|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 2 | Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is an aggressive human cancer with increasing incidence worldwide.Multiple efforts have been made to explore pharmaceutical therapies to treat HCC,such as targeted tyrosine kinase inhibitors,immune based therapies and combination of chemotherapy.However,limitations exist in current strategies including chemoresistance for instance.Tumor initiation and progression is driven by reprogramming of metabolism,in particular during HCC development.Recently,metabolic associated fatty liver disease(MAFLD),a reappraisal of new nomenclature for nonalcoholic fatty liver disease(NAFLD),indicates growing appreciation of metabolism in the pathogenesis of liver disease,including HCC,thereby suggesting new strategies by targeting abnormal metabolism for HCC treatment.In this review,we introduce directions by highlighting the metabolic targets in glucose,fatty acid,amino acid and glutamine metabolism,which are suitable for HCC pharmaceutical intervention.We also summarize and discuss current pharmaceutical agents and studies targeting deregulated metabolism during HCC treatment.Furthermore,opportunities and challenges in the discovery and development of HCC therapy targeting metabolism are discussed. | Danyu Du Chan Liu Mengyao Qin Xiao Zhang Tao Xi Shengtao Yuan Haiping Hao Jing Xiong | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 27 |
| 3 | The WUSCHEL Related Homeobox Protein WOX7 Regulates the Sugar Response of Lateral Root Development in Arabidopsis thaliana显示文摘糖在底层支持侧面的根形成,但是在高 C/N 或 C/P 比率变得禁止。糖怎么压制侧面的根形成,然而是不清楚的。这里,我们报导那 WOX7, WUSCHEL 的一个成员联系了 homeobox (WOX ) 家庭抄写因素,以一种糖依赖者方式禁止侧面的根开发。侧面的根 primordia 的数字在 wox7 异种增加了,但是在植物减少了过去表示的 WOX7。表示 WOX7-VP16 熔化蛋白质的植物比 wox7 生产了甚至更侧面的根,建议 WOX7 充当在侧面的根开发的一个 transcriptional 抑压者。WOX7 根本被表示侧面的根的阶段开发,而是它首先涉及侧面的根开始。与这一致, wox7 异种仅仅在侧面的根开发的早阶段举办了一项更高有丝分裂的活动。进一步的研究建议 WOX7 通过房间周期基因的直接压抑调整侧面的根开发,特别地 CYCD6; 1。WOX7 表示被糖提高,由植物生长素减少了,但是没对盐和甘露糖醇作出回应。在 wox7 异种, lateralroot 形成上的糖的效果被减轻。这些结果一起建议 WOX7 在在植物联合侧面的根发展节目和糖地位起一个重要作用。 | Danyu Kong Yueling Hao Hongchang Cui | 2016 | Molecular Plant2016，9，2： | 10 |
| 4 | Recent development of A_2B_2O_7 system transparent ceramics显示文摘A_2B_2O_7 system compounds, which usually present three phase structures mainly based on the ionic radius ratios of r_A and r_B(r_A/r_B), have been studied for potential applications in many fields, such as thermal barrier coatings, luminescence powders, fast-ion conductors, photocatalysts, and matrices for immobilization of highly active radionuclides. Since 2005, La_2Hf_2O_7 was fabricated into transparent ceramics and much more attentions were paid on A_2B_2O_7 transparent ceramics for new applications. In this review, the development of A_2B_2O_7 system transparent ceramics was described. The structure characteristics, powder synthesis method, and sintering techniques of the final A_2B_2O_7 transparent ceramics were summarized. After that, the mostly reported A_2Hf_2O_7, A_2Zr_2O_7, and A_2Ti_2O_7 system transparent ceramics were systematically introduced. The potential application fields and future development trends were also discussed, focusing on scintillators, optical elements, and other luminescent materials. | Zhengjuan WANG Guohong ZHOU Danyu JIANG Shiwei WANG | 2018 | Journal of Advanced Ceramics2018，7，4： | 8 |
