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| 1 | β3-adrenergic receptors mediate choroidal endothelial cell invasion,proliferation,and cell elongation显示文摘 | Jena JS David OZ James TR | 2005 | Experimental Eye Research2005，80，1： | 1 |
| 2 | Off-pump right atrial thrombectomy for heparin-induced thrombocytopenia with thrombosis显示文摘 | Jeffrey A Morgan Aftab R Kherani Deon W Vigilance Faisal H Cheema Nicholas J Colletti David I Sahar Kung-Ming Jan David L Diuguid Roman Nowygrod Mehmet C Oz Michael Argenziano | 2003 | The Annals of Thoracic Surgery2003，，2： | 1 |
| 3 | Evidence for current-controlled morphology along the western slope of Hatton Bank (Rockall Plateau, NE Atlantic Ocean)显示文摘 | Miriam Sayago-Gil David Long Kenneth Hitchen Víctor Díaz-del-Río Luis Miguel Fernández-Salas Pablo Durán-Mu?oz | 2010 | Geo - Marine Letters2010，，2： | 1 |
| 4 | Interstitial lung disease in rheumatoid arthritis:Current concepts in pathogenesis,diagnosis and therapeutics显示文摘Rheumatoid arthritis(RA) is the most common chronic autoimmune inflammatory joint disease. RA-associated interstitial lung disease(RA-ILD) is a major extraarticular complication and causes symptoms that lead to a deterioration in the quality of life, high utilization of health resources, and an increased risk of earlier mortality. Early in the course of RA-ILD, symptoms are highly variable, making the diagnosis difficult. Therefore, a rational diagnostic strategy that combines an adequate clinical assessment with the appropriate use of clinical tests, including pulmonary function tests and high-resolution computed tomography, should be used. In special cases, lung biopsy or bronchioalveolar lavage should be performed to achieve an early diagnosis. Several distinct histopathological subtypes of RA-ILD are currently recognized. These subtypes also have different clinical presentations, which vary in therapeutic response and prognosis. This article reviews current evidence about the epidemiology of RA-ILD and discusses the varying prevalence rates observed in different studies. Additionally, aspects of RA-ILD pathogenesis, including the role of cytokines and other molecules such as autoantibodies, as well as the evidence linking several drugs used to treat RA with lung damage will be discussed. Some aspects of the clinical characteristics of RA-ILD are noted, and diagnostic strategies are reviewed. Finally, this article analyzes current treatments for RA-ILD, including immunosuppressive therapies and biologic agents, as well as other therapeutic modalities. The prognosis of this severe complication of RA is discussed. Additionally, this paper examines updated evidence from studies identifying an association between drugs used for the treatment of RA and the development of ILD. | Eva M Olivas-Flores David Bonilla-Lara Jorge I Gamez-Nava Alberto D Rocha-Muoz Laura Gonzalez-Lopez | 2015 | World Journal of Rheumatology2015，5，1： | 1 |
| 5 | Hypothermic Oxygenated Machine Perfusion in Porcine Donation After Circulatory Determination of Death Liver Transplant显示文摘 | Constantino Fondevila Amelia J. Hessheimer Mark-Hugo J. Maathuis Javier Mu?oz Pilar Taurá David Calatayud Henri Leuvenink Antoni Rimola Juan C. García-Valdecasas Rutger J. Ploeg | 2012 | Transplantation Journal2012，，1： | 1 |
| 6 | Defective thymopoiesis and poor peripheral homeostatic replenishment of T-helper cells cause T-cell lymphopenia in cirrhosis<!-- Doctopic: CIRR -->显示文摘 | Margaret Lario Leticia Mu?oz María Ubeda María-José Borrero Javier Martínez Jorge Monserrat David Díaz Melchor álvarez-Mon Agustín Albillos | 2013 | Journal of Hepatology2013，，： | 1 |
| 7 | Effect of Thyroid Hormone Replacement on Lipoprotein(a), Lipids, and Apolipoproteins in Subjects With Hypothyroidism显示文摘 | María L. Martínez Triguero Antonio Hernández-Mijares Tu T. Nguyen Maria L. Mu?oz Hector Pe?a Carlos Morillas David Lorente Irene Lluch Ernesto Molina | 1998 | Mayo Clinic Proceedings1998，，9： | 1 |
| 8 | Incremental Value of Three‐Dimensional Transesophageal Echocardiography over Two‐Dimensional Transesophageal Echocardiography in the Assessment of L ambl’s Excrescences and Nodules of A rantius on the Aortic Valve显示文摘 | Bhavin Dumaswala Komal Dumaswala Ming Chon Hsiung Luis David Meggo Quiroz Aylin Sungur Maximilliano German Amado Escanuela Kruti Mehta Tugba Kemaloglu Oz Kunal Bhagatwala Nidhi M. Karia Navin C. Nanda | 2013 | Echocardiography2013，，8： | 1 |
| 9 | β3-Adrenergic receptor mediate choroidal cell invasion, proliferation, and cell elongation显示文摘 | Jena JS David OZ James T | 2005 | Expermental Eye Research2005，80，： | 1 |
| 10 | Issues in the Reconstruction of Gene Order Evolution显示文摘As genomes evolve over hundreds of millions years, the chromosomes become rearranged, with segments of some chromosomes inverted, while other chromosomes reciprocally exchange chunks from their ends. These rearrangements lead to the scrambling of the elements of one genome with respect to another descended from a common ancestor. Multidisciplinary work undertakes to mathematically model these processes and to develop statistical analyses and mathematical algorithms to understand the scrambling in the chromosomes of two or more related genomes. A major focus is the reconstruction of the gene order of the ancestral genomes. | David Sankoff 郑春芳 Adriana Muoz 杨振宇 Zaky Adam Robert Warren 蔡维仁 祝谦 | 2010 | Journal of Computer Science & Technology2010，25，1： | 0 |
