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| 1 | DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways显示文摘Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellular stresses;however,its critical role in GC remains poorly understood.The present study aimed to investigate the poten-tial relationship and the underlying mechanism between DDIT4 and GC development.Methods:We used western blotting,real-time polymerase chain reaction,and immunohistochemical or immunoflu-orescence to determine DDIT4 expression in GC cells and tissues.High-content screening,cell counting kit-8 assays,colony formation,and in vivo tumorigenesis assays were performed to evaluate cell proliferation.Flow cytometry was used to investigate cell apoptosis and cell cycle distribution.Results:DDIT4 was upregulated in GC cells and tissue.Furthermore,downregulating DDIT4 in GC cells inhibited proliferation both in vitro and in vivo and increased 5-fluorouracil-induced apoptosis and cell cycle arrest.In contrast,ectopic expression of DDIT4 in normal gastric epithelial cells promoted proliferation and attenuated chemosensitivity.Further analysis indicated that the mitogen-activated protein kinase and p53 signaling pathways were involved in the suppression of proliferation,and increased chemosensitivity upon DDIT4 downregulation.Conclusion:DDIT4 promotes GC proliferation and tumorigenesis,providing new insights into the role of DDIT4 in the tumorigenesis of human GC. | Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan | 2018 | Cancer Communications2018，38，1： | 10 |
| 2 | Inhalable oridonin-loaded poly(lactic-co-glycolic)acid large porous microparticles for in situ treatment of primary non-small cell lung cancer显示文摘Non-small cell lung cancer(NSCLC) accounts for about 85% of all lung cancers. Traditional chemotherapy for this disease leads to serious side effects. Here we prepared an inhalable oridonin-loaded poly(lactic-co-glycolic)acid(PLGA) large porous microparticle(LPMP) for in situ treatment of NSCLC with the emulsion/solvent evaporation/freeze-drying method. The LPMPs were smooth spheres with many internal pores. Despite a geometric diameter of 10 mm, the aerodynamic diameter of the spheres was only 2.72 mm, leading to highly efficient lung deposition. In vitro studies showed that most of oridonin was released after 1 h, whereas the alveolar macrophage uptake of LPMPs occurred after 8 h, so that most of oridonin would enter the surroundings without undergoing phagocytosis. Rat primary NSCLC models were built and administered with saline, oridonin powder, gemcitabine, and oridonin-loaded LPMPs via airway, respectively. The LPMPs showed strong anticancer effects. Oridonin showed strong angiogenesis inhibition and apoptosis. Relevant mechanisms are thought to include oridonin-induced mitochondrial dysfunction accompanied by low mitochondrial membrane potentials, downregulation of BCL-2 expressions, upregulation of expressions of BAX, caspase-3 and caspase-9. The oridonin-loaded PLGALPMPs showed high anti-NSCLC effects after pulmonary delivery. In conclusion, LPMPs are promising dry powder inhalations for in situ treatment of lung cancer. | Lifei Zhu Miao Li Xiaoyan Liu Lina Du Yiguang Jin | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 7 |
| 3 | Development and validation of an ocean wave retrieval algorithm for VV-polarization Sentinel-1 SAR data显示文摘The purpose is to study the accuracy of ocean wave parameters retrieved from C-band VV-polarization Sentinel-1Synthetic Aperture Radar(SAR) images, including both significant wave height(SWH) and mean wave period(MWP), which are both calculated from a SAR-derived wave spectrum. The wind direction from in situ buoys is used and then the wind speed is retrieved by using a new C-band geophysical model function(GMF) model,denoted as C-SARMOD. Continuously, an algorithm parameterized first-guess spectra method(PFSM) is employed to retrieve the SWH and the MWP by using the SAR-derived wind speed. Forty–five VV-polarization Sentinel-1 SAR images are collected, which cover the in situ buoys around US coastal waters. A total of 52 subscenes are selected from those images. The retrieval results are compared with the measurements from in situ buoys. The comparison performs good for a wind retrieval, showing a 1.6 m/s standard deviation(STD) of the wind speed, while a 0.54 m STD of the SWH and a 2.14 s STD of the MWP are exhibited with an acceptable error.Additional 50 images taken in China's seas were also implemented by using the algorithm PFSM, showing a 0.67 m STD of the SWH and a 2.21 s STD of the MWP compared with European Centre for Medium-range Weather Forecasts(ECMWF) reanalysis grids wave data. The results indicate that the algorithm PFSM works for the wave retrieval from VV-polarization Sentinel-1 SAR image through SAR-derived wind speed by using the new GMF C-SARMOD. | LIN Bo SHAO Weizeng LI Xiaofeng LI Huan DU Xiaoqing JI Qiyan CAI Lina | 2017 | Acta Oceanologica Sinica2017，36，7： | 7 |