| 5 | A Phytophthora capsid Effector Targets ACD11 Binding Partners that Regulate ROS-Mediated Defense Response in Arabidopsis显示文摘Reactive oxygen species (ROS) play a vital role in plant immune response, but the genes involved in the regulation of ROS are scantily reported. Phytophthora pathogens produce a large number of effectors to promote infection, but the modes of action adopted are largely unknown. Here, we report that RxLR207 could activate ROS-mediated cell death in Nicotiana benthamiana and was essential for virulence of P. capsici. We found that this effector targeted BPA1 (binding partner of ACD11) and four members of BPLs (BPAl-Like proteins)in Arabidopsis, and the bpa1 and bpl mutants had enhanced ROS accumulation and cell death under biotic or abiotic stresses. Furthermore, we showed that BPA1 and several BPLs functioned redundantly in plant immunity to P. capsici. We discovered that BPA1 and all six BPLs interacted with ACD11, and stabilization of ACD11 was impaired in the bpa 1, bpl2, bpl3, and bpl4 mutants. RxLR207 could promote the degradation of BPA1, BPL1, BPL2, and BPL4 to disrupt ACD11 stabilization in a 26S proteasome-dependent manner. Taken together, these fin dings indicate the important roles of Arabidopsis BPA1 and its homologs in ROS homeostasis and defense response, highlighting the usefulness of a pathogen effector-directed approach as a promising strategy for the discovery of novel plant immune regulators. | Qi Li Gan Ai Danyu Shen Fen Zou Ji Wang Tian Bai Yanyu Chen Shutian Li Meixiang Zhang Maofeng Jing Daolong Dou | 2019 | Molecular Plant2019，12，4： | 5 |
| 6 | AtTHIC, a gene involved in thiamine biosynthesis in Arabidopsis thaliana显示文摘抗神经炎素(维生素 B (1 )) 是为有机体的必要混合物。它包含嘧啶戒指结构和噻唑戒指结构。抗神经炎素的这二一半独立地被综合然后一起联合了。这里,我们报导 AtTHIC 的分子的描述,它在 Arabidopsis 涉及抗神经炎素生合成。AtTHIC 类似于 Escherichia 关口 i ThiC,它在初核质涉及嘧啶生合成。AtTHIC 的 Heterologous 表示能机能上地补充 E 的 thiC 大美人异种。关口 i。由在它的倡导者区域的 T-DNA 插入的 AtTHIC 表示的 Downregulation 在植物导致了抗神经炎素内容的激烈的减小,击倒的变异的 thic1 在正常文化条件下面显示出白化体(白叶子) 和致命的显型。thic1 异种能被抗神经炎素的补充救,它的缺点功能能被 AtTHIC cDNA 的表示补充。短暂表示分析表明 AtTHIC 蛋白质指向质体和叶绿体。AtTHIC 强烈在叶子,花和 siliques 被表示, AtTHIC 的抄写是外来的抗神经炎素调整的 down。在结论, AtTHIC 是在 Arabidopsis 的抗神经炎素生合成小径涉及嘧啶合成的基因,并且我们的结果为阐明提供一些新线索在植物的抗神经炎素生合成的小径。 | Danyu Kong Yuxing Zhu Huilan Wu Xudong Cheng Hui Liang Hong-Qing Ling | 2008 | Cell Research2008，18，5： | 4 |
| 7 | Preclinical efficacy against acute myeloid leukaemia of SH1573, a novel mutant IDH2 inhibitor approved for clinical trials in China显示文摘Acute myeloid leukaemia(AML) is the most common form of acute leukaemia in adults,with increasing incidence with age and a generally poor prognosis.Almost 20% of AML patients express mutant isocitrate dehydrogenase 2(mIDH2),which leads to the accumulation of the carcinogenic metabolite 2-hydroxyglutarate(2-HG),resulting in poor prognosis.Thus,global institutions have been working to develop mIDH2 inhibitors.SH1573 is a novel mIDH2 inhibitor that we independently designed and synthesised.We have conducted a comprehensive study on its pharmacodynamics,pharmacokinetics and safety.First,SH1573 exhibited a strong selective inhibition of mIDH2 R140 Q protein,which could effectively reduce the production of 2-HG in cell lines,serum and tumors of an animal model.It could also promote the differentiation of mutant AML cell lines and granulocytes in PDX models.Then,it was confirmed that SH1573 possessed characteristics of high bioavailability,good metabolic stability and wide tissue distribution.Finally,toxicological data showed that SH1573 had no effects on the respiratory system,cardiovascular system and nervous system,and was genetically safe.This research successfully promoted the approval of SH1573 for clinical trials(CTR20200247).All experiments demonstrated that,as a potential drug against mIDH2 R140 Q acute myeloid leukaemia,SH1573 was effective and safe. | Zhiqiang Wang Zhibo Zhang Yong Li Li Sun Dezhen Peng Danyu Du Xian Zhang Luwei Han Liwen Zhao Ligong Lu Hongzhi Du Shengtao Yuan Meixiao Zhan | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 3 |
