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| 1 | 高强度聚焦超声治疗不能手术胰腺癌的1年生存分析:中国和保加利亚的多中心临床研究显示文摘目的:通过多中心临床研究分析高强度聚焦超声治疗不能手术胰腺癌的1年生存情况。方法:2013年1月到2014年1月,中国和保加利亚的不能手术的胰腺癌患者32例,男/女=20/12,年龄41~81(59.8±9.1)岁。胰腺癌病灶最大径20~60(39.3±9.6)mm,远处转移/无转移的患者18/14例。接受HIFU和/或化疗。记录术后并发症,疼痛变化和生存情况。使用Kaplan-Meier法计算总生存率和中位生存时间,比较化疗与否、是否发生远处转移的患者生存率有无差异(Log-Rank检验)。结果:术后1月,皮肤浅Ⅱ°烧伤者2例,经保守处理后1~2周愈合。伴有胰腺癌相关性疼痛症状的患者30例与术前比较,减轻的24例(80.0%),不变的5例(16.7%),加重的1例(3.3%)。所有患者的1年生存率为38.4%,中位生存时间为12个月。接受辅助化疗的患者1年生存率为57.4%,中位生存时间12月;未接受辅助化疗的患者1年生存率为20.8%,中位生存时间为6月;二者间比较有显著性差异。伴有远处转移的患者1年生存率为0%,中位生存时间为7月;无远处转移的患者1年生存率为49.2%,中位生存时间为12月;二者间比较无统计学差异。结论:中国和保加利亚的不能手术胰腺癌患者均能安全完成HIFU治疗,1年生存率和中位生存时间优于其它非手术治疗手段。辅助化疗能增加生存受益,远处转移是预后不良因素。 | 周崑 Dobromir Dimitrov Dimitrov Tihomir Vencislavov Andreev 汪亮 Hyuliya Erdzhanova Feradova Grigor Angelov Gorchev 朱辉 王智彪 | 2015 | 重庆医科大学学报2015，40，3： | 11 |
| 2 | Mechanisms of Atrial Tachyarrhythmias Associated With Coronary Artery Occlusion in a Chronic Canine Model显示文摘 | Kunihiro Nishida Xiao Yan Qi Reza Wakili Philippe Comtois Denis Chartier Masahide Harada Yu-ki Iwasaki Philippe Romeo Ange Maguy Dobromir Dobrev Georghia Michael Mario Talajic Stanley Nattel | 2011 | Circulation2011，，2： | 2 |
| 3 | Projected effectiveness of HIV detection during early infection and rapid ART initiation among MSM and transgender women in Peru: A modeling study显示文摘Background:The Sabes study,a treatment as prevention intervention in Peru,tested the hypothesis that initiating antiretroviral therapy(ART)early in HIV infection when viral load is high,would markedly reduce onward HIV transmission among high-risk men who have sex with men(MSM)and transgender women(TW).We investigated the potential population-level benefits of detection of HIV early after acquisition and rapid initiation of ART.Methods:We designed a transmission dynamic model to simulate the HIV epidemic among MSM and TW in Peru,calibrated to data on HIV prevalence and ART coverage from 2004 to 2011.We assessed the impact of an intervention starting in 2018 in which up to 50%of the new infections were diagnosed within three months of acquisition and initiated on ART within 1 month of diagnosis.We estimated the impact of the intervention over 20 years using the cumulative prevented fraction of new HIV infections compared to scenarios without intervention.Findings:Our model suggests that only 19%of the infected MSM and TW are virally suppressed in 2018 and 35%e40%of the new HIV infections are transmitted from contacts with acutely-infected partners.An intervention reaching 10%of all acutely infected MSM and TW is projected to prevent 13.3%[Uncertainty interval:11.9%e14.3%]of the new infections over 20 years and reduce HIV incidence in 2038 by 24%.Reaching 50%of all acutely infected MSM and TWwill increase the prevalence of viral suppression in 2038 to 59%and prevent 41%of expected infections over 20 years.Reaching 50%of the high-risk MSM and TW in acute phase would reduce HIV incidence in 2038 by 60%and prevent 36%of new infections between 2018 and 2038.Conclusions:Early detection of HIV infections and rapid initiation of ART among MSM is desirable as it would increase the effectiveness of the HIV prevention program in Peru.Targeting high-risk MSM and TW will be highly efficient. | Dobromir Dimitrov Daniel Wood Angela Ulrich David A.Swan Blythe Adamson Javier R.Lama Jorge Sanchez Ann Duerr | 2019 | Infectious Disease Modelling2019，4，1： | 2 |
| 4 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 5 | Recent advances in the molecular pathophysiology of atrial fibrillation显示文摘 | Wakili Reza Voigt Niels K??b Stefan Dobrev Dobromir Nattel Stanley | 2011 | Journal of Clinical Investigation2011，，： | 1 |