| 11 | Exploring technologies to better link physical evidence and digital information for disaster victim identification显示文摘Disaster victim identification(DVI)entails a protracted process of evidence collection and data matching to reconcile physical remains with victim identity.Technology is critical to DVI by enabling the linkage of physical evidence to information.However,labelling physical remains and collecting data at the scene are dominated by low-technology paper-based practices.We ask,how can technology help us tag and track the victims of disaster?Our response to this question has two parts.First,we conducted a human–computer interaction led investigation into the systematic factors impacting DVI tagging and tracking processes.Through interviews with Australian DVI practitioners,we explored how technologies to improve linkage might fit with prevailing work practices and preferences;practical and social considerations;and existing systems and processes.We focused on tagging and tracking activities throughout the DVI process.Using insights from these interviews and relevant literature,we identified four critical themes:protocols and training;stress and stressors;the plurality of information capture and management systems;and practicalities and constraints.Second,these findings were iteratively discussed by the authors,who have combined expertise across electronics,data science,cybersecurity,human–computer interaction and forensic pathology.We applied the themes identified in the first part of the investigation to critically review technologies that could support DVI practitioners by enhancing DVI processes that link physical evidence to information.This resulted in an overview of candidate technologies matched with consideration of their key attributes.This study recognises the importance of considering human factors that can affect technology adoption into existing practices.Consequently,we provide a searchable table(as Supplementary information)that relates technologies to the key considerations and attributes relevant to DVI practice,for readers to apply to their own context.While this research directly contributes to DVI,it also has applications to other domains in which a physical/digital linkage is required,and particularly within high stress environments with little room for error. | David Lovell Kellie Vella Diego Muñoz Matt McKague Margot Brereton Peter Ellis | 2022 | Forensic Sciences Research2022，7，3： | 0 |
| 12 | Pathological response to neoadjuvant therapy with chemotherapy vs chemoradiotherapy in stage III NSCLC-contribution of IASLC recommendations显示文摘BACKGROUND Neoadjuvant treatment(NT)with chemotherapy(Ch)is a standard option for resectable stage III(N2)NSCLC.Several studies have suggested benefits with the addition of radiotherapy(RT)to NT Ch.The International Association for the Study of Lung Cancer(IASLC)published recommendations for the pathological response(PHR)of NSCLC resection specimens after NT.AIM To contribute to the IASLC recommendations showing our results of PHR to NT Ch vs NT chemoradiotherapy(ChRT).METHODS We analyzed 67 consecutive patients with resectable stage III NSCLC with positive mediastinal nodes treated with surgery after NT Ch or NT ChRT between 2013 and 2020.After NT,all patients were evaluated for radiological response(RR)according to Response Evaluation Criteria in Solid Tumours criteria and evaluated for surgery by a specialized group of thoracic surgeons.All histological samples were examined by the same two pathologists.PHR was evaluated by the percentage of viable cells in the tumor and the resected lymph nodes.RESULTS Forty patients underwent NT ChRT and 27 NT Ch.Fifty-six(83.6%)patients underwent surgery(35 ChRT and 21 Ch).The median time from ChRT to surgery was 6 wk(3-19)and 8 wk(3-21)for Ch patients.We observed significant differences in RR,with disease progression in 2.5%and 14.8%of patients with ChRT and Ch,respectively,and partial response in 62.5%ChRT vs 29.6%Ch(P=0.025).In PHR we observed≤10%viable cells in the tumor in 19(54.4%)and 2 cases(9.5%),and in the resected lymph nodes(RLN)30(85.7%)and 7(33.3%)in ChRT and Ch,respectively(P=0.001).Downstaging was greater in the ChRT compared to the Ch group(80%vs 33.3%;P=0.002).In the univariate analysis,NT ChRT had a significant impact on partial RR[odds ratio(OR)12.5;95%confidence interval(CI):1.21-128.61;P=0.034],a decreased risk of persistence of cancer cells in the tumor and RLN and an 87.5%increased probability for achieving downstaging(OR 8;95%CI:2.34-27.32;P=0.001).CONCLUSION We found significant benefits in RR and PHR by adding RT to Ch as NT.A longer follow-up is necessary to assess the impact on clinical outcomes. | Diego Muñoz-Guglielmetti David Sanchez-Lorente Roxana Reyes Daniel Martinez Carmen Lucena Marc Boada Pilar Paredes Marta Parera-Roig Ivan Vollmer Joel Mases Roberto Martin-Deleon Sergi Castillo Mariana Benegas Silvia Muñoz Maria Mayoral Carla Cases Meritxell Mollà Francesc Casas | 2021 | World Journal of Clinical Oncology2021，12，11： | 0 |
