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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Interactions Between the Intestinal Microbiome and Liver Diseases显示文摘 | Bernd Schnabl David A. Brenner | 2014 | Gastroenterology2014，，： | 7 |
| 3 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 4 | Biosorption potential of cerium ions using Spirulina biomass显示文摘Two types of cyanobacteria of the genus Arthrospira(commonly known as Spirulina) were tested for biosorption of cerium(III) ions from aqueous solutions. An endemic type(ES) found in the northern Negev desert, Israel, and a commercial powder(CS) were used in this study. Biosorption was evaluated as a function of p H, contact time, initial metal concentration, number of sorption-desorption cycles, and salt concentration. The optimum p H range for biosorption was found to be 5.0–5.5. The kinetic characteristics of both Spirulina types were found to be highly compatible with a pseudo-second order kinetic model. The adsorption isotherms of both types were found to be well-suited to Langmuir and Freundlich adsorption isotherms. Maximum biosorption uptakes, according to the Langmuir model, were 18.1 and 38.2 mg/g, for ES and CS, respectively. Sodium chloride concentrations of up to 5 g/L had a minor effect on cerium biosorption. Desorption efficiency was found to be greater than 97% with 0.1 mol/L HNO_3 after three sorption-desorption cycles, without significant loss in the biosorption capacity. The results indicated the feasibility of cerium recovery from industrial wastes using Spirulina biomass. | David Sadovsky Asher Brenner Boaz Astrachan Boaz Asaf Raphael Gonen | 2016 | Journal of Rare Earths2016，34，6： | 4 |
| 5 | Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice显示文摘 | Kouichi Miura Yuzo Kodama Sayaka Inokuchi Bernd Schnabl Tomonori Aoyama Hirohide Ohnishi Jerrold M. Olefsky David A. Brenner Ekihiro Seki | 2010 | Gastroenterology2010，，1： | 3 |
| 6 | Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium显示文摘 | Vishnudutt Purohit J. Christian Bode Christiane Bode David A. Brenner Mashkoor A. Choudhry Frank Hamilton Y. James Kang Ali Keshavarzian Radhakrishna Rao R. Balfour Sartor Christine Swanson Jerrold R. Turner | 2008 | Alcohol2008，，5： | 3 |
| 7 | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease显示文摘 | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Ian Nicholas Crispe | 2011 | Gastroenterology Research and Practice2011，，： | 3 |
| 8 | Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis显示文摘 | Kojiro Taura Samuele De Minicis Ekihiro Seki Etsuro Hatano Keiko Iwaisako Christoph H. Osterreicher Yuzo Kodama Kouichi Miura Iwao Ikai Shinji Uemoto David A. Brenner | 2008 | Gastroenterology2008，，5： | 3 |
| 9 | Toll-Like Receptor 2–Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice显示文摘 | Phillipp Hartmann Michael Haimerl Magdalena Mazagova David A. Brenner Bernd Schnabl | 2012 | Gastroenterology2012，，5： | 2 |
| 10 | Recent advancement of molecular mechanisms of liver fibrosis显示文摘 | Ekihiro Seki David A. Brenner | 2015 | J Hepatobiliary Pancreat Sci2015，，： | 2 |
| 11 | Toll‐like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice显示文摘 | Kouichi Miura Ling Yang Nico van Rooijen David A. Brenner Hirohide Ohnishi Ekihiro Seki | 2013 | Hepatology2013，，2： | 2 |
| 12 | Anti-fibrogenic strategies and the regression of fibrosis显示文摘 | Tatiana Kisseleva David A. Brenner | 2011 | Best Practice & Research Clinical Gastroenterology2011，，2： | 2 |
| 13 | Solar Forcing of Drought Frequency in the Maya Lowlands 显示文摘 | David A Hodell Mark Brenner Jason H Curtis | 2001 | SCIENCE2001，292，18： | 1 |
| 14 | Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice显示文摘 | Fanli Meng Kai Wang Tomonori Aoyama Sergei I. Grivennikov YongHan Paik David Scholten Min Cong Keiko Iwaisako Xiao Liu Mingjun Zhang Christoph H. ?sterreicher Felix Stickel Klaus Ley David A. Brenner Tatiana Kisseleva | 2012 | Gastroenterology2012，，3： | 1 |
| 15 | Rippe,new aspects of hepatic fibrosis显示文摘 | David A Brenner Tim Waterboer Sung Kyu Choi Jeffrey N Lindquist | 2000 | J Hepatol2000，32，： | 1 |
| 16 | Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43^(G298S) ALS mouse model显示文摘Background:In vivo diffusion tensor imaging(DTI)of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis(ALS).Methods:Ten mice with TDP-43^(G298S) overexpression under control of the Thy1.2 promoter and 10 wild type(wt)underwent longitudinal DTI scans at 11.7 T,including one baseline and one follow-up scan with an interval of about 5months.Whole brain-based spatial statistics(WBSS)of DTI-based parameter maps was used to identify longitudinal alterations of TDP-43^(G298S) mice compared to wt at the cohort level.Results were supplemented by tractwise fractional anisotropy statistics(TFAS)and histological evaluation of motor cortex for signs of neuronal loss.Results:Alterations at the cohort level in TDP-43^(G298S) mice were observed cross-sectionally and longitudinally in motor areas M1/M2 and in transcallosal fibers but not in the corticospinal tract.Neuronal loss in layer V of motor cortex was detected in TDP-43^(G298S) at the later(but not at the earlier)timepoint compared to wt.Conclusion:DTI mapping of TDP-43^(G298S) mice demonstrated progression in motor areas M1/M2.WBSS and TFAS are useful techniques to localize TDP-43^(G298S) associated alterations over time in this ALS mouse model,as a biological marker. | Hans-Peter Müller David Brenner Francesco Roselli Diana Wiesner Alireza Abaei Martin Gorges Karin M.Danzer Albert C.Ludolph William Tsao Philip C.Wong Volker Rasche Jochen H.Weishaupt Jan Kassubek | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 17 | Hepatic stellate cells as a target for the treatment of liver fibrosis 显示文摘 | Bamon B David A Brenner | 2001 | Seminars in Liver Disease2001，21，3： | 1 |
| 18 | Influence of vegeta-tion change on watershed hydrology: implications for paleocli-matic interpretation of lacustrine 显示文摘 | Michael F David A Mark Brenner | 2002 | Journey of Paleolimnolo-gy2002，27，： | 1 |
| 19 | The use of RO to remove emerging micropollutants following CAS/UF or MBR treatment of municipal wastewater显示文摘 | Eyal Sahar Inbal David Yelena Gelman Haim Chikurel Avi Aharoni Rami Messalem Asher Brenner | 2010 | Desalination2010，，1： | 1 |
| 20 | Outcome of a Workshop on Applications of Protein Models in Biomedical Research显示文摘 | Torsten Schwede Andrej Sali Barry Honig Michael Levitt Helen M. Berman David Jones Steven E. Brenner Stephen K. Burley Rhiju Das Nikolay V. Dokholyan Roland L. Dunbrack Krzysztof Fidelis Andras Fiser Adam Godzik Yuanpeng Janet Huang Christine Humblet Matt | 2009 | Structure2009，，2： | 1 |
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