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| 1 | Classification and regionalization of the forming environment of windblown sand disasters along the Tarim Desert Highway显示文摘Through the systematic field survey and observations, the factor quantification as well as setting the criteria, the sand disaster-forming environment along the Tarim Desert Highway can be divided into four grades by the classification and regionalization based on fuzzy mathematics. The length of the regions with significant sand disaster accounted for 37.1% of the total highway length. Particularly, the area along the Tarim Desert Highway, based on the sand disaster-forming environment classification as well as the difference in the five basic landform units along the highway, combined with the difference of wind regime, can be divided into five regions, in which the length of the regions suffering severe sand damage occupied 64.3% of the total highway length. In addition, the index of disaster formation grade along the highway decreased from north to south, showing a repeated spatial pattern in small length scales. | LEI JiaQiang LI ShengYu FAN DongDong ZHOU HongWei GU Feng QIU YongZhi XU Bo LIU Shang DU WenYi YAN ZengHui WANG YongChang | 2008 | Chinese Science Bulletin2008，53，S2： | 11 |
| 2 | Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons显示文摘Lgr5+intestinal stem cells(ISCs)reside within specialized niches at the crypt base and harbor self-renewal and differentiation capacities.ISCs in the crypt base are sustained by their surrounding niche for precise modulation of self-renewal and differentiation.However,how intestinal cells in the crypt niche and microbiota in enteric cavity coordinately regulate ISC stemness remains unclear.Here,we show that ISCs are regulated by microbiota and niche enteric serotonergic neurons.The gut microbiota metabolite valeric acid promotes Tph2 expression in enteric serotonergic neurons via blocking the recruitment of the NuRD complex onto Tph2 promoter.5-hydroxytryptamine(5-HT)in turn activates PGE2 production in a PGE2+macrophage subset through its receptors HTR2A/3 A;and PGE2 via binding its receptors EP1/EP4,promotes Wnt/β-catenin signaling in ISCs to promote their self-renewal.Our findings illustrate a complex crosstalk among microbiota,intestinal nerve cells,intestinal immune cells and ISCs,revealing a new layer of ISC regulation by niche cells and microbiota. | Pingping Zhu Tiankun Lu Jiayi Wu Dongdong Fan Benyu Liu Xiaoxiao Zhu Hui Guo Ying Du Feng Liu Yong Tian Zusen Fan | 2022 | Cell Research2022，32，6： | 8 |
| 3 | Atomic mobilities and diffusivities in Al alloys显示文摘Knowledge of diffusivity is a prerequisite for understanding many scientific and technological disciplines.In this paper,firstly major experimental methods,which are employed to provide various diffusivity data,are briefly described.Secondly,the fundamentals of various computational methods,including first-principles method,embedded atomic method/molecular dynamic simulation,semi-empirical approaches,and phenomenological DICTRA technique,are demonstrated.Diffusion models recently developed for order/disorder transitions and stoichiometric compounds are also briefly depicted.Thirdly,a newly established diffusivity database for liquid,fcc_A1,L12,bcc_A2,bcc_B2,and intermetallic phases in the multicomponent Al alloys is presented via a few case studies in binary,ternary and quaternary systems.And the integration of various computational techniques and experimental methods is highlighted.The reliability of this diffusivity database is validated by comparing the calculated and measured concentration profiles,diffusion paths,and Kirkendall shifts in various binary,ternary and quaternary diffusion couples.Next,the established diffusivity databases along with thermodynamic and other thermo-physical properties are utilized to simulate the microstructural evolution for Al alloys during solidification,interdiffusion and precipitation.A special discussion is presented on the phase-field simulation of interdiffusion microstructures in a series of Ni-Al diffusion couples composed of γ,γ',and β phases under the effects of both coherent strain and external compressive force.Future orientations in the establishment of next generation of diffusivity database are finally addressed. | DU Yong ZHANG LiJun CUI SenLin ZHAO DongDong LIU DanDan ZHANG WeiBin SUN WeiHua JIE WanQi | 2012 | Science China(Technological Sciences)2012，55，2： | 6 |
