|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Body condition score prior to parturition is associated with plasma and adipose tissue biomarkers of lipid metabolism and inflammation in Holstein cows显示文摘Background: Previous research has revealed a strong inflammatory response within adipose(AT) tissue during the transition into lactation. Whether this effect is a result of oxidative stress induced by lipolysis and fatty acid oxidation associated with differences in prepartum body condition score remains to be determined. The objectives of this study were to investigate systemic biomarkers of energy balance and inflammation and the expression of lipid metabolismand inflammation-related genes in AT during the transition period in dairy cows.Results: Twenty multiparous Holstein cows were retrospectively divided by body condition score(BCS) prior to parturition into two groups(10 cows/group): BCS ≤ 3.25(Lo BCS) and BCS ≥ 3.75(Hi BCS). Subcutaneous adipose tissue was biopsied from the tail-head region at d-10, 7 and 20 relative to parturition. Plasma was used to evaluate biomarkers of energy balance(EBAL) [free fatty acids(NEFA), glycerol, insulin] and inflammation [IL-1β, haptoglobin, myeloperoxidase, and reactive oxygen metabolites(ROM)]. Although insulin concentration was not affected by BCS, NEFA was overal greater and glycerol lower in HiB CS cows. Greater activity of myeloperoxidase in plasma coincided with increased haptoglobin and IL-1β postpartum in LoB CS cows.Among genes related with oxidative stress, the expression of the cytosolic antioxidant enzyme SOD1 was greater in LoB CS compared to HiB CS. Cows in LoB CS compared with HiB CS had greater overal expression of ABDH5 and ATGL along with ADIPOQ, indicating enhanced basal lipolysis and secretion of adiponectin. Expression of CPT1 A, ACADVL, and ACOX1 was greater overal in HiB CS than LoB CS indicating enhanced NEFA oxidation. Although the temporal increase in plasma NEFA regardless of BCS coincided with the profile of CPT1 A, the gradual decrease in genes related with reesterification of NEFA(PCK1) and glycerol efflux(AQP7) coupled with an increase in glycerol kinase(GK) suggested some stimulation of NEFA utilization within adipose tissue. This idea is supported in part by the gradual decrease in insulin regardless of BCS. Although expression of the inflammation-related gene toll-like receptor 4( TLR4) was greater in Hi BCS versus Lo BCS cows at-10 d, expression of TLR9 was greater in Hi BCS versus Lo BCS at 20 d.These profiles did not seem to be associated with concentrations of pro-inflammatory biomarkers or ROM.Conclusions: Overall, data indicated that cows with BCS 3.25 or lower before calving experienced greater alterations in systemic inflammation and basal lipolysis without excessive increases in NEFA plasma concentrations.Despite the greater plasma NEFA around parturition, cows with BCS 3.75 or higher seemed to have a more active system for catabolism of NEFA and utilization of glycerol within adipose tissue. A linkage between those pathways and risk of disorders postpartum remains to be determined. | Abdulrahman Alharthi Zheng Zhou Vincenzo Lopreiato Erminio Trevisi Juan J.Loor | 2018 | Journal of Animal Science and Biotechnology2018，9，2： | 3 |
