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| 1 | A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C显示文摘 | Bruno Sangro Carlos Gomez-Martin Manuel de la Mata Mercedes I?arrairaegui Elena Garralda Pilar Barrera Jose Ignacio Riezu-Boj Esther Larrea Carlos Alfaro Pablo Sarobe Juan José Lasarte Jose L. Pérez-Gracia Ignacio Melero Jesús Prieto | 2013 | Journal of Hepatology2013，，： | 6 |
| 2 | Effectiveness of an intervention for reducing social stigma towards mental illness in adolescents显示文摘AIM: To evaluate the effectiveness of an intervention for reducing social stigma towards mental illness in adolescents. The effect of gender and knowledge of someone with mental illness was measured. METHODS: Two hundred and eighty secondary school students were evaluated using the Community Attitudes towards Mental Illness(CAMI) questionnaire. The schools were randomized and some received the intervention and others acted as the control group. The programme consisted of providing information via a documentary film and of contact with healthcare staff in order to reduce the social stigma within the school environment. RESULTS: The intervention was effective in reducing the CAMI authoritarianism and social restrictiveness subscales. The intervention showed significant changes in girls in terms of authoritarianism and social restrictiveness, while boys only showed significant changes in authoritarianism. Following the intervention, a significant reduction was found in authoritarianism and social restrictiveness in those who knew someone with mental illness, and only in authoritarianism in those who did not know anyone with mental illness. CONCLUSION: The intervention was effective to reduce social stigma towards people with mental illness, especially in the area of authoritarianism. Some differences were found depending on gender and whether or not the subjects knew someone with mental illness. | Regina Vila-Badia Francisco Martínez-Zambrano Otilia Arenas Emma Casas-Anguera Esther García-Morales Raúl Villellas José Ramón Martín María Belén Pérez-Franco Tamara Valduciel Diana Casellas Mar García-Franco Jose Miguel Joaquim Balsera Gemma Pascual Eugènia Julia Susana Ochoa | 2016 | World Journal of Psychiatry2016，6，2： | 4 |
| 3 | ATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients显示文摘AIM:To investigate if the presence of relevant genetic polymorphisms has effect on the effectual clearance of bacteria by monocytes and granulocytes in patients with Crohn’s disease(CD).METHODS:In this study,we assessed the differential responses in phagocytosis by measuring the phagocytic activity and the percentage of active phagocytic monocytes and granulocytes in inflammatory bowel disease patients as well as healthy controls.As both autophagy related like 1(ATG16L1)and immunityrelated guanosine triphosphatase gene are autophagy genes associated with CD and more recently nucleo-tide-binding ligomerization domain-containing protein2(NOD2)has been identified as a potent inducer of autophagy we genotyped the patients for these variants and correlated this to the phagocytic reaction.The genotyping was done with restriction fragment length polymorphisms analysis and the phagocytosis was determined with the pHrodo?Escherichia coli Bioparticles Phagocytosis kit for flowcytometry.RESULTS:In this study,we demonstrate that analysis of the monocyte and granulocyte populations of patients with CD and ulcerative colitis showed a comparable phagocytic activity(ratio of mean fluorescence intensity)between the patient groups and the healthy controls.CD patients show a significantly higher phagocytic capacity(ratio mean percentage of phagocytic cells)compared to healthy controls(51.91%±2.85%vs 37.67%±7.06%,P=0.05).The extend of disease was not of influence.However,variants of ATG16L1(WT:2.03±0.19 vs homozygoot variant:4.38±0.37,P<0.009)as well as NOD2(C-ins)(heterozygous variant:42.08±2.94 vs homozygous variant:75.58±4.34(P=0.05)are associated with the phagocytic activity in patients with CD.CONCLUSION:Monocytes of CD patients show enhanced phagocytosis associated with the presence of ATG16L1 and NOD2 variants.This could be part of the pathophysiological mechanism resulting in the disease. | Simone CS Wolfkamp Caroline Verseyden Esther WM Vogels Sander Meisner Kirsten Boonstra Charlotte P Peters Pieter CF Stokkers Anje A te Velde | 2014 | World Journal of Gastroenterology2014，20，10： | 2 |
