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| 1 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 2 | 动态88小时:美国地质调查局国家地震信息中心对2011年3月11日M_W9.0日本地震的响应显示文摘引言
2011年3月11日日本本州岛东海岸附近海域发生的M9.0地震(Tohoku earthquake,以下称“东日本大地震”——译者注)及其引发的海啸造成数以万计的人员死亡,造成的财产损失可能超过1万亿美元,这是有历史记录以来最严重的自然灾害之一。 | Gavin P Hayes Paul S Earle Harley M Benz David J Wald Richard W Briggs 左玉玲(译) 郑需要(校) | 2011 | 国际地震动态2011，，8： | 4 |
| 3 | 美国国家级干旱监测业务产品介绍显示文摘 | Mark Svoboda Doug LeComte Mike Hayes Richard Heim Karin Gleason Jim Angel Brad Rippey Rich Tinker Mike Palecki David Stooksbury David Miskus Scott Stephens 王涓力(译) | 2006 | 干旱气象2006，24，1： | 3 |
| 4 | Stem cell differentiation and human liver disease显示文摘Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology. | Wen-Li Zhou Claire N Medine Liang Zhu David C Hay | 2012 | World Journal of Gastroenterology2012，18，17： | 3 |
| 5 | Management and Outcome of Permanent Pacemaker and Implantable Cardioverter-Defibrillator Infections显示文摘 | Muhammad R. Sohail Daniel Z. Uslan Akbar H. Khan Paul A. Friedman David L. Hayes Walter R. Wilson James M. Steckelberg Sarah Stoner Larry M. Baddour | 2007 | Journal of the American College of Cardiology2007，，18： | 2 |
| 6 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 7 | Global spread of dengue virus types: mapping the 70-year history显示文摘 | Jane P. Messina Oliver J. Brady Thomas W. Scott Chenting Zou David M. Pigott Kirsten Duda Samir Bhatt Leah Katzelnick Rosalind E. Howes Katherine E. Battle Cameron P. Simmons Simon I. Hay | 2013 | Trends in Microbiology2013，，： | 2 |
| 8 | Energy security and sustainability in Northeast Asia显示文摘 | David von Hippel Tatsujiro Suzuki James H. Williams Timothy Savage Peter Hayes | 2009 | Energy Policy2009，，11： | 1 |
| 9 | Value pricing: How low can you go?显示文摘 | David K. Hayes Lynn M. Huffman | 1995 | Cornell Hotel and Restaurant Administration Quarterly1995，，1： | 1 |
| 10 | Pacemaker lead extraction with the laser sheath: results of the pacing lead extraction with the excimer sheath (PLEXES) trial 1 1 No financial support was received for performing the procedures or collecting the data, or for data analysis.显示文摘 | Bruce L Wilkoff Charles L Byrd Charles J Love David L Hayes T.Duncan Sellers Raymond Schaerf Victor Parsonnet Laurence M Epstein Robert A Sorrentino Christopher Reiser | 1999 | Journal of the American College of Cardiology1999，，6： | 1 |
| 11 | Helping Teachers to Cope with Large Classes 显示文摘 | David | 1997 | ELTJournal1997，52，： | 1 |
| 12 | Using concept mapping to measure learning quality显示文摘 | David Hay Ian Kinchin | | 0，，2： | 1 |
| 13 | Optoelectronic Device Simulation of Bragg Reflectors and Their Influence on Surface-Emitting Laser Characteristics显示文摘 | David W Winston Russell E Hayes | 1998 | IEEE Journal of Quantum Electronics1998，34，4： | 1 |
| 14 | Dynamic Response of Layered Structures Subject to Blast Effects of Non-Nuclear Weaponry显示文摘 | Tedesco J W Hayes J R David J R | 1987 | Computers and Structures1987，26，12： | 1 |
| 15 | Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual显示文摘 | S.Eva Singletary Craig Allred Pandora Ashley Lawrence W Bassett Donald Berry Kirby I Bland Patrick I Borgen Gary M Clark Stephen B Edge Daniel F Hayes Lorie L Hughes Robert V.P Hutter Monica Morrow David L Page Abram Recht Richard L Theriault Ann Thor Don | 2003 | Surgical Clinics of North America2003，，4： | 1 |
| 16 | Long-term changes in serum cholesterol level does not influence the progression of coronary calcification显示文摘 | Alexander Tenenbaum Joseph Shemesh Nira Koren-Morag Enrique Z. Fisman Yehuda Adler Ilan Goldenberg David Tanne Ilan Hay Ehud Schwammenthal Michael Motro | 2010 | International Journal of Cardiology2010，，2： | 1 |
| 17 | Modifying the treatment:Pa- tient compliance, patient control, and medical care 显示文摘 | HAYES - BAUTISTA DAVID E | 1976 | Social Sci- ence and Medicine1976，10，5： | 1 |
| 18 | Helping teach- ers to cope with large class 显示文摘 | David Hayes | 1997 | ELT1997，，： | 1 |
| 19 | Cyclic Model of information seeking in hyperlinked environments:The role of goals selfefficacy and intrinsic motivation 显示文摘 | David P Song M Hayes A | 2006 | Human Compu Studi2006，65，5： | 1 |
| 20 | Pathogenesis of bronchopulmonary dysplasia显示文摘 | Don Hayes Jr David J Feola Brian S Murphy | 2010 | Respiration2010，79，： | 1 |
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