| 8 | Targeting of anti-microbial proteins to the hyphal surface amplifies protection of crop plants against Phytophthora pathogens显示文摘Phytophthora pathogens are a persistent threat to the world's commercially important agricultural crops,including potato and soybean.Current strategies aim at reducing crop losses rely mostly on disease-resistance breeding and chemical pesticides,which can be frequently overcome by the rapid adaptive evolution of pathogens.Transgenic crops with intrinsic disease resista nee offer a promising alternative and con tinue to be developed.Here,we explored Phytophthora-derived PI3P(phosphatidylinositol 3-phosphate)as a novel control target,using proteins that bind this lipid to direct secreted anti-microbial peptides and proteins(AMPs)to the surface of Phytophthora pathogens.In transgenic Nicotiana benthamiana,soybean,and potato plants,significantly enhanced resistance to different pathogen isolates was achieved by expression of two AMPs(GAFP1 or GAFP3 from the Chinese medicinal herb Gastrodia elata)fused with a PI3P-specific binding domain(FYVE).Using the soybean pathogen P.sojae as an example,we demonstrated that the FYVE domain could boost the activities of GAFPs in multiple independent assays,including those performed in vitro,in vivo,and in planta.Mutational analysis of P.sojae PI3K1 and PI3K2 genes of this pathogen confirmed that the enhanced activities of the targeted GAFPs were correlated with PI3P levels in the pathogen.Collectively,our study provides a new strategy that could be used to confer resistance not only to Phytophthora pathogens in many plants but also potentially to many other kinds of plant pathogens with unique targets. | Yang Zhou Kun Yang Qiang Yan Xiaodan Wang Ming Cheng Jierui Si Xue Xue Danyu Shen Maofeng Jing Brett M.Tyler Daolong Dou | 2021 | Molecular Plant2021，14，8： | 2 |
| 9 | Environmental behaviors of phoxim with two formulations in bamboo forest under soil surface mulching显示文摘Phoxim(emulsifiable concentrate(EC) and granules(G)) has been widely used in bamboo forests. The persistence and magnitude of phoxim residues in the crop and soil must be investigated to ensure human and environmental safety. The environmental behaviors of the two formulations were investigated in a bamboo forest under soil surface mulching conditions(CP) and non-covered cultivation conditions(NCP). The half-lives of phoxim in soil under the two conditions in soil were 4.1–6.2 days(EC) and 31.5–49.5 days(G),respectively. Phoxim in EC could be leached from the topsoil into the subsoil. A minimized leaching effect was observed for G under NCP. Inversely, an enhanced leaching effect was observed for G under CP. The G formulation resulted in more parent compound(in bamboo shoots) and metabolite(in soil) residues of phoxim than in the case of EC, especially under CP conditions. In addition, the intensity and duration of the formulation effect on soil p H adjustment from G were more