| 2 | Supplemental Smartamine M in higher-energy diets during the prepartal period improves hepatic biomarkers of health and oxidative status in Holstein cows显示文摘Background: Feeding higher-energy prepartum is a common practice in the dairy industry. However, recent data underscore how it could reduce performance, deepen negative energy balance, and augment inflammation and oxidative stress in fresh cows. We tested the effectiveness of rumen-protected methionine in preventing the negative effect of feeding a higher-energy prepartum. Multiparous Holstein cows were fed a control lower-energy diet(CON, 1.24 Mcal/kg DM; high-straw) during the whole dry period(~50 d), or were switched to a higher-energy(OVE, 1.54 Mcal/kg DM), or OVE plus Smartamine M(OVE + SM; Adisseo NA) during the last 21 d before calving.Afterwards cows received the same lactation diet(1.75 Mcal/kg DM). Smartamine M was top-dressed on the OVE diet(0.07% of DM) from -21 through 30 d in milk(DIM). Liver samples were obtained via percutaneous biopsy at -10, 7 and 21 DIM. Expression of genes associated with energy and lipid metabolism, hepatokines, methionine cycle, antioxidant capacity and inflammation was measured.Results: Postpartal dry matter intake, milk yield, and energy-corrected milk were higher in CON and OVE + SM compared with OVE. Furthermore, milk protein and fat percentages were greater in OVE + SM compared with CON and OVE. Expression of the gluconeogenic gene PCK1 and the lipid-metabolism transcription regulator PPARA was again greater with CON and OVE + SM compared with OVE. Expression of the lipoprotein synthesis enzyme MTTP was lower in OVE + SM than CON or OVE. Similarly, the hepatokine FGF21, which correlates with severity of negative energy balance, was increased postpartum only in OVE compared to the other two groups. These results indicate greater liver metabolism and functions to support a greater production in OVE + SM. At 7 DIM, the enzyme GSR involved in the synthesis of glutathione tended to be upregulated in OVE than CON-fed cows, suggesting a greater antioxidant demand in overfed cows. Feeding OVE + SM resulted in lower similar expression of GSR compared with CON. Expression of the methionine cycle enzymes SAHH and MTR, both of which help synthesize methionine endogenously, was greater prepartum in OVE + SM compared with both CON and OVE, and at 7 DIM for CON and OVE + SM compared with OVE, suggesting greater Met availability. It is noteworthy that DNMT3A, which utilizes S-adenosylmethionine generated in the methionine cycle, was greater in OVE and OVE + SM indicating higher-energy diets might enhance DNA methylation, thus, Met utilization.Conclusions: Data indicate that supplemental Smartamine M was able to compensate for the negative effect of prepartal energy-overfeeding by alleviating the demand for intracellular antioxidants, thus, contributing to the increase in production. Moreover Smartamine M improved hepatic lipid and glucose metabolism, leading to greater liver function and better overall health. | Mario Vailati-Riboni Johan S.Osorio Erminio Trevisi Daniel Luchini Juan J.Loor | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 3 |
| 3 | Maternal supply of methionine during late-pregnancy enhances rate of Holstein calf development in utero and postnatal growth to a greater extent than colostrum source显示文摘Background: Pregnancy and early life are critical periods of plasticity during which the fetus and neonate may be influenced by environmental factors such as nutrition.Maternal methionine(Met) supply in non-ruminants during pregnancy can affect offspring development and growth.Thus,the objective of this study was to investigate if increasing Met supply during late-pregnancy affects developmental parameters of the calf at birth and if either maternal Met or colostrum from Met-fed cows alters calf growth.Calves born to Holstein cows individually-fed a