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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Loss of Halophytism by Interference with SOS1 Expression1[W][OA]显示文摘 | Oh Dong-Ha Leidi Eduardo Zhang Quan Hwang Sung-Min Li Youzhi Quintero Francisco J Jiang Xingyu D’Urzo Matilde Paino Lee Sang Yeol Zhao Yanxiu Bahk Jeong Dong Bressan Ray A Yun Dae-Jin Pardo José M Bohnert Hans J | 2009 | Plant Physiology2009，，1： | 1 |
| 3 | Detrimental effects of tropisetron on permanent ischemie stroke in the rat 显示文摘 | Eduardo C J Eduardo M Bernd L F | 2008 | BMC Neuroscience2008，9，6： | 1 |
| 4 | Heavy metals distribution in soils surrounding an abandoned mine in NW Madrid (Spain) and their transference to wild flora显示文摘 | Eduardo M J Jesus M P Rebeca M | 2009 | Journal of Hazardous Materials2009，162，23： | 1 |
| 5 | Co-continuous composites for high-temperature applications显示文摘 | Eduardo D R Nash J M Williams J C | 2007 | Materials Science and Engineering2007，463，1： | 1 |
| 6 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 7 | Experiments on virulence dose and portals of entry for Aeromonas hydrophila in walking catfish显示文摘 | GILDA D L LAWRENCE J A EDUARDO M L | 1996 | J Aquat Anita Health1996，8，4： | 1 |
| 8 | Global epidemiology of per- iodontal diseases in children and young persons显示文摘 | Albandar J M Tinoco Eduardo M B | 2002 | Pe- riodon- tol2002，29，： | 1 |
| 9 | The mechanical behavior and nanostructureof silica nanowires via simulations显示文摘 | Lilian P Ddvila Valerie J Leppert Eduardo M Bringab | 2009 | Scripta Mater2009，60，： | 1 |
| 10 | Identi- fication of QTLs related to sugar and organic acid com- position in melon using near-isogenie lines显示文摘 | Obando-Ulloa J M Eduardo I Monforte A J | 2009 | Sci Hot- tic2009，121，： | 1 |
| 11 | Chlorination methods applied to recover refractory metals from tin slags 显示文摘 | Eduardo A B Francisco J M | 2008 | Minerals Engineering2008，21，： | 1 |
| 12 | Kinetic modeling of naphtha catalytic reforming reactions 显示文摘 | JORGE A J EDUARDO V M | 2000 | Energy & Fuels2000，14，5： | 1 |
| 13 | Newcastle dis ease:Evolution of genotypes and the related diagnostic challenges显示文摘 | Patti J M Eduardo L D Claudio L A | 2010 | Infect Genet Evol2010，10，： | 1 |
| 14 | ZSM5 growth on a FeCrAl steel support:Coating characteristics upon the catalytic behavior in the NOx SCR 显示文摘 | Zamaro J M Maria A U Eduardo E M | 2008 | Microporous and Mesoporous Materials2008，，115： | 1 |
| 15 | Effect of light cycles(night/day)on CO2 fixation and biomass production by microalgae in photobioreactors显示文摘 | Eduardo J L Carlos H G S Lucy M C F L | | 0，，01： | 1 |
| 16 | Seismic history analy- sis of asymmetric buildings with soil-structure inter- action显示文摘 | Lin J L Tsai K C Eduardo M | 2009 | Journal of Structural Engineering2009，135，2： | 1 |
| 17 | A review of bioohars ' potential role in the remediation,revegeta-tion and restoration of contaminated soils 显示文摘 | Luke B Eduardo M J Jose L G Eva H Brett R Tom S | 2011 | Environmental Pollution2011，，159： | 1 |
| 18 | Identification of QTLs related to sugar and organic acid composition in melon using near-isogenic lines显示文摘 | Obando-ulloa J M Eduardo I Monforte A J | 2009 | Scientia Horticulturae2009，121，4： | 1 |
| 19 | Estimating FA- PAR from Nine Vegetation Indices for Irrigated and Nonirrigated Faba Bean and Semi leafless Pea Canopies 显示文摘 | Eduardo R Conde J R M nguez M I | 1998 | Remote Sensing of Environment1998，66，1： | 1 |
| 20 | Analysis and experimentation of nonlinear adaptive controllers for series resonant converter显示文摘 | CARRASCO J M EDUARDO Galvan | 2000 | IEEE Transactions On Power Electronics2000，15，3： | 1 |
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