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| 1 | Corticosteroids for severe influenza pneumonia: A critical appraisal显示文摘Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit(ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in s evere influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials. | Wagner Luis Nedel David Garcia Nora Jorge Ibrain Figueira Salluh Thiago Lisboa Pedro Póvoa | 2016 | World Journal of Critical Care Medicine2016，5，1： | 3 |
| 2 | Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus显示文摘 | David Z.I. Cherney Bruce A. Perkins Nima Soleymanlou Maria Maione Vesta Lai Alana Lee Nora M. Fagan Hans J. Woerle Odd Erik Johansen Uli C. Broedl Maximilian von Eynatten | 2014 | Circulation2014，，： | 2 |
| 3 | Radiofrequency Ablation in 447 Complex Unresectable Liver Tumors: Lessons Learned显示文摘 | Richard J. Bleicher MD David P. Allegra MD Dean T. Nora MD Thomas F. Wood MD Leland J. Foshag MD Anton J. Bilchik MD PhD | 2003 | Annals of Surgical Oncology2003，，1： | 1 |
| 4 | Variable length equalizers for broadband mobile systems 显示文摘 | Felip R P Noras J M David G M | 2000 | Proceedings of IEEE VTC2000，9，5： | 1 |
| 5 | An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium显示文摘 | Brintha K. Enestvedt Ian M. Gralnek Nora Mattek David A. Lieberman Glenn Eisen | 2008 | Gastrointestinal Endoscopy2008，，3： | 1 |
| 6 | Sodium-Glucose Cotransporter 2 Inhibition and Glycemic Control in Type 1 Diabetes: Results of an 8-Week Open-Label Proof-of-Concept Trial显示文摘 | Perkins Bruce A Cherney David ZI Partridge Helen Soleymanlou Nima Tschirhart Holly Zinman Bernard Fagan Nora M Kaspers Stefan Woerle Hans-Juergen Broedl Uli C Johansen Odd-Erik | 2014 | Diabetes Care2014，，5： | 1 |
| 7 | Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet显示文摘 | Nora Chen Rebecca Bezzina Edward Hinch Paul A. Lewandowski David Cameron-Smith Michael L. Mathai Markandeya Jois Andrew J. Sinclair Denovan P. Begg John D. Wark Harrison S. Weisinger Richard S. Weisinger | 2009 | Nutrition Research2009，，11： | 1 |
| 8 | Technical Details of Sentinel Lymph Node Mapping in Colorectal Cancer and Its Impact on Staging显示文摘 | Sukamal Saha MD FRCS (C) David Wiese MD Julio Badin MD Thomas Beutler MD Dean Nora MD B. K. Ganatra MD Dilip Desai MD S. Kaushal MD M. Nagaraju MD Madan Arora MD Trevor Singh MD | 2000 | Annals of Surgical Oncology2000，，2： | 1 |
| 9 | Impact of Induction Chemotherapy and Preoperative Chemoradiotherapy on Operative Morbidity and Mortality in Patients with Locoregional Adenocarcinoma of the Stomach or Gastroesophageal Junction显示文摘 | Kazumasa Fujitani Jaffer A. Ajani Christopher H. Crane Barry W. Feig Peter W. Pisters Nora Janjan Garrett L. Walsh Stephen G. Swisher Ara A. Vaporciyan David Rice Angela Welch Jackie Baker Josephine Faust Paul F. Mansfield | 2007 | Annals of Surgical Oncology2007，，7： | 1 |
| 10 | Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation 显示文摘 | David H Michael A Nora T | 1999 | Cancer Res1999，59，： | 1 |
| 11 | Impact of Induction Chemotherapy and Preoperative Chemoradiotherapy on Operative Morbidity and Mortality in Patients with Locoregional Adenocarcinoma of the Stomach or Gastroesophageal Junction显示文摘 | Kazumasa Fujitani Jaffer A. Ajani Christopher H. Crane Barry W. Feig Peter W. Pisters Nora Janjan Garrett L. Walsh Stephen G. Swisher Ara A. Vaporciyan David Rice Angela Welch Jackie Baker Josephine Faust Paul F. Mansfield | 2007 | Annals of Surgical Oncology2007，，7： | 1 |
| 12 | Immunohistochemistry as First-line Screening for Detecting Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome: A 2-antibody Panel May be as Predictive as a 4-antibody Panel显示文摘 | Jinru Shia Laura H. Tang Efsevia Vakiani Jose G. Guillem Zsofia K. Stadler Robert A. Soslow Nora Katabi Martin R. Weiser Philip B. Paty Larissa K. Temple Garrett M. Nash W. Douglas Wong Kenneth Offit David S. Klimstra | 2009 | The American Journal of Surgical Pathology2009，，： | 1 |
| 13 | Variable length equalizers for broadband mobile systems显示文摘 | Felip R P Noras J M David G M | 2000 | Proceedings of IEEE VTC2000，9，5： | 1 |
| 14 | American Society for Therapeutic Radiology and Oncology (ASTRO) and American College of Radiology (ACR) Practice Guideline for the Performance of Stereotactic Body Radiation Therapy显示文摘 | Louis Potters Brian Kavanagh James M. Galvin James M. Hevezi Nora A. Janjan David A. Larson Minesh P. Mehta Samuel Ryu Michael Steinberg Robert Timmerman James S. Welsh Seth A. Rosenthal | 2010 | International Journal of Radiation Oncology, Biology, Physics2010，，2： | 1 |
| 15 | Effects of Hypothermia for Perinatal Asphyxia on Childhood Outcomes显示文摘 | Denis Azzopardi Brenda Strohm Neil Marlow Peter Brocklehurst Aniko Deierl Oya Eddama Julia Goodwin Henry L. Halliday Edmund Juszczak Olga Kapellou Malcolm Levene Louise Linsell Omar Omar Marianne Thoresen Nora Tusor Andrew Whitelaw A. David Edwards | 2014 | The New England Journal of Medicine2014，，： | 1 |
