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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Research on solar aided coal-fired power generation system and performance analysis显示文摘Integrating solar power utilization systems with coal-fired power units, the solar aided coal-fired power generation (SACPG) shows a significant prospect for the large-scale utilization of solar energy and energy saving of thermal power units. The methods and mechanism of system integration were studied. The parabolic trough solar collectors were used to collect solar energy and the integration scheme of SACPG system was determined considering the matching of working fluid flows and energy flows. The thermodynamic characteristics of solar thermal power generation and their effects on the performance of thermal power units were studied, and based on this the integration and optimization model of system structure and parameters were built up. The integration rules and coupling mecha- nism of SACPG systems were summarized in accordance with simulation results. The economic analysis of this SACPG system showed that the solar LEC of a typical SACPG system, considering CO2 avoidance, is 0.098 $/kW·h, lower than that of SEGS, 0.14 $/kW·h. | YANG YongPing CUI YingHong HOU HongJuan GUO XiYan YANG ZhiPing WANG NinLing | 2008 | Science China(Technological Sciences)2008，51，8： | 30 |
| 3 | Measures against the adverse impact of natural wind on air-cooled condensers in power plant显示文摘The natural wind plays disadvantageous roles in the operation of air-cooled steam condensers in power plant.It is of use to take various measures against the adverse effect of wind for the performance improvement of air-cooled condensers.Based on representative 2×600 MW direct air-cooled power plant,three ways that can arrange and optimize the flow field of cooling air thus enhance the heat transfer of air-cooled condensers were proposed.The physical and mathematical models of air-cooled condensers with various flow leading measures were presented and the flow and temperature fields of cooling air were obtained by CFD simulation.The back pressures of turbine were calculated for different measures on the basis of the heat transfer model of air-cooled condensers.The results show that the performance of air-cooled condensers is improved thus the back pressure of turbine is lowered to some extent by taking measures against the adverse impact of natural wind. | YANG LiJun,DU XiaoZe & YANG YongPing Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education of China,North China Electric Power University,Beijing 102206,China | 2010 | Science China(Technological Sciences)2010，53，5： | 21 |
| 4 | ELASTIC MODULUS REDUCTION METHOD FOR LIMIT LOAD EVALUATION OF FRAME STRUCTURES显示文摘A new strategy for elastic modulus adjustment is proposed based on the element bearing ratio (EBR),and the elastic modulus reduction method (EMRM) is proposed for limit load evaluation of frame structures. The EBR is defined employing the generalized yield criterion,and the reference EBR is determined by introducing the extrema and the degree of uniformity of EBR in the structure. The elastic modulus in the element with an EBR greater than the reference one is reduced based on the linear elastic finite element analysis and the equilibrium of strain energy. The lower-bound of limit-loads of frame structures are analyzed and the numerical example demonstrates the flexibility,accuracy and effciency of the proposed method. | Lufeng Yang Bo Yu Yongping Qiao | 2009 | Acta Mechanica Solida Sinica2009，22，2： | 20 |
| 5 | CFD simulation of particle suspension in a stirred tank显示文摘Particle suspension characteristics are predicted computationally in a stirred tank driven by a Smith turbine.In order to verify the hydrodynamic model and numerical method,the predicted power number and flow pattern are compared with designed values and simulated results from the literature,respectively.The effects of particle density,particle diameter,liquid viscosity and initial solid loading on particle suspension behavior are investigated by using the Eulerian-Eulerian two-fluid model and the standard k-s turbulence model.The results indicate that solid concentration distribution depends on the flow field in the stirred tank.Higher particle density or larger particle size results in less homogenous distribution of solid particles in the tank.Increasing initial solid loading has an adverse impact on the homogeneous suspension of solid particles in a low-viscosity liquid,whilst more uniform particle distribution is found in a high-viscosity liquid. | Nana Qi Hu Zhang Kai Zhang Gang Xu Yongping Yang | 2013 | Particuology2013，11，3： | 19 |
