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| 1 | PM_(2.5) in China:Measurements,sources,visibility and health effects,and mitigation显示文摘Concern over the health effects of fine particles in the ambient environment led the U.S. Environmental Protection Agency to develop the first standard for PM2.5(particulate matter less than 2.5 jxm) in 1997. The Particle Technology Laboratory at the University of Minnesota has helped to establish the PM2.5 standard by developing many instruments and samplers to perform atmospheric measurements. In this paper, we review various aspects of PM2.5, including its measurement, source apportionment, visibility and health effects, and mitigation. We focus on PM2.5 studies in China and where appropriate, compare them with those obtained in the U.S. Based on accurate PM2.5 sampling, chemical analysis, and source apportionment models, the major PM2.5 sources in China have been identified to be coal combustion, motor vehicle emissions, and industrial sources. Atmospheric visibility has been found to correlate well with PM2.5concentration. Sulfate, ammonium, and nitrate carried by PM2.5, commonly found in coal burning and vehicle emissions, are the dominant contributors to regional haze in China. Short-term exposure to PM2.5 is strongly associated with the increased risk of morbidity and mortality from cardiovascular and respiratory diseases in China. The strategy for PM2.5 mitigation must be based on reducing the pollutants from the two primary sources of coal-fired power plants and vehicle emissions. Although conventional Particulate Emission Control Devices(PECD) such as electrostatic precipitators in Chinese coal-fired power plants are generally effective for large particles, most of them may not have high collection efficiency of PM2.5.Baghouse filtration is gradually incorporated into the PECD to increase the PM2.5 collection efficiency.By adopting stringent vehicle emissions standard such as Euro 5 and 6, the emissions from vehicles can be gradually reduced over the years. An integrative approach, from collaboration among academia,government, and industries, can effectively manage and mitigate the PM2.5 pollution in China. | David Y.H.Pui Sheng-Chieh Chen Zhili Zuo | 2014 | Particuology2014，12，2： | 171 |
| 2 | The Global Boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the uppermost of the Ordovician System)显示文摘 | Xu Chen Jiayu Rong Junxuan Fan Renbin Zhan Charles E. Mitchell David A. T. Harper Michael J. Melchin Ping'an Peng Stan C. Finney Xiaofeng Wang | 2006 | Episodes2006，29，3： | 61 |
| 3 | aunalysis of the Genome Sequence of the Medicinal Plant Salvia miltiorrhiza显示文摘 | Haibin Xu Jingyuan Song Hongmei Luo Yujun Zhang Qiushi Li Yingjie Zhu Jiang Xu Ying Li Chi Song Bo Wang Wei Sun Guoan Shen Xin Zhang Jun Qian Aijia Ji Zhichao Xu Xiang Luo Liu He Chuyuan Li Chao Sun Haixia Yah Guanghong Cui Xiwen Li Xian 'en Li Jianhe Wei Juyan Liu Yitao Wang Alice Hayward David Nelson Zemin Ning Reuben J. Peters Xiaoquan Qi Shilin Chen | 2016 | Molecular Plant2016，9，6： | 70 |
| 4 | Trend of declining stroke mortality in China:reasons and analysis显示文摘Introduction There is a downward trend of stroke-related mortality in the USA.By reviewing all published articles on stroke mortality in China,we analysed its trend and possible factors that have influenced the trend.Methods Both English and Chinese literatures were searched on the mortality of stroke or cerebrovascular diseases in China.Potential papers related to this topic were identified from PubMed,Medline,Embase,Cochrane Library,Wanfang Database,SINOMED and China National Knowledge Infrastructure databases.Results Comparing the results from the most recent population-based epidemiological survey and databank from the national Center for Disease Control and Prevention,the age-adjusted stroke mortality rate has shown a downward trend among both urban and rural population in the past 30 years in China.Comparing with 30 years ago,the rate of stroke mortality has decreased by more than 31%in urban/suburban population and 11%in rural population.In men,the age-adjusted stroke mortality rate decreased by 18.9%and in women by 24.9%between 1994 and 2013.Factors that may have contributed to the