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| 1 | Traditional Chinese Medicine in the prevention and treatment of stable angina pectoris in patients with coronary heart disease based on the theory of 'phlegm and blood stasis' under guidance of evidence-based medicine:a prospective cohort study显示文摘OBJECTIVE: To ascertain whether continuous treatment with Traditional Chinese Medicine(TCM) combined with standardized drug therapy from Western Medicine can further reduce the incidence of cardiovascular events in patients with coronary heart disease and angina and reduce the incidence of angina pectoris in patients with coronary heart disease.METHODS: A multicenter, prospective cohort study of 1042 patients in 22 hospitals was conducted. A total of 423 patients with angina pectoris were treated with standardized Western Medicine alone(control group) and 619 with a combination of Chinese and Western Medicine(exposure group). The two groups underwent follow-up for 1 year to establish whether there was any improvement in the incidence of cardiovascular events or change in the curative effect.RESULTS: The incidence of primary endpoint events in the combined-exposure group decreased by 0.45%(P > 0.05) and the incidence of secondary terminal events decreased by 5.25% in comparison with the control group(P < 0.05). The total angina pectoris score clearly decreased in the Western Medicine group over the first 6 months, but the decline was more apparent in the combined-exposure group.CONCLUSION: Compared with treatment using standardized Western Medicine alone, providing TCM combined with Western medical treatment reduced the incidence of cardiovascular events in patients with stable angina pectoris(grade Ⅱ endpoint) and effectively improved the curative effect. | CHEN Ying XIAO Xue XU Xiaolin DENG Yue ZHANG Zepeng | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 19 |
| 2 | Identification of mecciRNAs and their roles in the mitochondrial entry of proteins显示文摘Mammalian mitochondria have small genomes encoding very limited numbers of proteins.Over one thousand proteins and noncoding RNAs encoded by the nuclear genome must be imported from the cytosol into the mitochondria.Here,we report the identification of hundreds of circular RNAs(mecciRNAs)encoded by the mitochondrial genome.We provide both in vitro and in vivo evidence to show that mecciRNAs facilitate the mitochondrial entry of nuclear-encoded proteins by serving as molecular chaperones in the folding of imported proteins.Known components involved in mitochondrial protein and RNA importation,such as TOM40 and PNPASE,interact with mecciRNAs and regulate protein entry.The expression of mecciRNAs is regulated,and these transcripts are critical for the adaption of mitochondria to physiological conditions and diseases such as stresses and cancers by modulating mitochondrial protein importation.mecciRNAs and their associated physiological roles add categories and functions to the known eukaryotic circular RNAs and shed novel light on the communication between mitochondria and the nucleus. | Xu Liu Xiaolin Wang Jingxin Li Shanshan Hu Yuqi Deng Hao Yin Xichen Bao Qiangfeng Cliff Zhang Geng Wang Baolong Wang Qinghua Shi Ge Shan | 2020 | Science China(Life Sciences)2020，63，10： | 15 |
