Angiographic embolization (AE) as an adjunct non-operative treatment of intrahepatic arterial bleeding has been widely used. The present study aimed to evaluate the efficacy of selective AE in patients with hepatic trauma.METHODS: Seventy patients with intrahepatic arterial bleeding after blunt abdominal trauma who had undergone selective AE in 10 years at this institution were retrospectively reviewed.The criteria for selective AE included active extravasation on contrast-enhanced CT, an episode of hypotension or a decrease in hemoglobin level during the non-operative treatment. The data of the patients included demographics,grade of liver injuries, mechanism of blunt abdominal trauma,associated intra-abdominal injuries, indications for AE,angiographic findings, type of AE, and AE-related hepatobiliary complications. RESULTS: In the 70 patients, 32 (45.71%) had high-grade liver injuries. Extravazation during the early arterial phase mainly involved the right hepatic segments. Thirteen (18.57%) patients underwent embolization of intrahepatic branches and the extrahepatic trunk and these patients all developed AE-related hepatobiliary complications. In 19 patients with AE-related complications, 14 received minimally invasive treatment and recovered without severe sequelae. CONCLUSIONS: AE is an adjunct treatment for liver injuries.Selective and/or super-selective AE should be advocated to decrease the incidence and severity of AE-related hepatobiliary complications. | Ya-Lin Kong Hong-Yi Zhang Xiao-Jun He Gang Zhao Cheng-Li Liu Mei Xiao Yu-Ying Zhen | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 2 |
| 20 | Arctic multiyear sea ice variability observed from satellites:a review显示文摘In comparison with seasonal sea ice(first-year ice,FY ice),multiyear(MY)sea ice is thicker and has more opportunity to survive through the summer melting seasons.Therefore,the variability of wintertime MY ice plays a vital role in modulating the variations in the Arctic sea ice minimum extent during the following summer.As a response,the ice-ocean-atmosphere interactions may be significantly affected by the variations in the MY ice cover.Satellite observations are characterized by their capability to capture the spatiotemporal changes of Arctic sea ice.During the recent decades,many active and passive sensors onboard a variety of satellites(QuikSCAT,ASCAT,SSMIS,ICESat,CryoSat-2,etc.)have been used to monitor the dramatic loss of Arctic MY ice.The main objective of this study is to outline the advances and remaining challenges in monitoring the MY ice changes through the utilization of multiple satellite observations.We summarize the primary satellite data sources that are used to identify MY ice.The methodology to classify MY ice and derive MY ice concentration is reviewed.The interannual variability and trends in the MY ice time series in terms of coverage,thickness,volume,and age composition are evaluated.The potential causes associated with the observed Arctic MY ice loss are outlined,which are primarily related to the export and melting mechanisms.In addition,the causes to the MY ice depletion from the perspective of the oceanic water inflow from Pacific and Atlantic Oceans and the water vapor intrusion,as well as the roles of synoptic weather,are analyzed.The remaining challenges and possible upcoming research subjects in detecting the rapidly changing Arctic MY ice using the combined application of multisource remote sensing techniques are discussed.Moreover,some suggestions for the future application of satellite observations on the investigations of MY ice cover changes are proposed. | BI Haibo LIANG Yu WANG Yunhe LIANG Xi ZHANG Zehua DU Tingqin YU Qinglong HUANG Jue KONG Mei HUANG Haijun | 2020 | Journal of Oceanology and Limnology2020，38，4： | 2 |
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