|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anti-PD-L1/TGF-BR fusion protein (SHR-1701) overcomes disrupted lymphocyte recovery-induced resistance to PD-1/PD-L1 inhibitors in lung cancer显示文摘Background:Second-generation programmed cell death-protein 1/pro-grammed death-ligand 1(PD-1/PD-L1)inhibitors,such as bintrafusp alfa(M7824),SHR-1701,and YM101,have been developed to simultaneously block PD-1/PD-L1 and transforming growth factor-beta/transforming growth factor-beta receptor(TGF-P/TGF-βR).Consequently,it is necessary to identify predictive factors of lung cancer patients who are not only resistant to PD-1/PD-LI inhibitors but also sensitive to bifunctional drugs.The purpose of this study was to search for such predictors.Methods:Multivariable Cox regression was used to study the association between the clinical outcome of treatment with PD-1/PD-L1 inhibitors and lym-phocyte recovery after lymphopenia in lung cancer patients.Murine CMT167 lung cancer cells were engineered to express the firefly luciferase gene and implanted orthotopically in the lung of syngeneic mice.Bioluminescence imag-ing,flow cytometry,and immunohistochemistry were employed to detrmine response to immunotherapy and function of tumor-infiltrating immune cells.Results:For lung cancer patients treated with anti-PD-1/PD-LI antibodies,poor lymphocyte recovery was associated with a shorter progression-free survival(PFS;P<0.001),an accumulation of regulatory T cells(Tregs),and an elimi-nation of CD8+T cells in the peripheral blood.Levels of CD8+T cells and Treg cells were also imbalanced in the tumors and peripheral immune organs of mice with poor lymphocyte recovery after chemotherapy.Moreover,these mice failed to respond to anti-PD-1 antibodies but remained sensitive to the anti-PD-LI/TGF-βR fusion protein(SHR-1701).Consistently,SHR-1701 but not anti-PD-1 antibod-ies,markedly enhanced IFN-γproduction and Ki-67 expression in peripheral CD8+T cells from patients with impaired lymphocyte recovery.Conclusions:Lung cancer patients with poor lymphocyte recovery and suffer-ing from persistent lymphopenia after previous chemotherapy are resistant to anti-PD-1/PD-L1 antibodies but might be sensitive to second-generation agents such as SHR-1701. | Bo Cheng Kaikai Ding Pengxiang Chen Jianxiong Ji Tao Luo Xiaofan Guo Wei Qiu Chunhong Ma Xue Meng Jian Wang Jinming Yu Yuan Liu | 2022 | Cancer Communications2022，42，1： | 5 |
| 2 | Investigation and analysis of the linkage mechanism and whole process cost of livestock manure organic fertilizer显示文摘In recent years,the utilization of manure resources for livestock and poultry farming has attracted a widespread attention,and manure resources utilization models suitable for different regional characteristics have formed gradually.Among them,the production of organic fertilizer from animal manure is a vital utilization method.However,there are still some problems such as high production costs,difficult sales,and the unwillingness of farmers to use organic fertilizers which have affected the breeding cycle and the sustainability of manure treatment in livestock and poultry breeding.This article selected 371 organic fertilizer plants,related farms and farmers in China,focusing on the main links of the entire process of livestock manure-organic fertilizer-farm application,and studied the mode of animal manure collection by organic fertilizer plants.The costs of organic fertilizer production and farmland application were discussed.Moreover,suggestions were made for the promotion and implementation of large-scale organic fertilizers to make good utilization of manure resources in livestock and poultry farming. | Shanshan Dong Bin Sui Yujun Shen Haibo Meng Lixin Zhao Jingtao Ding Haibin Zhou Xi Zhang Hongsheng Cheng Jian Wang Ran Li Liqiu Song Pengxiang Xu Ji Li | 2020 | International Journal of Agricultural and Biological Engineering2020，13，2： | 2 |
