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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 3 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 4 | Dynamic quantization of uncertain linear networked control systems显示文摘 | LIU Kun EMILIA F KARL H J | 2015 | Automatica2015，，59： | 1 |
| 5 | Purification,Partial characterization and mode of action of enterococcin EFS2,an antilisterial bacteriocin produced by a swain of Enterococcusfaecalis isolation from a cheese显示文摘 | Sophie M P Emilia F Richard J | 1996 | International Journal of Food Microbiology1996，30，： | 1 |
| 6 | Estab- lishment of the Genetic/Genomic Competency Center for Education显示文摘 | Calzone K A Jerome-D'Emilia B Jenkins J | 2011 | J Nurs Scholarsh2011，43，4： | 1 |
| 7 | Antimierobial activity and chemical composition of essential oil from Hedychiumcoronarium 显示文摘 | Beena J Akhila R Emilia A | 2007 | Phytotherapy Research2007，21，5： | 1 |
| 8 | Purification, Partial characterization and mode of action of enterococcin EFS2,an antilisterial bacteriocin produced by a strain of of Enterococcus faecalis isolation from a cheese显示文摘 | Sophie M P Emilia F Richard J | 1996 | Int J Food Microbiol1996，30，6： | 1 |
| 9 | The clinical and genetic manifestations of hereditary nonpolyposis colorectal carcinoma 显示文摘 | D'Emilia J C Rodriguez-Bigas M A Petrelli N J | 1995 | Am J Surg1995，169，： | 1 |
| 10 | Characterizing the mecha- nisms of central and peripheral forms of neurostimulation in chronic dysphagic stroke patients 显示文摘 | Emilia M Satish M Samantha J | 2014 | Brain Stimul2014，7，1： | 1 |
| 11 | Use of onion extract to prevent enzymatic browning of frozen Agaricus bisporus mushrooms显示文摘 | EMILIA B GRAZYNA J | 2015 | International Journal of Refrigeration2015，57，： | 1 |
| 12 | Analytical tokamak equilibrium for shaped plasmas显示文摘 | Zheng S B Wootton A J Solano Emilia R | 1996 | Phys Plasmas1996，3，3： | 1 |
| 13 | Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study显示文摘 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mohammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf | 2008 | The Lancet2008，，9634： | 1 |
| 14 | Adenovirus-mediated Gene Transfer of CTLA-4Ig Fusion Protein in Suppression of Experimental Autoimmune Arthritis显示文摘 | Margaret J D Marc F | 2000 | Arthritis Rheum2000，43，8： | 1 |
| 15 | Failure behaviour wellbore cement in the presence of water and supercritical CO2显示文摘 | EMILIA L CHRISTOPHER J SPIERS C | 2009 | Energy Procedia2009，1，1： | 1 |
| 16 | Vibrations characters of a cooling tower shell显示文摘 | EMILIA J ZDENEK B ONDREJ F | 1983 | Journal of Wind Engineering and Industrial Aerodynamics1983，12，： | 1 |
| 17 | Adjunctive Functional Pharyngeal Electrical Stimulation Reverses Swallowing Disability After Brain Lesions显示文摘 | Vanoo J Salil S Pippa T Emilia M | 2010 | Gastroenterology2010，138，5： | 1 |
| 18 | Enzymatic modification of cassava starch by fungal lipase显示文摘 | Akhila Rajan J D Sudha T Emilia Abraham | 2008 | Industrial Crops and Products2008，，27： | 1 |
| 19 | Alcohol dehydrogenase (ADH) isoenzymes and aldehyde dehydrogenase (ALDH) activity in the sera of patients with acute and chronic pancreatitis显示文摘 | WOJCIECH J EMILIA K MAGDALENA L D | | 0，，： | 1 |
| 20 | Use of a comprehensive panel of biomarkers to predict response to a fluorouracil–oxaliplatin regimen in patients with metastatic colorectal cancer显示文摘 | Maria J Lamas Goretti Duran Emilia Balboa Beatriz Bernardez Manuel Touris Yolanda Vidal Elena Gallardo Rafael Lopez Angel Carracedo Francisco Barros | 2011 | Pharmacogenomics2011，，3： | 1 |
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