| 4 | Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th)1, Th2,Th17, and regulatory T cell responses显示文摘OBJECTIVE:To examine the effects of catalpol and rhein on pro-and anti-inflammatory responses in C57 BL/6 mice with experimental autoimmune encephalomyelitis(EAE),a model of multiple sclerosis.METHODS:Female C57 BL/6 mice were randomly divided into four groups(n=30):(a)normal salinecontrol,(b)EAE control,(c)EAE+prednisone acetate(PA,6 mg/kg),and(d)EAE+catalpol(40 mg/kg)and rhein(5 mg/kg).EAE was induced by injection of myelin oligodendrocyte glycoprotein 35-55 plus pertussis toxin.Treatments were orally administered daily for 40 d.Disease progression and neurological function were assessed using a semi-quantitative scale of tail and limb paralysis.Brains and spinal cords were collected on Days 6,20,and 40 and assessed for histopathological changes by hematoxylin and eosin staining.Production of interleukin(IL)-2,IL-4,IL-10,and IL-17 A protein was measured by enzyme-linked immunosorbent assay.Expression of the T helper(Th)1-,Th2-,Th17-,and regulatory T cell(Treg)-specific transcription factors T-bet,GATA3,ROR-γt,and Foxp3,respectively,were analyzed by quantitative reverse-transcription polymerase chain reaction and western blot analysis.RESULTS:Combination treatment with catalpol and rhein significantly alleviated the clinical disability and neurological dysfunction of mice with EAE.Catalpol and rhein treatment also reduced the infiltration of pro-inflammatory T cells into pathological lesions;significantly increased the expression of the anti-inflammatory factors GATA3,Foxp3,IL-4,and IL-10;and significantly decreased the expression of the pro-inflammatory factors T-bet,ROR-γt,IL-2,and IL-17 A.CONCLUSION:Catalpol and rhein reduced the neurological disabilities of mice with EAE,at least in part by rebalancing the pro-and anti-inflammatory environment in the brains and spinal cords. | Wei Mingyan Yang Tao Li Qian Zhou Dongdong Du Zongpan Fan Yongping | 2019 | Journal of Traditional Chinese Medicine2019，39，6： | 3 |
| 5 | Research on mechanics properties of crop stalks:A review显示文摘As one of the foundational research areas in agricultural engineering,the study of agricultural materials includes an important branch:mechanics properties of crop stalks.This branch is now widely associated with design and improvement of agricultural equipment,breeding of new species,and development of reinforced composites.This article presents an overview of research on mechanics properties of crop stalks,including the mechanics measurement experiments,mechanics model and theory,microstructure and composition,and mechanics simulation experiments.The current research relies mainly on the mechanics theory of engineering material,neglects the fact that crop stalk is a biological material with complex structure,anisotropy,viscoelasticity and rheology.In addition,some simulation experiments are conducted in idealized conditions,beyond the application.Hence,the paper proposes to create new material models for crop stalks,conduct more practical and effective simulation experiments,and promote cooperation in interdisciplinary studies for the development of mechanics properties of crop stalks in the future research. | Du Dongdong Wang Jun | 2016 | International Journal of Agricultural and Biological Engineering2016，9，6： | 3 |
