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| 1 | ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer显示文摘The Serine-Glycien-One-Carbon(SGOC)pathway is pivotal in multiple anabolic processes.Expression levels of SGOC genes are deregulated under tumoeigenic condltions,suggesting panicipation of oncogenes in deregulating the SGOC biosynthetic pathway.However,the underlying mechanism remains elusive.Here,we identifed that Interleukin enfiarccer-binding factor 3(ILF3)is overexpressed in primary CRC patient specimens and correlates with poor progroosis.ILF3 is critical in regulating the SGOC pathway by directly regulating the mRNA stability of SGOC genes,thereby increasing SGOC genes expression and facilitating tumor growth.Mehhanktic studies showed that the EGF-MIEK-ERK pathway nnediates ILF3 phosphorylation,which hin ders E3 ligase speckle-type POZ protein(SPOP)-mediated poly-ubiquitination and degradation of ILF3.Sign iftca ntly,combination of SGOC inhibitor and the anti-EGFR monoclonal antibody cetuximab can hinder the growth of patient-derived xenografts that sustain high ERK-ILF3 levels.Taken together,deregutation of ILF3 via the EGF-ERK signaling plays an important role in systemic serine metabolic reprogramming and confers a predilection toward CRC development.Our findings indicate that clinical evaluation of SCOC inhibitor is warranted for CRC patients with ILF3 overexpression. | Kai Li Jian-lin Wu Baifu Qin Zongmin Fan Qin Tang Weisi Lu Haipeng Zhang Fan Xing Manqi Meng Shaomin Zou Wenxia Wei Honglei Chen Jian Cai Huaiming Wang Hui Zhang Jiayue Cai Ling Fang Xiqing Bian Chuangqi Chen Ping Lan Bart Ghesquiere Lekun Fang Mong-Hong Lee | 2020 | Cell Research2020，30，2： | 6 |
| 2 | Simultaneous enhancement in strength and elongation of waterborne polyurethane and role of star-like network with lignin core显示文摘 | Cui Guojuan Fan Honglei Xia Wenbing | 2008 | Journal of Applied Polymer Science2008，109，1： | 1 |
| 3 | Highly efficient synthesis of cyclic carbonates from CO 2 and epoxides catalyzed by KI/lecithin显示文摘 | Jinliang Song Binbin Zhang Peng Zhang Jun Ma Jinli Liu Honglei Fan Tao Jiang Buxing Han | 2011 | Catalysis Today2011，，1： | 1 |
| 4 | Expression of PI3K, PTEN and Akt in small intestinaladenocarcinoma detected by quantum dots-based immunofluorescencetechnology显示文摘 | Yi Zhang Xue Yao Congqing Jiang Junqiu Yue Jing Guan Honglei Cheng Mohammed Hajirashid Yan Wang Lifang Fan | 2013 | Cancer Biomarkers2013，，4： | 1 |
| 5 | Preparation of Porous Silicon by Pulse Etching Method显示文摘 | Fan Honglei Hou Xiaoyuan Zhang Pulong | 1995 | Chinese Journal of Semiconductors1995，16，： | 1 |
| 6 | Simultaneous enhancement in strength and elongation of waterborne polyurethane and role of star-like network withlignin core显示文摘 | GUOJUAN CUI HONGLEI FAN WENBING XIA | 2008 | J Appl Polym Sci2008，109，： | 1 |
| 7 | Preparation of porous silicon by pulse etching methed显示文摘 | Fan Honglei Hou Xiaoyuan Li Zheshen | 1995 | Chinese Journal of Semiconductors1995，16，2： | 1 |
| 8 | Thermal formation mechanism and size control of spherical hematite nanoparticle显示文摘 | Fan Honglei Song Baozhen Liu Juhua | 2005 | Materials Chemistry and Physics2005，，89： | 1 |
| 9 | Efficient dehydration of carbohydrates to 5-hydroxymethylfurfural in ionic liquids catalyzed by tin(Ⅳ) phosphonate and zirconium phosphonate显示文摘In this work,we synthesized tin(IV)phosphonate(SnBPMA)and zirconium phosphonate(ZrBPMA)by the reaction of SnCl4·5H2O or ZrOCl2·8H2O with N,N-bis(phosphonomethyl)aminoacetic acid,which was synthesized from a biomaterial glycine through a Mannich-type reaction.The SnBPMA and ZrBPMA were very efficient heterogeneous catalysts for the dehydration of fructose to produce 5-hydroxymethylfurfural(HMF),and the SnBPMA had higher activity than the ZrBPMA.The effects of solvents,temperature,reaction time,and reactant/solvent weight ratio on the reaction catalyzed by SnBPMA were investigated.It was demonstrated that the yield of HMF could reach 86.5%with 1-ethyl-3-methylimidazolium bromide([Emim]Br)as solvent,and the SnBPMA and SnBPMA/[Emim]Br catalytic system could be reused five times without considerable reduction in catalytic efficiency.Further study indicated that the SnBPMA and ZrBPMA in[Emim]Br were also effective for the dehydration of sucrose and inulin to produce HMF with satisfactory yields. | NING Hui SONG JinLiang HOU MinQiang YANG DeZhong FAN HongLei HAN BuXing | 2013 | Science China Chemistry2013，56，11： | 1 |
