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| 1 | Response of Pinus taiwanensis growth to climate changes at its southern limit of Daiyun Mountain, China's Mainland Fujian Province显示文摘The Pinus taiwanensis trees of a Chinese endemic species form pure forests at infertile sites in humid subtropical China, which can aid soil reservation and ecological resiliency at such sites. Herein, we used dendrochronological methods to investigate the growth patterns and their relationship with climate by analyzing 158 cores of 79 P. taiwanensis trees at 4 sites in their southernmost distribution in China's Mainland at Daiyun Mountain in Fujian Province. Tree growths at sites with favorable conditions generally showed an age-related growth trend, which decreased from approximately 5 mm to 0.5 mm in about a century. Trees in moderately stressed environments established high growth in their juvenile periods but were highly susceptible to environmental stresses such as a sharp growth decline in the 1990 s. The temperature in February and the moisture in July are the major limiting factors for most of the tree growths, except for a few extremely stressed P. taiwanensis trees. The growth of the dwarf P. taiwanensis trees, with all ring diameters of the first 20 years less than 4 mm, is mainly limited by the dry climate in May. Under the potential future warming trend, drought stress can be particularly threatening to these dwarf P. taiwanensis trees, which are likely to be the germplasm resources for this species in this region. | CHEN Dan FANG KeYan LI YingJun DONG ZhiPeng ZHANG Yu ZHOU FeiFei | 2016 | Science China Earth Sciences2016，59，2： | 6 |
| 2 | Ferroptosis as a novel form of regulated cell death:Implications in the pathogenesis,oncometabolism and treatment of human cancer显示文摘The treatment of cancer mainly involves surgical excision supplemented by radiotherapy and chemotherapy.Chemotherapy drugs act by interfering with tumor growth and inducing the death of cancer cells.Anti-tumor drugs were developed to induce apoptosis,but some patient’s show apoptosis escape and chemotherapy resistance.Therefore,other forms of cell death that can overcome the resistance of tumor cells are important in the context of cancer treatment.Ferroptosis is a newly discovered iron-dependent,non-apoptotic type of cell death that is highly negatively correlated with cancer development.Ferroptosis is mainly caused by the abnormal increase in iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis.This review summarizes the progression and regulatory mechanism of ferroptosis in cancer and discusses its possible clinical applications in cancer diagnosis and treatment. | Feifei Pu Fengxia Chen Zhicai Zhang Deyao Shi Binlong Zhong Xiao Lv Andrew Blake Tucker Jiaming Fan Alexander J.Li Kevin Qin Daniel Hu Connie Chen Hao Wang Fang He Na Ni Linjuan Huang Qing Liu William Wagstaff Hue H.Luu Rex C.Haydon Le Shen Tong-Chuan He Jianxiang Liu Zengwu Shao | 2022 | Genes & Diseases2022，9，2： | 6 |
| 3 | Growth of Anisotropic Platinum Nanostructures Catalyzed by Gold Seed Nanoparticles显示文摘This paper reports an effective method for the synthesis of platinum nanostructures with anisotropic morphologies by decomposition of platinum dichloride in oleylamine at intermediate temperatures catalyzed by gold seed nanoparticles.A small quantity of spherical gold nanoparticles formed in situ was used to trigger the nucleation and anisotropic growth of the Pt nanocrystals.By varying the amount of gold seed nanoparticles,porous fl ower-like,irregular polyhedron-shaped,multi-branched rod shaped,and caterpillar-like Pt nanostructures were produced in high yields at 190240°C in reaction times of a few minutes.Control of morphology under different conditions has been systematically studied and a kinetically controlled induced growth mechanism has been proposed. | Zheng Fang Yuliang Zhang Feifei Du Xinhua Zhong | 2008 | Nano Research2008，1，3： | 3 |