| 6 | Analysis and test of splitting failure in the cutting process of cabbage root显示文摘Cabbage harvester is very useful to replace the manual cabbage harvesting in China.The cutter with single-point clamping way can reduce the maximum and the average cutting force effectively,but may increase the splitting failure.In this study,the mechanics model of cabbage root with single-point clamping way in cutting process was established.According to the analysis of mechanics model,when the sheer stress exceeded the sheer strength(τa>τ0),splitting failure began to occur.Meanwhile,if the maximum normal stress exceeded the tensile strength(σmax>σ0),the splitting failure would further become riving failure.The positions of splitting failure would almost locate at the cutting depth l equaled to R+r(l=R+r).To reduce the splitting failure,single factor and multi-factor cutting tests about the effect of sliding angle,cutting speed and cutting diameter on splitting failure were carried out.The results showed that the splitting failure would reduce with the increase of sliding angle,cutting speed and cutting diameter.Sliding angle,cutting speed,cutting diameter and the interactions of cutting speed with sliding angle and cutting diameter had significant effect on splitting failure level,and the interaction of sliding angle with cutting diameter and the 3 factors’interaction had no effect.To minimize splitting failure levels,the best cutting combination was that:sliding angle 40°,cutting speed 300 mm/min and cutting diameter 35 mm.This research can provide a basis of how to design a cutter for the cabbage harvester including the optimized cutting combination. | Du Dongdong Wang Jun Qiu Shanshan | 2015 | International Journal of Agricultural and Biological Engineering2015，8，4： | 3 |
| 7 | Ferric oxide nanosheet-engineered Mg alloy for synergetic osteosarcoma photothermal/chemodynamic therapy显示文摘Osteosarcoma(OS)is a malignant tumor with a high rate of recurrence.Recently,biodegradable Mg-based implants have become a new therapeutic platform for bone-related diseases.However,poor biosafety and deficient intelligent tumor-killing ability of Mg-based implants are still the main challenges for the pre-cise treatment of OS.Herein,based on the excellent catalytic and photothermal conversion properties of nanozyme ferric oxide(Fe_(3)O_(4)),a novel two-step hydrothermal method for in situ preparation of Fe_(3)O_(4)nanosheets on the surface of plasma electrolytic oxidation(PEO)-treated Mg alloy using Mg-Fe layered double hydroxides(Mg-Fe LDH)as precursor was proposed.Compared with Mg alloy,there were no obvious corrosion cracks on the surface of Fe_(3)O_(4)nanosheets-coated Mg alloy(Fe_(3)O_(4)-NS)immersed in 0.9 wt.%NaCl for 14 days,which demonstrated the corrosion resistance of Mg alloy was significantly enhanced.Cytocompatibility experiments and hemolysis assay confirmed the great biocompatibility of Fe_(3)O_(4)-NS,especially,hemolysis ratio was lower than 1%.Meanwhile,Fe_(3)O_(4)-NS presented excellent cat-alytic oxidation capacity in the presence of H_(2)O_(2),and its temperature can significantly increase from 27℃to approximately 56℃under NIR irradiation.Therefore,intelligent responsive Fe_(3)O_(4)nanosheets-engineered Mg-based implants demonstrated excellent antitumor properties in vivo and in vitro due to their photothermal and chemodynamic synergetic effects.This study provides a novel approach for the preparation of Fe_(3)O_(4)coatings on the surface of Mg alloys and a new strategy for the treatment of OS. | Huihui Du Dongdong Zhang Ru Xu Juning Xie Shiwei Guan Shuhan Chen Feng Peng Shi Qian Xuanyong Liu | 2023 | Journal of Materials Science & Technology2023，，7： | 2 |
| 8 | Low-temperature plasma technology for electrocatalysis显示文摘Electrochemical reactions were widely used in energy storage and conversion devices. The development of low-cost, highly efficient and stable electrocatalyst is essential to a large-scale application of energy storage and conversion devices. Recently, emerging plasma technology has been employed as one of the practical ways to synthesize and modify electrocatalysts due to its unique property. In this review, we summarized the latest applications of plasma in energy storage and conversion, including using it as the preparation and modification technology of the various electrocatalysts and the usage of it as the synthesis technology directly. Firstly, we presented the definition and types of plasma reactors and their respective characteristics. Then, these applications of plasma technology in many essential electrode reactions including carbon dioxide reduction reaction(CO_2RR), nitrogen fixation, oxygen reduction reaction(ORR), oxygen evolution reaction(OER) and hydrogen evolution reaction(HER) were introduced.Finally, the challenges and outlook of plasma technology in energy storage and conversion were summarized, and the solutions and prospected its development in the future were present. Through reviewing the related aspects, readers can have a deeper understanding of the application prospects of plasma in electrocatalysis. | Dongdong Wang Yuqin Zou Li Tao Yiqiong Zhang Zhijuan Liu Shiqian Du Shuangquan Zang Shuangyin Wang | 2019 | Chinese Chemical Letters2019，30，4： | 2 |