trend of decreased stroke mortality rate include(1)improved healthcare coverage and healthcare environment;(2)improved treatment options and medical technology;(3)support by government to educate the public on stroke and stroke prevention;and(4)improved public knowledge on stroke.Conclusions The age-adjusted stroke mortality rate in China has shown a downward trend among both urban and rural population in the past 30 years.The major influencing factors that helped in reducing stroke mortality in China included improved healthcare coverage,healthcare environment,the updated treatment options and modern medical technology. | Wenzhi Wang David Wang Hongmei Liu Haixin Sun Bin Jiang Xiaojuan Ru Dongling Sun Zhenghong Chen Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，3： | 52 |
| 5 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 6 | Impact of oxygation on soil respiration, yield and water use efficiency of three crop species显示文摘Oxygation refers to irrigation of crops with aerated water,through air injection using the venturi principle or the supply of hydrogen peroxide in the root zone,both using subsurface drip irrigation(SDI)system.Oxygation improves water use efficiency(WUE),producing more yield and,and therefore,optimizes the use of drip and SDI.But the efficiency of oxygation is quite possibly dependent on a number of factors.The primary objective of this study was,therefore,to quantify the effects of oxygation,emitter depths and soil type on crop root zone oxygen content,soil respiration,plant physiological response,biomass yield,quality and WUE of three crop species.Methods This study investigated the potential of oxygation to enhance soil respiration,plant growth,yield and water use efficiencies(WUE)of cotton and wheat in experiments in enclosed heavy-duty concrete troughs(tubs)and pineapple and cotton in field experiments.Experimental treatments in tubs for wheat included comparisons between two soil types(vertisol and ferrosol)and superimposed were two oxygation methods(Mazzei air injector and Seair Diffusion System)compared to a control,and for cotton,emitters at two depths using Mazzei air injectors were compared to a control.The field experiments compared Mazzei air injectors and a control for cotton in Emerald and pineapple in Yeppoon,both in central Queensland,Australia.Important findings In all experiments,soil oxygen content and soil respiration markedly increased in response to the oxygation treatments.The O2 concentration in the crop root zone increased by 2.4–32.6%,for oxygation compared to control at the same depth.The soil respiration increased by 42–100%.The number of wheat ears,leaf dry weight and total dry matter were significantly greater in Mazzei and Seair oxygation compared to the control.Fresh biomass of wheat increased by 11 and 8%,and dry weight of wheat increased by 8 and 3%in Mazzei and Seair oxygation treatments compared to the control,respectively.Likewise,the irrigation water use efficiency increased with oxygation compared to the control in wheat.The yield,WUE and number of other physiological parameters in wheat were enhanced in vertisol compared to ferrosol.The seed cotton yield in the tub experiment increased with oxygation by 14%,and significant differences for fresh biomass,dry matter and yield were also noted between oxygation and the control in the field.Lint yield and WUE both increased by 7%using Mazzei in the cotton field trial during 2008–09.There were significant effects of oxygation on pineapple fresh biomass,and dry matter weight,industry yield and a number of quality parameters were significantly improved.The total fruit yield and marketable increased by 17 and 4%and marketable WUE increased by 3%using Mazzei.Our data suggest that the benefits of oxygation are notable not only for dicotyledonous cotton but also for monocotyledonous wheat and pineapple representing different rooting morphologies and CO_(2) fixation pathways. | Xinming Chen Jay Dhungel Surya P.Bhattarai Manouchehr Torabi Lance Pendergast David J.Midmore | 2011 | Journal of Plant Ecology2011，4，4： | 46 |