| 4 | A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres显示文摘The object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time(37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third,the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the most similar release profile with the real time release. Four different types of progesterone PLGA microspheres were used to verify the method, and all the deduced function correlated well with the real time releases, for R2 = 0.9912, 0.9781, 0.9918 and 0.9972, respectively. | Mingzhu Ye Hongliang Duan Lixia Yao Yicheng Fang Xiaoyu Zhang Ling Dong Feifei Yang Xinggang Yang Weisan Pan | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 3 |
| 5 | A novel lignite pre-drying system with low-grade heat integration for modern lignite power plants显示文摘The lignite pre-drying process plays an important role in modern lignite power plants and the fluidized bed dryer with internal heat utilization is a promising drying method which has both high efficiency and cost-effectiveness. After conducting an in-depth analysis of a typical lignite pre-drying power plant, this work proposed a novel lignite pre-drying system with low-grade heat integration. Through system integration, the low-temperature evaporation of the lignite was recovered to heat the combustion air, while the residual heat from the flue gases was used to heat the feed or condensed water, thereby saving a portion of heat from the steam bleeds of the high and intermediate pressure turbines. The results for a1,000 MW lignite-fired power plant showed that, the proposed pre-drying system could yield an increase in net plant efficiency of approximately 3.6 % points and a reduction in the cost of electricity of $1.83/(MW h). The thermodynamic and economic performances were each superior to those of the existing pre-drying system, convincingly demonstrating that the research of this paper may provide a promising integrated lignite pre-drying method for the next-generation of lignite-fired power plants. | Cheng Xu Gang Xu Yu Han Feifei Liang Yaxiong Fang Yongping Yang | 2014 | Chinese Science Bulletin2014，59，33： | 2 |
| 6 | Nitrous oxide emissions from an intensively managed greenhouse vegetable cropping system in Northern China显示文摘 | Feifei He Rongfeng Jiang Qing Chen Fusuo Zhang Fang Su | 2008 | Environmental Pollution2008，，5： | 2 |
| 7 | Urban Expansion of China from the 1970s to 2020 Based on Remote Sensing Technology显示文摘Based on Remote Sensing (RS) and Geographical Information System (GIS) technology,urban expansion of 75 cities in China from the 1970s to 2020 was reconstructed by visual-interpretation method,which described the growing process of urban lands and its influences on local land use structures synchronously.By employing annual expansion area per city and urban expansion density,spatial-temporal characteristics and macro patterns of urban expansion were analyzed from the aspects of regional-distributions,administrative-levels and population-sizes comprehensively.Results indicate that:1) urban expansion in China was universal,distinct,persistent,periodic and fluctuating.In the past five decades,urban lands of 75 monitored cities in China expanded dramatically from 3606.26 km2 to 30 521.13 km2.2) Though urban expansion presented significant differences from the aspects of regional distribution,administrative levels,and population sizes,it exhibited a deceleration trend in the 13th Five-Year Plan among all kinds of cities.3) Cultivated lands were the first land resource for urban expansion,and 55.17% of newly-expanded urban lands appeared by encroaching this land use type.China’s urban expansion has caused sustained pressure on cultivated land protection,especially in super megacities,and the contradiction between urban expansion and cultivated land protection will always exist.4) The compactness of urban lands in China increased before 1987 and reduced in the next three decades,which was consistent with the implementation of major policies and the deployment of national strategies,and is expected to become compact with a stopping declining or even rebounding after the 13th Five-Year Plan. | LIU Fang ZHANG Zengxiang ZHAO Xiaoli LIU Bin WANG Xiao YI Ling ZUO Lijun XU Jinyong HU Shunguang SUN Feifei WANG Yafei | 2021 | Chinese Geographical Science2021，31，5： | 2 |