| 9 | Room temperature synthesis of stable silica-coated CsPbBr3 quantum dots for amplified spontaneous emission显示文摘All-inorganic cesium lead bromide(CsPbBr;)perovskite quantum dots(QDs)with excellent optical properties have been regarded as good gain materials for amplified spontancous cmission(ASE).However,the poor stability as the results of the high sensitivity to heat and moisture limits their further applications.Here,we report a facile one-pot approach to synthesize CsPbBr,@SiO,QDs at room tcmperature.Duc to the effective defects passivation using SiO2,as-prepared CsPbBr,@SiO;QDs present an enhanced photolumincscence quantum yicld(PLQY)and chemical stability.The PLQy of CsPbBr,@SiO,QDs reaches 71.6%which is higher than 46%in pure CsPbBr,QDs.The PL intensity of CsPbBr;@SiO,QDs maintains 84%while remaining 24%in pure CsPbBr3 after 80 min heating at 60℃.The ASE performance of the films is also studied under a two-photon-pumped laser.Compared with the films using pure CsPbBr;QDs,those with as-prepared CsPbBr3@SiO2 QDs exhibit a reduced threshold of ASE.The work suggests that room-temperature-synthesized SiO2-coated perovskites QDs are promising candidates for lascr devices. | QIONGHUA MO TONGCHAO SHI WENSI CAI SHUANGYI ZHAO DONGDONG YAN JUAN DU ZHIGANG ZANG | 2020 | Photonics Research2020，8，10： | 2 |
| 10 | Literature review and economic evaluation of oral and intramuscular ziprasidone treatment among patients with schizophrenia in China显示文摘Background Over 10 million Chinese are affected by schizophrenia. The annual cost of schizophrenia in China was estimated at US$2586 per patient.Aims The study has two aims:(1) to conduct a targeted literature review of the economic literature on oral ziprasidone in China, and(2) to develop an inpatient economic model that compared the cost of intramuscular ziprasidone with other regimens including electroconvulsive therapy(ECT) for the management of acute agitation in patients with schizophrenia from a hospital's perspective in China.Methods A targeted literature review was conducted using PubMed and the Chinese literature databases for studies published between January 2007 and December2017. Studies that assessed costs associated with oral ziprasidone treatment for schizophrenia in China were summarised. In the inpatient economic model,cost measures included hospital room and board,antipsychotics,ECT and medications for the management of extrapyramidal symptoms(EPS). Input for standard antipsychotic regimens and unit cost were obtained from the literature. Hospital length of stay(LOS), utilisation of ECT and incidence of EPS were derived from the literature and supplemented/validated with a survey of psychiatrists in China. Cost was presented in 2017 Chinese yuan.Results The average estimated LOS was 29 days with ziprasidone, 33 days with risperidone+benzodiazepine,32 days with olanzapine, 35 days with haloperidol and 29 days with ECT. The cost of antipsychotics was $1260 with ziprasidone, $137 with risperidone+benzodiazepine, $913 with olanzapine and $210 with haloperidol; ECT treatment costs $785. The base-case analysis suggested that higher antipsychotic cost with ziprasidone was offset by savings with shorter LOS. Using intramuscular ziprasidone for acute management was associated with a total cost of $11157, the lowest among all antipsychotic regimens($11 424 with risperidone+benzodiazepine, $11 711 with olanzapine and $11 912 with haloperidol) and slightly higher than ECT($10 606). The cost of antipsychotics and ECT accounted for 1 %-11 % of the total cost. Varying LOS between the lower and upper bounds of the 95% CI, the total cost was comparable between these regimens.Conclusions Overall, the cost for the management of acute agitation was similar between intramuscular ziprasidone and other antipsychotics. Compared with other antipsychotics, the higher medication cost of intramuscular ziprasidone can be offset by savings with shorter hospital stay. The results from this economic analysis were complementary to the findings in the published literature assessing the economic outcomes of oral ziprasidone. | Yu-Chen Yeh Xin Yu Congpei Zhang Wei Hao Fen Du Dongdong Liu Lili Yang Xin Gao | 2018 | General Psychiatry2018，31，6： | 2 |