| 4 | Oxidative Desulfurization of Fuel Oil at Room Temperature Catalyzed by Ordered Meso-macroporous HPW/SiO2显示文摘A serial of ordered meso-macroporous phosphotungstic acid(HPW) supported on SiO2 nanocomposites were successfully prepared by a homogeneous precipitation method, using monodispersed polystyrene(PS) microspheres and cationic surfactant as structure directing agent. These nanocomposites were used as catalysts for oxidative desulfurization(ODS) of model fuel. The materials were characterized by scanning electron microscopy(SEM), transmission electron microscopy(TEM), N2 adsorption-desorption isothrem, X-ray diffraction(XRD), and Fourier transform infrared spectra(FTIR). The characterization results suggested that the as-prepared material possessed ordered meso-macroporous architectures with Keggin type phosphotungstic acid dispersed homogeneously in SiO2 matrix. Under the selected reaction conditions, dibenzothiophene(DBT) in model fuel can be removed within 2 h at room temperature(30 ℃). In addition, only 1.2% of efficiency lose than the fresh catalyst even after 5 cycles. | 郭振冉 杜岳 雷家珩 ZHOU Lina DU Xiaodi | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，5： | 5 |
| 5 | Sedimentology and Sequence Stratigraphy of Marine to Lacustrine Deltaic Deposits in a Craton Basin and Their Controlling Factors: Shan 2 Member–He 8 Member(Guadalupian–Lopingian, Permian), Southeast Ordos Basin, North China显示文摘The Shan 2 Member, Shan 1 Member and He 8 Member of the Mid–Late Permian Shanxi and lower Xiashihezi formations, in the southeastern Ordos Basin, together comprise ~150 m of deltaic deposits. This sequence records an overall evolution from deep marine environment to shallow lake associated with braided river, braided river delta and meandering river delta. Core description, well log interpretation, and stable isotope analysis, including carbon, oxygen and strontium, were conducted to understand the sedimentary evolution of Shan 2 to He 8 Member. The Shanxi Formation, which consists of the Shan 2 and Shan 1 members, is characterized by a tidal-influenced meandering river delta environment and a higher δ^(13)C value and ^(87)Sr?(^(86)Sr) ratio and a lower δ^(18)O value. The He 8 Member, the basal part of the Xiashihezi Formation, is featured by a braided river to braided river delta system and a lower δ^(13)C value, ^(87)Sr?(^(86)Sr) ratio, and a higher δ^(18)O value. Four third-order depositional sequences separated by five sequence boundaries are determined. Coarsening upward sequences of the Shan 2 Member–He 8 Member indicate a general regression trend, which can be correlated to global sea-level fall occurring during the Roadian–Wuchiapingian, as also evidenced by previous published zircon U–Pb results. The coal-bearing sequence(Shanxi Formation) to non-coal-bearing sequence(He 8 Member), as well as a decrease of ^(87)Sr?(^(86)Sr), suggest a trend from humid to arid climates. A combined effect of sea-level drop and a small uplift at the end of Shanxi Formation are proposed. | SHAN Xin YU Xinghe Peter CLIFT LI Yalong JIN Lina SU Dongxu DU Yonghui ZHOU Jinsong HAN Xiaoqin | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 4 |
| 6 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsq0nnovwbovq96c00.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 7 | Molecular phylogenetic evidence that the Chinese viviparid genus Margarya(Gastropoda:Viviparidae) is polyphyletic显示文摘We investigated the phylogeny of the viviparid genus Margarya,endemic to Yunnan,China,using two mitochondrial gene fragments(COI and 16S rRNA).The molecular phylogeny based on the combined dataset indicates that Margarya is polyphyletic,as two of the three well-supported clades containing species of Margarya also comprise species from other viviparid genera.In one clade,sequences of four species of Margarya even cluster indiscriminately with those of two species of Cipangopaludina,indicating that the current state of Asian viviparid taxonomy needs to be revised.Additionally,these data suggest that shell evolution in viviparids is complex,as even the large and strongly sculptured shells of Margarya,which are outstanding among Asian viviparids,can apparently be easily converted to simple smooth shells.The molecular data also indicate that the species status of the six extant species of Margarya should be re-assessed. | DU LiNa YANG JunXing RINTELEN Thomas von CHEN XiaoYong ALDRIDGE David | 2013 | Chinese Science Bulletin2013，58，17： | 3 |