| 10 | Design and experiment of a subsoiling variable rate fertilization machine显示文摘In order to improve soil fertility and fertilizer utilization,a subsoiling variable rate fertilization machine based on conservation tillage and precision agriculture was designed and tested.The relationship between suspension parameters and penetrating distance was analyzed,and a matching model between fertilizing quantity and penetrating distance was established.The variable rate fertilization control machine was developed based on an Advantech PCM-9363 industrial control mainboard.The machine operates under two patterns:DGPS-based positioning and straight-line path positioning based on a planar coordinate system.This machine can perform on-demand fertilization according to the spatial differences in soil nutrients and the prescription maps pre-set before the operation.Field experiments showed the machine has a subsoiling stability of 92.5%,a soil breaking rate of 61.1%,a maximum positioning relative error of 2.68%and a maximum variable rate fertilization error of 3.89%.The subsoiling performance and variable rate fertilization indices of this machine satisfy the requirements of GB/T24675.2-2009.The tested indices meet the national and industrial standards and satisfy the design requirements.The findings of the research can be used as the structural design of the subsoiling variable rate fertilization machine. | Jiangtao Qi Xinliang Tian Yang Li Xuhui Fan Hongfang Yuan Jiale Zhao Honglei Jia | 2020 | International Journal of Agricultural and Biological Engineering2020，13，4： | 1 |
| 11 | Molecular characterization and phylogenetic analysis of the reticuloendotheliosis virus isolated from wild birds in Northeast China显示文摘 | Lili Jiang Xiaole Qi Yulong Gao Yuping Hua Kai Li Xiaoyun Deng Qi Wang Lizhou Zhang Hongliang Chai Yuming Chen Chunhong Yin Honglei Gao Liting Qin Yongqiang Wang Yue Qu Qiang Chen Zhaobin Fan Xiaomei Wang | 2013 | Veterinary Microbiology (-)2013，，1： | 1 |
| 12 | Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses显示文摘 | Yi Shi Wei Zhang Fei Wang Jianxun Qi Ying Wu Hao Song Feng Gao Yuhai Bi Yanfang Zhang Zheng Fan Chengfeng Qin Honglei Sun Jinhua Liu Joel Haywood Wenjun Liu Weimin Gong Dayan Wang Yuelong Shu Yu Wang Jinghua Yan George F. Gao | 2013 | Science2013，，6155： | 1 |
| 13 | Genetic dissection of and genomic selection for seed weight, pod length,and pod width in soybean显示文摘A biparental soybean population of 364 recombinant inbred lines(RILs)derived from Zhongdou 41×ZYD02.878 was used to identify quantitative trait loci(QTL)associated with hundred-seed weight(100-SW),pod length(PL),and pod width(PW).100-SW,PL,and PW showed moderate correlations among one another,and 100-SW was correlated most strongly with PW(0.64–0.74).Respectively 74,70,75 and19 QTL accounting for 38.7%–78.8%of total phenotypic variance were identified by inclusive composite interval mapping,restricted two-stage multi-locus genome-wide association analysis,3 variancecomponent multi-locus random-SNP-effect mixed linear model analysis,and conditional genome-wide association analysis.Of these QTL,189 were novel,and 24 were detected by multiple methods.Six loci were associated with 100-SW,PL,and PW and may be pleiotropic loci.A total of 284 candidate genes were identified in colocalizing QTL regions,including the verified gene Seed thickness 1(ST1).Eleven genes with functions involved in pectin biosynthesis,phytohormone,ubiquitin-protein,and photosynthesis pathways were prioritized by examining single nucleotide polymorphism(SNP)variation,calculating genetic differentiation index,and inquiring gene expression.The prediction accuracies of genomic selection(GS)for 100-SW,PL,and PW based on single trait-associated markers reached 0.82,0.76,and 0.86 respectively,but selection index(SI)-assisted GS strategy did not increase GS efficiency and inclusion of trait-associated markers as fixed effects reduced prediction accuracy.These results shed light on the genetic basis of 100-SW,PL,and PW and provide GS models for these traits with potential application in breeding programs. | Yijie Chen Yajun Xiong Huilong Hong Gang Li Jie Gao Qingyuan Guo Rujian Sun Honglei Ren Fan Zhang Jun Wang Jian Song Lijuan Qiu | 2023 | The Crop Journal2023，11，3： | 0 |
