|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th e role of ferroptosis in ionizing radiation-induced cell death and tumor suppression显示文摘Ferroptosis,a form of regulated cell death caused by lipid peroxidation,was recently identified as a natural tumor suppression mechanism.Here,we show that ionizing radiation(IR)induces ferroptosis in cancer cells.Mechanistically,IR induces not only reactive oxygen species(ROS)but also the expression of ACSL4,a lipid metabolism enzyme required for ferroptosis,resulting in elevated lipid peroxidation and ferroptosis.ACSL4 ablation largely abolishes IR-induced ferroptosis and promotes radioresistance.IR also induces the expression of ferroptosis inhibitors,including SLC7A11 and GPX4;as an adaptive response.IR-or KEAP1 deficiencyinduced SLC7A11 expression promotes radioresistance through inhibiting ferroptosis.Inactivating SLC7A11 or GPX4 with ferroptosis inducers(FINs)sensitizes radioresistant cancer cells and xenograft tumors to IR.Furthermore,radiotherapy induces ferroptosis in cancer patients,and increased ferroptosis correlates with better response and longer survival to radiotherapy in cancer patients.Our study reveals a previously unrecognized link between IR and ferroptosis and indicates that further exploration of the combination of radiotherapy and FINs in cancer treatment is warranted. | Guang Lei Yilei Zhang Pranavi Koppula Xiaoguang Liu Jie Zhang Steven HLin Jaffer AAjani Qin Xiao Zhongxing Liao Hui Wang Boyi Gan | 2020 | Cell Research2020，30，2： | 88 |
| 2 | Intensity-modulated radiation therapy with concurrent chemotherapy for locally advanced cervical and upper thoracic esophageal cancer显示文摘AIM: To evaluate the dosimetry, efficacy and toxicity of intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy for patients with locally advanced cervical and upper thoracic esophageal cancer. METHODS: A retrospective study was performed on 7 patients who were definitively treated with IMRT and concurrent chemotherapy. Patients who did not receive IMRT radiation and concurrent chemotherapy were not included in this analysis. IMRT plans were evaluated to assess the tumor coverage and normal tissue avoidance. Treatment response was evaluated and toxicities were assessed. RESULTS: Five- to nine-beam IMRT were used to deliver a total dose of 59.4-66 Gy (median: 64.8 Gy) to the primary tumor with 6-MV photons. The minimum dose received by the planning tumor volume (PTV) of the gross tumor volume boost was 91.2%-98.2% of the prescription dose (standard deviation [SD]: 3.7%-5.7%). The minimum dose received by the PTV of the clinical tumor volume was 93.8%-104.8% (SD: 4.3%-11.1%) of the prescribed dose. With a median follow-up of 15 mo (range: 3-21 mo), all 6 evaluable patients achieved complete response. Of them, 2 developed localrecurrences and 2 had distant metastases, 3 survived with no evidence of disease. After treatment, 2 patients developed esophageal stricture requiring frequent dilation and 1 patient developed tracheal-esophageal fi stula. CONCLUSION: Concurrent IMRT and chemotherapy resulted in an excellent early response in patients with locally advanced cervical and upper thoracic esophageal cancer. However, local and distant recurrence and toxicity remain to be a problem. Innovative approaches are needed to improve the outcome. | Shu-Lian Wang Zhongxing Liao Helen Liu( Jaffer Ajani Stephen Swisher James D Cox Ritsuko Komaki | 2006 | World Journal of Gastroenterology2006，12，34： | 27 |
| 3 | Updated Analysis of SWOG-Directed Intergroup Study 0116: A Phase III Trial of Adjuvant Radiochemotherapy Versus Observation After Curative Gastric Cancer Resection显示文摘 | Stephen R. Smalley Jacqueline K. Benedetti Daniel G. Haller Scott A. Hundahl Norman C. Estes Jaffer A. Ajani Leonard L. Gunderson Bryan Goldman James A. Martenson J. Milburn Jessup Grant N. Stemmermann Charles D. Blanke John S. Macdonald | 2012 | Journal of Clinical Oncology2012，，19： | 13 |