| 6 | Spiral Computed Tomography and Magnetic Resonance Angiography Evaluation in Budd-Chiari Syndrome显示文摘 | Lupescu IG Dobromir C Popa GA | 2008 | J Gastrointestin Liver Dis2008，17，2： | 1 |
| 7 | Spiral Computed Tomography and Magnetic Resonance Angiography Evaluation in Budd Chiari Syndrome显示文摘 | Lupescu IG Dobromir C Popa GA | 2008 | J Gastrointestin Liver Dis2008，17，2： | 1 |
| 8 | Using conjoint analysis to detect discrimination: Revealing covert preferences from overt choices 显示文摘 | Eugene M Caruso Dobromir A Rahnev Mahzarin R Banaji | 2009 | Social Cognition2009，27，1： | 1 |
| 9 | Genetic Variation in Titin in Arrhythmogenic Right Ventricular Cardiomyopathy–Overlap Syndromes显示文摘 | Matthew Taylor Sharon Graw Gianfranco Sinagra Carl Barnes Dobromir Slavov Francesca Brun Bruno Pinamonti Ernesto E. Salcedo William Sauer Stylianos Pyxaras Brian Anderson Bernd Simon Julius Bogomolovas Siegfried Labeit Henk Granzier Luisa Mestroni | 2011 | Circulation2011，，8： | 1 |
| 10 | SCN5A Mutations Associate With Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism显示文摘 | William P. McNair Gianfranco Sinagra Matthew R.G. Taylor Andrea Di Lenarda Debra A. Ferguson Ernesto E. Salcedo Dobromir Slavov Xiao Zhu John H. Caldwell Luisa Mestroni | 2011 | Journal of the American College of Cardiology2011，，21： | 1 |
| 11 | Controversies in Cardiovascular Research: Role of Ryanodine Receptor Phosphorylation in Heart Failure and Ar- rhythmias显示文摘 | Dobromir D Wehrens XH | 2014 | Ciw Res2014，114，8： | 1 |
| 12 | Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression显示文摘 | Jordi Heijman Niels Voigt Stanley Nattel Dobromir Dobrev | 2014 | Circulation Research2014，，9： | 1 |
| 13 | Cellular and Molecular Mechanisms of Atrial Arrhythmogenesis in Patients With Paroxysmal Atrial Fibrillation显示文摘 | Niels Voigt Jordi Heijman Qiongling Wang David Y. Chiang Na Li Matthias Karck Xander H.T. Wehrens Stanley Nattel Dobromir Dobrev | 2014 | Circulation2014，，2： | 1 |
| 14 | Complete mathematical analysis of predator - prey models with linear prey growth and Beddington - DeAngelis functional response显示文摘 | Dobromir T D Hristo V K | 2005 | Appl Math Comp2005，162，2： | 1 |
| 15 | XPS study of the ion-exchange capacity of the native and surface oxidized viscose fibers显示文摘 | Marius Dobromir Gabriela Biliuta Dumitru Luca Magdalena Aflori Valeria Harabagiu Sergiu Coseri | 2011 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2011，，1： | 1 |
| 16 | Surface charac- terization of sputtered N:TiO2 thin films within a wide range of dopant concentration 显示文摘 | Manole A V Dobromir M Apetvei R | 2014 | Ceramics International2014，40，7： | 1 |
| 17 | Complete Mathematical AnalySis of Predator-prey Models with Linear Prey Growth and Beddington,DeAngelis Functional Response 显示文摘 | Dobromir T Dimitrov Hristo V Kojoouharov | 2005 | Applied Mathematics and Computation2005，，162： | 1 |
| 18 | Bootstrapped two-electrode biosignal amplifier 显示文摘 | DOBROMIR P D TATYANA N NIKOLAY M | 2008 | Medical and Biological Engineering and Computing2008，46，6： | 1 |
| 19 | Complete mathematical analysis of predator-prey models with linear prey growth and Beddington-DeAngelis functional response显示文摘 | Dimitrov Dobromir T Kojoouharov Hristo V | 2005 | Applied Mathematics and Computation2005，162，2： | 1 |
| 20 | Integrated measurements of 218Po, 214Pb and 214Bi + 214Po in air under environmental concentrations显示文摘 | Dobromir S Pressyanov | 1997 | Nucl Instrum Methods1997，397，： | 1 |
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