| 7 | The Critical Rainfall Characteristics for Torrents and Debris Flows in the Wenchuan Earthquake Stricken Area显示文摘Critical rainfall assessment is a very important tool for hazard management of torrents and debris flows in mountainous areas. The Wenchuan Earthquake 2008 caused huge casualties and property damages in the earthquake-stricken area,which also generated large quantities of loose solid materials and increased occurrence probabilities of debris flows. There is an urgent need to quantify the critical rainfall distribution in the area so that better hazard management could be planned and if real time rainfall forecast is available,torrent and debris flow early-warning could be issued in advance. This study is based on 49-year observations (1954-2003) of up to 678 torrent and debris flow events. Detailed contour maps of 1 hour and 24 hour critical rainfalls have been generated (Due to the data limitation,there was insufficient 10 minute critical rainfall to make its contour map). Generally,the contour maps from 1 hour and 24 hours have similar patterns. Three zones with low,medium and high critical rainfalls have been identified. The characteristics of the critical rainfall zones are linked with the local vegetation cover and land forms. Further studies and observations are needed to validate the finding and improve the contour maps. | CHEN Ningsheng YANG Chenglin ZHOU Wei HU Guisheng LI Huan David Han | 2009 | Journal of Mountain Science2009，6，4： | 35 |
| 8 | FXR: a metabolic regulator and cell protector显示文摘Farnesoid X 受体(FXR ) 是激活 ligand 的抄写因素的原子受体总科的一个成员。作为一个新陈代谢的管理者, FXR 戏在胆汁酸,胆固醇,类脂化合物,和葡萄糖新陈代谢给角色调音。因此, FXR 是为很多新陈代谢的混乱的一个潜在的药目标,特别那些与新陈代谢的症候群有关。更最近,我们的组和其它扩大了 FXR 的功能到非常新陈代谢的规定,它在肠,肝新生,和 hepatocarcinogenesis 包括抗菌剂生长。这些新调查结果比以前想建议 FXR 有宽广得多的角色,并且也为多重疾病作为一个药目标加亮 FXR。这评论总结 FXR 的基本信息,但是集中于它的新功能。 | Yan-Dong Wang Wei-Dong Chen David D Moore Wendong Huang | 2008 | Cell Research2008，18，11： | 33 |
| 9 | 陆面水文过程与大气模式的耦合及其在黑河流域的应用显示文摘陆面过程模式对陆面水文过程有比较详尽的描述,然而,目前的陆面水文过程只考虑了垂直方向的水分运移,比较适合平坦地区的模拟,而在地形坡度较大的山区只考虑垂直方向的水分移动是不够的,尤其是目前随着计算机条件提高,分辨率越来越高,地表水以及土壤水的侧向流动成为山区水文过程必须考虑的部分。同时,目前的陆面过程模式中的径流量是作为诊断量处理,不参与运算。针对以上问题,对Noah陆面过程模式进行了改进,增加了地表积水和积水蒸发、坡面汇流方案、次表面流方案,并且将Routing模块通过次网格过程与大气中尺度模式MM5耦合,发展了高分辨率大气-水文耦合模式。运用发展的高分辨率大气-水文耦合模式,对黑河流域中上游2003年6月23-25日降水过程进行了模拟,研究了陆面水循环过程对大气场的影响。结果表明陆面水循环过程对近地层大气影响很大,首先影响了土壤的湿度与蒸发,进而对边界层稳定性,云结构、云水、雨水含量产生影响,对区域降水也有一定影响。 | 高艳红 程国栋 崔文瑞 CHEN Fei David Gochis YU Wei | 2006 | 地球科学进展2006，21，12： | 29 |
| 10 | Environmental records of lacustrine sediments in different time scales:Sediment grain size as an example显示文摘Sediment grain size is a conventional proxy of climatic changes. Larger sediment grain size is often interpreted to indicate dry climate during lower lake level while smaller sedi- ment grain size implies wet climate during higher lake level. Through detailed study on sediment grain sizes in Lake Erhai and Lake Chenghai, this paper reveals the different indication signifi- cances of sediment grain sizes in different time scales, different resolution investigations. For long time-scale and low resolution (102a or 103a) studies, larger sediment grain size indicates lower lake level, smaller lake area and drier climate while smaller sediment grain size indicates higher lake level, larger lake area and wetter climate. For short time-scale and high resolution (a or 10a) studies, larger sediment grain size reflects more rainfall and wetter climate while smaller sediment grain size reflects less rainfall and drier climate. Environmental information revealed by lacustrine sediment records is often different in different time scales because of the variance of sedimentation resolution, sampling resolution and dating precision. Therefore, paleoclimate im- plications of environmental proxies in long time-scale and low resolution investigations could not be mechanically applied to short time-scale and high resolution studies. Only after synthetically analyzing the influence manner and extent of all factors on the sediment records in different time scales, can credible conclusions be obtained. | CHEN Jing’an1, WAN Guojiang1, David Dian Zhang2, ZHANG Feng1 & HUANG Ronggui1 1. State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 2. Department of Geography and Geology, University of Hong Kong, Pokfulam Road, Hong Kong, China | 2004 | Science China Earth Sciences2004，47，10： | 27 |