| 4 | Is endoscopic ultrasound examination necessary in the management of esophageal cancer?显示文摘Despite substantial efforts at early diagnosis, accurate staging and advanced treatments, esophageal cancer(EC) continues to be an ominous disease worldwide. Risk factors for esophageal carcinomas include obesity, gastroesophageal reflux disease, hard-alcohol use and tobacco smoking. Five-year survival rates have improved from 5% to 20% since the 1970 s, the result of advances in diagnostic staging and treatment. As the most sensitive test for locoregional staging of EC, endoscopic ultrasound(EUS) influences the development of an optimal oncologic treatment plan for a significant minority of patients with early cancers, which appropriately balances the risks and benefits of surgery, chemotherapy and radiation. EUS is costly, and may not be available at all centers. Thus, the yield of EUS needs to be thoughtfully considered for each patient. Localized intramucosal cancers occasionally require endoscopic resection(ER) for histologic staging or treatment; EUS evaluation may detect suspicious lymph nodes prior to exposing the patient to the risks of ER. Although positron emission tomography(PET) has been increasingly utilized in staging EC, it may be unnecessary for clinical staging of early, localized EC and carries the risk of false-positive metastasis(over staging). In EC patients with evidence of advanced disease, EUS or PET may be used to define the radiotherapy field. Multimodality staging with EUS, crosssectional imaging and histopathologic analysis of ER, remains the standard-of-care in the evaluation of early esophageal cancers. Herein, published data regarding use of EUS for intramucosal, local, regional and metastatic esophageal cancers are reviewed. An algorithm to illustrate the current use of EUS at The University of Texas MD Anderson Cancer Center is presented. | Tomas DaVee Jaffer A Ajani Jeffrey H Lee | 2017 | World Journal of Gastroenterology2017，23，5： | 11 |
| 5 | 转录因子Sp1在胃癌组织中的表达及其与胃癌预后的关系显示文摘目的探讨转录因子Sp1在胃癌组织中的表达情况及与胃癌患者预后的关系。方法采用免疫组化方法,检测Sp1在86例胃癌组织、53例淋巴结转移灶和57例正常胃黏膜组织中的表达情况,利用凝胶电泳迁移率分析(EMSA)检测正常胃黏膜组织和胃癌组织中的Sp1活性。应用Cox比例风险回归模型进行多因素分析,确立影响预后的独立因素。结果Sp1蛋白主要在黏液颈细胞胞核内表达,在胃小凹和腺上皮细胞中未见表达。同时,SP1在胃癌组织中高表达,而在胃癌邻近组织、胃癌间质细胞和腺体细胞中呈弱表达或无表达。在胃癌组织中,Sp1阴性表达、弱表达和高表达患者的中位生存时间分别为43个月、47个月和8个月,生存率差异有统计学意义(P<0.01)。多因素分析显示,Sp1表达、肿瘤分期是影响患者预后的独立因素。结论Sp1在胃癌组织中高表达,可作为预测胃癌患者预后的重要指标。 | 王理伟 李琦 华召来 周翡 Keping Xie Daoyan Wei James Yao Jaffer Ajani | 2007 | 中华肿瘤杂志2007，29，2： | 10 |
| 6 | Medical management of gastric cancer:A 2014 update显示文摘Gastric cancer represents a serious health problem on a global scale. It is the second leading cause of cancer-related death worldwide. Novel therapeutic targets are desperately needed because the meager improvement in the cure rate of about 10% realized by adjunctive treatments to surgery is unacceptable as > 50% patients with localized gastric cancer succumb to their disease. Either postoperative chemoradiotherapy(United States),pre-and post-operative chemotherapy(Europe),and adjuvant chemotherapy after a D2 resection(Asia) can all be regarded as standards of care in the localized gastric cancer management. In metastatic disease the addition of trastuzumab to chemotherapy is standard of care in Her2 positive disease. In the HER2 negative population,the treatments remain limited.In the first line setting,the standard of care is a combination of fluoropyrimidine and platinum containing chemotherapy,with or without epirubicin or docetaxel.The results of targeted therapy trials have by and large been disappointing,but none of these trials looked at an appropriately enriched population.Finally there is a meager overall survival benefit in treating patients with metastatic disease in the second line setting,with either irinotecan,docetaxel or ramucirumab however none of these drugs have been compared head to head in a well-powered randomized controlled trial. | Elena Elimova Hironori Shiozaki Roopma Wadhwa Kazuki Sudo Qiongrong Chen Jeannelyn S Estrella Mariela A Blum Brian Badgwell Prajnan Das Shumei Song Jaffer A Ajani | 2014 | World Journal of Gastroenterology2014，20，38： | 10 |
