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| 1 | How reliable is current imaging in restaging rectal cancer after neoadjuvant therapy?显示文摘In patients with advanced rectal cancer,neoadjuvant chemo radiotherapy provides tumor downstaging and downsizing and complete pathological response in up to 30%of cases.After proctectomy complete pathological response is associated with low rates of local recurrence and excellent long term survival.Several authors claim a less invasive surgery or a non operative policy in patients with partial or clinical complete response respectively,however to identify patients with true complete pathological response before surgical resection remains a challenge.Current imaging techniques have been reported to be highly accurate in the primary staging of rectal cancer,however neoadjuvant therapy course produces deep modifications on cancer tissue and on surrounding structures such as overgrowth fibrosis,deep stroma alteration,wall thickness,muscle disarrangement,tumor necrosis,calcification,and inflammatory infiltration.As a result,the same imaging techniques,when used for restaging,are far less accurate.Local tumor extent may be overestimated or underestimated.The diagnostic accuracy of clinical examination,rectal ultrasound,computed tomography,magnetic resonance imaging,and positron emission tomography using 18F-fluoro-2’-deoxy-Dglucose ranges between 25%and 75%being less than 60%in most studies,both for rectal wall invasion and for lymph nodes involvement.In particular the ability to predict complete pathological response,in order to tailor the surgical approach,remains low.Due to the radio-induced tissue modifications,combined with imaging technical aspects,low rate accuracy is achieved,making modern imaging techniques still unreliable in restaging rectal cancer after chemo-radiotherapy. | Paola De Nardi Michele Carvello | 2013 | World Journal of Gastroenterology2013，19，36： | 13 |
| 2 | Multidisciplinary treatment of rectal cancer in 2014: Where are we going?显示文摘In the present review we discuss the recent developments and future directions in the multimodal treatment of locally advanced rectal cancer, with respect to staging and re-staging modalities, to the current role of neoadjuvant chemo-radiation and to the conservative and more limited surgical approaches based on tumour response after neoadjuvant combined therapy. When initial tumor staging is considered a high accuracy has been reported for T pre-treatment staging, while preoperative lymph node mapping is still suboptimal. With respect to tumour re-staging, all the current available modalities still present a limited accuracy, in particular in defining a complete response. The role of short vs long-course radiotherapy regimens as well as the optimal time of surgery are still unclear and under investigation by means of ongoing randomized trials. Observational management or local excision following tumour complete response are promising alternatives to total mesorectal excision, but need further evaluation, and their use outside of a clinical trial is not recommended.The preoperative selection of patients who will benefit from neoadjuvant radiotherapy or not, as well as the proper identification of a clinical complete tumour response after combined treatment modalities,will influence the future directions in the treatment of locally advanced rectal cancer. | Andrea Vignali Paola De Nardi | 2014 | World Journal of Gastroenterology2014，20，32： | 5 |
| 3 | Overexpression of microRNA-145 in atherosclerotic plaques from hypertensive patients显示文摘 | Donato Santovito Claudia Mandolini Pamela Marcantonio Velia De Nardis Marco Bucci Camilla Paganelli Francesco Magnacca Sante Ucchino Daniela Mastroiacovo Giovambattista Desideri Andrea Mezzetti Francesco Cipollone | 2012 | Expert Opinion on Therapeutic Targets2012，，3： | 2 |
| 4 | Reduction in gram- positive pneumonia and antibiotic consumption following the use of a SDD protocol including nasal and oral mupirocin显示文摘 | Nardi G Di - Silvestre AD De - Monte A | 2001 | Eur J Emerg Med2001，8，3： | 1 |
| 5 | Partial replacement ofω-6fatty acids with medium-chain triglycerides,but not olive oil,improve colon cytokine response and damage in experimental colitis显示文摘 | Bertevello PL De Nardi L Torrinhas RS | 2012 | JPEN J Parenter Enteral Nutr2012，36，4： | 1 |
| 6 | Reduction in grampositive pneumonia and antibiotic consumption following the use of a SDD protocol including nusal and oral mupirocin 显示文摘 | Nardi G Di - Silvestre AD De - Monte A | 2001 | Eur J Emerg Med2001，8，3： | 1 |
| 7 | One-year appraisal of a new aortic root conduit with sinuses of Valsalva 显示文摘 | De Paulis R De Matteis GM Nardi P | 2002 | J Thorac Cardiovasc Surg2002，123，： | 1 |
| 8 | A new aortic Dacron conduit for surgical treatment of aortic root pathology显示文摘 | De Paulis R De Matteis GM Nardi P | 2000 | Ital Heart J2000，1，7： | 1 |
| 9 | Ifosfamide and vinorelbine in advanced pretreated ovarian cancer: a phase Ⅱ study显示文摘 | Nardi M De Marco S Fabi A | 2000 | Cancer Chemother Pharmacol2000，45，6： | 1 |
| 10 | Recurrent Giant Liposarcoma of the Spermatic Cord显示文摘 | De Nardi P Bissolati M Cristallo M | | 0，，01： | 1 |
| 11 | Susceptibility variation of Malassezia pachydermatis to antifungal agents according to isolate source 显示文摘 | Weiler CB de Jesus FP Nardi GH | 2013 | BrazJMicrobiol2013，44，1： | 1 |
| 12 | One-year appraisal of a new aortic root conduit with sinuses of Valsalva显示文摘 | De Paulis R De Matteis GM Nardi P | 2002 | J Thorac Cardiovasc Surg2002，123，1： | 1 |
| 13 | Analysis of valve mo- tion after the reimplantation type of valve-sparing procedure ( David I) with a new aortic root conduit 显示文摘 | De Paulis R De Matteis GM Nardi P | 2002 | Ann Thorac Surg2002，74，1： | 1 |
| 14 | Analysis of valve motion after the reimplantation type of valve-sparing procedure (David Ⅰ) with a new aortic root conduit显示文摘 | De Paulis R De Matteis GM Nardi P | 2002 | Ann Thorac Surg2002，74，1： | 1 |
| 15 | The use of inductively coupled plasma mass spectrometry (ICP-MS) for the determination of toxic and essential elements in different types of food samples显示文摘 | Elene P. Nardi Fábio S. Evangelista Luciano Tormen Tatiana D. Saint′Pierre Adilson J. Curtius Samuel S. de Souza Fernando Barbosa | 2008 | Food Chemistry2008，，3： | 1 |
| 16 | Analysis of valve motion after the reimplantation type of valve-sparing procedure (David I) with a new aortic root conduit显示文摘 | De Paulis R De Matteis GM Nardi P | 2002 | Ann Thorac Surg2002，74，1： | 1 |
| 17 | Reduction in gram-positive pneumonia and antibiotic consumption following the use of a SDD protocol including nasal and oral mupirocin显示文摘 | NARDI G di SILVESTRE A D de MONTE A | 2001 | Eur J Emerg Med2001，8，3： | 1 |
| 18 | Rectal distensibility and symptoms after stapled and Milligan-Morgan operation for hemor-rhoids显示文摘 | Corsetti M De Nardi P Di Pietro S | | 0，，： | 1 |
| 19 | Entrepreneurship,frictions and wealth显示文摘 | CAGETTI M AND DE NARDI M | 2006 | Journal of Political Economy2006，114，5： | 1 |
| 20 | One-year appraisal of a new aortic root conduit with sinuses of Valsalva显示文摘 | De Paulis R De Matteis GM Nardi P | 2002 | J Thorac Cardiovasc Surg2002，123，1： | 1 |
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