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| 1 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 2 | Hypertensive stretch regulates endothelial exocytosis of WeibeI-Palade bodies through VEGF receptor 2 signaling pathways显示文摘Weibel-Palade 身体(WPB ) 的调整 endothelial exocytosis,在白血球 trafficking 的第一个阶段,在发炎和损害起一个枢轴的作用。尖锐的机械段仔细与脉管的发炎被联系了,尽管精确机制是未知的。这里,我们证明那高血压的段通过 VEGF 受体 2 调整 endothelial 房间(EC ) 的 WPB 的 exocytosis (VEGFR2 ) 表明小径。段触发一个快速的版本(在分钟以内) 从在有教养的人的 EC 的 WPB 的 von Willebrand 因素和 interleukin-8,通过 P-selectin 的 translocation 把在白血球和 EC 之间的相互作用提升到房间膜。我们进一步证明那高血压的段显著地导致未经触动的 EC 的 P-selectin translocation 并且两个都提高白血球粘附前 vivo 并且在 vivo。导致段的 endothelial exocytosis 经由 VEGFR2/PLCγ 被调停; 1/calcium 小径。有趣地,段也经由一条 VEGFR2/Akt/nitric 氧化物小径导致否定反馈。如此的双效果在颈动脉动脉片断,以及在尖锐高血压的老鼠模型用药理学和基因途径被证实。这些研究为 endothelial exocytosis 作为有势力收缩筋揭示机械段,它被 VEGFR2 发信号调制。因此, VEGFR2 发信号小径可以在限制高血压的段相关的发炎代表新奇治疗学的目标。 | Yan Xiong Zhenqian Hu Xiaofan Han Beibei Jiang Rongli Zhan Xiaoyu Zhang Yao Lu Chenyang Geng Wei Li Yulong He Yingqing Huo Masabuml Shlbuya Jincai Luo | 2013 | Cell Research2013，23，6： | 7 |
| 3 | Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity显示文摘As a first-line treatment,radiotherapy(RT)is known to modulate the immune microenvironment of glioma,but it is unknown whether the meningeal lymphatic vessel(MLV)-cervical lymph node(CLN)network regulates the process or influences RT efficacy.Here,we show that the MLV-CLN network contributes to RT efficacy in brain tumors and mediates the RT-modulated anti-tumor immunity that is enhanced by vascular endothelial growth factor C(VEGF-C).Meningeal lymphatic dysfunction impaired tumorderived dendritic cell(DC)trafficking and CD8^(+)T cell activation after RT,whereas tumors overexpressing VEGF-C with meningeal lymphatic expansion were highly sensitive to RT.Mechanistically,VEGF-C-driven modulation of RT-triggered anti-tumor immunity was attributed to C-C Motif Chemokine Ligand 21(CCL21)-dependent DC trafficking and CD8^(+)T cell activation.Notably,delivery of VEGF-C mRNA significantly enhanced RT efficacy and anti-tumor immunity in brain tumors.These findings suggest an essential role of the MLV-CLN network in RT-triggered anti-tumor immunity,and highlight the potential of VEGF-C mRNA for brain tumor therapy. | Changping Zhou Lu Ma Han Xu Yingqing Huo Jincai Luo | 2022 | Cell Research2022，32，6： | 3 |
| 4 | Upper Paleozoic Shale Gas Accumulation Conditions of the Tiemulike Formation in Yining Basin显示文摘1 Introduction Yining basin,an independent unit of the YiliZhongtianshan micro plate(Wang et al.,2007;Han et al.,2011),is an intermontane superimposed basin(Dai et al.,2015).Yining basin has well-developed Tiemulike dark shale with normal lake facies formed in late period of middle Permian,which has good foreground material conditions of shale gas reservoirs from the study | FENG Yangwei LU Jincai JIANG Ting NIU Yazhuo CHEN Gaochao XU Wei | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 1 |
| 5 | Effect of six flavonoid compounds from Ixeris Sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils 显示文摘 | Jincai Lu Xizhi Feng Qishi Sun | 2002 | Clinica Chimica Acta2002，316，： | 1 |
| 6 | Effect of six flavonoid compounds from Ixeris sonchifolia on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils显示文摘 | Jincai Lu Xizhi Feng Qishi Sun Huangwei Lu Masanobu Manabe Kazunori Sugahara Deshun Ma Yasuhiro Sagara Hiroyuki Kodama | 2002 | Clinica Chimica Acta2002，，1： | 1 |
| 7 | Effect of six flavonoid compounds from Ixeris sonchifolia on Stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils显示文摘 | LU Jincai FENG Xizhi SUN Qishi | 2002 | Clinica Chimica Acta2002，316，12： | 1 |
| 8 | The expression and clinical significance of microRNA-1258 and heparanase in human breast cancer显示文摘 | Dabei Tang Qingyuan Zhang Shu Zhao Jincai Wang Kangping LU Ying Song Ling Zhao Xinmei Kang Jingxuan Wang Shanqi Xu Lantian Tian | 2013 | Clinical Biochemistry (-)2013，，10： | 1 |
