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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging显示文摘前列腺癌症和 prostatic 石灰化在老人有高发生。我们试图在检测前列腺癌症和 prostatic 石灰化调查危险性加权的成像的诊断能力。156 个人的一个全部的数字,与前列腺癌症包括 34 并且 122 在这研究与良性的前列腺被注册。计算断层摄影术,常规磁性的回声成像,散开加权的成像,和危险性加权的成像在所有病人上被执行。112 prostatic 石灰化在 87 个病人被检测。常规磁性的回声成像,明显的散开系数,和在检测前列腺癌症和 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性是计算的。McNemars Chi 平方测试被用来在在这些技术之间的敏感和特性比较差别。结果证明在检测 prostatic 癌症的过滤危险性的阶段图象的敏感和特性比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。另外,在检测 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性比得上计算断层摄影术的并且比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。在前列腺癌症给危险性加权的成像(SWI ) 的高发生反常,我们断定危险性加权的成像在检测前列腺癌症比常规磁性的回声成像,散开加权的成像,和计算断层摄影术更敏感、特定。而且,危险性加权的成像能识别类似于计算断层摄影术的 prostatic 石灰化,并且它比常规磁性的回声成像和散开加权的成像好一些。 | Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi E Mark Haacke Meiyun Wang | 2017 | Asian Journal of Andrology2017，19，4： | 7 |
| 3 | Examples of unusual ionospheric observations by the CSES prior to earthquakes显示文摘The CSES(China seismic electromagnetic satellite) was launched on February 2, 2018 in a circular polar orbit at an altitude of~507 km. One of the main objectives of CSES is to search for and characterize ionospheric perturbations that can be associated with seismic activities, to better understand the generation mechanism of such perturbations. Its scientific payload can measure a broad frequency range of electromagnetic waves and some important plasma parameters. This paper is a first-hand study of unusual observations recorded by the CSES over seismic regions prior to four earthquakes with M >7.0 since the satellite's launch. CSES detectors measured irregularities near the epicenter of these four earthquakes. It is already clear that data from instruments onboard the CSES will be of significant help in studies of characteristics of ionospheric perturbations related to earthquakes and their generation mechanisms. | Rui Yan XuHui Shen JianPing Huang Qiao Wang Wei Chu DaPeng Liu YanYan Yang HengXin Lu Song Xu | 2018 | Earth and Planetary Physics2018，2，6： | 7 |
| 4 | Development of a CH4 dehydroaromatization–catalyst regeneration fluidized bed system显示文摘A pilot-scale methane dehydroaromatization–H_2regeneration fluidized bed system(MDARS)was developed.In the MDARS,the catalyst circulation between a fluidized bed reactor and a fluidized bed regenerator with the help of a catalyst feeder allowed methane dehydroaromatization(MDA)and H_2regeneration to be carried out simultaneously,which is good for maintaining a stable MDA catalytic activity.A fixed bed reactor(FB)and a single fluidized bed reactor(SFB)were also used for a comparative study.The experimental results showed that the catalytic activity in the MDARS was more stable than that in the FB and SFB reactors.The effects of some parameters of MDARS on the CH_4conversion and product selectivity were investigated.To verify the feasibility and reliability of the MDARS,an eight-hour long-term test was carried out,which demonstrated that the operation of the MDARS was stable and that the catalytic activity remained stable throughout the entire experimental period. | Peng Yan Zhanguo Zhang Dapeng Li Xu Cheng Xinzhuang Zhang Fan Yang Chuanfeng Huang Xiaoxun Ma | 2018 | Chinese Journal of Chemical Engineering2018，26，9： | 5 |
| 5 | Application system and data description of the China Seismo-Electromagnetic Satellite显示文摘The China Seismo-Electromagnetic Satellite, launched into orbit from Jiuquan Satellite Launch Centre on February 2 nd, 2018, is China's first space satellite dedicated to geophysical exporation. The satellite carries eight scientific payloads including high-precision magnetometers to detect electromagnetic changes in space, in particular changes associated with global earthquake disasters. In order to encourage and facilitate use by geophysical scientists of data from the satellite's payloads, this paper introduces the application systems developed for the China Seismo-Electromagnetic Satellite by the Institute of Crustal Dynamics, China Earthquake Administration;these include platform construction, data classification, data storage, data format, and data access and acquisition. | JianPing Huang XuHui Shen XueMin Zhang HengXin Lu Qiao Tan Qiao Wang Rui Yan Wei Chu YanYan Yang DaPeng Liu Song Xu | 2018 | Earth and Planetary Physics2018，2，6： | 5 |