| 11 | On the tuning of electrical and thermal transport in thermoelectrics: an integrated theory–experiment perspective显示文摘During the last two decades,we have witnessed great progress in research on thermoelectrics.There are two primary focuses.One is the fundamental understanding of electrical and thermal transport,enabled by the interplay of theory and experiment;the other is the substantial enhancement of the performance of various thermoelectric materials,through synergistic optimisation of those intercorrelated transport parameters.Here we review some of the successful strategies for tuning electrical and thermal transport.For electrical transport,we start from the classical but still very active strategy of tuning band degeneracy(or band convergence),then discuss the engineering of carrier scattering,and finally address the concept of conduction channels and conductive networks that emerge in complex thermoelectric materials.For thermal transport,we summarise the approaches for studying thermal transport based on phonon–phonon interactions valid for conventional solids,as well as some quantitative efforts for nanostructures.We also discuss the thermal transport in complex materials with chemical-bond hierarchy,in which a portion of the atoms(or subunits)are weakly bonded to the rest of the structure,leading to an intrinsic manifestation of part-crystalline part-liquid state at elevated temperatures.In this review,we provide a summary of achievements made in recent studies of thermoelectric transport properties,and demonstrate how they have led to improvements in thermoelectric performance by the integration of modern theory and experiment,and point out some challenges and possible directions. | Jiong Yang Lili Xi Wujie Qiu Lihua Wu Xun Shi Lidong Chen Jihui Yang Wenqing Zhang Ctirad Uher David J Singh | 2016 | npj Computational Materials2016，，1： | 24 |
| 12 | Phases of Environmental Evolution Indicated by Primary Chemical Elements and Paleontological Records in the Upper Pleistocene-Holocene Series for the Salawusu River Valley,China显示文摘岩性学的研究,沉积褪色,分发整齐 ofSiO_2 和 Al_2O_3 满足并且 Al_2O_3/SiO_2 比率允许我们划分 Milanggouwan 节在中国的 Salawusu 河山谷代表进六个片断的上面的 Pleistocene-HoloceneSeries : MGS1, MGS2, MGS3, MGS4, MGS5 和 MGS6。边界为 MGS1 ( Dishaogouwan 和 DagouwanFormations )变老, MGS2 (上面的 Chengchuan 形成), MGS3 (中间的 Chengchuan 形成), MGS4 (更低的 Chengchuan 形成),分别地, MGS5 ( Salawusu 形成的大多数阶层)和 MGS6 ( Salawusu 形成的底部和 Lishi 形成的顶)从深海沉积或大陆冰川 MIS1 , MIS2 , MIS3 , MIS4 , MIS5 和 MIS6 对应于那些。MGS5 能被细分进五子段(MGS5a, MGS5b, MGS5c, MGS5d 和 MGS5e ) ,这些子段的边界年龄分别地 MIS5a, MIS5b, MIS5c, MIS5d 和 MIS5e 对应于那些。古环境和苍白的生态学由主要化学元素,石块脊椎动物,软体动物和花粉谷物显示了的 Basedon ,我们假设 MGS5 的子段匹配的那 MGS1 , MGS2 , MGS3 , MGS4 , MGS5 和 MGS6and 为在深海沉积和大陆冰川的氧同位素的相应阶段,并且潜水艇以气候的人物, MIS5 上演进一步向现象解释那决定了晚第四级的阶层的形成和 Salawusu 的古生物学这些现象在世界气候联系到变化(并且特别地在东方亚洲季风) 在冰川、间冰期的句号期间。 | LI Baosheng WEN Xiaohao QIU Shifan David Dian ZHANG DU Shuhuan CHEN Deniu OU Xianjiao NIU Dongfeng | 2007 | Acta Geologica Sinica(English Edition)2007，81，4： | 17 |
| 13 | Distinctive melt activity and chromite mineralization in Luobusa and Purang ophiolites, southern Tibet: constraints from trace element compositions of chromite and olivine显示文摘To investigate the factors controlling the mineralization in ophiolites we systematically compared the petrology and mineral compositions of the harzburgites/lherzolites, dunites and chromitites in the Luobusa and Purang ophiolites. Generally, the petrological features and trace element compositions of chromite and olivine in peridotite and chromitite are distinctly different between the two ophiolites.In Luobusa, boninitic melts are inferred to have interacted with the harzburgites and modified the distributions of some trace elements(e.g., Ni, Mn and V) in chromite and olivine. The subsequently formed dunites and chromitites experienced significant elemental exchange. In contrast, the Purang ophiolite contains a wider range of chromitite compositions and records diverse melt activities, such as the growth of relatively abundant secondary clinopyroxene. The metasomatic melts were enriched in Al and depleted in Si, Na and highly incompatible trace elements(e.g., Nb, Zr). Such melts resemble MORBlike melts proposed in the literature but are assumed to