|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics显示文摘Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies for hematological malignancies.Here,we constructed a spatiotemporal transcriptome map of mouse fetal liver(FL)as a platform for hypothesis generation and subsequent experimental validation of novel regulatory mechanisms.Single-cell transcriptomics revealed three transcriptionally heterogeneous HSC/MPP subsets,among which a CD93-enriched subset exhibited enhanced stem cell properties.Moreover,by employing integrative analysis of single-cell and spatial transcriptomics,we identified novel HSC/MPP‘pocket-like’units(HSC PLUS),composed of niche cells(hepatoblasts,stromal cells,endothelial cells,and macrophages)and enriched with growth factors.Unexpectedly,macrophages showed an 11-fold enrichment in the HSC PLUS.Functionally,macrophage-HSC/MPP co-culture assay and candidate molecule testing,respectively,validated the supportive role of macrophages and growth factors(MDK,PTN,and IGFBP5)in HSC/MPP expansion.Finally,cross-species analysis and functional validation showed conserved cell-cell interactions and expansion mechanisms but divergent transcriptome signatures between mouse and human FL HSCs/MPPs.Taken together,these results provide an essential resource for understanding HSC/MPP development in FL,and novel insight into functional HSC/MPP expansion ex vivo. | Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu | 2022 | Cell Research2022，32，1： | 4 |
| 2 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 3 | Chronology and paleoenvironmental records of a drill core in the central Tengger Desert of China显示文摘 | Zaijun Li Donghuai Sun Fahu Chen Fei Wang Yuebao Zhang Feng Guo Xin Wang Baofeng Li | 2014 | Quaternary Science Reviews2014，，： | 1 |
| 4 | Stable periodic waves in coupled kuramoto-sivashinsky-korteweg-de vries equations显示文摘 | FENG Baofeng MALOMED B A KAWAHARA T | 2002 | Journal of the Physical Society of Japan2002，71，11： | 1 |
| 5 | Stable periodic waves in coupled kuramoto-sivashinsky-kortewegdevries equations显示文摘 | FENG Baofeng MALOMEDBA KAWAHARAT | 2002 | Journal of the Physical Society of Japan2002，71，11： | 1 |
| 6 | Observa- tion of shear-induced hybrid shish kebab in the injection molded bars of linear polyethylene containing inorganic whisk- ers 显示文摘 | NING Nanying LUO Feng PAN Baofeng | 2007 | Macromolecules2007，40，24： | 1 |
| 7 | Stable periodic waves in coupled Kuramoto-Sivashinsky-Korteweg-Devries equations 显示文摘 | Feng Baofeng Malomedba Kawaharat | 2002 | Journal of the Physical Society of Japan2002，71，11： | 1 |
| 8 | Transplanted iPSC-derived neural stem cells for spinal cord injury显示文摘Spinal cord injury(SCI),one of the most devastating central nervous system(CNS)disorders,can lead to severe neurological disabilities,the most severe forms of which include persistent paraplegia or quadriplegia.The efficacy of induced pluripotent stem cell(iPSC)derived neural stem cells(NSC)transplantation on functional recovery following acute spinal cord injury(SCI)was detected.NSC derived from iPSC was characterized by expression of specific markers(SOX2,nestin and PAX6). | Kong Desheng Feng Baofeng Guo Ruigyun Ernest Asiamah He Jingjing Zhang Shuhan Lyu Fei Liu Xin Ma Jun Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 9 | Fragmentation of brain apolipoprotein E(ApoE)and its relevance in late onset Alzheimer's disease显示文摘Late-onset Alzheimer's disease(LOAD)is the most common cause of dementia in the elderly.Polymorphism in apolipoprotein E(ApoE)gene(ε2,ε3,and ε4)is the greatest LOAD risk factor.The translation products are ApoE2,ApoE3,and ApoE4,respectively.ApoE fragments are present in senile plaques and neurofibillary tangles but their contributions to AD pathogenesis are not clear. | Ernest Asiamah Jingjing He Ruiyun Guo Baofeng Feng Desheng Kong Xin Liu Jun Ma Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 10 | Clinical efficacy and safety of mesenchymal stem cells in patients with diabetes mellitus显示文摘Diabetes mellitus(DM)as a chronic metabolic disease is threatening human health seriously.The aim of this study was to systematically review the evidence from RCTs and conduct comprehensive assessment of therapeutic efficacy and safety of mesenchymal stem cells(MSCs)in DM.PubMed,Web of Science,Ovid,the Cochrane Library and CNKI were searched until April 30,2020.Seven RCTs were eligible,including 413 participants. | He Jingjing Kong Desheng Asiamah Ernest Am ponsah Guo Ruiyun Feng Baofeng Ma Jun Timothy O'Brien Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | Generation of a human iPSC line from a sporadic amyotrophic lateral sclerosis patient and motor neuron differentiation显示文摘Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease that affects motor neurons in the central nervous system,which leads to muscle.atrophy and progressive paralysis.W hile mutations in several genes responsible for familial ALS have been identified,the pathogenesis of sporadic ALS,which accounts for approximately 90%of all ALS cases,remains unclear. | Feng Baofeng Asiamah Ernest Am ponsah Guo Ruiyun Kong Desheng He Jingjing Ma Jun Cui Huixian | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 12 | Establishment of amyotrophic lateral sclerosis induced pluripotent stem cells and neuronal differentiation显示文摘Amyotrophic lateral sclerosis(ALS)is a motor neuron disease that seriously threatens the health of patients.The mechanism is unclear.Most ALS disease models cannot accurately reflect the pathological characteristics of ALS.Induced pluripotent stem cells(iPSC)can best mimic lesions and is used to reveal the mechanism of ALS and develop therapeutic drugs.In the process of iPSC reprogramming,the selection of somatic cells and the optimization of conditions are critical to the progress of iPSC culture.Skin biopsies were used in this study to optimize the isolation and culture method of fibroblasts,and established a optimized somatic cell culture process with high tissue utilization rate,short culture period and high success rate. | Guo Ruiyun Feng Baofeng Kong Desheng Ernest Asiamah He Jingjing Lv Fei Ma Jun Huixian Cui | 2021 | 解剖学杂志2021，44，S01： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员