basal control [CON; 1.47 Mcal/kg dry matter(DM) and 15.3% crude protein] diet with no added Met or CON plus ethylcellulose rumen-protected Met(MET; Mepron? at 0.09% of diet DM; Evonik Nutrition & Care GmbH,Germany)during the last 28 ± 2 d of pregnancy were used.A total of 39 calves were in CON(n = 22 bulls,17 heifers) and 42 in MET(n = 20 bulls,22 heifers).At birth,calves were randomly allocated considering dam treatment and colostrum as fol ows: 1) calves from CON cows and colostrum from CON cows(n = 21); 2) calves from CON cows and colostrum from MET cows(n = 18); 3) calves from MET cows and colostrum from MET cows(n = 22); and 4) calves from MET cows and colostrum from CON cows(n = 20).Al calves were housed,managed,and fed individual y during the first 9 wk of life.Results: Despite greater daily DM intake pre-partum in cows fed MET(15.7 vs.14.4 ± 0.12 kg/d,P < 0.05),colostrum quality and quantity were not affected by maternal diet.At birth,MET calves had greater(P ≤ 0.05) body weight(BW,44.1 vs.42.1 ± 0.70 kg),hip height(HH,81.3 vs.79.6 ± 0.53 cm) and wither height(WH,77.8 vs.75.9 ± 0.47 cm).In contrast,concentrations of His,Lys,and Asn in plasma were lower(P ≤ 0.05) in MET calves.Regardless of colostrum source,the greater BW,HH,and WH in MET calves at birth persisted through 9 wk of age resulting in average responses of + 3.1 kg BW,+ 1.9 cm HH,and + 1.8 cm WH compared with CON.Average daily gain during the 9 wk was(P < 0.05) 0.72 ± 0.02 kg/d in MET compared with 0.67 ± 0.02 kg/d in CON calves.Respiratory scores were normal and did not differ(P > 0.05) due to maternal Met supply or colostrum source.However,fecal scores tended to be lower(P ≤ 0.10) in MET calves regardless of colostrum source.Conclusions: Increasing the maternal supply of MET during late-pregnancy enhanced growth in utero as wel as during the pre-weaning and early post-weaning periods.Although the ~ 1 kg/d greater DM intake during the last 2–3 wk prior to parturition could explain a portion of the 2 kg extra body mass of MET calves at birth,other mechanisms potential y encompassing nutrient assimilation efficiency likely played a role.Assessing the exact mechanisms sensitive to supply of Met or total amino acid supply during the latter stages of growth in utero merit further research. | Abdulrahman S.Alharthi Fernanda Batistel Mohamed K.Abdelmegeid Gustavo Lascano Claudia Parys Ariane Helmbrecht Erminio Trevisi Juan J.Loor | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 4 | Role of nutraceuticals during the transition period of dairy cows: a review显示文摘The transition period of dairy cattle is characterized by a number of metabolic, endocrine, physiologic, and immune adaptations, including the occurrence of negative energy balance, hypocalcemia, liver dysfunction, overt systemic inflammatory response, and oxidative stress status. The degree and length of time during which these systems remain out of balance could render cows more susceptible to disease, poor reproductive outcomes, and less efficient for milk production and quality. Studies on both monogastrics and ruminants have reported the health benefits of nutraceuticals(e.g. probiotics, prebiotics, dietary lipids, functional peptides, phytoextracts) beyond nutritional value, interacting at different levels of the animal's physiology. From a physiological standpoint, it seems unrealistic to disregard any systemic inflammatory processes. However, an alternate approach is to modulate the inflammatory process per se and to resolve the systemic response as quickly as possible.To this aim, a growing body of