| 11 | Assessment of the atomic mobility in fcc AI-Cu-Mg alloys显示文摘 | Zhang Weibin Du Yong Zhao Dongdong | 2010 | Computer Coupling of Phase Diagrams andThermochemistry2010，34，3： | 1 |
| 12 | Enzymatic formation of curcumin in vitro and in vivo显示文摘 | Jiaqing wang Taotao Xiong Jie Zhou Hongjian He Dongdong Wu Xuewen Du Xingyi Li Bing Xu | 2018 | Nano Research2018，11，6： | 1 |
| 13 | Seismic collapse simulation of existing masonry buildings with different retrofitting techniques显示文摘Masonry buildings are primarily constructed out of bricks and mortar which become discrete pieces and cannot sustain horizontal forces created by a strong earthquake.The collapse of masonry walls may cause significant human casualties and economic losses.To maintain their integrity,several methods have been developed to retrofit existing masonry buildings,such as the constructional RC frame which has been extensively used in China.In this study,a new method using precast steel reinforced concrete(PSRC)panels is developed.To demonstrate its effectiveness,numerical studies are conducted to investigate and compare the collapse behavior of a structure without retrofitting,retrofitted with a constructional RC frame,and retrofitted with external PSRC walls(PSRCW).Sophisticated finite element models(FEM)were developed and nonlinear time history analyses were carried out.The results show that the existing masonry building is severely damaged under occasional earthquakes,and totally collapsed under rare earthquakes.Both retrofitting techniques improve the seismic performance of existing masonry buildings.However,it is found that several occasional earthquakes caused collapse or partial collapse of the building retrofitted with the constructional RC frame,while the one retrofitted by the proposed PSRC wall system survives even under rare earthquakes.The effectiveness of the proposed retrofitting method on existing masonry buildings is thus fully demonstrated. | Ge Dongdong Du Chunbo Miao Qisong Chen Xi | 2021 | Earthquake Engineering and Engineering Vibration2021，20，1： | 1 |
| 14 | ^(64)Cu radiolabeled nanomaterials for positron emission tomography(PET)imaging显示文摘The prevalence of positron emission tomography(PET)imaging has advanced biomedical applications for its ultrahigh sensitivity,deep tissue penetration and quantitative visualization of diseases in vivo.^(64)Cu with ideal half-life and decay characteristics has been designed as radioactive probes for disease diagnosis.The currently reported ^(64)Cu-labeled nanomaterials have the advantages of long circulation time in serum,good biocompatibility and mature preparation methods,and have been used in vivo PET imaging,biodistribution and pharmacokinetic monitoring,and imaging guided therapy.At the same time,suitable carrier characteristics and radiolabeling strategies are particularly important in the ^(64)Cu PET imaging process.In this review,we summarize different imaging probe designs and ^(64)Cu radiolabeling strategies,as well as their eventual applications in biomedicine.The potential challenges and prospects of ^(64)Cu labeled nanomaterials are also described,which provides broad prospects for radiolabeling strategies and further applications. | Xueqian Chen Wenchao Niu Zhongying Du Yong Zhang Dongdong Su Xueyun Gao | 2022 | Chinese Chemical Letters2022，33，7： | 1 |
