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| 1 | Colorectal cancer and 18FDG-PET/CT:What about adding the T to the N parameter in loco-regional staging?显示文摘AIM:To evaluate whether FDG-positron emission tomography(PET)/computed tomography(CT)may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.METHODS:Thirty four consecutive patients(20 men and 14 women;mean age:63 years)with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study.All patients underwent FDG-PET/CT preoperatively.The primary tumor site and extent were evaluated on PET/CT images.Colorectal wall invasion was analysed according to a modified T classification that considers only three stages(≤T2,T3,T4).Assessment of accuracy was carried out using 95%confidence intervals for T.RESULTS:Thirty five/37(94.6%)adenocarcinomas were identified and correctly located on PET/CT images.PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3%(95%CI:87%-100%).All T1,T3 and T4 lesions were correctly staged,while two T2 neoplasms were overstated as T3.CONCLUSION:Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer. | Pier Paolo Mainenti Delfina Iodice Sabrina Segreto Giovanni Storto Mario Magliulo Giovanni Domenico De Palma Marco Salvatore Leonardo Pace | 2011 | World Journal of Gastroenterology2011，17，11： | 5 |
| 2 | HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing显示文摘Post-transcriptional gene silencing mediated by microRNAs(miRNAs)modulates numerous developmental and stress response pathways.For the last two decades,HASTY(HST),the ortholog of human EXPORTIN 5,was considered to be a candidate protein that exports plant miRNAs from the nucleus to the cytoplasm.Here,we report that HST functions in the miRNA pathway independent of its cargo-exporting activity in Arabidopsis.We found that Arabidopsis mutants with impaired HST shuttling exhibit normal subcellular distribution of miRNAs.Interestingly,protein-protein interaction and microscopy assays showed that HST directly interacts with the microprocessor core component DCL1 through its N-terminal domain.Moreover,mass spectrometry analysis revealed that HST also interacts independently of its N-terminal domain with the mediator complex subunit MED37.Further experiments revealed that HST could act as a scaffold to facilitate the recruitment of DCL1 to genomic MIRNA loci by stabilizing the DCL1-MED37 complex,which in turn promotes the transcription and proper processing of primary miRNA transcripts(primiRNAs).Taken together,these results suggest that HST is likely associated with the formation of the miRNA biogenesis complex at MIRNA genes,promoting the transcription and processing of primiRNAs rather than the direct export of processed miRNAs from the nucleus. | Damian A.Cambiagno Axel J.Giudicatti Agustin L.Arce Delfina Gagliardi Lei Li Wei Yuan Derek S.Lundberg Detlef Weigel Pablo A.Manavella | 2021 | Molecular Plant2021，14，3： | 5 |
| 3 | CURLY LEAF Regulates MicroRNA Activity by Controlling ARGONAUTE 1 Degradation in Plants显示文摘CURLY LEAF ( CLF) encodes the methyltransferase subunit of the Polycomb Repressor Complex 2 (PRC2), which regulates the expression of target genes through H3K27 trimethylation. We isolated a new CLF mutant allele ( clf-78) using a genetic screen designed to identify microRNA (miRNA) deficient mutants. CLF mutant plants showed impaired miRNA activity caused by increased ubiquitination and enhanced degradation of ARGONAUTE 1 (AGO1) in specific tissues. Such CLF-mediated AGO1 regulation was evident when plants were exposed to UV radiation, which caused increased susceptibility of clf mutants to some UV-induced responses. Furthermore, we showed that CLF directly regulates FBW2, which in turn triggers AGO1 degradation in the clf mutants. Interestingly, AGO1 bound to a target appeared particularly prone to degradation in the mutant plants, a process that was exacerbated when the complex bound a non-cleavable target. Thus, prolonged AGO1–target interaction seems to favor AGO1 degradation, suggesting that non-cleavable miRNA targets may overcome translation inhibition by modulating AGO1 stability in plants. | Delfina A.Re Damian A.Cambiagno Agustin LArce Ariel HTomassi Marisol Giustozzi Paula Casati Federico DAriel Pablo A.Manavella | 2020 | Molecular Plant2020，13，1： | 2 |