| 9 | Physicochemical properties and antioxidant activities of polysaccharides extracted from Panax ginseng C.A.Meyer with graded percipitation method显示文摘Ginseng polysaccharides were extracted by water decoction from Panax ginseng C.A.Meyer(Cultivated Ginseng),named CGPS.Four polysaccharide fractions,CGPS-20,CGPS-40,CGPS-60 and CGPS-80,were precipitated at final ethanol concentrations of 20%,40%,60%and 80%,respectively.Physicochemical properties,molecular weight,monosaccharide composition and antioxidant capacity of polysaccharide fractions were all investigated.The results indicated that changing the concentration of ethanol could precipitate polysaccharides into fractions with different molecular weights,functional group composition and physicochemical properties,eventually leading to differences in antioxidant activity,which would help to find a simple,efficient,and reliable method for rapid extraction and purification of antioxidant polysaccharides from Panax ginseng C.A.Meyer.Among the four polysaccharide fractions,CGPS-80 had lower molecular weight,higher contents of uronic acid and total phenolic,and stronger scavenging ability on DPPH∙and ABTS∙+radicals. | Xinying Wang Yue Lin Jia Liu Zhaojun Wang Linlin Liu Yingling Wang Jincai Lu | 2020 | Asian Journal of Traditional Medicines2020，15，6： | 0 |
| 10 | Antimicrobial activities and analysis of the crude extract,fractions and compounds from the Lomatogonium rotatum显示文摘This study was evaluated the antimicrobial activities of the crude extract,different fractions,and compounds from the plant of Lomatogonium carinthiacum.The fractions of chloroform and compounds 5,2 and 6 exhibited stronger antimicrobial activities.Compound 5 was the most active while Staphylococcus aureus and Candida albicans were sensitive to all the tested compounds.The existence of a relationship between the xanthone structures and inhibition of microorganism activity.The antimicrobial activity of this plant was reported here firstly.The results provided evidence that the studied plant extract,fractions as well as some of the isolated compounds might be potential sources of new antimicrobial drug. | Ruoning Wang Qin He Qingdi Mu Mengyuan Tan Jing Wang Chongning Lv Hang He Jincai Lu Lingyun Jia | 2020 | Asian Journal of Traditional Medicines2020，15，4： | 0 |
| 11 | Determination of Shallow Impurity Concentration in Detector-grade Silicon by FT-IR Spectroscopy at 4.2K显示文摘A Nicolet-200SXV FT-IR spectrometer combined with an exciting light set-up has been applied to determine the shallowimpurity concentration in detector--grade silicon.The detection sensitivity of boron concentration is high up to 7.8×10-12.Thecalibration curve of boron concentration in high-purity silicon has been obtained,from which the experimental value ofcalibration factor of boron concentration in silicon is demonstrated to be 1.15×1013cm-1. | Zhang, Jichang Wu, Jiangen Qu, Fengyuan Ye, Hongjuan Xiao, Jincai Yu, Zhiyi Lu, Wei | 1989 | Rare Metals1989，9，4： | 0 |
| 12 | Activity of xanthones isolated from Lomatogonium rotatum显示文摘Thirteen xanthones were isolated from L.rotatum,which were established as l,8-dihydroxy-3,4,5-trimethoxyxanthone(1);l-hydroxy-3异,8-trimethoxyxanthone(2);8-hydroxy-l,3?5-trimethoxyxaiithone(3);l-hydroxy-3,4,5-trimethoxyxanthone(4);l-hydroxy-3,5,8-trimethoxyxanthone(5);l,4,8-trihydroxy-5,6-dimethoxyxanthone(6);l,3,8-trihydroxy-4,7-dimethoxyxanthone(;7)l,8-dihydroxy-3,7-dimethoxyxanthone(8);l-hydroxy-3,5-dimethoxyxanthone(9);l-hydroxy-2,3,4,5-tetramethoxyxanthone(;10)l-hydroxy-2,3,4,7-tetramethoxyxanthone(11);l,7-dihydroxy-3,8-dimethoxyxanthone(12);rel-l,3,5,8-tetrahydroxy-2,4,6,7-tetrahydroxanthen-9-one(13).Compounds 4,6,7,9,10,11,12 and 13 are reported for the first time from Lomatogonium.Furthermore,the activity of xanthones was assessed. | Qingdi Mu Qin He Mengyuan Tan Ruoning Wang Jing Wang Chongning Lv Hang He Jincai Lu Lingyun Jia | 2020 | Asian Journal of Traditional Medicines2020，15，3： | 0 |
| 13 | The fingerprint and flavonoids contents by HPLC and the UPLC-DAD-Q-TOF-MS analysis of Sedum aizoon L.显示文摘Fingerprint analysis of Sedum aizoon L.was carried by High-performance liquid chromatography.There were 27 common peaks in the fingerprint of 10 samples.Eight of these common peaks,peaks 1(arbutin),4(gallic acid),10(myricetin-3-O-β-D-glucopyranoside),14(myricetin-3-O-α-L-rhamnopyranoside),19(quercetin-3-O-α-L-rhamnopyranoside),22(kaempferol-3-O-α-L-rhamnopyranoside),24(quercetin)and 26(kaempferol)were identified by reference substances.Moreover,six flavonoid compounds were simultaneously determined by the above method.By comparing with the constituents in the aerial parts,roots and flowers,it’s easy found that the aerial parts of S.aizoon had abundant flavonoids and the flavonoid aglycones mostly exist in the roots,while the flavonoid glycosides largely existing in the flowers.In addition,an UPLC-DAD-Q-TOF-MS method was developed for qualitative analysis of the aerial parts of S.aizoon.This study may provide a preliminary reference for the quality control of S.aizoon. | Tanye Xu Chongning Lv Jincai Lu | 2019 | Journal of Polyphenols2019，1，1： | 0 |
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