| 14 | Mitigating Lattice Distortion of High‑Voltage LiCoO_(2)via Core‑Shell Structure Induced by Cationic Heterogeneous Co‑Doping for Lithium‑Ion Batteries显示文摘Inactive elemental doping is commonly used to improve the structural stability of high-voltage layered transition-metal oxide cathodes.However,the one-step co-doping strategy usually results in small grain size since the low diffusivity ions such as Ti^(4+)will be concentrated on grain boundaries,which hinders the grain growth.In order to synthesize large single-crystal layered oxide cathodes,considering the different diffusivities of different dopant ions,we propose a simple two-step multi-element co-doping strategy to fabricate core–shell structured LiCoO_(2)(CS-LCO).In the current work,the high-diffusivity Al^(3+)/Mg^(2+)ions occupy the core of single-crystal grain while the low diffusivity Ti^(4+)ions enrich the shell layer.The Ti^(4+)-enriched shell layer(~12 nm)with Co/Ti substitution and stronger Ti–O bond gives rise to less oxygen ligand holes.In-situ XRD demonstrates the constrained contraction of c-axis lattice parameter and mitigated structural distortion.Under a high upper cut-off voltage of 4.6 V,the single-crystal CS-LCO maintains a reversible capacity of 159.8 mAh g^(−1)with a good retention of~89%after 300 cycles,and reaches a high specific capacity of 163.8 mAh g^(−1)at 5C.The proposed strategy can be extended to other pairs of low-(Zr^(4+),Ta^(5+),and W6+,etc.)and high-diffusivity cations(Zn^(2+),Ni^(2+),and Fe^(3+),etc.)for rational design of advanced layered oxide core–shell structured cathodes for lithium-ion batteries. | Zezhou Lin Ke Fan Tiancheng Liu Zhihang Xu Gao Chen Honglei Zhang Hao Li Xuyun Guo Xi Zhang Ye Zhu Peiyu Hou Haitao Huang | 2024 | Nano-Micro Letters2024，16，3： | 0 |
| 15 | Parallel numerical simulation on CO2 geologic storage in Ordos Basin, China显示文摘The authors developed a 3-D numerical injection model on parallel TOUGH2-FLAC3 D based on the site-specific stratigraphic information in Ordos Basin to simulate the Shenhua CO_2 geological storage( CGS)demonstration project injection process for three years and forecast CO_2 migration and layers displacement after injection for seven years. The results suggested that CO_2 migration did not stop after three years of consecutive injection,but migration rate was slowing down with time. As a result,displacement near injection well increased with injection and decreased slowly after injection. The maximum displacement of surface center occurred near the end of injection,which was only 1. 24 cm. According to the displacement result,it is safe to continue injecting for this project. | LEI Honglei ZHANG Yanjun WU Fan HU Zhongjun YU Ziwang ZHU Chengcheng LU Tianqi | 2017 | Global Geology2017，20，3： | 0 |
| 16 | Damage Mechanism and Structure Analysis of Used Clay Checker Bricks for Regenerators of Coke Ovens显示文摘During long-term use,the clay checker bricks for regenerators of coke ovens on gas side react with the impurities containing Fe and K20,causing foaming,softening and deformation,which is not only related with the impurity content and properties of the clay checker bricks,but also related with the type and the composition of the dust in the gas.After long term use,the clay checker bricks of coke ovens on air side have relative lower impurities containing Fe and K20.The inferior clay checker bricks,with high impurity content and high porosity,are easy to pulverize and deteriorate due to the oxidationreduction reaction with the iron oxide and the gas.The gas quality shall be concerned for long service life of the coke oven regenerators. | XU Guotao YANG Fan FENG Qiang WANG Dachun ZHANG Yanwen ZHANG Honglei LIU Li | 2019 | China's Refractories2019，28，4： | 0 |