| 6 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 7 | Eco-environment range in the source regions of the Yangtze and Yellow rivers显示文摘Based on geographical and hydrological extents delimited, four principles are identified, as the bases for delineating the ranges of the source regions of the Yangtze and Yellow rivers in the paper. According to the comprehensive analysis of topographical characteristics, climate conditions, vegetation distribution and hydrological features, the source region ranges for eco-environmental study are defined. The eastern boundary point is Dari hydrological station in the upper reach of the Yellow River. The watershed above Dari hydrological station is the source region of the Yellow River which drains an area of 4.49×10 4 km 2 . Natural environment is characterized by the major topographical types of plateau lakes and marshland, gentle landforms, alpine cold semi-arid climate, and steppe and meadow vegetation in the source region of the Yellow River. The eastern boundary point is the convergent site of the Nieqiaqu and the Tongtian River in the upstream of the Yangtze River. The watershed above the convergent site is the source region of the Yangtze River, with a watershed area of 12.24×10 4 km 2 . Hills and alpine plain topography, gentle terrain, alpine cold arid and semi-arid climate, and alpine cold grassland and meadow are natural conditions in the source region of the Yangtze River. | DING Yongjian,YANG Jianping,LIU Shiyin,CHEN Rensheng,WANG Genxu,SHEN Yongping,WANG Jian,XIE Changwei,ZHANG Shiqing(Cold and Arid Regions Environmental and Engineering Research Institute, CAS, Lanzhou 730000, China) | 2003 | Journal of Geographical Sciences2003，13，2： | 18 |
| 8 | Hydrology and water resources variation and its response to regional climate change in Xinjiang显示文摘Based on the surface runoff, temperature and precipitation data over the last 50 years from eight representative rivers in Xinjiang, using Mann-Kendall trend and jump detection method, the paper investigated the long-term trend and jump point of time series, the surface runoff, mean annual temperature and annual precipitation. Meanwhile, the paper analyzed the relationship between runoff and temperature and precipitation, and the flood frequency and peak flow. Results showed that climate of all parts of Xinjiang conformably has experienced an increase in temperature and precipitation since the mid-1980s. Northern Xinjiang was the area that changed most significantly followed by southern and eastern Xinjiang. Affected by temperature and precipitation variation, river runoff had changed both inter-annually and intra-annually. The surface runoff of most rivers has increased significantly since the early 1990s, and some of them have even witnessed the earlier spring floods, later summer floods and increasing flood peaks. The variation characteristics were closely related with the replenishment types of rivers. Flood frequency and peak flow increased all over Xinjiang. Climate warming has had an effect on the regional hydrological cycle. | XU Changchun CHEN Yaning YANG Yuhui HAO Xingming SHEN Yongping | 2010 | Journal of Geographical Sciences2010，20，4： | 17 |
| 9 | Influence of Gd_2O_3 and Yb_2O_3 Co-doping on Phase Stability,Thermo-physical Properties and Sintering of 8YSZ显示文摘The role of multicomponent rare earth oxides in phase stability, thermophysical properties and sintering for ZrO2-based thermal barrier coatings (TBCs) materials is investigated. 8YSZ codoped with 3 mol% Gd2O3 and 3 mol% Yb2O3 (GYb-YSZ) powders are synthesized by solid state reaction for 24 h at various temperatures. As temperature increases, stabilizers are dissolved into zirconia matrix gradually. Synthesized at 1 500 °C, GYb-YSZ is basically composed of cubic phase. GYb-YSZ exhibits excellent phase stability and sinters lower than 8YSZ by nearly three times. The thermal conductivity of GYb-YSZ is much lower than that of 8YSZ, and the thermal expansion coefficient of GYb-YSZ is comparable to that of 8YSZ. The influence of Gd2O3 and Yb2O3 co-doping on phase stability, thermal conductivity and sintering of 8YSZ is discussed. | ZHANG Yanli GUO Lei YANG Yongping GUO Hongbo ZHANG Hongju GONG Shengkai | 2012 | Chinese Journal of Aeronautics2012，25，6： | 17 |