| 4 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 5 | Sludge dewatering and stabilization in drying reed beds:characterization of three full-scale systems in Catolonia,Spain显示文摘 | ENRICA U ESTHER L ANNA P | 2009 | Bioresource Technology2009，100，17： | 1 |
| 6 | A study of the overcharge reaction of Lithium ion batteries显示文摘 | Randolph A L Marcus J P Esther S T | 2001 | J Power Sources2001，，98： | 1 |
| 7 | Pulmonary lymphangiectasia: diagnosis and clinical course显示文摘 | Esther C R Jr Barker P M | 2004 | Pediatr Pulmonol2004，38，4： | 1 |
| 8 | Diagnostic value of N-terminal pro- brain natriuretic peptide in pleura] effusions of cardiac origin 显示文摘 | Luis V Esther SJ Antonio P | 2011 | Arch Bronconeumol2011，47，5： | 1 |
| 9 | Abuse testing of lithium-ion battcries characterization of the overcharge reaction of LiCoO2/graphite cells显示文摘 | Randolph A L Marcus J P Esther S T | 2001 | J Electrochem Soc2001，148，8： | 1 |
| 10 | Differential association of oral and transder?mal oestrogen replacement therapy with venous thromboem?bolism risk显示文摘 | Scarabin P Y Oger E Plu -Bureau G (for the ESTHER Study Group) | 2003 | Lancet2003，362，9382： | 1 |
| 11 | Aortic dissection : diagnosis and follow- up with helical CT显示文摘 | Carmen S Esther P Sergi Q | 1999 | Radiographics1999，19，1： | 1 |
| 12 | Silk Fibroin as a Vehicle forDrug Delivery Applications 显示文摘 | Esther W Hans P M Lorenz M | 2011 | J Control Release2011，150，： | 1 |
| 13 | Determination of aromatic and polycyclic aromatic hydrocarbons in gasoline using programmed temperature vaporization-gas chromatography–mass spectrometry显示文摘 | José Luis Pérez Pavón Miguel del Nogal Sánchez María Esther Fernández Laespada Bernardo Moreno Cordero | 2008 | Journal of Chromatography A2008，1202，2： | 1 |
| 14 | Innovation strategy and performance during economic transition:evidences in Beijing显示文摘 | Guan J C Richard c M Esther P Y | 2009 | China Research Policy2009，2，38： | 1 |
| 15 | Characterisation of T and B lymphocytes infiltrating abdominal aortic aneurysms显示文摘 | Esther Ocana Juan - Carlos Bohórquez José Pérez- Requena | 2003 | Atherosclerosis2003，170，： | 1 |
| 16 | New Diagnostic and Therapeutic Approaches to Treat Ventricular Tachycardias Originating at the Summit of the Left Ventricle: Role of Merged Hemodynamic–MRI and Alternative Ablation Sources显示文摘 | Felipe Atienza ángel Arenal Esther Pérez-David Jaime Elízaga Juan Enrique Ortu?o María Jesús Ledesma-Carbayo Damián Sánchez-Quintana Francisco Fernández-Avilés | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，6： | 1 |
| 17 | Reaction of Cp* RuCl(PPh3)2 with Dioxygen and Formation of a Neutral Complex Cp* RuCl(O2) (PPh3) 显示文摘 | Roman Torres-Lubian J Esther Sanchez-Castro M Juarez-Saavedra P | 2002 | J Organomet Chem2002，663，： | 1 |
| 18 | The challenge of micropollutants in aquatic systems显示文摘 | Schwarzenbach R P Esther B I Escher K | 2006 | Science2006，313，5790： | 1 |
| 19 | Advanced oxidation processes for organic contaminant destruction based on the Fenton reaction and related chemistry显示文摘 | Joseph J P Esther O Allison M | 2006 | Environmental Science and Technology2006，36，1： | 1 |
| 20 | A study of the overcharge reaction of lithium-ion batteries显示文摘 | Randolph A L Marcus J P Esther S T | 2001 | Journal of Power Sources2001，9798，： | 1 |
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