|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels显示文摘Brachydactyly 打 A1 (BDA1 ) ,第一在人记录了孟德尔的正染色体的主导的混乱,被弄短或中间的指骨的缺席描绘。在印度刺猬(IHH ) 基因的异质接合的错误感觉变化作为 BDA1 的一个原因被识别了;然而,这些变化的生物化学的后果是不清楚的。在这份报纸,我们在印度刺猬(IhhN ) 的 N 终端碎片分析了三个 BDA1 变化(E95K, D100E,和 E131K ) 。结构的分析证明 E95K 变化在一条钙绑定沟把一个否定地控告的区域改变到一个断然控告的区域,并且 D100E 变化改变本地第三级的结构。而且,我们证明 E95K 和 D100E 变化导致了一温度敏感并且 IhhN 的钙依赖者不稳定性,它可能经由 lysosome 贡献变异的蛋白质的提高的细胞内部的降级。尤其是,所有三个变化影响了对受体 Patched1 (PTC1 ) 有约束力的 Hh,减少它的能力导致细胞的区别。我们建议这些是引起 BDA1 的变化的普通特征,影响 Hh 第三级的结构,细胞内部的命运,到受体 / 搭挡的绑定,和到细胞外的部件的绑定。这些特征的联合改变发信号的能力和范围,但是影响是可能的是变量和变化依赖者。在发信号的范围的潜在的变化被和 heparan 硫酸盐的一个提高的相互作用与 E95K 变化,然而并非 E131K 变化为 IHH 描绘。一起拿,我们的结果建议这些 IHH 变化影响在多重层次,引起的反常骨头发展和反常的位形成发信号的 Hh。 | Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He | 2011 | Cell Research2011，21，9： | 6 |
| 2 | Effect of six flavonoid compounds from Ixeris Sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils 显示文摘 | Jincai Lu Xizhi Feng Qishi Sun | 2002 | Clinica Chimica Acta2002，316，： | 1 |
| 3 | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils显示文摘 | Jincai Lu Xizhi Feng Qishi Sun Huangwei Lu Masanobu Manabe Kazunori Sugahara Deshun Ma Yasuhiro Sagara Hiroyuki Kodama | 2002 | Clinica Chimica Acta2002，，1： | 1 |
| 4 | Two novel flavonoids from lxeris sorzchifolia 显示文摘 | Feng Xizhi Xu Suixu Dong Mei | 2000 | J Chin Pharm Sci2000，9，3： | 1 |
| 5 | A new trierpenoidal saponin from Ixeris sonchifolia and its cytotoxic activity显示文摘 | FENG Xizhi DONG M XU Suixu | 2001 | Pharmazie2001，56，8： | 1 |
| 6 | Photo-responsive shape memory polymer composites enabled by doping with biomass-derived carbon nanomaterials显示文摘As photothermal conversion agents,carbon nanomaterials are widely applied in polymers for light-triggered shape memory behaviors on account of their excellent light absorption.However,they are usually derived from non-renewable fossil resources,which go against the demand for sustainable development.Biomass-derived carbon nanomaterials are expected as alternatives if they are designed with good dispersibility as well as splendid photothermal properties.Up to date,very few researches focused on this area.Herein,we report a novel light-triggered shape memory composite by incorporating renewable biomass-derived carbon nanomaterials into acrylate polymers without deep purification and processing.These functionalized carbon nanomaterials not only have stable dispersion in polymers as fillers,but also can endow the polymers with excellent and stable thermal and photothermal responsive properties in biological friendly environment.With the introduction of biomass-derived carbon nanomaterials,the mechanical properties of the composites are also further enhanced with the formation of hydrogen bonding between the carbon nanomaterials and the polymers.Notably,the doping of 1%carbon nanomaterials endows the polymer with sufficient hydrogen bonds that not only exhibit excellent thermal and photothermal responsive properties,but also with enough space for the motion of chains.These properties make such composite a promising and safe candidate for shape memory applications,which provide a new avenue in smart fabrics or intelligent soft robotics. | Nina Yan Zhiyu Zheng Yunliang Liu Xizhi Jiang Jiamin Wu Min Feng Lei Xu Qingbao Guan Haitao Li | 2022 | Nano Research2022，15，2： | 1 |
| 7 | Effect of six flavonoid compounds from Ixeris sonchifolia on Stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils显示文摘 | LU Jincai FENG Xizhi SUN Qishi | 2002 | Clinica Chimica Acta2002，316，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员