| 3 | Genome of Wild Mandarin and Domestication History of Mandarin显示文摘官员(柠檬 reticulata ) 是世界范围的最重要的柠檬庄稼之一。它的驯服被相信发生在华南,它是四几千年的官员耕作的中心之一。我们在 Nanling 区域附近收集了官员的自然野人口并且在附近栽培了 landraces。我们发现柠檬性的酸水平戏剧性地在栽培官员被减少。理解 ? 官员驯服的基因基础,我们 de novo 装配了野官员的一个草稿染色体并且分析了一套 104 个柠檬染色体。我们发现 Mangshan 官员是一种原始类型并且二个独立驯服事件发生了,分别地导致在北方和南方 Nanling 山的二组栽培官员(MD1 和 MD2 ) 。二个瓶颈和有效人口尺寸的二扩大为栽培官员的 MD1 组被识别。然而,在 MD2 组织 ? 在人口尺寸有长、连续的减少。MD1 和 MD2 官员从栽培 pummelo 种类显示出种间的基因渗入的不同模式。我们在官员的驯服期间在选择下面可能在基因在柠檬酸盐内容的规定包含了的 aconitate hydratase (ACO ) 识别了高分叉的一个区域,它是。这研究为现存野官员人口的地理起源提供具体基因证据并且使驯服和官员的进化历史清楚些。 | Lun Wang Fa He Yue Huang Jiaxian He Shuizhi Yang Jiwu Zeng Chongling Deng Xiaolin Jiang Yiwen Fang Shaohua Wen Rangwei Xu Huiwen Yu Xiaoming Yang Guangyan Zhong Chuanwu Chen Xiang Yan Changfu Zhou Hongyan Zhang Zongzhou Xie Robert M. Larkin Xiuxin Deng Qiang Xu | 2018 | Molecular Plant2018，11，8： | 14 |
| 4 | Endovascular stent-induced alterations in host artery mechanical environments and their roles in stent restenosis and late thrombosis显示文摘Cardiovascular stent restenosis remains a major challenge in interventional treatment of cardiovascular occlusive disease.Although the changes in arterial mechanical environment due to stent implantation are the main causes of the initiation of restenosis and thrombosis,the mechanisms that cause this initiation are still not fully understood.In this article,we reviewed the studies on the issue of stent-induced alterations in arterial mechanical environment and discussed their roles in stent restenosis and late thrombosis from three aspects:(i)the interaction of the stent with host blood vessel,involve the response of vascular wall,the mechanism of mechanical signal transmission,the process of re-endothelialization and late thrombosis;(ii)the changes of hemodynamics in the lumen of the vascular segment and(iii)the changes of mechanical microenvironment within the vascular segment wall due to stent implantation.This review has summarized and analyzed current work in order to better solve the two main problems after stent implantation,namely in stent restenosis and late thrombosis,meanwhile propose the deficiencies of current work for future reference. | Jinxuan Wang Xuepu Jin Yuhua Huang Xiaolin Ran Desha Luo Dongchuan Yang Dongyu Jia Kang Zhang Jianhua Tong Xiaoyan Deng Guixue Wang | 2018 | Regenerative Biomaterials2018，5，3： | 13 |
| 5 | Stratigraphy of the Triassic-Jurassic Boundary Successions of the Southern Margin of the Junggar Basin,Northwestern China显示文摘The Triassic-Jurassic(Tr-J) boundary marks a major extinction event,which(~200 Ma) resulted in global extinctions of fauna and flora both in the marine and terrestrial realms.There prevail great challenges in determining the exact location of the terrestrial Tr-J boundary,because of endemism of taxa and the scarcity of fossils in terrestrial settings leading to difficulties in linking marine and terrestrial sedimentary successions.Investigation based on palynology and bivalves has been carried out over a 1113 m thick section,which is subdivided into 132 beds,along the Haojiagou valley on the southern margin of the Junggar Basin of the northern Xinjiang,northwestern China.The terrestrial Lower Jurassic is conformably resting on the Upper Triassic strata.The Upper Triassic covers the Huangshanjie Formation overlaid by the Haojiagou Formation,while the Lower Jurassic comprises the Badaowan Formation followed by the Sangonghe Formation.Fifty six pollen and spore taxa and one algal taxon were identified from the sediments.Based on the key-species and abundance of spores and pollen,three zones were erected:the Late Triassic(Rhaetian) Aratrisporites-Alisporites Assemblage,the Early Jurassic(Hettangian) Perinopollenites-Pinuspollenites