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| 1 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 2 | Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms显示文摘 | Ellen S. Regalado Dong-chuan Guo Carlos Villamizar Nili Avidan Dawna Gilchrist Barbara McGillivray Lorne Clarke Francois Bernier Regie L. Santos-Cortez Suzanne M. Leal Aida M. Bertoli-Avella Jay Shendure Mark J. Rieder Deborah A. Nickerson Dianna M. Milew | 2011 | Circulation Research2011，，6： | 1 |
| 3 | Certificate Chain discovery in SPKI/SDSI显示文摘 | Dwaine Clarke Jean Email Ellen Carl Ellison | 2001 | Journal of Computer Security2001，9，4： | 1 |
| 4 | Disparities in Breast Cancer Survival Among Asian Women by Ethnicity and Immigrant Status: A Population-Based Study显示文摘 | Gomez Scarlett Lin Clarke Christina A Shema Sarah J Chang Ellen T Keegan Theresa H M Glaser Sally L | 2010 | American Journal of Public Health2010，，5： | 1 |
| 5 | Certificate Chain Discovery in SPKI/SDSI显示文摘 | Clarke D Ellen J Ellison C | 2002 | Journal of Computer Security2002，9，4： | 1 |
| 6 | Responsiveness of 2 Scales to Evaluate Lateropulsion or Pusher Syndrome Recovery After Stroke显示文摘 | Ellen Clark Keith D. Hill T. David Punt | 2012 | Archives of Physical Medicine and Rehabilitation2012，，1： | 1 |
| 7 | Monitoring geomagnetically induced currents in the Scottish power grid显示文摘 | Thomson A W P Clark T D G Ellen Clarke | 2000 | British Geological Survey2000，，： | 1 |
| 8 | Partially covered self- expandable metallic stems for benign biliary strictures due to chronic pancreatitis 显示文摘 | Behm B Brock A Clarke BW Ellen K | 2009 | Endoscopy2009，41，6： | 1 |
| 9 | Comparison of Continuous Epidural Infusion of a Local Anesthetic and Administration of Systemic Narcotics in the Management of Pain after Total Knee Replacement Surgery显示文摘 | P. Prithvi Raj Donna C. Knarr Ellen Vigdorth Donald D. Denson Charles E. Pither Craig T. Hartrick Clark N. Hopson H&OV0324 kan H. Edstr?m | 1987 | Anesthesia & Analgesia1987，，5： | 1 |
| 10 | Partially covered self-expandable metallic stents for benign biliary strictures due to chronic pancreatitis显示文摘 | B. Behm A. Brock B. Clarke K. Ellen P. Northup J. Dumonceau M. Kahaleh | 2009 | Endoscopy2009，，06： | 1 |
| 11 | Caswell Effect of Corticosteroids and Neuropeptides on the Expression of Defensins in Bovine Tracheal Epithelial Cells显示文摘 | Gordon B.Mitchell Muthafar H.Al-Haddawi Mary Ellen Clark | | 0，，03： | 1 |
| 12 | Biofeedback Therapy for Defecatory Dysfunction: “Real Life” Experience显示文摘 | Daniela Jodorkovsky Kerry B. Dunbar Susan L. Gearhart Ellen M. Stein John O. Clarke | 2013 | Journal of Clinical Gastroenterology2013，，3： | 1 |
| 13 | Teenagers With Familial Adenomatous Polyposis显示文摘 | James M. Church Ellen McGannon Carol Burke Brian Clark | 2002 | Diseases of the Colon & Rectum2002，，7： | 1 |
| 14 | Molecular phylogeny, morphology, pigment chemistry and ecology in Hygrophoraceae (Agaricales)显示文摘Molecular phylogenies using 1–4 gene regions and information on ecology,morphology and pigment chemistry were used in a partial revision of the agaric family Hygrophoraceae.The phylogenetically supported genera we recognize here in the Hygrophoraceae based on these and previous analyses are:Acantholichen,Ampulloclitocybe,Arrhenia,Cantharellula,Cantharocybe,Chromosera,Chrysomphalina,Cora,Corella,Cuphophyllus,Cyphellostereum,Dictyonema,Eonema,Gliophorus,Haasiella,Humidicutis,Hygroaster,Hygrocybe,Hygrophorus,Lichenomphalia,Neohygrocybe,Porpolomopsis and Pseudoarmillariella.A new genus that is sister to Chromosera is described as Gloioxanthomyces.Revisions were made at the ranks of subfamily,tribe,genus,subgenus,section and subsection.We present three new subfamilies,eight tribes(five new),eight subgenera(one new,one new combination and one stat.nov.),26 sections(five new and three new combinations and two stat.nov.)and 14 subsections(two new,two stat.nov.).Species of Chromosera,Gliophorus,Humidicutis,and Neohygrocybe are often treated within the genus Hygrocybe;we therefore provide valid names in both classification systems.We used a minimalist approach in transferring genera and creating new names and combinations.Consequently,we retain in the Hygrophoraceae the basal cuphophylloid grade comprising the genera Cuphophyllus,Ampulloclitocybe andCantharocybe,despite weak phylogenetic support.We include Aeruginospora and Semiomphalina in Hygrophoraceae based on morphology though molecular data are lacking.The lower hygrophoroid clade is basal to Hygrophoraceae s.s.,comprising the genera Aphroditeola,Macrotyphula,Phyllotopsis,Pleurocybella,Sarcomyxa,Tricholomopsis and Typhula. | D.Jean Lodge Mahajabeen Padamsee P.Brandon Matheny M.Catherine Aime Sharon A.Cantrell David Boertmann Alexander Kovalenko Alfredo Vizzini Bryn T.M.Dentinger Paul M.Kirk A.Martyn Ainsworth Jean-Marc Moncalvo Rytas Vilgalys Ellen Larsson Robert Lücking Gareth W.Griffith Matthew E.Smith Lorelei L.Norvell Dennis E.Desjardin Scott A.Redhead Clark L.Ovrebo Edgar B.Lickey Enrico Ercole Karen W.Hughes Régis Courtecuisse Anthony Young Manfred Binder Andrew M.Minnis Daniel L.Lindner Beatriz Ortiz-Santana John Haight Thomas Læssøe Timothy J.Baroni József Geml Tsutomu Hattori | 2014 | Fungal Diversity2014，，1： | 0 |
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