be more hydrous than typical MORB because of presence of hydrous minerals. The parental magmas of the Purang dunites and intermediate chromitites are inferred to be compositionally intermediate between boninitic and MORB-like melts. In addition,the more refractory nature of the Luobusa harzburgites facilitated a high Cr concentration gradient with the interacting melts, making it easier to increase Cr in the melts. Crystallization of clinopyroxene and amphibole in the Purang ophiolite accommodated significant amounts of Cr and water, respectively,and negatively affected Cr concentration and chromite crystallization. The concentration of chromite to form chromitites requires the presence of focused melt channels. | Benxun Su Meifu Zhou Jiejun Jing Paul T. Robinson Chen Chen Yan Xiao Xia Liu Rendeng Shi Davide Lenaz Yan Hu | 2019 | Science Bulletin2019，64，2： | 15 |
| 14 | The endless tale of non-homologous end-joining显示文摘脱氧核糖核酸双海滨裂缝(DSB ) 被离子辐射和反应的氧种类在房间介绍。另外,他们通常在 V (D) J 再结合期间被产生,发展中的免疫系统的一个必要方面。有效地修理这些 DSB 的失败能在更高的脊椎动物的免疫系统导致染色体破裂,房间死亡,癌症的发作,和缺点。幸好,所有哺乳动物的房间拥有调停的二条酶的小径 DSB 的修理:相应再结合并且非相应加入结束(NHEJ ) 。NHEJ 过程利用捕获破脱氧核糖核酸分子的两结束,在 synaptic DNA 蛋白质建筑群一起带他们,并且最后修理脱氧核糖核酸裂缝的酶。在这评论,在 NHEJ 过程起一个作用的所有已知的酶被讨论,为这些酶的合作的一个工作模型在 DSB 修理期间被介绍。 | Eric Weterings David J Chen | 2008 | Cell Research2008，18，1： | 13 |
| 15 | Abscisic Acid Receptors:Past,Present and Future显示文摘Abscisic acid(ABA) is the key plant stress hormone.Consistent with the earlier studies in support of the presence of both membrane-and cytoplasm-localized ABA receptors,recent studies have identified multi-ple ABA receptors located in various subcellular locations.These include a chloroplast envelope-localized receptor(the H subunit of Chloro-plast Mg2+-chelatase/ABA Receptor),two plasma membrane-localized receptors(G-protein Coupled Receptor 2 and GPCR-type G proteins),and one cytosol/nucleus-localized Pyrabactin Resistant(PYR)/PYR-Like(PYL)/Regulatory Component of ABA Receptor 1(RCAR).Although the downstream molecular events for most of the identified ABA receptors are currently unknown,one of them,PYR/PYL/RCAR was found to directly bind and regulate the activity of a long-known central regulator of ABA signaling,the A-group protein phosphatase 2C(PP2C).Together with the Sucrose Non-fermentation Kinase Subfamily 2(SnRK2s) protein kinases,a central signaling complex(ABA-PYR-PP2Cs-SnRK2s) that is responsible for ABA signal perception and transduction is supported by abundant genetic,physiological,biochemical and structural evidence.The identification of multiple ABA receptors has advanced our understanding of ABA signal perception and transduction while adding an extra layer of complexity. | Jianjun Guo Xiaohan Yang David J. Weston Jin-Gui Chen | 2011 | Journal of Integrative Plant Biology2011，53，6： | 13 |
| 16 | Hybrid graphene metasurfaces for highspeed mid-infrared light modulation and single-pixel imaging显示文摘During the past decades,major advances have been made in both the generation and detection of infrared light;however,its efficient wavefront manipulation and information processing still encounter great challenges.Efficient and fast optoelectronic modulators and spatial light modulators are required for mid-infrared imaging,sensing,security screening,communication and navigation,to name a few.However,their development remains elusive,and prevailing methods reported so far have suffered from drawbacks that significantly limit their practical applications.In this study,by leveraging graphene and metasurfaces,we demonstrate a high-performance free-space mid-infrared modulator operating at gigahertz speeds,low gate voltage and room temperature.We further pixelate the hybrid graphene metasurface to form a prototype spatial light modulator for high frame rate single-pixel imaging,suggesting orders of magnitude improvement over conventional liquid crystal or micromirror-based spatial light modulators.This work opens up the possibility of exploring wavefront engineering for infrared technologies for which fast temporal and spatial modulations are indispensable. | Beibei Zeng Zhiqin Huang Akhilesh Singh Yu Yao Abul K.Azad Aditya D.Mohite Antoinette J.Taylor David R.Smith Hou-Tong Chen | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 