| 8 | Proteome changes in banana fruit peel tissue in response to ethylene and high-temperature treatments显示文摘Banana(Musa AAA group)is one of the most consumed fruits in the world due to its flavor and nutritional value.As a typical climacteric fruit,banana responds to ethylene treatment,which induces rapid changes of color,flavor(aroma and taste),sweetness and nutritional composition.It has also been reported that ripening bananas at temperatures above 24℃ inhibits chlorophyll breakdown and color formation but increases the rate of senescence.To gain fundamental knowledge about the effects of high temperature and ethylene on banana ripening,a quantitative proteomic study employing multiplex peptide stable isotope dimethyl labeling was conducted.In this study,green(immature)untreated banana fruit were subjected to treatment with 10μL L^(−1) of ethylene for 24 h.After ethylene treatment,treated and untreated fruit were stored at 20 or 30℃ for 24 h.Fruit peel tissues were then sampled after 0 and 1 day of storage,and peel color and chlorophyll fluorescence were evaluated.Quantitative proteomic analysis was conducted on the fruit peels after 1 day of storage.In total,413 common proteins were identified and quantified from two biological replicates.Among these proteins,91 changed significantly in response to ethylene and high-temperature treatments.Cluster analysis on these 91 proteins identified 7 groups of changed proteins.Ethylene treatment and storage at 20℃ induced 40 proteins that are correlated with pathogen resistance,cell wall metabolism,ethylene biosynthesis,allergens and ribosomal proteins,and it repressed 36 proteins that are associated with fatty acid and lipid metabolism,redox–oxidative responses,and protein biosynthesis and modification.Ethylene treatment and storage at 30℃ induced 32 proteins,which were mainly similar to those in group 1 but also included 8 proteins in group 3(identified as chitinase,cinnamyl alcohol dehydrogenase 1,cysteine synthase,villin-2,leucine-transfer RNA ligase,CP47 protein and calmodulin)and repressed 43 proteins in 4 groups(groups 4–7),of which 6 were associated with photosynthesis II oxygen-evolving protein,the photosynthesis I reaction center,sugar metabolism,the redox–oxidative system and fatty acid metabolism.Differences in the response to ethylene and holding temperature at 30℃ were also revealed and have been discussed.The identities and quantities of the proteins found were linked with quality changes.This study demonstrates that ethylene and high temperature influence banana fruit ripening and senescence at the proteomic level and reveals the mechanisms by which high temperature accelerates banana fruit ripening. | Lina Du Jun Song Charles Forney Leslie Campbell Palmer Sherry Fillmore ZhaoQi Zhang | 2016 | Horticulture Research2016，3，1： | 3 |
| 9 | Humic acid transport in saturated porous media:Influence of flow velocity and influent concentration显示文摘Understanding the transport of humic acids(HAs)in porous media can provide important and practical evidence needed for accurate prediction of organic/inorganic contaminant transport in different environmental media and interfaces.A series of column transport experiments was conducted to evaluate the transport of HA in different porous media at different flow velocities and influent HA concentrations.Low flow velocity and influent concentration were found to favor the adsorption and deposition of HA onto sand grains packed into columns and to give higher equilibrium distribution coefficients and deposition rate coefficients,which resulted in an increased fraction of HA being retained in columns.Consequently,retardation factors were increased and the transport of HA through the columns was delayed.These results suggest that the transport of HA in porous media is primarily controlled by the attachment of HA to the solid matrix.Accordingly,this attachment should be considered in studies of HA behavior in porous media. | Xiaorong Wei Mingan Shao Lina Du Robert Horton | 2014 | Journal of Environmental Sciences2014，26，12： | 3 |
