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| 1 | Immunopathobiology and therapeutic targets related to cytokines in liver diseases显示文摘Chronic liver injury with any etiology can progress to fibrosis and the end-stage diseases cirrhosis and hepatocellular carcinoma.The progression of liver disease is controlled by a variety of factors,including liver injury,inflammatory cells,inflammatory mediators,cytokines,and the gut microbiome.In the current review,we discuss recent data on a large number of cytokines that play important roles in regulating liver injury,inflammation,fibrosis,and regeneration,with a focus on interferons and T helper(Th)1,Th2,Th9,Th17,interleukin(IL)-1 family,IL-6 family,and IL-20 family cytokines.Hepatocytes can also produce certain cytokines(such as IL-7,IL-11;and IL-33),and the functions of these cytokines in the liver are briefly summarized.Several cytokines have great therapeutic potential,and some are currently being tested as therapeutic targets in clinical trials for the treatment of liver diseases,which are also described. | Yong He Seonghwan Hwang Yeni Ait Ahmed Dechun Feng Na Li Marcelle Ribeiro Fouad Lafdil Tatiana Kisseleva Gyongyi Szabo Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，1： | 14 |
| 2 | Enhanced anti-tumor immunity ex vivo induced by GM-CSF gene transducted dendritic cell vaccine显示文摘学习的目的是调查是否的目的树枝状的房间(DC ) 先锋,由 chemokine ligand 的注射招募了 3 (CCL3 ) ,在 granulocyte 巨噬细胞殖民地刺激以后导致提高的反肿瘤免疫在老鼠前 vivo 的因素(GM-CSF ) transfection。615 只老鼠经由尾巴静脉与 CCL3 被注射的方法。刚孤立的 B220-CD11c+ 房间与 cytokines 是有教养的。为 adenoviral (广告) 调停的基因 transduction, DC 是在感染(MOI ) 的复合的不同比率的转移 AdGM-CSF 基因决定最佳的基因 transfection 条件,并且在 transfection 以后检测 GM-CSF 的表示。GM-CSF 修改基因的 DC 的变化被词法观察,显型分析,和混合淋巴细胞反应(MLR ) 分析。DC 被装载,胃的癌症抗原由冻结并且融化的方法获得了。刺激 DC 种痘导致了 T 淋巴细胞,和 T 房间的杀死的效果到胃的癌症房间是由 MTT 的 assayed。INF- 生产与 INF- ELISA 工具包被决定。结果 B220-CD11c+ 房间数字在 CCL3 注射以后增加了。ELISA 结果证明在 GM-CSF 基因修正以后, DC 能生产 GM-CSF 的高水平。DC 是什么时候,在等于 1:100 的 MOI 转移了 AdGM-CSF 基因,在文化上层清液的 GM-CSF 水平到达了浸透[(130.00 ???????????????? ″ ? 匠牵楶楶? 僚 ??? 吗?? | Songbing He Liang Wang Kang Sun Yanyun Zhang Dechun Li | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，3： | 3 |
| 3 | Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles显示文摘This study established a dog model of acute multiple cauda equina constriction by experimental constriction injury (48 hours) of the lumbosacral central processes in dorsal root ganglia neurons. The repair effect of intrathecal injection of brain-derived neurotrophic factor with 15 mg encapsulated biodegradable poly(lactide-co-glycolide) nanoparticles on this injury was then analyzed. Dorsal root ganglion cells (L7) of all experimental dogs were analyzed using hematoxylin-eosin staining and immunohistochemistry at 1, 2 and 4 weeks following model induction. Intrathecal injection of brain-derived neurotrophic factor can relieve degeneration and inflammation, and elevate the expression of brain-derived neurotrophic factor in sensory neurons of compressed dorsal root ganglion. Simultaneously, intrathecal injection of brain-derived neurotrophic factor obviously improved neurological function in the dog model of acute multiple cauda equina constriction. Results verified that sustained intraspinal delivery of brain-derived neurotrophic factor encapsulated in biodegradable nanoparticles promoted the repair of histomorphology and function of neurons within the dorsal root ganglia in dogs with acute and severe cauda equina syndrome. | Junming Tan Jiangang Shi Guodong Shi Yanling Liu Xiaohong Liu Chaoyang Wang Dechun Chen Shunming Xing Lianbing Shen Lianshun Jia Xiaojian Ye Hailong He Jiashun Li | 2013 | Neural Regeneration Research2013，8，3： | 2 |
| 4 | Kupffer cell restoration after partial hepatectomy is mainly driven by local cell proliferation in IL-6-dependent autocrine and paracrine manners显示文摘Kupffer cells(KCs),which are liver-resident macrophages,originate from the fetal yolk sac and represent one of the largest macrophage populations in the body.However,the current data on the origin of the cells that restore macrophages during liver injury and regeneration remain controversial.Here,we address the question of whether liver macrophage restoration results from circulating monocyte infiltration or local KC proliferation in regenerating livers after partial hepatectomy(PHx)and uncover the underlying mechanisms.By using several strains of genetically modified mice and performing immunohistochemical analyses,we demonstrated that local KC proliferation mainly contributed to the restoration of liver macrophages after PHx.Peak KC proliferation was impaired in Il6-knockout(KO)mice and restored after the administration of IL-6 protein,whereas KC proliferation was not affected in Il4-KO or Csf2-KO mice.The source of IL-6 was identified using hepatocyte-and myeloid-specific Il6-KO mice and the results revealed that both hepatocytes and myeloid cells contribute to IL-6 production after PHx.Moreover,peak KC proliferation was also impaired in myeloid-specific Il6 receptor-KO mice after PHx,suggesting that IL-6 signaling directly promotes KC proliferation.Studies using several inhibitors to block the IL-6 signaling pathway revealed that sirtuin 1(SIRT1)contributed