| 4 | Preoxygenation in the obese patient:effects of position on tolerance to apnoea显示文摘 | ALTERMATT F R MUNOZ H R DELFINA A E | 2005 | Br J Anaesth2005，95，5： | 1 |
| 5 | Increased resistance in BALB/c mice to reinfection with Candida albicans is due to immunoneutralization of a virulence-associated immunomodulatoryprotein 显示文摘 | Delfina Tavares Paula Ferreira Mario Arala-Chaves | 2003 | Microbiology2003，149，： | 1 |
| 6 | Visualizing processes on the web 显示文摘 | Delfina Malandrino Giuseppina Palmieri Vittorio Scarano | 2007 | Journal of Visual languages and Computing2007，，18： | 1 |
| 7 | Intestinal absorption of zearalenone and in vitro study of non - nutritive sorbent materials显示文摘 | Ramos A J Hemandez M Pla - Delfina J M | 1996 | Pharmaceutics1996，128，12： | 1 |
| 8 | Helicobacter pylori Eradication and Change in Markers of Iron Stores Among Non–iron-deficient Children in El Paso, Texas: An Etiologic Intervention Study显示文摘 | Victor M Cardenas Carmen A Prieto-Jimenez Zuber D Mulla Jose O Rivera Delfina C Dominguez David Y Graham Melchor Ortiz | 2011 | Journal of Pediatric Gastroenterology and Nutrition2011，，3： | 1 |
| 9 | Intimate partner violence:A loop of abuse,depression and victimization显示文摘Intimate partner violence has been recognized as a serious public health issue.Exposure to violence contributes to the genesis of,and exacerbates,mental health conditions,and existing mental health problems increase vulnerability to partner violence,a loop that imprisons victims and perpetuates the abuse.A recently described phenomenon is when male violence against females occurs within intimate relationships during youth,and it is termed adolescent or teen dating violence.In this narrative review,factors associated with intimate partner violence and consequences of exposure of children to parental domestic violence are discussed,along with possible intensification of violence against women with the spread of coronavirus disease 2019 pandemic and subsequent lockdown.Intervention programs with a multicomponent approach involving many health care settings and research have a pivotal role in developing additional strategies for addressing violence and to provide tailored interventions to victims.Prevention policy with a particular attention on healthy child and adolescent development is mandatory in the struggle against all forms of violence. | Marianna Mazza Giuseppe Marano Angela Gonsalez del Castillo Daniela Chieffo Laura Monti Delfina Janiri Lorenzo Moccia Gabriele Sani | 2021 | World Journal of Psychiatry2021，11，6： | 1 |
| 10 | Evaluation of a Novel Stool Native Catalase Antigen Test for Helicobacter pylori Infection in Asymptomatic North American Children显示文摘 | Victor M Cardenas Delfina C Dominguez Flor A Puentes Corinne C Aragaki Karen J Goodman David Y Graham Yoshihiro Fukuda | 2008 | Journal of Pediatric Gastroenterology and Nutrition2008，，4： | 1 |
| 11 | Intestinal absorption of zearalenone and in vitro study of non-nutritive sorbent materials显示文摘 | Hernández E Plá-Delfina JM | 1996 | Ira J Pharm1996，128，12： | 1 |
| 12 | Increased resistance in BALB/c mice to reinfection with Candida albicans is due to immunoneutraliza-tion of virulence-associated immunomodulatory protein显示文摘 | Delfina T Paula F Mario A C | 2003 | Microbiology2003，149，： | 1 |
| 13 | C-reactive protein is differentially modulated by co-existing infections,vitamin deficiencies and maternal factors in pregnant and lactating indigenous Panamanian women显示文摘Background:The usefulness of C-reactive protein(CRP)as a non-specific marker of inflammation during pregnancy and lactation is unclear in impoverished populations where co-existing infections and vitamin deficiencies are common.Methods:This cross-sectional study in Panama recruited 120 pregnant and 99 lactating Ngäbe-Buglewomen from 14 communities in rural Panama.Obstetric history,indoor wood smoke exposure,fieldwork,BMI,vitamins A,B_(12),D,and folic acid,and inflammation markers(CRP,neutrophil/lymphocyte ratio(NLR),plateletcrit and cytokines)were measured.Multiple regressions explored both associations of CRP with other inflammatory markers and associations of CRP and elevated CRP based on trimester-specific cut-offs with maternal factors,infections and vitamin deficiencies.Results:CRP was higher in pregnancy(51.4±4.7 nmol/L)than lactation(27.8±3.5 nmol/L)and was elevated above trimester specific cut-offs in 21%of pregnant and 30%of lactating