| 10 | Axial gradient excitation accelerates volumetric imaging of two-photon microscopy显示文摘Two-photon excitation fluorescence microscopy(TPM),owing to its capacity for subcellular resolution,intrinsic optical sectioning,and superior penetration depth in turbid samples,has revolutionized biomedical research.However,its layer-by-layer scanning to form a three-dimensional image inherently limits the volumetric imaging speed and increases phototoxicity significantly.In this study,we develop a gradient excitation technique to accelerate TPM volumetric imaging.The axial positions of the fluorophores can be decoded from the intensity ratio of the paired images obtained by sequentially exciting the specimen with two axially elongated two-photon beams of complementary gradient intensities.We achieved a 0.63μm axial localization precision and demonstrate the flexibility of the gradient TPM on various sparsely labeled samples,including bead phantoms,mouse brain tissues,and live macrophages.Compared with traditional TPM,our technique improves volumetric imaging speed(by at least sixfold),decreases photobleaching(i.e.,less than 2.07±2.89%in 25 min),and minimizes photodamages. | Yufeng Gao Xianyuan Xia Lina Liu Ting Wu Tingai Chen Jia Yu Zhili Xu Liang Wang Fei Yan Zhuo Du Jun Chu Yang Zhan Bo Peng Hui Li Wei Zheng | 2022 | Photonics Research2022，10，3： | 3 |
| 11 | Serum uric acid and risk of incident diabetes in middle-aged and elderly Chinese adults: prospective cohort study显示文摘The association between serum uric acid and the risk of incident diabetes in Chinese adults remains unknown.This study aimed to investigate this association in a community-dwelling population aged≥40 years in Shanghai,China.Oral glucose tole3rance test was conducted during baseline and follow-up visits.Relative risk regression was utilized to examine the associations between baseline gender-specific serum uric acid levels and incident diabetes risk.A total of 613(10.3%)incident diabetes cases were identified during the follow-up visit after 4.5 years.Fasting plasma glucose,postload glucose,and glycated hemoglobin A1c during the follow-up visit progressively increased across the sex-specific quartiles of serum uric acid(all Ps<0.05).The incidence rate of diabetes increased across the quartiles of serum uric acid(7.43%,8.77%,11.47%,and 13.43%).Multivariate adjusted regression analysis revealed that individuals in the highest quartile had 1.36-fold increased risk of diabetes compared with those in the lowest quartile of serum uric acid(odds ratio(95%confidence interval)=1.36(1.06−1.73)).Stratified analysis indicated that the association was only observed in women.Accordingly,serum uric acid was associated with the increased risk of incident diabetes among middle-aged and elderly Chinese women. | Di Cheng Chunyan Hu Rui Du Hongyan Qi Lin Lin Xueyan Wu Lina Ma Kui Peng Mian Li Min Xu Yu Xu Yufang Bi Weiqing Wang Yuhong Chen Jieli Lu | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 12 | Measurement and correlation of solubility of meropenem trihydrate in binary(water+acetone/tetrahydrofuran) solvent mixtures显示文摘The solubility of meropenem trihydrate in water+acetone mixtures and water+tetrahydrofuran mixtures were determined from T=(278.15 to 303.15) K by static method under atmospheric pressure.Effects of solvent composition and temperature on solubility of meropenem trihydrate were discussed.To extend the applicability of the solubility data,experimental solubility data in two kinds of binary solvent mixtures were correlated by the Apelblat equation and NIBS/Redlich–Kister model.It was found that the two models could satisfactorily correlate the experimental data and the Apelblat equation could give better correlation results. | Lina Zhou Shichao Du Ting Wang Songgu Wu Zhiqiang Guo Zhao Wang Ling Zhou | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 2 |