| 10 | Evaluation of solar aided biomass power generation systems with parabolic trough field显示文摘Solar and biomass are both renewable energy resources.Using biomass as fuel is becoming more and more attractive after governments increase the tariff for the electricity from the renewable sources.However the costs of power from a biomass power generation plant depend greatly on the availability and quality of the biomass resource.The commercialization of solar alone thermal power generation is hindered by its high initial investment and low thermal efficiency.In this paper,a concept of integrating solar into a biomass power generation system is put forward.In the system the oil heated by a parabolic trough solar field is used to replace the extraction steam to preheat the feed water(entering a biomass boiler) and the previous extraction steam thus saved can continue to do work in the lower stages of turbine.The performance of the hybrid system with different replacements is analyzed and compared through two typical solar aided biomass generating units.The results show that the integration not only reduces the consumption of biomass fuel(at the same generation capacity) but is also proved to be an efficient way to convert solar thermal energy into power.The results also show that with the same solar aperture area,the higher the grade of the replaced extraction steam,the better the thermal performance and economy. | HOU HongJuan YANG YongPing HU Eric SONG JiFeng DONG ChangQing MAO Jian | 2011 | Science China(Technological Sciences)2011，54，6： | 15 |
| 11 | Monitoring of frozen soil hydrology in macro-scale in the Qinghai-Xizang Plateau显示文摘Monitoring of frozen soil hydrology in macro-scale was performed by Chinese and Japanese scientists from 1997 to 1998. Quality measured data were obtained. Measured data on soil moisture and temperature are preliminarily analyzed. Based on profiles of soil temperature and moisture in individual measured sites, intra-annual freezing and melting process of soil is discussed. Maximum frozen and thawed depths and frozen days in various depths are estimated. The work emphasized the spatial distribution on soil temperature and moisture in macro-scale and the effect of topography on conditions of soil water and heat. | Yongjian Ding Baisheng Ye Shiying Liu Yongping Shen Shaoling Wang Meixie Yang | 2000 | Chinese Science Bulletin2000，45，12： | 13 |
| 12 | Situation and Prospect of Energy Consumption for China's Thermal Power Generation显示文摘 | YANG Yongping YANG Zhiping XU Gang WANG Ningling | 2013 | 中国电机工程学报2013，33，23： | 11 |
| 13 | Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens,a natural waste recycler显示文摘The black soldier fly(BSF),Hermetia illucens(Diptera:Stratiomyidae),is renowned for its bioconversion of organic waste into a sustainable source of animal feed.We report a high-quality genome of 1.1 Gb and a consensus set of 16,770 gene models for this beneficial species.Compared to those of other dipteran species,the BSF genome has undergone a substantial expansion in functional modules related to septic adaptation,including immune system factors,olfactory receptors,and cytochrome P450s.We further profiled midgut transcriptomes and associated microbiomes of BSF larvae fed with representative types of organic waste.We find that the pathways related to digestive system and fighting infection are commonly enriched and that Firmicutes bacteria dominate the microbial community in BSF across all diets.To extend its potential practical applications,we further developed an efficient CRISPR/Cas9-based gene editing approach and implemented this to yield flightless and enhanced feeding capacity phenotypes,both of which could expand BSF production capabilities.Our study provides valuable genomic and technical resources for optimizing BSF lines for industrialization. | Shuai Zhan Gangqi Fang Minmin Cai Zongqing Kou Jun Xu Yanghui Cao Liang Bai Yixiang Zhang Yongmao Jiang Xingyu Luo Jian Xu Xia Xu Longyu Zheng Ziniu Yu Hong Yang Zhijian Zhang Sibao Wang Jeffery K.Tomberlin Jibin Zhang Yongping Huang | 2020 | Cell Research2020，30，1： | 9 |
| 14 | Thermo-flow characteristics and air flow field leading of the air-cooled condenser cell in a power plant显示文摘Special A-frame geometry of the air-cooled condenser cell and the complicated flow field at the exit of the axial flow fan bring on the air mal-distribution on the surface of the finned tube bundles and the deteriorated thermo-flow performances of a condenser cell.It is of benefit to the design and operation optimization of the direct dry cooling system in a power plant to investigate the thermo-flow characteristics of the condenser cell and propose the flow leading measures of cooling air.On the basis of the representative configuration of the air-cooled condenser cell in a 600 MW direct dry cooling power plant,the computational models of the air side fluid and heat flows are built,in which the actual fan blade geometric details are considered.Various flow field leading ways of cooling air are presented and the thermo-flow characteristics in the A-frame condenser cell and through the finned tube bundles are compared.Results show that the flow field leading measures can result in the increased volumetric flow rate and heat rejection,thus bringing on the improved performance of the condenser cell.The improvement of thermo-flow performances depends upon the geometric details of the flow guiding device. | ZHANG WanXi YANG LiJun DU XiaoZe YANG YongPing | 2011 | Science China(Technological Sciences)2011，54，9： | 8 |