| 17 | A Fixed Point Theorem for a Pair of Generalized Nonexpansive Mappings in Uniformly Convex Metric Spaces显示文摘In uniformly convex metric spaces,we study the existence and uniqueness of a common fixed point for a pair of generalized nonexpansive mappings with some weak conditions.Meanwhile,we introduce a new Krasnoselskii type iterative algorithm for approximating the common fixed point.A numerical example is also given to demonstrate the main result.Our results generalize and improve some recent corresponding results. | Chao Wang Honglei Fan | 2022 | Journal of Mathematical Study2022，55，4： | 0 |
| 18 | Complete degradation of high-loaded phenol using tungstate-based ionic liquids with long chain substituent at mild conditions显示文摘Phenol in waste water threatens human health and is difficultly to be decomposed by nature.Efficient degradation of high-loaded phenol in water under mild condition is still a great challenge.Herein,ionic liquids with tungstate anion were designed and prepared.It was found that dodecyltrimethylammonium tungstate could catalyzed degradation of phenol into gases and water thoroughly at 323 k in 8 h.Tungstate anion revealed good catalytic oxidative activity and long carbon chain group connecting with cation of ionic liquids enriched phenol around catalysts,which induced the complete degradation of phenol at mild conditions.Increasing the amounts of hydrogen peroxide benefited to the total degradation of phenol.In addition,the ionic liquid could be reused for its excellent thermal stability.Our work provided a different strategy to treat waste water containing phenol efficiently. | Yingying Yang Honglei Fan Tianbin Wu Guanying Yang Buxing Han | 2023 | Green Energy & Environment2023，8，2： | 0 |
| 19 | Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023 edition)显示文摘To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization,led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles,research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles,Professional Committee on Extracellular Vesicle Research and Application,Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal Vesicles.Based on the collation of relevant literature,we have adopted the Delphi method,the consensus meeting method combined with the nominal group method to form a discussion draft of“Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles(2023)”.The first draft was discussed in online and offline meetings on October 12,14,November 2,2022 and April and May 2023 on the current status of research,nomenclature,isolation methods,quality standards and research applications of extracellular vesicles of Chinese herbal medicines,and 13 consensus opinions were finally formed.At the Third Academic Conference on Research and Application of Chinese Herbal Vesicles,held on May 26,2023,Kewei Zhao,convenor of the consensus,presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal Vesicles.The consensus highlights the characteristics and advantages of Chinese medicine,inherits the essence,and keeps the righteousness and innovation,aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad,decode the mystery behind Chinese herbal vesicles together,establish a safe,effective and controllable accurate Chinese herbal vesicle prevention and treatment system,and build a bridge for Chinese medicine to the world. | Qing Zhao Tong Wang Hongbin Wang Peng Cao Chengyu Jiang Hongzhi Qiao Lihua Peng Xingdong Lin Yunyao Jiang Honglei Jin Huantian Zhang Shengpeng Wang Yang Wang Ying Wang Xi Chen Junbing Fan Bo Li Geng Li Bifeng Liu Zhiyang Li Suhua Qi Mingzhen Zhang Jianjian Zheng Jiuyao Zhou Lei Zheng Kewei Zhao | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
| 20 | On the Error Estimation of the Ishikawa Iteration Process and Data Dependence for Strongly Demicontractive Mappings in Hilbert Spaces显示文摘In this paper, we consider the error estimation of the Ishikawa iteration process for strongly demicontractive(SDC) mappings in real Hilbert spaces(without the Lipschitz condition), some convergence theorems of the Ishikawa iteration process are also obtained. Moreover,we provide data dependence results for SDC mappings in three cases. Some numerical examples are given to verify our results. | Chao WANG Honglei FAN | 2022 | Journal of Mathematical Research with Applications2022，42，5： | 0 |
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