literature underscores the efficacy of nutraceuticals(active compounds) during the critical phase of the transition period. Supplementation of essential fatty acids throughout a 2-month period(i.e. a month before and a month after calving) successfully attenuates the inflammatory status with a quicker resolution of phenomenon. In this context, the inflammatory and immune response scenario has been recognized to be targeted by the beneficial effect of methyl donors, such as methionine and choline, directly and indirectly modulating such response with the increase of antioxidants GSH and taurine. Indirectly by the establishment of a healthy gastrointestinal tract, yeast and yeast-based products showed to modulate the immune response, mitigating negative effects associated with parturition stress and consequent disorders.The use of phytoproducts has garnered high interest because of their wide range of actions on multiple tissue targets encompassing a series of antimicrobial, antiviral, antioxidant, immune-stimulating, rumen fermentation, and microbial modulation effects. In this review, we provide perspectives on investigations of regulating the immune responses and metabolism using several nutraceuticals in the periparturient cow. | Vincenzo Lopreiato Matteo Mezzetti Luca Cattaneo Giulia Ferronato Andrea Minuti Erminio Trevisi | 2021 | Journal of Animal Science and Biotechnology2021，12，1： | 3 |
| 5 | Semen analysis in chronic bacterial prostatitis: diagnostic and therapeutic implications显示文摘意义和在长期的细菌的前列腺炎的精液分析的诊断价值广泛地被辩论了并且仍然保持争论。在前列腺炎病人的细菌学的 workup 调查精液文化的诊断关联,我们回顾地分析了 696 个征兆的病人的一个临床的数据库。所有病人习惯性地受到四眼镜的测试,由精液文化和分析列在后面。这允许从数据库把,并且把三种不同诊断情形测试的“二眼镜”的 pre-/post- 按摩和标准“四眼镜”的测试与“五眼镜”的测试(四眼镜的正 post-VB3 精液文化) 作比较。“五眼镜”的测试在相对敏感和更小的减小显示出 3.6 褶层或 6.5 褶层增加(在为传统的 uropathogens (TU ) 的相对特性的 -13.2% 或 -14.7%) 与四眼镜或二眼镜的测试相比分别地。在 ROC 曲线和 Jouden 下面的区域是索引而积极、否定的可能性的比率比比较仪低,被增加,显示“五眼镜”的试金可能在证实两标准测试的否定结果是优异的。五 -- ,四 -- ,并且二眼镜的测试检测了 TU (Enterobacteriaceae, Enterococci,等等) 在在 130, 56,和 45 个病人的 120, 33,和 20 个病人和不平常的病原体(Streptococci,另外的克积极的种类, Mycoplasmata,和其它) 分别地。当病人们受到药理学治疗时,包括 fluoroquinolone 和 macrolide 的联合,处于根除率的差别都没在与不同测试诊断的组之间被观察,不管病原体范畴。根除与长期的症状 / 症状宽恕被联系;在症状 / 症状分数的重要团体之间的差别都没在整个一个 24 月的离开治疗后续时期被观察。在结论,我们的数据当这测试被用来补充四眼镜的 Meares 和 Stamey 测试时,在前列腺炎病人的诊断 workup 支持精液分析的实用性。microbiological 试金的改进传送重要诊断、治疗学的含意。 | Vittorio Magri Florian M. E. Wagenlehner Emanuele Montanari Emanuela Marras Viviana Orlandi Antonella Restelli Erminio Torresani Kurt G. Naber Gianpaolo Perletti | 2009 | Asian Journal of Andrology2009，11，4： | 2 |
| 6 | A Clinical Outcome-Based Prospective Study on Venous Thromboembolism After Cancer Surgery: The @RISTOS Project显示文摘 | Giancarlo Agnelli Giorgio Bolis Lorenzo Capussotti Roberto Mario Scarpa Francesco Tonelli Erminio Bonizzoni Marco Moia Fabio Parazzini Romina Rossi Francesco Sonaglia Bettina Valarani Carlo Bianchini Gualberto Gussoni | 2006 | Annals of Surgery2006，，1： | 2 |
| 7 | Nadroparin for the prevention of thromboembolic events in ambulatory patients with metastatic or locally advanced solid cancer receiving chemotherapy: a randomised, placebo-controlled, double-blind study显示文摘 | Giancarlo Agnelli Gualberto Gussoni Carlo Bianchini Melina Verso Mario Mandalà Luigi Cavanna Sandro Barni Roberto Labianca Franco Buzzi Giovanni Scambia Rodolfo Passalacqua Sergio Ricci Giampietro Gasparini Vito Lorusso Erminio Bonizzoni Maurizio Tonato | 2009 | Lancet Oncology2009，，10： | 1 |
| 8 | Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder显示文摘 | Marin Veldic Bashkim Kadriu Ekrem Maloku Roberto C. Agis-Balboa Alessandro Guidotti John M. Davis Erminio Costa | 2007 | Schizophrenia Research2007，，1： | 1 |