| 15 | FHY3 and FAR1 Integrate Light Signals with the miR156-SPL Module-Mediated Aging Pathway to Regulate Arabidopsis Flowering显示文摘In response to competition for light from their neighbors,shade-intolerant plants flower precociously to ensure reproductive success and survival.However,the molecular mechanisms underlying this key developmental switch are not well understood.Here,we show that a pair of Arabidopsis transcription factors essential for phytochrome A signaling,FAR-RED ELONGATED HYPOCOTYL3(FHY3)and FAR-RED IMPAIRED RESPONSE1(FAR1),regulate flowering time by integrating environmental light signals with the miR156-SPL module-mediated aging pathway.We found that FHY3 and FAR1 directly interact with three flowering-promoting SQUAMOSA-PROMOTER BINDING PROTEIN-LIKE(SPL)transcription factors,SPL3,SPL4,and SPL5,and inhibit their binding to the promoters of several key flowering regulatory genes,including FRUITFUL(FUL),LEAFY(LFY),APETALA1(AP1),and MIR172C,thus downregulating their transcript levels and delaying flowering.Under simulated shade conditions,levels of SPL3/4/5 proteins increase,whereas levels of FHY3 and FAR1 proteins decline,thus releasing SPL3/4/5 from FHY3/FAR1 inhibition to allow activation of FUL,LFY,AP1,and MIR172C and,consequently,early flowering.Taken together,these results unravel a novel mechanism whereby plants regulate flowering time by integrating environmental cues(such as light conditions)and an internal developmental program(the miR156-SPL module-mediated aging pathway). | Yurong Xie Qin Zhou Yongping Zhao Quanquan Li Yang Liu Mengdi Ma Baobao Wang Rongxin Shen Zhigang Zheng Haiyang Wang | 2020 | Molecular Plant2020，13，3： | 8 |
| 16 | Effect of vernalization on tuberization and flowering in the Tibetan turnip is associated with changes in the expression of FLC homologues显示文摘The turnip(Brassica rapa var. rapa) is a biennial crop that is planted in late summer/early fall and forms fleshy tubers for food in temperate regions. The harvested tubers then overwinter and are planted again the next spring for flowering and seeds. FLOWERING LOCUS C(FLC) is a MADS-box transcription factor that acts as a major repressor of floral transition by suppressing the flowering promoters FT and SOC1. Here we show that vernalization effectively represses tuber formation and promotes flowering in Tibetan turnip. We functionally characterized four FLC homologues(BrrFLC1,FLC2, FLC3, and FLC5), and found that BrrFLC2 and BrrFLC1 play a major role in repressing flowering in turnip and in transgenic Arabidopsis. In contrast, tuber formation was correlated with BrrFLC1 expression in the hypocotyl and was repressed under cold treatment following the quantitative downregulation of BrrFLC1. Grafting experiments of non-vernalized and vernalized turnips revealed that vernalization independently suppressed tuberization in the tuber or hypocotyl of the rootstock or scion, which occurred in parallel with the reduction in BrrFLC1 activity. Together, our results demonstrate that the Tibetan turnip is highly responsive to cold exposure, which is associated with the expression levels of BrrFLC genes. | Yan Zheng Landi Luo Yuanyuan Liu Yunqiang Yang Chuntao Wang Xiangxiang Kong Yongping Yang | 2018 | Plant Diversity2018，40，2： | 7 |
| 17 | Progress and prospects of innovative coal-fired power plants within the energy internet显示文摘The development of electrical engineering and electronic, communications, smart power grid, and ultra-high voltage transmission technologies have driven the energy system revolution to the next generation: the energy internet. Progressive penetration of intermittent renewable energy sources into the energy system has led to unprecedented challenges to the currently wide use of coal-fired power generation technologies. Here, the applications and prospects of advanced coal-fired power generation technologies are analyzed. These technologies can be summarized into three categories:(1) large-scale and higher parameters coal-fired power generation technologies, including 620/650/700 oC ultra-supercritical thermal power and double reheat ultra-supercritical coal-fired power generation technologies;(2) system innovation and specific, highefficiency thermal cycles, which consist of renewable energy-aided coal-fired power generation technologies, a supercritical CO_2 Brayton cycle for coal-fired power plants, large-scale air-cooling coal-fired power plant technologies, and innovative layouts for waste heat utilization and enhanced energy cascade utilization;(3) coal-fired power generation