|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Differential hepatic features presenting in Wilson disease-associated cirrhosis and hepatitis B-associated cirrhosis显示文摘BACKGROUND Cirrhosis is a chronic late stage liver disease associated with hepatitis viruses,alcoholism, and metabolic disorders, such as Wilson disease(WD). There are no clear markers or clinical features that define cirrhosis originating from these disparate origins. We hypothesized that cirrhosis is not one disease and cirrhosis of different etiology may have differential clinical hepatic features.AIM To delineate the liver features between WD-associated cirrhosis and hepatitis Bassociated cirrhosis in the Chinese population.METHODS In this observational study, we reviewed the medical data of consecutive inpatients who had WD-associated cirrhosis or hepatitis B-associated cirrhosis from January 2010 to August 2018, and excluded patients who had carcinoma,severe heart or pulmonary diseases, or other liver diseases. According to the etiology of cirrhosis, patients were divided into two groups: WD-associated cirrhosis group(60 patients) and hepatitis B-associated cirrhosis group(56 patients). The liver fibrosis degree, liver function indices, and portal hypertension features of these patients were compared between the two groups.RESULTS No inter-group differences were observed in the diagnostic liver fibrosis markers,however, clinical features clearly defined the origin of cirrhosis. WD-associated cirrhosis patients(16-29 years) had lower levels of alanine transaminase,aspartate transaminase, and bilirubin, lower prothrombin time, lower incidence of hepatic encephalopathy, and lower portal vein diameter(P < 0.05), compared to cirrhosis resulting from hepatitis B in older patients(45-62 years). Importantly,they had decreased risks of progression from Child-Pugh grade A to B(odds ratio = 0.046, 95% confidence interval: 0.006-0.387, P = 0.005) and of ascites(odds ratio = 0.08, 95% confidence interval: 0.01-0.48, P = 0.005). Conversely, WDassociated cirrhosis patients had a higher risk of splenomegaly(odds ratio = 4.15,95% confidence interval: 1.38-12.45, P = 0.011).CONCLUSION WD-associated cirrhosis presents a higher risk of splenomegaly associated with leukopenia and thrombocytopenia, although revealing milder liver dysfunction and portal hypertension symptoms, which recommends WD patients to be monitored for associated complications. | Hao-Jie Zhong Huan-Huan Sun Lan-Feng Xue Eileen M McGowan Yu Chen | 2019 | World Journal of Gastroenterology2019，25，3： | 19 |
| 2 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 3 | RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family显示文摘控制基因规定为维持繁殖潜力在配偶子开发期间是重要的。在哺乳动物的精子发生的复杂过程期间,尽管有重翻译要求,男细菌房间为继续的生长和区别经历不活跃的抄写的扩大时期。因此,精子发生高度依赖基因表示的 posttranscriptional 规定的机制,由 RNA 有约束力的蛋白质(RBP ) 便于,它仍然保持富有地在整个这进程表示了。一如此的组蛋白质是 Musashi 家庭,以前在果蝇识别了睾丸细菌房间开发和成熟分裂的同样批评的管理者,并且也出现对在老鼠的精子开发和繁殖潜力重要。这评论在男细菌房间开发的范围以内描述 RBP 的角色和函数,集中于我们在精子发生的 Musashi 蛋白质的最近的知识。RBP 在房间以内利用的功能的机制在与模式的关系深入地亚 cellular 本地化和阶段特定的表示的,和意义被构画出, posttranscriptional 规定的影响也被加亮。当原来在果蝇和 Xenopus 描绘了,我们在干细胞功能和房间命运决心强调 RBP 的 Musashi 家庭的历史的角色,并且与我们微分角色的当前的理解和哺乳动物的 Musashi 蛋白质, Musashi-1 和 Musashi-2 的功能得出结论,与我们在精子发生的调查结果的一个主要焦点。这评论两个都作为男配偶子开发的主人管理者加亮 RBP 的必要贡献到 posttranscriptional 规定和 Musashi 家庭的重要性。 | Jessie M Sutherland Nicole A Siddall Gary R Hime Eileen A McLaughlin | 2015 | Asian Journal of Andrology2015，17，4： | 4 |