Assemblage,and the Sinemurian Perinopollenites-Cycadopites Assemblage.The Tr-J boundary is placed between bed 44 and 45 coincident with the boundary between the Haojiagou and Badaowan formations.Beds with Ferganoconcha(?),Unio-Ferganoconcha and Waagenoperna-Yananoconcha bivalve assemblages are recognized.The Ferganoconcha(?) bed is limited to the upper Haojiagou Formation, Unio-Ferganoconcha and Waagenoperna-Yananoconcha assemblages are present in the middle and upper members of the Badaowan Formation.The sedimentary succession is interpreted as terrestrial with two mainly lake deposit intervals within Haojiagou and Badaowan formations,yielding fresh water algae and bivalves.However,the presence of brackish water algae Tasmanites and the marine-littoral facies bivalve Waagenoperna from the Badaowan Formation indicate that the Junggar Basin was influenced by sea water caused by transgressions from the northern Tethys,during the Sinemurian. | SHA Jingeng Vivi VAJDA PAN Yanhong Linda LARSSON YAO Xiaogang ZHANG Xiaolin WANG Yaqiong CHENG Xiansheng JIANG Baoyu DENG Shenghui CHEN Siwei PENG Bo | 2011 | Acta Geologica Sinica(English Edition)2011，85，2： | 7 |
| 6 | Vacancies and Antisites in B2 FeAl and DO_3 Fe_3Al with a Modified Analytic EAM Model显示文摘A simple modified analytic EAM model for bcc Fe and fcc Al was used to calculate the lattice constant and elastic constants of B2 FeAl and DO3 Fe3Al alloys. The formation energies of vacancy and antisite were also calculated. The present calculations are in agreement with the experimental data and the theoretical results obtained by other authors. | Xiaolin SHU, Wan gyu HU, Hanning XIAO and Huiqiu DENG College of Materials Science and Engineering, Hunan University, Changsha 410082, China Ban gwei ZHANG International Centre of Materials Physics, Chinese Academy of Sciences, S | 2001 | Journal of Materials Science & Technology2001，17，6： | 4 |
| 7 | Genome of a citrus rootstock and global DNA demethylation caused by heterografting显示文摘Grafting is an ancient technique used for plant propagation and improvement in horticultural crops for at least 1,500 years.Citrus plants,with a seed-to-seed cycle of 5–15 years,are among the fruit crops that were probably domesticated by grafting.Poncirus trifoliata,a widely used citrus rootstock,can promote early flowering,strengthen stress tolerance,and improve fruit quality via scion–rootstock interactions.Here,we report its genome assembly using PacBio sequencing.We obtained a final genome of 303 Mb with a contig N50 size of 1.17Mb and annotated 25,680 protein-coding genes.DNA methylome and transcriptome analyses indicated that the strong adaptability of P.trifoliata is likely attributable to its special epigenetic modification and expression pattern of resistance-related genes.Heterografting by using sweet orange as scion and P.trifoliata as rootstock and autografting using sweet orange as both scion and rootstock were performed to investigate the genetic effects of the rootstock.Single-base methylome analysis indicated that P.trifoliata as a rootstock caused DNA demethylation and a reduction in 24-nt small RNAs(sRNAs)in scions compared to the level observed with autografting,implying the involvement of sRNA-mediated graft-transmissible epigenetic modifications in citrus grafting.Taken together,the assembled genome for the citrus rootstock and the analysis of graft-induced epigenetic modifications provide global insights into the genetic effects of rootstock–scion interactions and grafting biology. | Yue Huang Yuantao Xu Xiaolin Jiang Huiwen Yu Huihui Jia Chunming Tan Gang Hu Yibo Hu Muhammad Junaid Rao Xiuxin Deng Qiang Xu | 2021 | Horticulture Research2021，8，1： | 4 |