| 13 | Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina显示文摘Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical models.Mesenchymal stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration,namely trophic factor deprivation and neuroinflammation.Most studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional improvement.However,little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous system.Here,we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system,focusing on recent work in the retina and the importance of the type of transplantation. | María Norte-Muñoz David García-Bernal Diego García-Ayuso Manuel Vidal-Sanz Marta Agudo-Barriuso | 2024 | Neural Regeneration Research2024，19，3： | 0 |
| 14 | Microphysiological systems for solid tumor immunotherapy:opportunities and challenges显示文摘Immunotherapy remains more effective for hematologic tumors than for solid tumors.One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate,which limits the cytotoxic capabilities of immune effector cells(e.g.,cytotoxic T and natural killer cells).This microenvironment is characterized by hypoxia,nutrient starvation,accumulated waste products,and acidic pH.Tumor-hijacked cells,such as fibroblasts,macrophages,and T regulatory cells,also contribute to this inhospitable microenvironment for immune cells by secreting immunosuppressive cytokines that suppress the antitumor immune response and lead to immune evasion.Thus,there is a strong interest in developing new drugs and cell formulations that modulate the tumor microenvironment and reduce tumor cell immune evasion.Microphysiological systems(MPSs)are versatile tools that may accelerate the development and evaluation of these therapies,although specific examples showcasing the potential of MPSs remain rare.Advances in microtechnologies have led to the development of sophisticated microfluidic devices used to recapitulate tumor complexity.The resulting models,also known as microphysiological systems(MPSs),are versatile tools with which to decipher the molecular mechanisms driving immune cell antitumor cytotoxicity,immune cell exhaustion,and immune cell exclusion and to evaluate new targeted immunotherapies.Here,we review existing microphysiological platforms to study immuno-oncological applications and discuss challenges and opportunities in the field. | Sara Abizanda-Campo María Virumbrales-Muñoz Mouhita Humayun Ines Marmol David J.Beebe Ignacio Ochoa Sara Oliván Jose M.Ayuso | 2023 | Microsystems & Nanoengineering2023，9，6： | 0 |
| 15 | Effects of fire history on animal communities:a systematic review显示文摘Fire is a natural agent with a paramount role in ecosystem functioning and biodiversity maintenance.Still,it can also act as a negative force against many ecosystems.Despite some knowledge of the interactions of fire and vegetation,there is no clear understanding of how different components of fire regimes(i.e.,severity,history,or frequency)influence known patterns of animal communities.Therefore,we performed a systematic review on the global responses of arthropods,birds,mammals,reptiles,and amphibians to different fire regimes.Specifically,we focused on assessing how fire severity,history,and frequency modulate the effect of fire on the richness and abundance of faunal communities.We conducted a systematic review of 566 papers retrieved from the Scopus database.We also scrutinized all the documents included in the meta‑analysis of Pastro et al.(Pastro et al.Glob Ecol Biogeogr 23:1146–1156,2014).Our selection criteria excluded studies without data on species richness or abundance.We also excluded studies without adequate controls and those without information about the fire regime of the study zone.After careful examination,we used data from 162 studies to perform a quantitative meta‑analysis.From the 162 studies meeting our selection criteria,nearly 60%of the studies are from North America,25%from Australia,11%from Europe,and 4%from the tropics.According to the ecological role of fire,90%of the studies were carried out in fire‑dependent ecosystems(i.e.,conifer forests,natural savannas,pastures).Finally,40%of the studies analyzed birds,22%mammals,and 20%arthropods.The meta‑analysis of the available evidence indicates that fire history is an important modulator of animal richness and abundance.Whether negative or positive,animal responses depended on the time since the last fire event.Considering that short‑term studies may not capture such a long‑term effect on fauna,this translates to more challenges at implementing fire management strategies.Whether or not we can anticipate the impact of the fire will then depend on future efforts to implement long‑term research. | Tania Marisol González Juan David González‑Trujillo Alberto Muñoz Dolors Armenteras | 2022 | Ecological Processes2022，11，1： | 0 |
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