| 6 | Internet-based collaborative pseudo-dynamic testing of multi-span bridge structure显示文摘In this paper, the first Internet-based collaborative pseudo-dynamic testing of a multi-span bridge system in China's Mainland is presented in detail, which has been carried out by the collaboration of Hunan University (HNU), Harbin Institute of Technology (HIT) and Tsinghua University (TU) in China's Mainland, and the University of Southern California (USC) in the USA. The prototype system of Russion River Bridge at Southern California in America is illustrated. Different testing specimens, testing equipments and substructure boundary conditions at HNU and HIT laboratories are described. A network protocol platform for collaborative pseudo-dynamic testing, called NetSLab, and some function modules developed on the use of its standardized interface are introduced. Aiming at the MTS system widely used in structural testing, two approaches are presented to implement the communication interface between NetSLab and testing equipment, respectively, studied by HNU and HIT. The integrated networked testing system and collaborative testing procedures are presented. The testing results manifest that the networked collaborative testing system with powerful capability provides a testing platform with good coordination for complex models or actual structures, and achieves remote sharing of testing equipments. | Dapeng Wang a, Shizhu Tiana, Xinjiang Caia, Yunlei Fan b, Yan Xiaob,c a School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China b School of Civil Engineering, Hunan University, Changsha 410082, China c Department of Civil Engineering, University of Southern California, Los Angeles, CA 90089, USA | 2009 | Progress in Natural Science:Materials International2009，19，5： | 4 |
| 7 | mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines显示文摘Although IL-12 plays a critical role in priming Th1 and cytotoxic T lymphocyte(CTL) responses, Toll-like receptor(TLR) signaling only induces low amounts of IL-12 in dendritic cells and macrophages, implying the existence of stringent regulatory mechanisms. In this study, we sought to uncover the mechanisms underlying TLR-induced IL-12 expression and the Th1 response. By systemic screening, we identified a number of protein kinases involved in the regulation of TLRinduced IL-12 expression. In particular, PI3 K, ERK, and m TOR play critical roles in the TLR-induced Th1 response by regulating IL-12 and IL-10 production in innate immune cells. Moreover, we identified c-fos as a key molecule that mediates m TOR-regulated IL-12 and IL-10 expression in TLR signaling. Mechanistically, m TOR plays a crucial role in c-fos expression, thereby modulating NFκB binding to promoters of IL-12 and IL-10. By controlling the expression of a special innate gene program, m TOR can specifically regulate the TLR-induced T cell response in vivo. Furthermore, blockade of m TOR by rapamycin efficiently boosted TLR-induced antigen-specific T and B cell responses to HBV and HCV vaccines. Taken together, these results reveal a novel mechanism through which m TOR regulates TLR-induced IL-12 and IL-10 production, contributing new insights for strategies to improve vaccine efficacy. | Li He Aiping Zang Min Du Dapeng Ma Chuanping Yuan Chun Zhou Jing Mu Huanjing Shi Dapeng Li Xulin Huang Qiang Deng Jianhua Xiao Huimin Yan Lijian Hui Ke Lan Sidong Xiong Xiaoxia Li Zhong Huang Hui Xiao | 2015 | Virologica Sinica2015，30，3： | 2 |