obvious than that from EC. Results showed that the environmental behaviors(distribution, degradation, residue) of phoxim in the bamboo forest were significantly influenced by the type of formulation. The prolongation effect from phoxim G might cause persistence and long-term environmental risk. However,bamboo shoot consumption could be considered relatively safe after applying the recommended dose of the two phoxim formulations. | Yihua Liu Zhanglin Ni Runhong Mo Danyu Shen Donglian Zhong Fubin Tang | 2015 | Journal of Environmental Sciences2015，27，9： | 2 |
| 10 | Recent progresses in the phenomenological description for the indentation size effect in microhardness testing of brittle ceramics显示文摘The indentation hardness of a given material is usually load-dependent and such a phenomenon is generally referred to as the indentation size effect(ISE).The existence of ISE means that,if hardness is used as a material selection criterion,it is clearly insufficient to quote a single hardness number.Several empirical or semi-empirical equations,including the Meyer’s law,the Hays-Kendall approach,the energy-balance approach,the proportional specimen resistance(PSR)model and the modified PSR model,etc.,have been proposed for the description of the variation of the indentation size with the applied test load and for determining the so-called load-independent hardness.This paper reviews these existing empirical equations,with a special emphasis on the analysis and the application of the modified PSR model. | Danyu JIANG | 2012 | Journal of Advanced Ceramics2012，1，1： | 2 |
| 11 | SPINDLY, ERECTA, and Its Ligand STOMAGEN Have a Role in Redox-Mediated Cortex Proliferation in the Arabidopsis Root显示文摘反应的氧种类(ROS ) 对所有生活有机体有害,因此,他们必须被移开保证正常生长和开发。ROS 也正在表明分子,但是到目前为止,很少在植物对 ROS 感觉和发展反应的机制被知道。我们这里报导那氢过氧化物在 Arabidopsis 根和那导致外皮增长细长纤弱(间谍) ,连接 O 的 glucosamine acetyltransferase,由维持细胞的氧化还原作用动态平衡调整外皮增长。我们也发现在充满白氨酸的受体 kinase ERECTA 和它的通常认为的肽 ligand STOMAGEN 的变化在根外皮增长上堵住氢过氧化物的效果。然而,而额外的外皮房间从内皮被生产, ERECTA 和 STOMAGEN 在脉管的织物被表示,建议细胞间的发信号的参与。间谍 ERECTA 显得行动下游,因为间谍变化仍然在 erecta 异种背景引起了外皮增长。我们因此有不仅获得了卓见进由哪个间谍调整根开发的机制而且揭开为在植物发信号的 ROS 的一条新奇小径。对氧化应力的保护的机制也被讨论的调停氧化还原作用的外皮增长的重要性。 | Hongchang Cui Danyu Konga Pengcheng Wei Yueling Hao Keiko U. Torii Jin Suk Lee Jie Li | 2014 | Molecular Plant2014，7，12： | 2 |
| 12 | Sequence Diversity and Enzyme Activity of Ferric-Chelate Reductase LeFRO1 in Tomato显示文摘Ferric-chelate reductase which functions in the reduction of ferric to ferrous iron on root surface is a critical protein for iron homeostasis in strategy I plants.LeFRO1 is a major ferric-chelate reductase involved in iron uptake in tomato.To identify the natural variations of LeFRO1 and to assess their effect on the ferric-chelate reductase activity,we cloned the coding sequences of LeFRO1 from 16 tomato varieties collected from different regions,and detected three types of LeFRO1(LeFR01^(MM),LeFRO1^(Ailsa) and LeFRO1^(Monita)) with five amino acid variations at the positions 21,24,112,195 and 582.Enzyme activity assay revealed that the three types of LeFRO1 possessed different ferric-chelate reductase activity(LeFRO1^(Ailsa)>LeFRO1^(MM)>LeFRO1^(Monita)).The 112th amino acid residue Ala of LeFRO1 is critical for maintaining the high activity of ferric-chelate reductase,because modification of this amino acid resulted in a significant reduction of enzyme activity.Further,we showed that the combination of the amino acid residue Ile at the site 24 with Lys at the site 582 played a positive role in the enzyme activity of LeFRO1.In conclusion,the findings are helpful to understand the natural adaptation mechanisms of plants to iron-limiting stress,and may provide new knowledge to select and manipulate LeFRO1 for improving the iron deficiency tolerance in tomato. | Danyu Kong Chunlin Chen Huilan Wu Ye Li Junming Li Hong-Qing Ling | 2013 | Journal of Genetics and Genomics2013，40，11： | 2 |