| 15 | Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy显示文摘Promoting metallic magnesium(Mg)-based implants to treat bone diseases in clinics,such as osteosarcoma and bacterial infection,remains a challenging topic.Herein,an iron hydroxide-based composite coating with a twostage nanosheet-like structure was fabricated on Mg alloy,and this was followed by a thermal reduction treatment to break some of the surface Fe–OH bonds.The coating demonstrated three positive changes in properties due to the defects.First,the removal of–OH made the coating superhydrophobic,and it had self-cleaning and antifouling properties.This is beneficial for keeping the implants clean and for anti-corrosion before implantation into the human body.Furthermore,the superhydrophobicity could be removed by immersing the implant in a 75%ethanol solution,to further facilitate biological action during service.Second,the color of the coating changed from yellow to brown-black,leading to an increase in the light absorption,which resulted in an excellent photothermal effect.Third,the defects increased the Fe2+content in the coating and highly improved peroxidase activity.Thus,the defect coating exhibited synergistic photothermal/chemodynamic therapeutic effects for bacteria and tumors.Moreover,the coating substantially enhanced the anti-corrosion and biocompatibility of the Mg alloys.Therefore,this study offers a novel multi-functional Mg-based implant for osteosarcoma therapy. | Dongdong Zhang Ru Xu Shuhan Chen Huihui Du Shi Qian Feng Peng Xuanyong Liu | 2023 | Bioactive Materials2023，，12： | 0 |
| 16 | Interfacial passivation of n-ZnO/p-Si heterojunction by CuI thin layer显示文摘The ZnO/Si heterojunction diode can be integrated with the Si process, which has attracted great attention in recent years. However, the large number of interface states at the ZnO/Si heterojunction interface could adversely affect its optoelectronic properties. Here, n-type ZnO thin film was deposited on p-Si substrate for formation of an n-ZnO/p-Si heterojunction substrate. To passivate the ZnO/Si interface, a thin Cul film interface passivation layer was inserted at the ZnO/p-Si heterojunction interface. Electrical characterization such as I-V and C-V characteristic curves confirmed the significant improvement of the heterojunction properties e.g. enhancement of forward current injection, reduction of reverse current and improvement of the rectification ratio. These results showed that the passivation of interface is critical for ZnO/Si heterojunctions. | Chao Xiong Jin Xiao Lei Chen Wenhan Du Weilong Xu Dongdong Hou | 2018 | Journal of Semiconductors2018，39，12： | 0 |
| 17 | Enhanced crystallization resistance and thermal stability via suppressing the metastable superlattice phase in Ni-(Pd)-P metallic glasses显示文摘Virtually,glass formation is to avoid crystallization during solidification,i.e.,a consequence of the competition between the undercooled liquid and primary crystalline phases.It is found that the crystallization resistance of the binary Ni-P system was drastically enhanced with alloying of Pd and correspondingly,the critical size for glass formation increased significantly from the micrometer to millimeter scale.Thermodynamically,the introduction of Pd could effectively increase the atomic size mismatch and heat of mixing,which are beneficial to stabilize the supercooled liquid.Kinetically,the introduction of Pd not only successfully suppresses the formation of metastable superlattice phase,which is prone to nucleation and growth in the supercooled liquid state,but also changes the crystallization mechanism from the primary to eutectic mode.The current finding sheds light on understanding glass formation of the most studied Pd-Ni-P system and the glass-forming ability in general. | Qing Du Xiongjun Liu Yihuan Cao Yuren Wen Dongdong Xiao Yuan Wu Hui Wang Zhaoping Lu | 2020 | Journal of Materials Science & Technology2020，42，7： | 0 |
| 18 | Supramolecular Nanofibers/Hydrogels of the Conjugates of Nucleobase,Saccharide,and Amino Acids显示文摘Three new hydrogelators based on the conjugates of three naturally occurring biological building blocks:nu-cleobase,saccharide,and amino acids,were explored.Being synthesized via a facile solid phase peptide synthesis route,the hydrogelators self-assemble in water to afford supramolecular nanofibers and hydrogels.Transmission electron microscopy,oscillation rheometry,and circular dichroism reveal that the hydrogels consist of largely he-lix-based nanofibers of the widths of 5-12 nm and exhibit storage moduli up to 1 kPa.These hydrogelators also exhibit excellent cell-compatibility.This work illustrates a new platform for constructing molecular soft materials for nanobiotechnology. | Dongdong Wu Xuewen Du Junfeng Shi Jie Zhou Bing Xu | 2014 | Chinese Journal of Chemistry2014，32，4： | 0 |