| 8 | Development of a CLDN18.2-targeting immuno-PET probe for non-invasive imaging in gastrointestinal tumors显示文摘Claudin18.2(CLDN18.2)is a tight junction protein that is overexpressed in a variety of solid tumors such as gastrointestinal cancer and oesophageal cancer.It has been identified as a promising target and a potential biomarker to diagnose tumor,evaluate efficacy,and determine patient prognosis.TST001 is a recombinant humanized CLDN18.2 antibody that selectively binds to the extracellular loop of human Claudin18.2.In this study,we constructed a solid target radionuclide zirconium-^(89)(^(89)Zr)labled-TST001 to detect the expression of in the human stomach cancer BGC823CLDN18.2 cell lines.The[^(89)Zr]Zr-desferrioxamine(DFO)-TST001 showed high radiochemical purity(RCP,>99%)and specific activity(24.15±1.34 GBq/mmol),and was stable in 5%human serum albumin,and phosphate buffer saline(>85%RCP at 96 h).The EC_(50) values of TST001 and DFO-TST001 were as high as 0.413±0.055 and 0.361±0.058 nM(P>0.05),respectively.The radiotracer had a significantly higher average standard uptake values in CLDN18.2-positive tumors than in CLDN18.2-negative tumors(1.11±0.02 vs.0.49±0.03,P=0.0016)2 days post injection(p.i.).BGC823CLDN18.2 mice models showed high tumor/muscle ratios 96 h p.i.with[^(89)Zr]Zr-DFO-TST001 was much higher than those of the other imaging groups.Immunohistochemistry results showed that BGC823CLDN18.2 tumors were highly positive(+++)for CLDN18.2,while those in the BGC823 group did not express CLDN18.2().The results of ex vivo biodistribution studies showed that there was a higher distribution in the BGC823CLDN18.2 tumor bearing mice(2.05±0.16%ID/g)than BGC823 mice(0.69±0.02%ID/g)and blocking group(0.72±0.02%ID/g).A dosimetry estimation study showed that the effective dose of[^(89)Zr]Zr-DFO-TST001 was 0.0705 mSv/MBq,which is within the range of acceptable doses for nuclear medicine research.Taken together,these results suggest that Good Manufacturing Practices produced by this immuno-positron emission tomography probe can detect CLDN18.2-overexpressing tumors. | Yan Chen Xingguo Hou Dapeng Li Jin Ding Jiayue Liu Zilei Wang Fei Teng Hongjun Li Fan Zhang Yi Gu Steven Yu Xueming Qian Zhi Yang Hua Zhu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 2 |
| 9 | The Langmuir Probe onboard CSES: data inversion analysis method and first results显示文摘The Langmuir Probe(LAP), onboard the China Seismo-Electromagnetic Satellite(CSES), has been designed for in situ measurements of bulk parameters of the ionosphere plasma, the first Chinese application of in-situ measurement technology in the field of space exploration. The two main parameters measured by LAP are electron density and temperature. In this paper, a brief description of the LAP and its work mode are provided. Based on characteristics of the LAP, and assuming an ideal plasma environment, we introduce in detail a method used to invert the I-V curve; the data products that can be accessed by users are shown. Based on the LAP data available, this paper reports that events such as earthquakes and magnetic storms are preceded and followed by obvious abnormal changes. We suggest that LAP could provide a valuable data set for studies of space weather, seismic events, and the ionospheric environment. | Rui Yan YiBing Guan XuHui Shen JianPing Huang XueMin Zhang Chao Liu DaPeng Liu | 2018 | Earth and Planetary Physics2018，2，6： | 2 |
| 10 | 电磁监测试验卫星及其初步成果显示文摘As the first satellite of the China national geophysical field observation series of stllite missions,the China Seismo--Electromagnetic Satellite(CSES)was designed upon an optimized CAST2000 platform for a sun synchronous orbit.Onboard CSES,there are total eight types of scientific payloads including the Search-coil Magnetometer,Electric Field Detector,High Precision Magnetometer,GNSS Occupation Receiver,Plasma Analyzer,Langmuir Probe,Energetic Particle Detector Package,and a Three-band Transmitter to individually acquire the global eletromagnetic field,elec-tromagnetic waves,ionospheric plasma parameters as well as energetic particles.Up to now,CSES has been operating normally in orbit for 2 years.By using the various sensor data acquired by CSES,we have achieved scientfic research in the areas of the global geomagnetic field modeling,space weather,earthquake event analysis,the Lithosphere-Atmo-sphere-lonosphere coupling mechanism and so on.. | SHEN Xuhui ZEREN Zhima YUAN Shigeng DAI Jianping HUANG Jianping ZHU Xinghong YANG Yanyan YAN Rui ZHAO Shufan LIU Dapeng ZHANG Zhenxia WANG Qiao CHU Wei LU Hengxin XU Song GUO Feng TAN Qiao LI Wenjing ZHOU Na | 2020 | Aerospace China2020，21，1： | 2 |