| 13 | Boron doped graphdiyne:A metal-free peroxidase mimetic nanozyme for antibacterial application显示文摘The abuse of conventional antibiotics leads to increasing bacterial resistance.Nanozyme is a new kind of ultra-efficient and safe nanomaterial with intrinsic enzyme-like activities,showing remarkable potential as a next generation nanobactericide.Graphdiyne(GDY)is a burgeoning two-dimensional(2D)carbon allotrope with intriguing physicochemical properties,holding a great promise as a metal-free nanozyme.In this study,a boron doped GDY nanosheet(B-GDY)was constructed to simulate the performance of peroxidase(POD).By promoting the decomposition of H_(2)O_(2) to produce reactive oxygen species(ROS),the bactericidal efficacies against both Gram-positive and Gram-negative bacteria were substantially enhanced attributed to the extremely high catalytic activity of B-GDY.In-depth density functional theory(DFT)calculations illuminate that doping of boron can introduce more active B-defect sites as well as lower Gibbs free energy during the H_(2)O_(2) decomposition reaction.Notably,B-GDY contributes to significant wound healing and excellent biocompatibility,reducing the biological burden.The design of this nanozyme opens a new avenue for the development of alternative antibiotics. | Xuelong Bi Qiang Bai Lina Wang Fanglin Du Manhong Liu William W.Yu Siheng Li Jiaqiang Li Zhiling Zhu Ning Sui Jin Zhang | 2022 | Nano Research2022，15，2： | 2 |
| 14 | Cholecystokinin octapeptide antagonizes apoptosis in human retinal pigment epithelial cells显示文摘Although cholecystokinin octapeptide-8 is important for neurological function, its neuroprotective properties remain unclear. We speculated that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against oxidative injury. In this study, retinal pigment epithelial cells were treated with peroxynitrite to induce oxidative stress. Peroxynitrite triggered apoptosis in these cells, and increased the expression of Fas-associated death domain, Bax, caspase-8 and Bcl-2. These changes were suppressed by treatment with cholecystokinin octapeptide-8. These results suggest that cholecystokinin octapeptide-8 can protect human retinal pigment epithelial cells against apoptosis induced by peroxynitrite. | Yuan Liu Yueling Zhang Zhaohui Gu Lina Hao Juan Du Qian Yang Suping Li Liying Wang Shilei Gong | 2014 | Neural Regeneration Research2014，9，14： | 2 |
| 15 | Phylogenetic Analysis of the Dengue Virus Strains Causing the 2019 Dengue Fever Outbreak in Hainan,China显示文摘Dengue virus is an arthropod-borne pathogen that is transmitted to humans primarily by Aedes spp.mosquitos,causing the acute infectious disease,dengue fever(DF).Until 2019,no dengue outbreak had been reported in Hainan Province for over 20 years.However,in early September of 2019,an increasing number of infected cases appeared and the DF outbreak lasted for over one month in Haikou City,Hainan Province.In our study,we collected 97 plasma samples from DF patients at three hospitals,as well as 1585 mosquito larvae samples from puddles in different areas of Haikou.There were 49(50.5%)plasma samples found to be strongly positive and 9(9.3%)plasma samples were weakly positive against the NS1 antigen.We discovered DENV both in the patient's plasma samples and mosquito larvae samples,and isolated the virus from C6/36 cells inoculated with the acute phase serum of patients.Phylogenetic analysis revealed that the new strains were the most closely related to the epidemic strain in the southern regions of China,belonging to lineageⅣ,genotypeⅠ,DENV-1.Compared to the seven closest strains from neighboring countries and provinces,a total of 18 amino acid mutations occurred in the coding sequences(CDS)of the new isolated strain,DENV1 HMU-HKU-2.Our data shows that dengue virus is re-emerged in Hainan,and pose new threats for public health.Thus regular molecular epidemiological surveillance is necessary for control and prevention of DENV transmission. | Jiang Du Liyuan Zhang Xiaoyuan Hu Ruoyan Peng Gaoyu Wang Yi Huang Wenqi Wang Kunliang Wu Qiang Wang Haoxiang Su Fan Yang Yun Zhang Chuanning Tang Xiuji Cui Lina Niu Gang Lu Meifang Xiao Yongguo Du Feifei Yin | 2021 | Virologica Sinica2021，36，4： | 2 |
| 16 | Colonization of endophyte Acremonium sp. D212 in Panax notoginseng and rice mediated by auxin and jasmonic acid显示文摘Endophytic fungi can be beneficial to plant growth. However, the molecular mechanisms under-lying colonization of Acremonium spp. remain unclear. In this study, a novel endophytic Acremonium strain was isolated from the buds of Panax notoginseng and named Acremonium sp. D212. The Acremonium sp. D212 could colonize the roots of P. notoginseng, enhance the resistance of P. notoginseng to root rot disease, and promote root growth and saponin bio-synthesis in P. notoginseng. Acremonium sp. D212 could secrete indole-3-acetic acid (IAA) and jasmonic acid (JA), and inoculation with the fungus increased the endogenous levels of IAA and JA in P. noto-ginseng. Colonization