| 7 | Evolution of gastric surgery techniques and outcomes显示文摘Surgical management of gastric cancer improves survival.However,for some time,surgeons have had diverse opinions about the extent of gastrectomy.Researchers have conducted many clinical studies,making slow but steady progress in determining the optimal surgical approach.The extent of lymph node dissection has been one of the major issues in surgery for gastric cancer.Many trials demonstrated that D2 dissection resulted in greater morbidity and mortality than D1 dissection.However,long-term outcomes demonstrated that D2 dissection resulted in longer survival than D1 dissection.In 2004,the Japan Clinical Oncology Group reported a pivotal trial which was performed to determine whether para-aortic lymph node dissection combined with D2 dissection was superior to D2 dissection alone and found no benefit of the additional surgery.Gastrectomy with pancreatectomy,splenectomy,and bursectomy was initially recommended as part of the D2 dissection.Now,pancreas-preserving total gastrectomy with D2 dissection is standard,and ongoing trials are addressing the role of splenectomy.Furthermore,the feasibility and safety of laparoscopic gastrectomy are well established.Survival and quality of life are increasingly recognized as the most important endpoints.In this review,we present perspectives on surgical techniques and important trials of these techniques in gastric cancer patients. | Hironori Shiozaki Yusuke Shimodaira Elena Elimova Roopma Wadhwa Kazuki Sudo Kazuto Harada Jeannelyn S.Estrella Prajnan Das Brian Badgwell Jaffer A.Ajani | 2016 | Chinese Journal of Cancer2016，35，8： | 9 |
| 8 | Endoscopic management of esophageal cancer显示文摘Esophageal cancer(EC)generally consists of squamous cell carcinoma(which arise from squamous epithelium)and adenocarcinoma(which arise from columnar epithelium).Due to the increased recognition of risk factors associated with EC and the development of screening programs,there has been an increase in the diagnosis of early EC.Early EC is amenable to curative therapy by endoscopy,which can be performed by either endoscopic resection or endoscopic ablation.Endoscopic resection consists of either endoscopic mucosal resection(preferred in cases of adenocarcinoma)or endoscopic submucosal dissection(preferred in cases of squamous cell carcinoma).Endoscopic ablation can be performed by either radiofrequency ablation,cryotherapy,argon plasma coagulation or photodynamic therapy,amongst others.Endoscopy can also assist in the management of complications post-esophageal surgery,such as anastomotic leaks and perforations.Finally,there is a growing role for endoscopy to manage end-of-life palliative symptoms,especially dysphagia.The growing use of esophageal stents,debulking therapy and dilation can assist in improving a patient’s quality of life.In this review,we examine the multiple roles of endoscopy in the management of patients with EC. | Osman Ahmed Jaffer A Ajani Jeffrey H Lee | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 6 |
| 9 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial显示文摘 | Hansjochen Wilke Kei Muro Eric Van Cutsem Sang-Cheul Oh Gy?rgy Bodoky Yasuhiro Shimada Shuichi Hironaka Naotoshi Sugimoto Oleg Lipatov Tae-You Kim David Cunningham Philippe Rougier Yoshito Komatsu Jaffer Ajani Michael Emig Roberto Carlesi David Ferry Kuma | 2014 | Lancet Oncology2014，，11： | 4 |