17 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 18 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 19 | A large outbreak of acute gastroenteritis caused by the human norovirus GII.17 strain at a university in Henan Province,China显示文摘Background:Human noroviruses are a major cause of viral gastroenteritis and are the main etiological agents of acute gastroenteritis outbreaks.An increasing number of outbreaks and sporadic cases of norovirus have been reported in China in recent years.There was a large acute gastroenteritis outbreak at a university in Henan Province,China in the past five years.We want to identify the source,transmission routes of the outbreak by epidemiological investigation and laboratory testing in order to provide the effective control measures.Methods:The clinical cases were investigated,and analysed by descriptive epidemiological methods according to factors such as time,department,grade and so on.Samples were collected from clinical cases,healthy persons,the environment,water,and food at the university.These samples were tested for potential bacteria and viruses.The samples that tested positive for norovirus were selected for whole genome sequencing and the sequences were then analysed.Results:From 4 March to 3 April 2015,a total of 753 acute diarrhoea cases were reported at the university;the attack rate was 3.29%.The epidemic curve showed two peaks,with the main peak occurring between 10 and 20 March,accounting for 85.26%of reported cases.The rates of norovirus detection in samples from confirmed cases,people without symptoms,and environmental samples were 32.72%,17.39%,and 9.17%,respectively.The phylogenetic analysis showed that the norovirus belonged to the genotype GII.17.Conclusions:This is the largest and most severe outbreak caused by genotype GII.17 norovirus in recent years in China.The GII.17 viruses displayed high epidemic activity and have become a dominant strain in China since the winter of 2014,having replaced the previously dominant GII.4 Sydney 2012 strain. | Xue-Yong Huang Jia Su Qian-Chao Lu Shi-Zheng Li Jia-Yong Zhao Meng-Lei Li Yi Li Xiao-Jing Shen Bai-Fan Zhang Hai-Feng Wang Yu-Jiao Mu Shu-Yu Wu Yan-Hua Du Li-Cheng Liu Wei-Jun Chen John David Klena Bian-Li Xu | 2017 | Infectious Diseases of Poverty2017，6，1： | 10 |
| 20 | A 2-kb Mycovirus Converts a Pathogenic Fungus into a Beneficial Endophyte for Brassica Protection and Yield Enhancement显示文摘Mycoviruses are viruses that infect fungi,and hypovirulence-associated mycoviruses have the potential to control fungal diseases.However,it is unclear how mycovirus-mediated hypovirulent strains live and survive in the field,and no mycovirus has been applied for field crop protection.In this study,we found that a previously identified small DNA mycovirus(SsHADV-1)can convert its host,Sclerotinia sclerotiorum,from a typical necrotrophic pathogen to a beneficial endophytic fungus.SsHADV-1 downregulates the expression of key pathogenicity factor genes in S.sclerotiorum during infection.When growing in rapeseed,the SsHADV-1-infected strain DT-8 significantly regulates the expression of rapeseed genes involved in defense,hormone signaling,and circadian rhythm pathways.As a result,plant growth is promoted and disease resistance is enhanced.Field experiments showed that spraying DT-8 at the early flowering stage can reduce the disease severity of rapeseed stem rot by 67.6%and improve yield by 14.9%.Moreover,we discovered that SsHADV-1 could also infect other S.sclerotiorum strains on DT-8-inoculated plants and that DT-8 could be recovered from dead plants.These findings suggest that the mycoviruses may have the ability to shape the origin of endophytism.Our discoveries suggest that mycoviruses may influence the origin of endophytism and may also offer a novel strategy for disease control in which mycovirus-infected strains are used to improve crop health and release mycoviruses into the field. | Hongxiang Zhang Jiatao Xie Yanping Fu Jiasen Cheng Zheng Qu Zhenzhen Zhao Shufen Cheng Tao Chen Bo Li Qianqian Wang Xinqiang Liu Binnian Tian David B.Collinge Daohong Jiang | 2020 | Molecular Plant2020，13，10： | 9 |
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