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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Liver transplantation for metastatic neuroendocrine tumor: A case report and review of the literature显示文摘Neuroendocrine tumors are divided into gastrointestinal carcinoids and pancreatic neuroendocrine tumors. The WHO has updated the classification of these lesions and has abandoned the term 'carcinoid'. Both types of tumors are divided into functional and non-functional tumors. They are characterized by slow growth and frequent metastasis to the liver and may be limited to the liver for long periods. The therapeutic approach to hepatic metastases should consider the number and distribution of the liver metastases as well as the severity of symptoms related to hormone production and tumor bulk. Surgery is generally considered as the first line therapy. In patients with unresectable liver metastases,alternative treatments are dependent on the type and the growth rate. Initial treatments consist of long acting somatostatin analogs and/or interferon. Streptozocinbased chemotherapy is usually reserved for symptomatic patients with rapidly advancing disease, but generally the therapy is poorly tolerated and its effects are short-lived.Locoregional therapy directed such as hepatic-artery embolization and chemoembolization, radiofrequency thermal ablation and cryosurgery, is often used instead of systemic therapy, if the disease is limited to the liver.However, liver transplantation should be considered in patients with neuroendocrine metastases to the liver that are not accessible to curative or cytoreductive surgery and if medical or locoregional treatment has failed and if there are life threatening hormonal symptoms. We report a case of liver transplantation for metastatic neuroendocrine tumor of unknown primary source and provide a detailed review of the world literature on this controversial topic. | Wojciech C Blonski K Rajender Reddy Abraham Shaked Evan Siegelman David C Metz | 2005 | World Journal of Gastroenterology2005，11，48： | 5 |
| 3 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 4 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 5 | Phytosterols - health benefits and potential concerns : a review 显示文摘 | David K T Shirley C C | 2005 | Nutrition Research2005，，25： | 1 |
| 6 | Simultaneous measurement of phytoplanktonic primary production,nutrient and light availability along a turbid,eutrophic UK east coast estuary(the Colne Estuary)显示文摘 | ESRA K GRAHAM J C U DAVID B N | 2002 | Marine Ecology Progress Series2002，231，： | 1 |
| 7 | Genome sequence and analysis of the soil cellulolytic actinomyeete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alia L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 8 | Ramsdellite-MnO2 for lithium batteries: The ramsdellite to spinel transformation显示文摘 | THACKERAY M M ROSSOUW M H GUMMOW R J LILES D C PEARCE K KOCK A D DAVID W I F HULLS S | 1993 | Electrochim Acta1993，38，9： | 1 |
| 9 | Basis for fusion inhibition by peptides: analysis of the heptad repeat regions of the fusion proteins from Nipah and Hendra viruses, newly emergent zoonotic paramyxoviruses显示文摘 | Xu Y H Gao S David K C | 2004 | Biochemical and Biophysical Research Communications2004，315，3： | 1 |
| 10 | Relationships between Leaf Area Index and Landsat TM Spectral Vegetation Indices across Three Temperate Zone Sites 显示文摘 | David PT Warren B C Robert E K | 1999 | Remote Sensing of Environment1999，70，： | 1 |
| 11 | Visible light photoredox catalysis with transition metal complexes:applications in organic synthesis显示文摘 | Christopher K P Danica A R David W C M | 2013 | Chem Rev2013，113，： | 1 |
| 12 | Creep properties andprecipitate evolution in A1-Li alloys microalloyed with Sc and Yb显示文摘 | Matthew E K David N S David C D | 2012 | Materials Science and Engineering A2012，550，： | 1 |
| 13 | y aminobutyric acid stimulates ethyIene biosynthesis in sunflower显示文摘 | ARUMUGAM K PARIANA T CHINNAPPA C C DAVID M R | 1997 | Plant Physiology1997，115，1： | 1 |
| 14 | Real-time landslide warning during heavy rainfall显示文摘 | David K K Raymond C W Robert K M | 1987 | Science1987，238，： | 1 |
| 15 | Ethnic and Socioeconomic Differences in Cardiovascular Disease Risk Factors显示文摘 | Marilyn A Helena C David K | 1998 | JAMA1998，280，： | 1 |
| 16 | Low cost scaleable parallel image processing system 显示文摘 | DAVID M H SHIR1SH P K C ALLAN H | 2001 | Micro- processors and Microsystems2001，25，14： | 1 |
| 17 | Quantitative measurement of deformation - induced martensite in 304 stainless steel by X - ray diffration 显示文摘 | Amar K De David C Murdock Martin C Mataya | 2004 | Scripta Materialia2004，50，： | 1 |
| 18 | Application of isotope dilution for precise measurement of Zr/Hf and 176Hf/177Hf ratios by mass spectrometry (ID-TIMS/ID-MC-ICP-MS) 显示文摘 | David K Birck J L Telouk P Allègre C J | 1999 | Chem Geol1999，157，12： | 1 |
| 19 | Fault tree analysis and treatment plant instrumentation 显示文摘 | David L K Richard C A | 1981 | Journal of Water Pollution Control Federation1981，53，1： | 1 |
| 20 | Reactive power optimisation with voltage stability consideration in power market显示文摘 | Lin X David A K Yu C W | 2003 | IEE Proceedings: Generation Transmission and Distribution2003，150，3： | 1 |
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