| 19 | Application of biofl oc technology in recirculation A rtemia culture system显示文摘Biofl oc technology(BFT)improves water quality,and productivity of the farmed species through converting ammonium nitrogen to microbial protein,stabilizing microbial community,and reducing the production cost.In this study,a small-scale biofl oc development unit was designed in combination of recirculation system(RAS)for Artemia culture.Artemia growth,water quality,and microbial composition of biofl ocs in RAS were studied in comparison with in-situ batch culture(Glu).Glucose was added in RAS and Glu at C/N ratio of 10.The cultures without glucose addition,but with 50%daily water renewal(WRe)and without water renewal(NWRe)were considered as the controls.Arte mia were cultured at 25℃ and salinity 30 for 24 days and fed formulated feed.The results showed that compared to the controls,Glu signifi cantly improved the Artemia biomass,increased the biofl oc volume,and reduced the content of total ammonia nitrogen(TAN),nitrite nitrogen(NO_(2)-N)and nitrate nitrogen(NO_(3)-N)in water column(P<0.05).In addition,RAS had similar results with Glu.High throughput sequencing analysis on biofl oc microbial composition demonstrated that glucose supplement shaped the microbial community structure,and increased proportion of potential probiotic bacteria and suppressed pathogenic bacteria growth.Furthermore,we analyzed the relationship between the microbial composition of biofl oc and environmental factors.Canonical correspondence analysis(CCA)indicated that inorganic nitrogen in culture water had great impact on biofl oc microbial composition in NWRe and WRe,whilst the dissolved organic carbon(DOC)modifi ed the microbial community in Glu and RAS.This study shows the advantages of BFT in Artemia culture and provides practical information for applying BFT-RAS in indoor Artemia culture. | Xuejiao LIANG Chi ZHANG Dongdong DU Meirong GAO Liying SUI | 2022 | Journal of Oceanology and Limnology2022，40，4： | 0 |
| 20 | Black Mn-containing layered double hydroxide coated magnesium alloy for osteosarcoma therapy, bacteria killing, and bone regeneration显示文摘Osteosarcoma (OS) tissue resection with distinctive bactericidal activity, followed by regeneration of bone de-fects, is a highly demanded clinical treatment. Biodegradable Mg-based implants with desirable osteopromotive and superior mechanical properties to polymers and ceramics are promising new platforms for treating bone-related diseases. Integration of biodegradation control, osteosarcoma destruction, anti-bacteria, and bone defect regeneration abilities on Mg-based implants by applying biosafe and facile strategy is a promising and challenging topic. Here, a black Mn-containing layered double hydroxide (LDH) nanosheet-modified Mg-based implants was developed. Benefiting from the distinctive capabilities of the constructed black LDH film, including near-infrared optical absorption and reactive oxygen species (ROS) generation in a tumor-specific microenvi-ronment, the tumor cells and tissue could be effectively eliminated. Concomitant bacteria could be killed by localized hyperthermia. Furthermore, the enhanced corrosion resistance and synergistic biofunctions of Mn and Mg ions of the constructed black LDH-modified Mg implants significantly facilitated cell adhesion, spreading and proliferation and osteogenic differentiation in vitro, and accelerated bone regeneration in vivo. This work offers a new platform and feasible strategy for OS therapeutics and bone defect regeneration, which broadens the biomedical application of Mg-based alloys. | Dongdong Zhang Shi Cheng Ji Tan Juning Xie Yu Zhang Shuhan Chen Huihui Du Shi Qian Yuqing Qiao Feng Peng Xuanyong Liu | 2022 | Bioactive Materials2022，7，11： | 0 |
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