| 8 | Oxidized mitochondrial DNA sensing by STING signaling promotes the antitumor effect of an irradiated immunogenic cancer cell vaccine显示文摘Exposure to ionizing radiation,a physical treatment that inactivates live tumor cells,has been extensively applied to enhance the antitumor responses induced by cancer cell vaccines in both animal research and human clinical trials.However,the mechanisms by which irradiated cells function as immunogenic tumor vaccines and induce effective antitumor responses have not been fully explored.Here,we demonstrate that oxidized mitochondrial DNA(mtDNA)and stimulator of interferon genes(STING)signaling play a key roles in the enhanced antitumor effect achieved with an irradiated tumor cell vaccine.Elevations in ROS and oxidized mtDNA 8-OHG content could be induced in irradiated tumor cells.Oxidized mtDNA derived from irradiated tumor cells gained access to the cytosol of dendritic cells(DCs).Oxidized mtDNA,as a DAMP or adjuvant,activated the STING-TBK1-IRF3-IFN-β pathway in DCs,which subsequently cross-presented irradiated tumor cell-derived antigens to CD8^(+)T cells and elicited antitumor immunity.The results of our study provide insight into the mechanism by which an irradiated cell vaccine mediates antitumor immunity,which may have implications for new strategies to improve the efficacy of irradiated vaccines. | Chunju Fang Fei Mo Li Liu Jing Du Min Luo Ke Men Feifei Na Wei Wang Hanshuo Yang Xiawei Wei | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 9 | Forecasting model of automobile logistics demand based on Gray Residual-BP neural network显示文摘 | Jichen Fang Feifei Gao Qiang Zhang | | 0，，08： | 1 |
| 10 | Electroaetive response of mesoporous silica and its nanocomposites with conducting polymers 显示文摘 | Fang Feifei Choi H J Ahn W S | 2009 | Composites Science and Technology2009，69，13： | 1 |
| 11 | Forecasting model of automobile logistics demand based on Gray Residual-BP neural network显示文摘 | Jichen Fang Feifei Gao Qiang Zhang | 2010 | Image and Signal Processing2010，，8： | 1 |
| 12 | Electrorheologicaland magnetorheological response of polypyrrole/ magne-tite nanocomposite particles 显示文摘 | Fang Feifei Liu Yingdan Choi H J | 2013 | Colloid Polym Sci2013，291，7： | 1 |
| 13 | 病例对照Meta分析显示男性乳腺癌与女性乳腺癌预后相同(英文)显示文摘Objective: Male breast cancer (MBC) is a rare disease, and studies to compare the prognosis between the MBC and female breast cancer (FBC) available now were case-control studies and population-based studies, however, with controversial outcomes. To further investigate whether sex affects the prognosis of breast cancer, we performed a meta-analysis based on all the peered papers. Methods: The PubMed database was screened. Subsequently, the hazard ratios (HRs) for overall survival (OS) and disease special survival (DSS), were pooled using the Review Manager 5.0 package. Results: This study comprised of 254 MBC and 733 FBC patients enrolled in six case-control studies. There was no statistically significant heterogeneity among the trials for either outcome variable. The pooled HR showed that there was no significant difference in 5-year or 10-year DSS (HR: 1.25, 95% CI: 0.76-2.08; HR: 1.04, 95% CI: 0.68-1.59) and 5-year or 10-year OS (HR: 0.76, 95% CI: 0.51-1.14; HR: 0.74, 95% CI: 0.54-1.02) between MBCs and FBCs. Conclusion: MBC and FBC with similar prognosis are found in this meta-analysis based on only case-control studies which matched main potential prognostic factors such as age, clinical stage, and time at diagnosis. | Feifei Zhou Rong Huang Jun Jiang Fang Wang Wenzhuo He Guifang Guo Liangping Xia | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，6： | 1 |
| 14 | 中国男性乳腺癌患者临床特征:公开发表文章的总结(英文)显示文摘Objective:The extremely low incidence of male breast cancer (MBC) leads to lack of prospective randomized phase III studies worldwide. Especially in China,all studies on Chinese patients with MBC were based on small sample size and single institute experience. The aim of this study was to provide overall view of characteristics of Chinese patients with MBC by means of summarizing all related papers published in Chinese journals. Methods: An online search was made in CBM,VIP,CNKI,and CBA databases to find all published articles of interest on Chinese patients with MBC. And eight subjects including the proportion of MBC in all breast cancer,age,tumor location,clinical stages,pathological subtypes,treatment modalities,ER/PR expression,and 5-year survival