of the Acremonium sp. D212 in the roots of the rice line Nipponbare was dependent on the concentration of methyl jasmonate (MeJA) (2–15μmol/L) and 1-naphthalenacetic acid (NAA) (10–20μmol/L). Moreover, the roots of the JA signaling-defective coi1-18 mutant were colonized by Acremonium sp. D212 to a lesser degree than those of the wild-type Nipponbare and miR393b-overexpressing lines, and the colonization was res-cued by MeJA but not by NAA. It suggests that the cross-talk between JA signaling and the auxin biosynthetic pathway plays a crucial role in the colonization of Acremonium sp. D212 in host plants. | Li Han Xuan Zhou Yiting Zhao Shusheng Zhu Lixia Wu Yunlu He Xiangrui Ping Xinqi Lu Wuying Huang Jie Qian Lina Zhang Xi Jiang Dan Zhu Chongyu Luo Saijie Li Qian Dong Qijing Fu Kaiyuan Deng Xin Wang Lei Wang Sheng Peng Jinsong Wu Weimin Li JiǐíFriml Youyong Zhu Xiahong He Yunlong Du | 2020 | Journal of Integrative Plant Biology2020，62，9： | 2 |
| 17 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 18 | Warm dense matter research at HIAF显示文摘The research activities on warm dense matter driven by intense heavy ion beams at the new project High Intensity heavy-ion AcceleratorFacility (HIAF) are presented. The ion beam parameters and the simulated accessible state of matter at HIAF are introduced, respectively. Theprogresses of the developed diagnostics for warm dense matter research including high energy electron radiography, multiple-channel pyrometer,in-situ energy loss and charge state of ion detector are briefly introduced. | Rui Cheng Yu Lei Xianming Zhou Yuyu Wang Yanhong Chen Yongtao Zhao Jieru Ren Lina Sheng Jiancheng Yang Zimin Zhang Yingchao Du Wei Gai Xinwen Ma Guoqing Xiao | 2018 | Matter and Radiation at Extremes2018，3，2： | 2 |
| 19 | Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-κB signaling pathway显示文摘Phycocyanin (PC), a natural algal protein, is reported for having anti-oxidant and antiinfl ammatory properties. We investigated its ability to attenuate lung infl ammation in mice subjected to X-ray radiation. Male C57BL/6 mice were assigned to the control, total body irradiation, PC pretreatment, and PC treatment groups. Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation, and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation. Lungs were collected on Day 7 after irradiation exposure. Hematoxylin and eosin staining of mouse lung sections showed considerable infl ammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group. Pretreatment or treatment with PC signifi cantly decreased levels of interleukin-6 and tumor necrosis factor-α in the lung, and also increased the relative mRNA expression of superoxide dismutase and glutathione. In vivo, PC signifi cantly reduced the expression of Toll-like receptor TLR2, myeloid diff erentiation primary response Myd88, and nuclear factor NF-κB, at both the transcriptional and translation level. Taken together, these data indicated that PC attenuated lung infl ammatory damage induced by radiation by blocking the TLR2- MyD88-NF-κB signaling pathway. Therefore, PC could be a protective agent against radiation-induced infl ammatory damage in normal tissues. | LIU Qi LI Wenjun LU Lina LIU Bin DU Zhenning QIN Song | 2019 | Journal of Oceanology and Limnology2019，37，5： | 2 |
| 20 | Preventive effect of nasal Timosaponin BII-loaded temperature-/ionsensitive in situ hydrogels on Alzheimer’s disease显示文摘Objective:To study the preventive effect of Timosaponin BII(T-BII)-loaded temperature/ion-sensitive nasal in situ hydrogels(ISGs)on Alzheimer's disease(AD),its preparation technology,characteristics and in vivo effects were evaluated.Methods:The morphological and rheological properties were evaluated.The preventive effects of T-BII ISG on scopolamine-induced AD in mice were determined with the index of muscarinicreceptor 1(M1)expression and pathological changes.Results:Results revealed that T-BII ISG significantly increased the content of M1 choline receptors in the hippocampus of mice and ameliorated the damage incurred to the hippocampal cornu ammonis 1(CA1)area.Conclusion:T-BII ISGs is a reasonable and convenient method of exerting an obvious preventive effect on mice with AD induced by scopolamine.This,thereby,lays forth a new treatment option for preventing AD. | Ge Ou Wenyuan Chen Meiyan Yang Qian Li Yuanyuan Zhang Delian Wan Lina Du Baiping Ma | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 1 |
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