| 10 | Detecting the QTL-allele system controlling seed-flooding tolerance in a nested association mapping population of soybean显示文摘Soil flooding stress,including seed-flooding,is a key issue in soybean production in highrainfall and poorly drained areas.A nested association mapping(NAM)population comprising 230 lines of two recombinant inbred line(RIL)populations with a common parent was established and tested for seed-flooding tolerance using relative seedling length as indicator in two environments.The population was genotyped using RAD-seq(restriction site-associated DNA sequencing)to generate 6137 SNPLDB(SNP linkage disequilibrium block)markers.Using RTM-GWAS(restricted two-stage multi-locus multiallele genome-wide association study),26 main-effect QTL with 63 alleles and 12 QEI(QTL×environment)QTL with 27 alleles in a total of 33 QTL with 78 alleles(12 dual-effect alleles)were identified,explaining respectively 50.95%and 14.79%of phenotypic variation.The QTL-alleles were organized into main-effect and QEI matrices to show the genetic architecture of seed-flooding tolerance of the three parents and the NAM population.From the main-effect matrix,the best genotype was predicted to have genotypic value 1.924,compared to the parental value range 0.652–1.069,and 33 candidate genes involved in six biological processes were identified and confirmed byχ2 test.The results may provide a way to match the breeding by design strategy. | Muhammad Jaffer Ali Guangnan Xing Jianbo He Tuanjie Zhao Junyi Gai | 2020 | The Crop Journal2020，8，5： | 3 |
| 11 | Diagnostic accuracy of EUS in differentiating mucosal versus submucosal invasion of superficial esophageal cancers: a systematic review and meta-analysis显示文摘 | Nirav Thosani Harvinder Singh Asha Kapadia Nobuo Ochi Jeffrey H. Lee Jaffer Ajani Stephen G. Swisher Wayne L. Hofstetter Sushovan Guha Manoop S. Bhutani | 2012 | Gastrointestinal Endoscopy2012，，2： | 3 |
| 12 | Sn_(4)P_(3)-induced crystalline/amorphous composite structures for enhanced sodium-ion battery anodes显示文摘The optimization of anode materials such as Sn,P and Sn4P3 in terms of capacity and cyclability is crucial to improve the overall performance of sodium-ion batteries.However,the delicate fabrication of these materials,including the balanced crystalline/amorphous domains,reasonable particle size and distribution,complementary components exhibiting synergetic reactions,among others,still greatly retards the realization of maximum performance.Herein,a series of Sn/P-based composite materials with a plum pudding configuration were fabricated to achieve controlled crystalline/amorphous structures as well as optimized size and distribution in a carbon framework.By using a facile and low-cost ball milling method,the structural transformation of Sn4P3 into phase-separated crystalline Sn and amorphous P in a carbonaceous framework can be finely controlled,producing a series of binary(Sn4 P3/C),quaternary(Sn4P3/Sn/P/C) and ternary(Sn/P/C) composites.Due to the complementary components,crystalline/amorphous adjustment,crystallite sizes and well-integrated interfaces,the quaternary Sn4P3/Sn/P/C composite showed the best electrochemical performance,with a noticeable long-cycle performance of 382 mA hg-1 and 86% capacity retention for nearly 300 cycles.Different from binary and ternary composites,the discharge of quaternary composite generates no noticeable signals of Na15Sn4 and Na3 P in the ex-situ X-ray diffraction patterns,suggesting the crystallite growth of sodiation products can be depressed.Moreover,Sn4 P3 in the quaternary composite can be partially regenerated in the desodiation reaction,implying the significant short-range interaction and thus better synergetic reactions between Sn and P components.The results demonstrate that the design and organization of crystalline/amorphous structures can serve as an efficient strategy to develop novel electrode materials for sodium ion batteries. | Jaffer Saddique Xu Zhang Tianhao Wu Heng Su Shiqi Liu Dian Zhang Yuefei Zhang Haijun Yu | 2020 | Journal of Materials Science & Technology2020，52，20： | 3 |