women.Vitamin deficiencies were common(vitamin A 29.6%;vitamin D 68.5%;vitamin B1268%;folic acid 25.5%)and over 50%of women had two or more concurrent deficiencies as well as multiple infections.Multiple regression models highlighted differences in variables associated with CRP between pregnancy and lactation.In pregnancy,CRP was positively associated with greater indoor wood smoke exposure,caries and hookworm and negatively associated with Ascaris and vaginal Lactobacillus and Bacteroides/Gardnerella scores.Consistent with this,greater wood smoke exposure,caries as well as higher diplococcal infection score increased the odds of trimester-elevated CRP concentrations whereas longer gestational age lowered the likelihood of a trimester-elevated CRP.During lactation,folic acid deficiency was associated with higher CRP whereas parity,number of eosinophils and Mobiluncus score were associated with lower CRP.Also,a higher BMI and Trichomonas vaginalis score increased the likelihood of an elevated CRP whereas higher parity and number of eosinophils were associated with lower likelihood of an elevated CRP.Conclusions:Infections both raise and lower CRP concentrations in pregnant and lactating mothers.Only folic acid deficiency during lactation was associated with higher CRP concentrations.Caution is required when interpreting CRP concentrations in pregnant and lactating women who have co-existing nutrient deficiencies and multiple infections. | Doris Gonzalez-Fernandez Emerita del Carmen Pons Delfina Rueda Odalis Teresa Sinisterra Enrique Murillo Marilyn E.Scott Kristine G.Koski | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
| 14 | Preventive or potential therapeutic value of nutraceuticals against ionizing radiation-induced oxida- tive stress in exposed subjects and frequent fliers显示文摘 | Maria Teresa Giardi Eleftherios Touloupakis Delfina Bertolotto | 2013 | Int J Mol Sci2013，14，17： | 1 |
| 15 | Greater Than 95% Success with 14‐day B ismuth Quadruple Anti‐ H elicobacter pylori Therapy: A Pilot Study in US H ispanics显示文摘 | Cesar O. Salazar Victor M. Cardenas Rita K. Reddy Delfina C. Dominguez Lindsey K. Snyder David Y. Graham | 2012 | Helicobacter2012，，5： | 1 |
| 16 | Privacy leakage on the Web: Diffusionand countermeasures 显示文摘 | Delfina M Vittorio S | 2013 | Computer Networks2013，57，： | 1 |
| 17 | Pre-oxygenation in the obese patient:effects of position on tolerance to apnoea显示文摘 | ALTERMATT FR MUNOZ HR DELFINA AE | 2005 | Br J Anaesth2005，95，5： | 1 |
| 18 | 锦绣中华 非遗点亮中轴线显示文摘2019年10月18日至24日的景山五彩缤纷、绚烂多姿。在文化和旅游部的支持下,由文化和旅游部恭王府博物馆牵头,联合中国纺织工业联合会非遗办公室、北京服装学院、北京市公园管理中心、中国国际时装周组委会、中央民族大学民族服饰研究所等单位联合主办的“锦绣中华——2019中国非物质文化遗产服饰秀”系列活动在北京景山公园拉开帷幕。 | Delfina 关欣(摄影) | 2019 | 环球飞行2019，0，11： | 0 |
| 19 | Plant breeding highlights master genes in major regulatory pathways显示文摘Bread wheat(Triticum aestivum),during its evolution,experienced severe genetic bottlenecks due to polyploidization and domestication.Then,breeding programs,triggered mainly by the Green Revolution within a narrow range of breeders'preferred parents,while increasing the global wheat productivity,produced a further and evident reduction of genetic diversity.A clear picture of the impact of domestication and breeding on genetic diversity was achieved after recent studies that highlight loci subjected to past or ongoing selection,described as selection signatures or selective sweeps. | Delfina Barabaschi Luigi Cattivelli | 2022 | Molecular Plant2022，15，3： | 0 |
| 20 | Fitness Cost Shapes Differential Evolutionary Dynamics of Disease Resistance Genes in Cultivated and Wild Plants显示文摘Polyploidy is characterized by the presence of two or more complete sets of chromosomes coming from intraspecies whole-genome duplication(i.e.,autopolyploidy)or from hybridization between distinct but related species(i.e.,allopolyploidy).Poly-ploidization is a driving force in the evolution of higher plants,most of the plant species have experienced ancient or recent genome duplication events that have led to several genome modifications,such as chromosomal reorganization,gene conversion,sub-genome dominance,alteration of gene expression patterns,and expansion/contraction of some gene families. | Delfina Barabaschi Alessandro Tondelli Giampiero Valè Luigi Cattivelli | 2020 | Molecular Plant2020，13，10： | 0 |
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