| 3 | Role of short amine in preparation and sizing performance of partly hydrolyzed ASA emulsion stabilized by Laponite particles显示文摘 | Ding Pengxiang LiuWenxia Zhao Zhenhuan | 2011 | Colloids and Surfaces A: Pbysicochemical and Engineering Aspects2011，384，13： | 1 |
| 4 | Roles of short amine in preparation and sizing performance of partly hydrolyzed ASA emul- sion stabilized by Laponite particles 显示文摘 | Ding Pengxiang Liu Wenxia Zhao Zhenghuan | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，384，3： | 1 |
| 5 | Roles of short amine in preparation and sizing performance of partly hydrolyzed ASA emul- sion stabilized by Laponite particles 显示文摘 | Ding Pengxiang Liu Wenxia Zhao Zhenghuan | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，384，13： | 1 |
| 6 | Zn(Ⅱ) can mediate self-association of the extracellular C-terminal domain of CD147显示文摘 | Shujuan Jin Pengfei Ding Pengxiang Chu Hongwei Li Jianbo Sun Dehai Liang Fei Song Bin Xia | 2018 | Protein & Cell2018，9，3： | 0 |
| 7 | Whistle signal variations among three Indo-Pacific humpback dolphin populations in the South China Sea:a combined effect of the Qiongzhou Strait’s geographical barrier function and local ambient noise?显示文摘Geographic variations in the dolphin whistles could be useful in assessing association and isolation among populations.Whistle of free-ranging Indo-Pacific humpback dolphins(Sousa chinensis)among the Pearl River Estuary(PRE),Leizhou Bei(LZB)and Sanniang Bay(SNB)populations were investigated.A total of 2850 whistles with legible fundamental contour were extracted and 15 acoustic parameters were measured.Contrary to SNB,PRE and LZB had the same relative proportion of tonal type compositions with flat and sine representing the most frequent types.The generalized linear model analysis showed significant acoustic difference among populations and tonal types.All frequency parameters in SNB were significantly higher than those in PRE and LZB,where no significant variation was observed in most of the parameters either at the population level or within each tonal type.Canonical discriminant functions analysis showed a smaller difference between PRE and LZB than between PRE and SNB and between LZB and SNB.Compared with previous recordings,recent recordings demonstrated a consistent pattern of becoming higher in whistle frequency parameters in both LZB and SNB populations,suggesting that noise pollution in LZB and SNB increasing with time according to the acoustic niche hypothesis.Dolphin whistle’s geographic variations could be shaped by the combined function of the geographical barrier function of the Qiongzhou strait and local ambient noise.Considering the isolated condition and the relatively smaller population size of the humpback dolphin in the SNB,more effective and proactive conservation actions should be taken to prevent the extinction of small populations. | Jing YUAN Zhitao WANG Pengxiang DUAN Yousheng XIAO Hongke ZHANG Zhixiong HUANG Ruichun ZHOU Hua WEN Kexiong WANG Ding WANG | 2021 | Integrative Zoology2021，16，4： | 0 |
| 8 | Screening for bacterial enzymes synthesizing GPR119 agonist in cAMP-responsive cells显示文摘G protein-coupled receptor 119(GPR119),encoded by human GPR119 gene,is considered as a novel member of cannabinoid receptors.GPR119 is expressed predominantly in the pancreas and gastrointestinal tract of rodents and humans,as well as in the brain of rodents.GPR119 has also been shown to regulate incretin and insulin hormone secretion.Activation of GPR119 causes a reduction in food intake and lowers gain of body weight in rats[1].Targeting GPR119 with specific agonists has thus been attempted as a novel strategy to treat obesity and diabetes[2–4].In addition,GPR119 also plays an important role in bone metabolism,thus making GPR119 a potential target for bone resorption-associated diseases[5]. | Junfang Jia Yun Chen Lin Xu Yun Yang Xingxing Xu Hongyu Ding Caiwei Jia Hong Gao Pengxiang Guo Ronggui Hu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员