| 11 | Environmental efficiency analysis of power industry in China based on an entropy SBM model显示文摘 | Yan Zhou Xinpeng Xing Kuangnan Fang Dapeng Liang Chunlin Xu | 2012 | Energy Policy2012，，： | 2 |
| 12 | HIV-1 Vif suppresses antiviral immunity by targeting STING显示文摘HIV-1 infection-induced cGAS–STING–TBK1–IRF3 signaling activates innate immunity to produce type I interferon(IFN).The HIV-1 nonstructural protein viral infectivity factor(Vif)is essential in HIV-1 replication,as it degrades the host restriction factor APOBEC3G.However,whether and how it regulates the host immune response remains to be determined.In this study,we found that Vif inhibited the production of type I IFN to promote immune evasion.HIV-1 infection induced the activation of the host tyrosine kinase FRK,which subsequently phosphorylated the immunoreceptor tyrosine-based inhibitory motif(ITIM)of Vif and enhanced the interaction between Vif and the cellular tyrosine phosphatase SHP-1 to inhibit type I IFN.Mechanistically,the association of Vif with SHP-1 facilitated SHP-1 recruitment to STING and inhibited the K63-linked ubiquitination of STING at Lys337 by dephosphorylating STING at Tyr162.However,the FRK inhibitor D-65495 counteracted the phosphorylation of Vif to block the immune evasion of HIV-1 and antagonize infection.These findings reveal a previously unknown mechanism through which HIV-1 evades antiviral immunity via the ITIM-containing protein to inhibit the posttranslational modification of STING.These results provide a molecular basis for the development of new therapeutic strategies to treat HIV-1 infection. | Yu Wang Gui Qian Lingyan Zhu Zhuo Zhao Yinan Liu Wendong Han Xiaokai Zhang Yihua Zhang Tingrong Xiong Hao Zeng Xianghui Yu Xiaofang Yu Xiaoyan Zhang Jianqing Xu Quanming Zou Dapeng Yan | 2022 | Cellular & Molecular Immunology2022，19，1： | 2 |
| 13 | A dual metal-organic framework strategy for synthesis of FeCo@NC bifunctional oxygen catalysts for clean energy application显示文摘Developing high efficient bifunctional oxygen electrocatalysts for clean energy applications like Zin-air battery(ZAB)is highly desired,because it would reduce the cost and speed up the practical application of ZAB.Here we use a dual metal-organic framework(MOF)synthesis strategy to prepare the N-doped carbon supported bimetallic FeCo nanoparticle catalysts(marked as FeCo@NC)by pyrolysis of Zn CoZIF/MIL-101(Fe)composite.The FeCo@NC exhibits remarkable electrocatalytic activity for ORR with half-wave potential of 0.89 V vs.the reversible hydrogen electrode(RHE)and robust durability for both ORR and OER(oxygen reduction reaction and oxygen evolution reaction),which is attributed to the generation of Fe_(0.26)Co_(0.74) crystalline phase and mesopores due to the dual-MOF synthesis strategy.The rechargeable ZAB based on FeCo@NC air electrode shows a maximum energy density of139.6 mW·cm^(-2) and excellent cyclic stability over 130 h,significantly surpassing the Pt and Ir-based ZAB.The present work provides a useful dual-MOF synthesis strategy for preparing high-performance multifunctional catalysts for ORR,OER and hydrogen evolution reaction(HER). | Jun Chen Liandong Li Liu Yang Chang Chen Shitao Wang Yan Huang Dapeng Cao | 2022 | Chinese Journal of Chemical Engineering2022，35，3： | 2 |
| 14 | Electrical and mechanical performance of graphene sheets exposed to oxidative environments显示文摘当暴露了到不同媒介时, Graphene 涂层被显示了保护内在的材料免受氧化的伤害。然而,在在房间温度的空中的 graphene 的使钝化的性质,对应于许多电子设备的操作条件,仍然保持不清楚。在这个工作,我们为时间的长时期在房间温度在空中分析 graphene/Cu 样品的氧化动力学(从 1 天到 113 天)用扫描电子显微镜学,传导性的原子力量显微镜学和钻电子显微镜学,并且我们把结果与那些为在 H2O2 对待的类似的样品获得了作比较。我们不同于暴露于 H2O2,在 graphene 领域边界的氧的累积在演变在的 graphene 表观察那一很控制了并且进步方法,在空中的 graphene 的本地氧化以一种混乱方式发生。在两个盒子中,在 graphene 领域边界形成的氧化物小丘能宣传到领域直到到达限制宽度和高度。我们的结果证明沿着域边界的内在的材料的本地氧化能戏剧性地减少粗糙,传导性,机械抵抗和 graphene 表的摩擦特征,哪个还原剂整个设备的性能。 | Mario Lanza Yan Wang Teng Gao Albin Bayerl Marc Porti Montserrat Nafria Yangbo Zhou Guangyin Jing Yanfeng Zhang Zhongfan Liu Dapeng Yu Huiling Duan | 2013 | Nano Research2013，6，7： | 2 |