| 8 | Fiber Bragg Grating (FBG) Sensors Used in Coal Mines显示文摘纤维布拉格栅栏(FBG ) 紧张传感器被用于在在 Dongtan 矿沿着号码 3203 煤采矿脸的废矿保留的网关的衬里的墙的压力变化的联机监视。结果证明有宽测量范围的 FBG 紧张传感器能在沿着废矿保留的网关的支持过程期间精确地测量压力变化并且能提供基础进一步优化支持结构并且决定沿着废矿保留的网关的支持计划。FBG 微地震的传感器在 Xinglong 矿被使用检测微地震的信号。信号受到欢迎并且分析了决定地点和微地震的事件警告的来源的精力水平。FBG 传感器和检测系统为微地震的察觉和地质的灾难察觉显示出一个重要潜力。 | Jinyu WANG Tongyu LIU Guangdong SONG Hongjing XIE Lianqing LI Xiaolin DENG Zhijie GONG | 2014 | Photonic Sensors2014，4，2： | 3 |
| 9 | Lifetime and Aging Degradation Prognostics for Lithium-ion Battery Packs Based on a Cell to Pack Method显示文摘Aging diagnosis of batteries is essential to ensure that the energy storage systems operate within a safe region.This paper proposes a novel cell to pack health and lifetime prognostics method based on the combination of transferred deep learning and Gaussian process regression.General health indicators are extracted from the partial discharge process.The sequential degradation model of the health indicator is developed based on a deep learning framework and is migrated for the battery pack degradation prediction.The future degraded capacities of both battery pack and each battery cell are probabilistically predicted to provide a comprehensive lifetime prognostic.Besides,only a few separate battery cells in the source domain and early data of battery packs in the target domain are needed for model construction.Experimental results show that the lifetime prediction errors are less than 25 cycles for the battery pack,even with only 50 cycles for model fine-tuning,which can save about 90%time for the aging experiment.Thus,it largely reduces the time and labor for battery pack investigation.The predicted capacity trends of the battery cells connected in the battery pack accurately reflect the actual degradation of each battery cell,which can reveal the weakest cell for maintenance in advance. | Yunhong Che Zhongwei Deng Xiaolin Tang Xianke Lin Xianghong Nie Xiaosong Hu | 2022 | Chinese Journal of Mechanical Engineering2022，35，1： | 3 |
| 10 | Producing nanocrystalline materials by machining 显示文摘 | Deng Wenjun Wan Zhenping Zhao Xiaolin | 2007 | Acta Scientiarum Naturalium Universitatis Sunyatsen I2007，46，6： | 1 |
| 11 | Optimization of preparation of activated carbon from cotton stalk by microwave assisted phos- phoric acid-chemical activation 显示文摘 | Hui Deng Genlin Zhang Xiaolin Xu | 2010 | Journal of Hazardous Materials2010，182，： | 1 |
| 12 | An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP + toxicity and GDNF neuroprotection 显示文摘 | Zeng XianMin Chen Jia Deng XiaoLin | 2006 | Neuropsychopharmacology2006，31，12： | 1 |
| 13 | Monodisperse magnetic single-crystal ferrite microspheres显示文摘 | Deng Hong Li Xiaolin Peng Qing | | 0，，： | 1 |
| 14 | Optimization of preparation of activated carbon from cotton stalk by microwave assisted phosphoric acid-chemical activation显示文摘 | Deng Hui Zhang Genlin xu Xiaolin | | 0，，： | 1 |
| 15 | Position sensorless control based on coordinate transformation for brushless DC motor drives显示文摘 | Wu Yuanyuan Deng Zhiquan Wang Xiaolin | 2010 | IEEE Transactions on Power Electronics2010，25，9： | 1 |
| 16 | Monte Carlo simulation of the surface segregation of Pt-Pd and Pt-Ir alloys with an analytic embedded-atom method 显示文摘 | Deng Huiqiu Hu Wangyu Shu Xiaolin | 2002 | Surf Sci2002，517，： | 1 |