| 13 | Factors affecting reproductive outcome of hysteroscopic adhesiolysis for Asherman's syndrome 显示文摘 | DanYu Tin-Chiu Li Enlan Xia | 2011 | Fertility and Sterility2011，15，3： | 1 |
| 14 | A 6-GHz ROM suitable for DDFS application in GaAs HBT technology显示文摘Read-only memory (ROM) is widely implemented as a phase-to-amplitude mapping block in direct digital frequency synthesizers (DDFS).This paper derives an equivalent model for the ROM in a DDFS to analyze and reduce the access time that is critical to the performance of the DDFS.Moreover,the signal skew observed in the simulation waveform is illustrated.The proposed 64×3-bit ROM is integrated as a part of an 8-bit DDFS,which operates functionally at 6 GHz.Measurement results demonstrate the improvement in the spur free dynamic range. | CHEN JianWu WANG Li WU DanYu CHEN GaoPeng JIN Zhi LIU XinYu | 2011 | Chinese Science Bulletin2011，56，21： | 1 |
| 15 | Effects of concentration, head group, and structure of surfactants on the degradation of phenanthrene显示文摘 | Danyue Jin Xia Jiang Xin Jing Ziqing Ou | 2006 | Journal of Hazardous Materials2006，，1： | 1 |
| 16 | A high-performance potassium-ion capacitor based on a porous carbon cathode originated from the Aldol reaction product显示文摘Potassium-ion capacitors(KICs) emerge as a promising substitute for the well-developed lithium-ion capacitors(LICs),however,the energy density of KICs is below expectations because of lacking a suitable electrical double-layer positive electrode.Using chemical activation of the Aldol reaction product of acetone with KOH,we synthesized a porous ca rbon with a Brunauer-Emmett-Teller surface area of up to 2947 m2/g and a narrow pore size distribution ranging from 1 nm to 3 nm.Half-cell(versus potassium metal) test demonstrates that this porous carbon has high capacitive performance in K+ based organic electrolytes.Furthermore,a novel KIC fabricated by this porous carbon as the cathode,yields high values of energy density and power density.The processes used to make this porous carbon are readily low-cost to fabricate metal-ion capacitors. | Xu Yu Mingjie Shao Xuemei Yang Chongxing Li Tong Li Danyu Li Rutao Wang Longwei Yin | 2020 | Chinese Chemical Letters2020，31，9： | 1 |
| 17 | BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells显示文摘 | Zhongwei Li Teng Fei Jianping Zhang Gaoyang Zhu Lu Wang Danyu Lu Xiaochun Chi Yan Teng Ning Hou Xiao Yang Hongquan Zhang Jing-Dong J. Han Ye-Guang Chen | 2012 | Cell Stem Cell2012，，2： | 1 |
| 18 | At tachment of ampicillin to expanded poly(tetrafluoroethylene) surface reactions leading to inhibition of microbial growth 显示文摘 | Aumsuwan N Danyus R C Heinhorst S Urban M W | 2008 | Biomacromolecules2008，9，： | 1 |
| 19 | 显示文摘 | Zhou Xingfu Chen Shuyi Zhang Danyu | 2006 | Langmuir2006，22，4： | 1 |
| 20 | Microwave - assisted organic acid pretrcatment for enzymatic hydroly- sis of rice straw 显示文摘 | Guifen Gong Danyu Liu Yudong Huang | 2010 | Biosystems engineering2010，107，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员