| 13 | Gastric cancer: Advances in adjuvant and adjunct therapy显示文摘 | Katsuhiko Higuchi MD Alexandria Phan MD Jaffer A. Ajani MD | 2003 | Current Treatment Options in Oncology2003，，5： | 2 |
| 14 | Incidence of kidney stones in kidney transplant recipients:A systematic review and meta-analysis显示文摘AIM To evaluate the incidence and characteristics of kidney stones in kidney transplant recipients. METHODS A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from the inception of the databases through March 2016. Studies assessing the incidence of kidney stones in kidney transplant recipients were included. We applied a randomeffects model to estimate the incidence of kidney stones.RESULTS Twenty one studies with 64416 kidney transplant patients were included in the analyses to assess the incidence of kidney stones after kidney transplantation. The estimated incidence of kidney stones was 1.0%(95%CI: 0.6%-1.4%). The mean duration to diagnosis of kidney stones after kidney transplantation was 28 ± 22 mo. The mean age of patients with kidney stones was 42 ± 7 years. Within reported studies, approximately 50% of kidney transplant recipients with kidney stones were males. 67% of kidney stones were calcium-based stones(30% mixed CaO x/CaP, 27%CaO x and 10%CaP), followed by struvite stones(20%) and uric acid stones(13%).CONCLUSION The estimated incidence of kidney stones in patients after kidney transplantation is 1.0%. Although calcium based stones are the most common kidney stones aftertransplantation, struvite stones(also known as 'infection stones') are not uncommon in kidney transplant recipients. These findings may impact the prevention and clinical management of kidney stones after kidney transplantation. | Wisit Cheungpasitporn Charat Thongprayoon Michael A Mao Wonngarm Kittanamongkolchai Insara J Jaffer Sathick Tsering Dhondup Stephen B Erickson | 2016 | World Journal of Transplantation2016，6，4： | 2 |
| 15 | Matrix metalloproteinase-9 deletion is associated with decreased mid-term vein wall fibrosis in experimental stasis DVT显示文摘 | Kristopher B. Deatrick Andrea Obi Catherine E. Luke Megan A. Elfline Vikram Sood Gilbert R. Upchurch Farouc Jaffer Thomas W. Wakefield Peter K. Henke | 2013 | Thrombosis Research2013，，： | 2 |
| 16 | Expression of epidermal growth factor receptor in esophageal and esophagogastric junction adenocarcinomas显示文摘 | Kim L.Wang Tsung‐TehWu In SeonChoi HuaminWang ErikaResetkova Arlene M.Correa Wayne L.Hofstetter Stephen G.Swisher Jaffer A.Ajani AsifRashid Constance T.Albarracin | 2007 | Cancer2007，，4： | 2 |
| 17 | Synthesis of BaWOq/NRGO-g-C3N4 nanocomposites with excellent multifunctional catalytic performance via microwave approach显示文摘 | M. Mohamed Jaffer SADIQ U. Sandhya SHENOY D. Krishna BHAT | 2018 | Frontiers of Materials Science2018，12，3： | 2 |
| 18 | Prognostic significance of differentially expressed miRNAs in esophageal cancer显示文摘 | YuxinHu Arlene M.Correa AshrafulHoque BaoxiangGuan FeiYe JieHuang Stephen G.Swisher Tsung TehWu Jaffer A.Ajani Xiao‐ChunXu | 2010 | Int J Cancer2010，，1： | 2 |
| 19 | Matching dependencies: semantics and query answering显示文摘匹配的相关性(MD ) 被用来说明地指定鉴定(或匹配) 在一些数据库元组的某些属性值,某类似什么时候在另外的值上调节,满足。他们的实施能被看作实体分辨率的自然归纳。在我们把称为 MD 实施的纯盒子的,从内在的数据域的任意的值能被用于值在普通那被用于匹配。然而,属性价值的变化的全面数字被期望被坚守最小。我们以语义和通过 MD 的实施清洗的数据的性质调查这个案例。我们描绘打算的干净例子,并且另外询问的干净答案,作为那些,那在清洗过程下面是不变的。计算干净例子和干净质问回答的复杂性被调查。取决于 MD 的易控制、难处理的案例被识别并且描绘。 | Jaffer GARDEZI Leopoldo BERTOSSI Iluju KIRINGA | 2012 | Frontiers of Computer Science2012，6，3： | 2 |
| 20 | Seeing within:molecular imaging of the cardiovascular system显示文摘 | Jaffer FA Weissleder R | 2004 | Circ Res2004，94，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员