| 16 | Is the gag reflex useful in the management of swallowing problems in acute stroke显示文摘 | Deborah R David S Nora D | 2005 | Dysphagia2005，20，2： | 1 |
| 17 | Radiofrequency Ablation in 447 Complex Unresectable Liver Tumors: Lessons Learned显示文摘 | Richard J. Bleicher MD David P. Allegra MD Dean T. Nora MD Thomas F. Wood MD Leland J. Foshag MD Anton J. Bilchik MD PhD | 2003 | Annals of Surgical Oncology2003，，1： | 1 |
| 18 | Digestibility,Antioxidant and Anti-Inflammatory Activities of Pecan Nutshell(Carya illioinensis)Extracts显示文摘Phenolic compounds are related to high biological activity,avoiding oxidation in food and human systems.Nutshells are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be studied.This research aimed to evaluate the antioxidant(DPPH,ABTS,FRAP and hemolysis)and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019,as well as the in vitro digestibility of their phenolic compounds,including flavonoids.Results showed that extracts from the crop production cycle 2018 obtained the highest yield,while those from 2019 contained the highest concentration of phenolic compounds,flavonoids and antioxidant capacity determined by DPPH(22.96 mmol ET),ABTS(91.55 mmol ET)and inhibition of hemolysis(92.12%).The anti-inflammatory activity exhibited an inhibition of the elastase enzyme up to 50 min and the bioaccessibility of phenolic compounds reached up to 32%.These results showed that pecan nutshell extracts are an important source of biologically active compounds,thus,they are suitable to be used as commodities in different fields such as agricultural,food and pharmaceutical industries.Future studies must be carried out in order to elucidate the activity of nutshell extracts within in vivo systems. | María Janeth Rodríguez-Roque Carmen Lizette Del-Toro-Sánchez Janet Madeline Chávez-Ayala Ricardo Iván González-Vega Liliana Maribel Pérez-Pérez Esteban Sánchez-Chávez Nora AideéSalas-Salazar Juan Manuel Soto-Parra Rey David Iturralde-García María Antonia Flores-Córdova | 2022 | Journal of Renewable Materials2022，10，10： | 0 |
| 19 | Septic shock 3.0 criteria application in severe COVID-19 patients:An unattended sepsis population with high mortality risk显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)can be associated with life-threatening organ dysfunction due to septic shock,frequently requiring intensive care unit(ICU)admission,respi-ratory and vasopressor support.There-fore,clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ support.Although most patients with severe COVID-19 meet the Sepsis-3.0 criteria for septic shock,it has been increasingly recognized that hyperlactatemia is frequently absent,possibly leading to an underestimation of illness severity and mortality risk.AIM To identify the proportion of severe COVID-19 patients with vasopressor support requirements,with and without hyperlactatemia,and describe their clinical outcomes and mortality METHODS We performed a single-center prospective cohort study.All adult patients admitted to the ICU with COVID-19 were included in the analysis and were further divided into three groups:Sepsis group,without both criteria;Vasoplegic Shock group,with persistent hypotension and vasopressor support without hyperlactatemia;and Septic Shock 3.0 group,with both criteria.COVID-19 was diagnosed using clinical and radiologic criteria with a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)positive RT-PCR test.RESULTS 118 patients(mean age 63 years,87%males)were included in the analysis(n=51 Sepsis group,n=26 Vasoplegic Shock group,and n=41 Septic Shock 3.0 group).SOFA score at ICU admission and ICU length of stay were different between the groups(P<0.001).Mortality was significantly higher in the Vasoplegic Shock and Septic Shock 3.0 groups when compared with the Sepsis group(P<0.001)without a significant difference between the former two groups(P=0.713).The log rank tests of Kaplan-Meier survival curves were also different(P=0.007).Ventilator-free days and vasopressor-free days were different between the Sepsis vs Vasoplegic Shock and Septic Shock 3.0 groups(both P<0.001),and similar in the last two groups(P=0.128 and P=0.133,respectively).Logistic regression identified the maximum dose of vasopressor therapy used(AOR 1.046;95%CI:1.012-1.082,P=0.008)and serum lactate level(AOR 1.542;95%CI:1.055-2.255,P=0.02)as the major explanatory variables of mortality rates(R20.79).CONCLUSION In severe COVID-19 patients,the Sepsis 3.0 criteria of septic shock may exclude approximately one third of patients with a similarly high risk of a poor outcome and mortality rate,which should be equally addressed. | JoséPedro Cidade LM Coelho Vasco Costa Rui Morais Patrícia Moniz Luís Morais Pedro Fidalgo António Tralhão Carolina Paulino David Nora Bernardino Valério Vítor Mendes Camila Tapadinhas Pedro Povoa | 2022 | World Journal of Critical Care Medicine2022，11，4： | 0 |
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