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| 1 | Combination drug regimens for metastatic clear cell renal cell carcinoma显示文摘Renal cell carcinomas(RCC)make up about 90%of kidney cancers,of which 80%are of the clear cell subtype.About 20%of patients are already metastatic at the time of diagnosis.Initial treatment is often cytoreductive nephrectomy,but systemic therapy is required for advanced RCC.Single agent targeted therapies are moderately toxic and only somewhat effective,leading to development of immunotherapies and combination therapies.This review identifies limitations of monotherapies for metastatic renal cell carcinoma,discusses recent advances in combination therapies,and highlights therapeutic options under development.The goal behind combining various modalities of systemic therapy is to potentiate a synergistic antitumor effect.However,combining targeted therapies may cause increased toxicity.The initial attempts to create therapeutic combinations based on inhibition of the vascular endothelial growth factor or mammalian target of rapamycin pathways were largely unsuccessful in achieving a profile of increased synergy without increased toxicity.To date,five combination therapies have been approved by the U.S.Food and Drug Administration,with the most recently approved therapies being a combination of checkpoint inhibition plus targeted therapy.Several other combination therapies are under development,including some in the phase 3 stage.The new wave of combination therapies for metastatic RCC has the potential to increase response rates and improve survival outcomes while maintaining tolerable side effect profiles. | Viraj V Khetani Daniella E Portal Mansi R Shah Tina Mayer Eric A Singer | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 2 | Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2R[gamma]c-deficient mice显示文摘 | Sarry Jean-Emmanuel Murphy Kathleen Perry Robin Sanchez Patricia V Secreto Anthony Keefer Cathy Swider Cezary R Strzelecki Anne-Claire Cavelier Cindy Récher Christian Mansat-De Mas Véronique Delabesse Eric Danet-Desnoyers G Carroll Martin | 2011 | Journal of Clinical Investigation2011，，1： | 2 |
| 3 | Phosphorus diagenesis in lake sediments:investigation using fractionation techniques显示文摘 | Michael R P Martin T A Eric L V | 1995 | Mar Freshwater Res1995，46，： | 1 |
| 4 | TPR study on the preparation of impregnated Co/SiO2 catalysts显示文摘 | ERIC V S SEWELL G S MAKHOTHE R A MAKHOTHE CRAIG M HEIKO M MARTIJIN D L CYRIL T O | 1996 | J Catal1996，162，2： | 1 |
| 5 | Assessing sediment removal capacity of vegetated and non vegetated settling ponds in prawn farms显示文摘 | Halmar H Peter V R Eric L P | 2003 | Aquacultural Engineering2003，27，： | 1 |
| 6 | Global estimates of evapotranspiration for climate studies using multi-sensor remote sensing data:Evaluation of three process-based approaches显示文摘 | Raghuveer K V Eric F W Craig R F | 2011 | Remote Sensing of Environment2011，115，3： | 1 |
| 7 | Effect of colostrums volume,interval between calving and first milking, and photoperiod on colostrums IgG concentrations in dairy cows 显示文摘 | Dawn E M Stephanie V N Eric D R et d | 2010 | JAVMA2010，237，4： | 1 |
| 8 | Selective involvement of IL-6 in the transcriptional activation of the suppressor of cytokines signaling-3 in the brain during systemic immune challenges 显示文摘 | Eric L Luc V Serge R | 2000 | Endocrinology2000，141，： | 1 |
| 9 | Estimations of soil organic carbon storage in cropland of China based on DNDC model显示文摘 | Tang H J Qiu J J Eric V R | 2006 | Geoderma2006，134，： | 1 |
| 10 | Incorporation of uranium in zirconolite (CaZrTi2O7 ) 显示文摘 | Eric R V Gregory R L Melody L C | 2002 | Journal of the American Ceramic Society2002，85，7： | 1 |
| 11 | Estimations of soil organic carbon storage in cropland of China based on DNDC model显示文摘 | Tang H J Qiu J J Eric V R | 2006 | Geoderma2006，134，： | 1 |
| 12 | MR imaging findings in 76 consecutive surgically proven cases of pericardial disease with CT and pathologic correlation显示文摘 | PhillipM Young James F Glockner Eric E Williamson Michael F Morris Philip A Araoz Paul R Julsrud Hartzell V SchafiF William D Edwards Jae K Oh Jerome F Breen | 2012 | The international journal of cardiovascular imaging2012，28，5： | 1 |
| 13 | Estimations of soil organic carbon storage in cropland of China based on DNDC Model显示文摘 | TANG H J QIU J J ERIC V R | 2006 | Geoderma2006，134，： | 1 |
| 14 | Effect of particle size on the room-temperature crystal structure of barium titanate显示文摘 | | 1994 | J Am Ceram1994，77，12： | 1 |
| 15 | Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial显示文摘 | Eric Lawitz Jay P Lalezari Tarek Hassanein Kris V Kowdley Fred F Poordad Aasim M Sheikh Nezam H Afdhal David E Bernstein Edwin DeJesus Bradley Freilich David R Nelson Douglas T Dieterich Ira M Jacobson Donald Jensen Gary A Abrams Jama M Darling Maribel Ro | 2013 | The Lancet Infectious Diseases2013，，5： | 1 |
| 16 | Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial显示文摘 | Eric Lawitz Jay P Lalezari Tarek Hassanein Kris V Kowdley Fred F Poordad Aasim M Sheikh Nezam H Afdhal David E Bernstein Edwin DeJesus Bradley Freilich David R Nelson Douglas T Dieterich Ira M Jacobson Donald Jensen Gary A Abrams Jama M Darling Maribel Ro | 2013 | The Lancet Infectious Diseases2013，，5： | 1 |
| 17 | Assessing sediment removal capacity of vegetated and non-vegetated settling ponds in prawn farms显示文摘 | HALMAR H PRTER V R ERIC L P | 2003 | Aquacultural Engineering2003，27，： | 1 |
| 18 | Effective Soft- ware Fault Localization Using an RBF Neural Network 显示文摘 | Eric W W Debroy V Golden R | 2011 | IEEE Transactions on Reliability2011，，99： | 1 |
| 19 | Estimations of soil organic carbon storage in cropland of China based on DNDC Model显示文摘 | Tang H J Qiu J J Eric V R | 2005 | Geoderma2005，134，： | 1 |
| 20 | Can consumers self-select for appropriate use of an over-the-counter statin? The self evaluation of lovastatin to enhance cholesterol treatment study显示文摘 | ERIC PB THEODORE V AMY R | 2008 | Am J Cardiol2008，101，10： | 1 |
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