| 9 | Incidence and Predictors of Drug-Eluting Stent Thrombosis During and After Discontinuation of Thienopyridine Treatment显示文摘 | Flavio Airoldi Antonio Colombo Nuccia Morici Azeem Latib John Cosgrave Lutz Buellesfeld Erminio Bonizzoni Mauro Carlino Ulrich Gerckens Cosmo Godino Gloria Melzi Iassen Michev Matteo Montorfano Giuseppe Massimo Sangiorgi Asif Qasim Alaide Chieffo Carlo Br | 2007 | Circulation2007，，7： | 1 |
| 10 | Percutaneous Cardiopulmonary Support for Catheter Ablation of Unstable Ventricular Arrhythmias in High-Risk Patients显示文摘 | Corrado Carbucicchio Paolo Della Bella Gaetano Fassini Nicola Trevisi Stefania Riva Francesco Giraldi Francesca Baratto Giancarlo Marenzi Erminio Sisillo Antonio Bartorelli Francesco Alamanni | 2009 | 2009，，7： | 1 |
| 11 | 4-Alkyl and 4-phe- nylcoumarins from Mesua ferrea as promising multidrug re- sistant antibacterials显示文摘 | Luisella V Erminio L Giovanni V | 2004 | Phytochemistry2004，65，： | 1 |
| 12 | Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions显示文摘 | Alessandro Vanoli Stefano La Rosa Ombretta Luinetti Catherine Klersy Rachele Manca Costanza Alvisi Sandro Rossi Erminio Trespi Adriano Zangrandi Fausto Sessa Carlo Capella Enrico Solcia | 2013 | Human Pathology2013，，9： | 1 |
| 13 | Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass显示文摘 | Antonio M. Calafiore Gabriele Di Giammarco Giovanni Teodori Giovanni Bosco Erminio D’Annunzio Antonio Barsotti Nicola Maddestra Leonardo Paloscia Giuseppe Vitolla Antonio Sciarra Carlo Fino Marco Contini | 1996 | The Annals of Thoracic Surgery1996，，6： | 1 |
| 14 | A Test of Internationali- zation Theory and International Theory: The Upjohn Company 显示文摘 | Fina Erminio Rugman Alan | 1996 | Management International Review1996，，： | 1 |
| 15 | A method for studying the evolution of naming error types in the recovery of acute aphasia:a single-patient and single-stimulus approach显示文摘 | Erminio Capitani Marcella Laiacona | 2004 | Neuropsychologia2004，42，： | 1 |
| 16 | Incidence and Predictors of Drug-Eluting Stent Thrombosis During and After Discontinuation of Thienopyridine Treatment显示文摘 | Flavio Airoldi Antonio Colombo Nuccia Morici Azeem Latib John Cosgrave Lutz Buellesfeld Erminio Bonizzoni Mauro Carlino Ulrich Gerckens Cosmo Godino Gloria Melzi Iassen Michev Matteo Montorfano Giuseppe Massimo Sangiorgi Asif Qasim Alaide Chieffo Carlo Br | 2007 | Circulation2007，，： | 1 |
| 17 | Intensive Structured Self-Monitoring of Blood Glucose and Glycemic Control in Noninsulin-Treated Type 2 Diabetes显示文摘 | Emanuele Bosi Marina Scavini Antonio Ceriello Domenico Cucinotta Antonio Tiengo Raffaele Marino Erminio Bonizzoni Francesco Giorgino | 2013 | Diabetes Care2013，，10： | 1 |
| 18 | Identification of a marine a- garolytie Pseudoalteromonas isolate and characterization of its extrac- cellular agarase显示文摘 | JORGE V RAUL A ERMINIO M | 1998 | Appl Environ Microb1998，64，11： | 1 |
| 19 | Co-infection in Children With Bloody Diarrhea Caused by Shiga Toxin–Producing Escherichia coli: Data of the North Italian HUS Network显示文摘 | Gianluigi Ardissino Ilaria Possenti Stefania Salardi Francesca Tel Elisa Colombo Sara Testa Laura Daprai Damiano Picicco Rosaria Maria Colombo Erminio Torresani | 2014 | Journal of Pediatric Gastroenterology and Nutrition2014，，2： | 1 |
| 20 | Identification of a Marine Agarolytic Pseudoalteromonas Isolate and Characterization of Its Extracellular Agarase显示文摘 | Jorge V Raul A Erminio M | 1998 | Applied and Environmental Microbiology1998，64，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员