to IL-6-mediated KC proliferation in vitro.Genetic deletion of the Sirt1 gene in myeloid cells,including KCs,impaired KC proliferation after PHx.In conclusion,our data suggest that KC repopulation after PHx is mainly driven by local KC proliferation,which is dependent on IL-6 and SIRT1 activation in KCs. | Yeni Ait Ahmed Yaojie Fu Robim M.Rodrigues Yong He Yukun Guan Adrien Guillot Ruixue Ren Dechun Feng Juan Hidalgo Cynthia Ju Fouad Lafdil Bin Gao | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | The appliances and prospects of aurum nanomaterials in biodiagnostics, imaging, drug delivery and combination therapy显示文摘Aurum nanomaterials(ANM), combining the features of nanotechnology and metal elements, have demonstrated enormous potential and aroused great attention on biomedical applications over the past few decades. Particularly, their advantages, such as controllable particle size, flexible surface modification, higher drug loading, good stability and biocompatibility, especially unique optical properties, promote the development of ANM in biomedical field. In this review, we will discuss the advanced preparation process of ANM and summarize their recent applications as well as their prospects in diagnosis and therapy. Besides, multi-functional ANM-based theranostic nanosystems will be introduced in details, including radiotherapy(RT), photothermal therapy(PTT), photodynamic therapy(PDT), immunotherapy(IT), and so on. | Dan Yang Feiyang Deng Dechun Liu Bo He Bing He Xing Tang Qiang Zhang | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 2 |
| 6 | Dissolved oxygen in aeration-driven piezo-catalytic for antibiotics pollutants removal in water显示文摘The misuse of antibiotics and oxygen-lacking in aquaculture causes serious water environmental problems.Herein,a piezoelectic odd-layered MoS_(2)is prepared and applied to piezo-catalytic remove tinidazole(TNZ)and other antibiotic pollutants with aeration as a piezo-driving force.About 89.6%of TNZ can be degraded by MoS_(2)under aeration in the presence of dissolved oxygen with a reaction rate constant of0.15 min^(-1),which is 2.4 times higher than that under N2atmosphere and quiescence conditions.Quenching experiments and electron paramagnetic resonance(EPR)tests identify that singlet oxygen(^(1)O_(2))and superoxide radical(O_(2)^(·-))are dominant reactive oxygen species in MoS_(2)/aeration system.These results demonstrate that MoS2can trigger a piezoelectric effect and produce charge carriers to generate reactive oxygen species with dissolved oxygen(DO)for contaminant degradation with the turbulence and water bubbles rupture driven by aeration. | Minxian Zhang Wanqian Guo Yingyin Chen Dechun He Abdulgalim B.Isaev Mingshan Zhu | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 7 | A novel sea-land segmentation based on integral image reconstruction in MWIR images显示文摘Dear editor,Middle wave infrared remote(MWIR)technology is the main approach in remote sensing applications,because thermal infrared can work all-time.The MWIR technology can provide valid object information in remote sensing technology than optical and synthetic aperture radar(SAR) | Yin ZHUANG Dechun GUO He CHEN Fukun BI Long MA Nouman Q.SOOMRO | 2017 | Science China(Information Sciences)2017，60，6： | 0 |
| 8 | AMBIGUITY FUNCTION OF INTERPULSE COSTAS FH RADAR SIGNAL显示文摘A new radar waveform utilizing Costas sequences and interpulse Frequency Hopping (FH) technique is developed, which is a good high range resolution radar signal. The interpulse Costas FH coherent pulse train is introduced and the system block diagram using the interpulse Costas FH waveform is given. In the paper, ambiguity function is employed to study interpulse Costas FH radar. The mathematical expression of the ambiguity function for this waveform is derived. The advantages of the waveform are interpreted by computer simulation. | Mu Shanxiang Kong Dechun Li Xingguo He Guodong (Nanjing University of Science and Technology, Nanjing 210094) | 2000 | Journal of Electronics(China)2000，17，2： | 0 |
| 9 | Liposomes and liposome-like nanoparticles:From anti-fungal infection to the COVID-19 pandemic treatment显示文摘The liposome is the first nanomedicine transformed into the market and applied to human patients.Since then,such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological drugs.Numerous investigations about liposome uses were conducted in different treatment fields,including anti-tumor,anti-fungal,anti-bacterial,and clinical analgesia,owing to liposome's ability to reduce drug cytotoxicity and improve the therapeutic efficacy and combinatorial delivery.In particular,two liposomal vaccines were approved in 2021 to combat COVID-19.Herein,the clinically used liposomes are reviewed by introducing various liposomal preparations in detail that are currently proceeding in the clinic or on the market.Finally,we discuss the challenges of developing liposomes and cutting-edge liposomal delivery for biological drugs and combination therapy. | Yonglong He Wanting Zhang Qingqing Xiao Lifang Fan Dechun Huang Wei Chen Wei He | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，6： | 0 |
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