| 4 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 5 | A striking local esophageal cytokine expression profile in eosinophilic esophagitis显示文摘 | Carine Blanchard Emily M. Stucke Beatriz Rodriguez-Jimenez Karen Burwinkel Margaret H. Collins Annette Ahrens Eileen S. Alexander Bridget K. Buckmeier Butz Sean C. Jameson Ajay Kaul James P. Franciosi Jonathan P. Kushner Philip E. Putnam J. Pablo Abonia M | 2010 | The Journal of Allergy and Clinical Immunology2010，，1： | 3 |
| 6 | The Gut Microbiota and the Liver Pathophysiological and Clinical Implications显示文摘 | Eamonn M .M. Quigley Catherine Stanton Eileen F. Murphy | 2012 | Journal of Hepatology2012，，： | 2 |
| 7 | The mechanical integrin cycle 显示文摘 | EILEEN P F SHEETZ M P | 2009 | Journal of Cell Science2009，122，2： | 1 |
| 8 | Conversion of vascular endothelial cells into multipotent stem-like cells显示文摘 | Damian Medici Eileen M Shore Vitali Y Lounev | | 0，，12： | 1 |
| 9 | Reliability and Validity of the Functional Analysis Screening Tool 显示文摘 | lwata Brian A Deleon Iser G Roscoe Eileen M | 2013 | Journal of Applied Behavior Analysis2013，，46： | 1 |
| 10 | England College Student Gender Stereo-types:Expectations About the Behavior of Male Subcategory Members显示文摘 | | 1992 | Sex Roles1992，27，1112： | 1 |
| 11 | Human Papillomavirus and Cervical Cancer显示文摘 | Eileen M Burd | 2003 | Clin Microbio Reviews2003，16，1： | 1 |
| 12 | Mercury methylation independent of the acetyl-coenzyme a pathway in sulfate-reducing bacterla显示文摘 | EILEEN B EKSTROM FRANCOIS MM MOREL JANINA M BENOIT | 2003 | Appl Envir Microbiol2003，69，： | 1 |
| 13 | Rapid estimation of canopy nitrogen of cereal crops at paddock scale using a canopy chlorophyll content index显示文摘 | Eileen M Perry Glenn J Fitzgerald James G | 2012 | Field Crops Research2012，134，： | 1 |
| 14 | Overexpresion of an osteogenic morphogen in fibrodysplasia ossificans progressiva 显示文摘 | Adam B Shafritz BA Eileen M | 1996 | N Engl J Med1996，335，： | 1 |
| 15 | O6 - Benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial Rat Glioma 显示文摘 | Laurence D Rhines Prakash Sampath Eileen Dolan M | 2000 | Cancer Research2000，60，： | 1 |
| 16 | Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots, a two - year summary, from the New England Newborn Screening Program 显示文摘 | Thomas HZ Eileen FF Deborah M | 2001 | Clin Chem2001，47，11： | 1 |
| 17 | The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice显示文摘 | Nicholas G Theodorakis Yi-ning Wang Nicholas J Skill Matthew A Metz Paul A Cahill Eileen M Redmond James V Sitzmann | 2003 | Gastroenterology2003，，5： | 1 |
| 18 | Cervical secretory immunoglobulin A in adolescent girls显示文摘 | Jonathan M Ellen Claudia J Lammel Mary-Ann Shafer Eileen Teitle Julius Schachter Richard S Stephens | 1999 | Journal of Adolescent Health1999，，2： | 1 |
| 19 | Androgen regulation of axon growth and neurite extension in motoneurons 显示文摘 | Keith N F Mariarita G Eileen M F | 2008 | Hormones and Behavior2008，53，2： | 1 |
| 20 | Bone marrow transplantation in a patient with fibrodysplasia显示文摘 | Kaplan F Ddvid L Eileen M | 2004 | Clin Orthop Relat Res2004，，422： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员