| 15 | A Textural and Mineralogical Study of the Shanzhuang Banded Iron Formation, Southeastern Margin of the North China Craton: Implications for the Overprint History of Hydrothermal Alteration and Supergenesis after Mineralization显示文摘The newly discovered Shanzhuang BIF is hosted in the Shancaoyu Formation of the Taishan Group within the Eastern Block,southeastern margin of the North China Craton.The ores can be subdivided into three types in terms of mineral assemblages,corresponding to three types(Ⅰ,Ⅱ,Ⅲ).The element concentration of the type Ⅰ magnetite is similar to that of the type Ⅱ magnetite,while the type Ⅲ magnetite is similar to that of the schist.In general,magnetite and hemat ite grains from the ores show high concentrations of Mn(1317,1162 ppm),Co(787,1023 ppm),Al(2224,2435 ppm)and Ti(540,300 ppm),Whereas magnetite is depleted in Si(420 ppm)and hematite enriched in Si(1690 ppm).Detailed petrographic and mineral chemical analysis of magnetite,hematite,amphibole/hornblende and pyroxene,reveals that almost all the minerals occur as subhedral-anhedral grains with pits and fractures,and the BIF is recrystallized to metamorphic assemblages of high amphibolite facies.Hornblende is highly enriched in Fe,Mg and Ca,but depleted in K and Na,mostly belonging to magnesiohornblende.In addition,the ratios of Mg/(Mg+Fe^2+),Fe^3+/(Fe^3++Fe^2+),Si/(Si+Ti+Al)and Al/Si are 0.48-0.64,0.17-0.36,0.79-0.88 and 0.14-0.27,respectively.It is suggested that hornblende is neither a typical magmatic origin nor a typical metamorphic.Pyroxene has the characteristics of high Ca and Fe,but low Ti and Al,with end-member components En,Wo and Fs in the ranges of 25.22-28.64 wt%,43.71-46.40 wt%and 24.51-27.62 wt%,respectively,belonging to clinopyroxene,and mostly diopside,might be formed during the prograde metamorphism in the absence of H2 O.The carbonate such as dolomite-ankerite series is probably a precursor mineral of the BIF deposit.Mass mineral chemical and structural characteristics indicate that the Shanzhuang iron deposit has been subjected to varying degrees of oxidized hydrothermal superimposed reformation,metamorphism,and supergenesis after mineralization,during which some elements have been migrated in some degree. | ZHANG Yan YU Xuefeng PENG Qiming LI Dapeng LI Xiaowei SHEN Kun ZHANG Shangkun SHANWei | 2020 | Acta Geologica Sinica(English Edition)2020，94，6： | 1 |
| 16 | Modulation of host signaling in the inflammatory response by enteropathogenic Escherichia coli virulence proteins显示文摘为了成功地感染,招待房间并且躲避主机免疫者反应,一个类型 III 分泌物系统(T3SS ) 被伤寒通常使用细菌的病原体象 enteropathogenic Escherichia coli (EPEC ) 那样。最近的调查结果表明了各种各样的受动器通过 T3SS 被注入主人房间并且在煽动性的发信号的小径上施加禁止的效果,破坏对这些病原体的有免疫力的回答。这里,我们考察针对探讨 EPEC 受动器蛋白质调制的几条重要煽动性的发信号小径的调整的最近的研究,例如原子 factor-B ( NF-B )和 激活mitogen 的蛋白质 kinase ( MAPK )小径,它在这块未经勘探的地和帮助里提供卓见进未完成的工作为 EPEC 受动器在煽动性的发信号的网络识别新奇位置。 | Xiaonan Zhuang Zijuan Chen Chenxi He Lin Wang Ruixue Zhou Dapeng Yan Baoxue Ge | 2017 | Cellular & Molecular Immunology2017，14，3： | 1 |
| 17 | Environmental efficiency of industrial sectors in China: An improved weighted SBM model显示文摘 | Yan Zhou Dapeng Liang Xinpeng Xing | 2013 | Mathematical and Computer Modelling . 2013 (5-6)2013，，： | 1 |
| 18 | Comparison of anew gold-immunochromatographic assay for the detection ofantibodies against avian influenza virus with hemagglutinationinhibition and agar gel immunodiffusion assays显示文摘 | Peng Dapeng Hu Sishun Hua Yan | 2007 | VeterinaryImmunology and Immunopathology2007，117，12： | 1 |
| 19 | Contributions of phosphorus on sedimentary phosphorus bioavailability under sediment resuspension conditions显示文摘 | Li Dapeng Huang Yong Fan Chengxin Yuan Yan | 2011 | Chemical Engineering Journal2011，，3： | 1 |
| 20 | The effect of sevoflu- rane anesthesia on cognitive function and the expression of insulin - like growth factor- 1 in CA1 re#on of hippecampus in old rats显示文摘 | PENG Sheng ZHANG Yan SUN Dapeng | 2011 | Molecular Biology Reports2011，38，2： | 1 |
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