combined with poly-generation technologies, which are represented by integrated gasification combined cycle(IGCC) and integrated gasification fuel cell(IGFC) technologies. Concerning the existing coal-fired power units, which are responsible for peak shaving, possible strategies for enhancing flexibility and operational stability are discussed. Furthermore, future trends for coal-fired power plants coupled with cyber-physical system(CPS) technologies are introduced. The development of advanced, coal-fired power generation technologies demonstrates the progress of science and is suitable for the sustainable development of human society. | Yongping Yang Chengzhou Li Ningling Wang Zhiping Yang | 2019 | Global Energy Interconnection2019，2，2： | 7 |
| 18 | Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated cases显示文摘Cryoablation 是为 hepatocellular 癌(HCC ) 的不太流行的经皮的夺格的治疗,并且关于它的实用性的当前的证据是有限的。我们在与经皮的 cryoablation 对待 1595 个 HCC 案例关于有效性,安全和这治疗的长期的结果给全面侧面报导我们的经验。从 2003 年 1 月到 2013 年 12 月,有 2313 个 HCC 小瘤的 1595 个病人在我们的中心与 2958 个 cryoablation 会议被切除。完全的脱离与 3.4 朠湥浯捩椠獮慴楢楬祴 ? 畢 ? 的一条吝啬的直径为 1893 个小瘤在 1294 个病人被完成 ?? 潣扭湩摥眠瑩 ??? 瑡整畮瑡摥琠敨攠瑸湥 ? 景朠湥浯捩椠獮慴楢楬祴椠 ? 牰浩牡 ? 塖′畴潭 ? 楴獳敵瑡吗?? | Guanghua Rong Wenlin Bai Zheng Dong Chunping Wang Yinying Lu Zhen Zeng Jianhui Qu Min Lou Hong Wang Xudong Gao Xiujuan Chang Linjing An Yan Chen Yongping Yang | 2015 | Frontiers of Medicine2015，9，1： | 7 |
| 19 | Effect of quercetin on the expression of Bcl-2/Bax apoptotic proteins in endometrial cells of lipopolysaccharide-induced-abortion mice显示文摘OBJECTIVE: To explore the effect of quercetin on the expressions of Bcl-2/Bax apoptotic proteins in endometrial cells in mice with abortion induced by lipopolysaccharide.METHODS: For in vivo experiment, twenty five Kunming mice were randomly divided into five groups at day 4 of pregnancy, with 5 mice per group. The mice were treated with lipopolysaccharide(LPS)through tail vein intravenous injection at day 4 of pregnancy, followed by different concentrations of quercetin by oral gavage consecutively at days 5 to6 of pregnancy. On day 7 of gestation, the mice were sacrificed and the histopathological changes of the uterus tissues were observed. Immunohistochemical staining was applied to the detection of Bcl-2/Bax apoptotic proteins in the endometrial cells. For in vitro experiment, the primary endometrial cells werecultured using a uterus tissue mass culturing method sampled at day 4.5 of pregnancy. The cells were treated with LPS with or without different dosages of quercetin, respectively, for 12 h after 80% confluence. The expression of Bcl-2/Bax apoptotic proteins were detected by western blotting.RESULTS: Both the in vivo and in vitro experiments showed decreased expression of Bcl-2 and enhanced expression of Bax after LPS treatment, leading to a decreased Bcl-2/Bax ratio. The expression of Bcl-2 significantly increased while the expression of Bax was significantly elevated, in the LPS plus quercetin group compared to the LPS only group.CONCLUSION: These results suggest that quercetin has protective effect by partially regulating the expression of Bcl-2/Bax proteins, which in turn inhibits endometrial cell apoptosis and benefits the embryo implantation. | Wang Xiaodan Yan Yongping Yang Liu Li Mu Zhong Xiuhui | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 7 |
| 20 | Numerical investigation on the cluster effect of an array of axial flow fans for air-cooled condensers in a power plant显示文摘The aerodynamic behavior of tens of axial flow fans incorporated with air-cooled condensers in a power plant is different from that of an individual fan.Investigation of the aerodynamic characteristics of axial flow fan array benefits its design optimization and running regulation.Based on a representative 2600 MW direct-dry cooling power plant,the flow rate of each fan and the overall flow rate of the fan array are obtained in the absence of ambient wind and at various wind speeds and directions,using CFD simulation.The cluster factor of each fan and the average cluster factor of the fan array are calculated and analyzed.Results show that the cluster factors are different from each other and that the cluster effect with ambient wind is significantly different from the cluster effect with no wind.The fan at the periphery of the array or upwind of the ambient wind generally has a small cluster factor.The average cluster factor of the array decreases with the increasing wind speeds and also varies widely with wind direction.The cluster effect of the axial flow fan array can be applied to optimize the design and operation of air-cooled condensers in a power plant. | YANG LiJun DU XiaoZe ZHANG Hui YANG YongPing | 2011 | Chinese Science Bulletin2011，56，21： | 6 |
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