rate were selected to calculate the proportion and their 95% interval confidence. Results: There were 122 papers with 2584 patients enrolled. The basic features of Chinese patients with MBC included:(1) MBC only with a proportion of 1.06% of all the breast cancer; (2) The mean age at diagnosis was 57.6 years old; (3) Tumor mainly located in the areolar region (74.83%) with obvious nipple and/or skin involvement; (4) Nearly 62.62% patients were in early stage before accepting treatment; (5) Infiltrating ductal carcinoma accounted for 79.05% of all pathological subtypes; (6) ER/PR expression rate was 65.86%; (7) Radical resection was up to 86.06% in all surgical modalities; (8) The 5-year survival rate was 57.33%. Conclusion: The results showed in this study were an overall view of Chinese patients with MBC whose characteristics were similar to that reported in the West. Though this study provided a little bit stronger confidence than a single study collected in this paper,studies with more powerful evidence are urgently demanding in China. | Liangping Xia Zhongyu Yuan Xi Wang Jiehua He Bei Zhang Guifang Guo Feifei Zhou Fang Wang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，6： | 1 |
| 15 | Core shell structured semi conducting PMMA/polyaniline snowman-like aniso tropic microparticles and their electrorheology 显示文摘 | Liu Yingdan Fang Feifei | 2010 | J Langmuir2010，26，12： | 1 |
| 16 | Stress sensitivity of formation during multi-cycle gas injection and production in an underground gas storage rebuilt from gas reservoirs显示文摘Permeability sensitivity to stress experiments were conducted on standard core samples taken from Wen 23 Gas Storage at multi-cycle injection and production conditions of the gas storage to study the change pattern of stress sensitivity of permeability.A method for calculating permeability under overburden pressure in the multi-cycle injection and production process was proposed,and the effect of stress sensitivity of reservoir permeability on gas well injectivity and productivity in UGS was analyzed.Retention rate of permeability decreased sharply first and then slowly with the increase of the UGS cycles.The stress sensitivity index of permeability decreased with the increase of cycle number of net stress variations in the increase process of net stress.The stress sensitivity index of permeability hardly changed with the increase of cycle number of net stress variations in the decrease process of net stress.With the increase of cycle number of net stress variation,the stress sensitivity index of permeability in the increase process of net stress approached that in the decrease process of net stress.The lower the reservoir permeability,the greater the irreversible permeability loss rate,the stronger the cyclic stress sensitivity,and the higher the stress sensitivity index of the reservoir,the stronger the reservoir stress sensitivity.The gas zones with permeability lower than 0.3’10-3 mm2 are not suitable as gas storage regions.Stress sensitivity of reservoir permeability has strong impact on gas well injectivity and productivity and mainly in the first few cycles. | LI Jiqiang ZHAO Guanqun QI Zhilin YIN Bingyi XU Xun FANG Feifei YANG Shenyao QI Guixue | 2021 | Petroleum Exploration and Development2021，48，4： | 1 |
| 17 | The stimulating effect of ghrelin on gastric motility and firing activity of gastric‐distension‐sensitive hippocampal neurons and its underlying regulation by the hypothalamus显示文摘 | Luo Xu Yanling Gong Hongbo Wang Xiangrong Sun Feifei Guo Shengli Gao Fang Gu | 2014 | Experimental Physiology2014，，1： | 1 |
| 18 | Synthesis of core-shell structured PS/Fe304 microbeads and their magnetorheology显示文摘 | Fang Feifei Ji Hye Kim Hyoung Jin Choi | 2009 | Polymer2009，50，10： | 1 |
| 19 | Two-layer coating with polymer and carbon nanotube on magnetic carbonyl iron particle and its magnetorheology显示文摘 | Fang Feifei Hyoung Jin Choi Choi W S | 2010 | Short Communication2010，288，3： | 1 |
| 20 | Core-shell-structured silica-coated magnetic carbonyliron microbead and its magnetorheology with anti-acidic characteristics显示文摘 | Liu Yingdan Fang Feifei Hyoung Jin Choi | 2011 | Short Communication2011，289，11： | 1 |
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