| 17 | Structure and performance of glass–ceramics obtained by Bayan Obo tailing and fly ash显示文摘 | Li Baowei Deng Leibo Zhang Xuefeng Jia Xiaolin | 2013 | Journal of Non-Crystalline Solids2013，，： | 1 |
| 18 | Sustainability of SARS-CoV-2 Induced Humoral Immune Responses in COVID-19 Patients from Hospitalization to Convalescence Over Six Months显示文摘Understanding the persistence of antibody in convalescent COVID-19 patients may help to answer the current major concerns such as the risk of reinfection,the protection period of vaccination and the possibility of building an active herd immunity.This retrospective cohort study included 172 COVID-19 patients who were hospitalized in Wuhan.A total of404 serum samples were obtained over six months from hospitalization to convalescence.Antibodies in the specimens were quantitatively analyzed by the capture chemiluminescence immunoassays(CLIA).All patients were positive for the anti-SARS-Co V-2 Ig M/Ig G at the onset of COVID-19 symptoms,and the Ig G antibody persisted in all the patients during the convalescence.However,only approximately 25%of patients can detect the Ig M antibodies,Ig M against N protein(NIg M)and receptor binding domain of S protein(RBD-Ig M)at the 27 th week.The titers of Ig M,N-Ig M and RBD-Ig M reduced to 16.7%,17.6%and 15.2%of their peak values respectively.In contrast,the titers of Ig G,N-Ig G and RBD-Ig G peaked at 4–5 th week and reduced to 85.9%,62.6%and 87.2%of their peak values respectively at the end of observation.Dynamic behavior of antibodies and their correlation in age,gender and severity groups were investigated.In general,the COVID-19 antibody was sustained at high levels for over six months in most of the convalescent patients.Only a few patients with antibody reducing to an undetectable level which needs further attention.The humoral immune response against SARS-Co V-2 infection in COVID-19 patients exhibits a typical dynamic of acquired immunity. | Yang Zheng Qing Zhang Ashaq Ali Ke Li Nan Shao Xiaoli Zhou Zhiqin Ye Xiaomin Chen Shanshan Cao Jing Cui Juan Zhou Dianbing Wang Baidong Hou Min Li Mengmeng Cui Lihua Deng Xinyi Sun Qian Zhang Qinfang Yang Yong li Hui Wang Yake Lei Bo Yu Yegang Cheng Xiaolin Tong Dong Men Xian-En Zhang | 2021 | Virologica Sinica2021，36，5： | 1 |
| 19 | Monodisperse magnetic single-crystal ferrite microspheres显示文摘 | Deng Hong Li Xiaolin Peng Qing | 2005 | Angewandte Chemie International Edition2005，117，18： | 1 |
| 20 | 传统止血和凝血试验与肝硬化急性上消化道出血的关系:一项回顾性研究显示文摘目的:回顾性比较伴与不伴急性上消化道出血(AUGIB)或急性食管静脉曲张出血(AEVB)的肝硬化患者止血/凝血指标的差异,包括血小板计数(PLT)、凝血酶原时间(PT)、国际标准化比率(INR)和活化部分凝血活酶时间(APTT)。方法:2012年1月至2014年6月间,共计1734例肝硬化患者纳入研究。根据其病史分为AUGIB组(497例)和无AUGIB组(1237例);同时根据内镜检查结果分为AEVB组(297例)和无AEVB组(1259例),另178例AUGIB患者由于缺乏内镜资料,既未入AEVB组,也未归入无AEVB组。结果:AUGIB组与无AUGIB组患者相比,PLT(99.99±89.90 vs 101.47±83.03,P=0.734)和APTT(42.96±15.20 vs 43.77±11.01,P=0.219)的差异无统计学意义,但PT显著延长(17.30±5.62 vs 16.03±4.68,P<0.001),INR显著增高(1.45±0.69 vs 1.31±0.59,P<0.001)。PT可以独立预测AUGIB的发生,PT越低,AUGIB出现的可能性越小(OR=0.968,95%CI:0.942-0.994)。AEVB组与无AEVB组患者相比,PLT显著减少(86.87±62.14 vs 101.74±83.62,P=0.004),APTT显著缩短(40.98±7.98 vs 43.72±10.97,P<0.001),但PT(16.53±3.71 vs 16.0464.68,P=0.088)和INR(1.35±0.41 vs 1.3160.59,P=0.225)的差异则无统计学意义。PLT可独立预测AEVB的发生,PLT越高,AEVB出现的可能性越大(OR=1.004,95%CI:1.002-1.006)。结论:PLT与肝硬化患者门脉高压出血密切相关。 | Jing Li Xingshun Qi Han Deng Ying Peng Lichun Shao Jiaxin Ma Xiaolin Sun Hongyu Li Xiaozhong Guo | 2016 | Gastroenterology Report2016，4，4： | 1 |
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