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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | Extraordinary simultaneous enhancement of the coercivity and remanence of dual alloy HRE-free Nd-Fe-B sintered magnets by post-sinter annealing显示文摘Post-sinter annealing process plays an important role in the microstructures and magnetic properties of the Nd-Fe-B sintered magnets.In this paper,systematically investigated are the magnetic properties and microstructures of the as-sintered and post-sinter annealed Nd-Fe-B magnets with Pr-Fe-Ga boundary addition.Two choice consecutive annealing methods are adopted at high and low temperatures,namely the 1 st annealing at 880℃ for 2 h and then the 2^(nd) annealing at 440℃ for 3 h.It is exceptional to find out that both the remanence and coercivity are improved after 2^(nd) annealing process for this type of magnet.The coercivity is hugely increased from 10.09 kOe for the as-sintered sample to 17.19 kOe for the 2^(nd) annealed magnet,with a significant increment of 70.37%in coercivity.The extraordinary magnetic properties of B_(r)=14.44 kGs,H_(cj)=17.19 kOe and(BH)_(max)=51.08 MGOe are obtained for the designated Nd-Fe-B sintered magnets without heavy rare earth(HRE)elements manufactured by dual alloy method.The Curie temperature is monotonically decreased from 634 K to 602 K while the c-axis alignment degree is optimized after annealing.Microstructural observation and analysis indicate that the elemental distribution patterns are altered after the 2^(nd) annealing.The diffusion of the aggregate(Pr,Nd,Cu,Ga)-rich phase from triple junctions into the grain boundary regions is ascribed to the formation of thin and continuous grain boundary layer,which is critical to improve the microstructures and magnetic properties. | Qingfang Huang Qingzheng Jiang Jifan Hu Sajjad Ur Rehman Gang Fu Qichen Quan Jixiang Huang Deqin Xu Dakun Chen Zhenchen Zhong | 2022 | Journal of Materials Science & Technology2022，，11： | 3 |
| 3 | Rare earth doping effects on superconducting properties of MgB_2:A review显示文摘Rare earth(RE) elements and their compounds have been doped into MgB_2 since the discovery of the superconductivity of MgB_2. The doping effects of RE elements and RE compounds are summarized in terms of different doping methods and the accompanying variations in the superconducting transition temperature, upper critical field, irreversibility field, and critical current density(Jc). Conclusions are drawn on the doping mechanisms to demonstrate the possibility of improvement of Jcin the future. REBy phase inclusions are observed in MgB_2 as nano-pinning centers with significant enhancement of Jcin MgB_2 doped with Y, La, Dy, Ho, Nd, etc. Furthermore, some REs with larger magnetic moments will provide more efficient flux pinning centers with larger pinning forces, which is different with the doping effects and mechanism of ferromagnetic transition metals in MgB_2. The co-doping effects of RE with other dopants are also reviewed due to the multiple advantages of different doping mechanisms. | Wenxian Li Jixiang Kang Siwei Fu Yemin Hu Pengfei Hu Mingyuan Zhu Ying Li | 2019 | Journal of Rare Earths2019，37，2： | 2 |
| 4 | Extension formulae on almost complex manifolds显示文摘We give the extension formulae on almost complex manifolds and give decompositions of the extension formulae.As applications,we study(n,0)-forms,the(n,0)-Dolbeault cohomology group and(n,q)-forms on almost complex manifolds. | Jixiang Fu Haisheng Liu | 2021 | Science China Mathematics2021，64，1： | 1 |
| 5 | Limiting behavior of a class of Hermitian Yang-Mills metrics, I显示文摘This paper begins to study the limiting behavior of a family of Hermitian Yang-Mills(HYM for brevity) metrics on a class of rank two slope stable vector bundles over a product of two elliptic curves with K?hler metrics ωε when ε → 0. Here, ωε are flat and have areas ε and ε-1 on the two elliptic curves, respectively.A family of Hermitian metrics on the vector bundle are explicitly constructed and with respect to them, the HYM metrics are normalized. We then compare the family of normalized HYM metrics with the family of constructed Hermitian metrics by doing estimates. We get the higher order estimates as long as the C^0-estimate is provided. We also get the estimate of the lower bound of the C^0-norm. If the desired estimate of the upper bound of the C^0-norm can be obtained, then it would be shown that these two families of metrics are close to arbitrary order in ε in any Cknorms. | Jixiang Fu | 2019 | Science China Mathematics2019，62，11： | 1 |
| 6 | LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma显示文摘This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma(HCC),further,to explore the effect of LPCAT1 on overall survival(OS)in patients with HCC,and its possible mechanism.Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues,and the associations between LPCAT1 expression and clinicopathological parameters.Survival analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with HCC.Univariate analysis and multivariate analysis were used to investigate the prognostic factors.Potential LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes(DEGs)screening.GO term enrichment analysis,KEGG pathway analysis and the PPI network were used to explore the potential mechanism.LPCAT1 was significantly overexpressed in HCC tumor tissues compared with normal tissues.The LPCAT1 expression was related to tumor grade,ECOG score,AFP and TNM stage,with P values of 0.000,0.000,0.007 and 0.000,respectively.Multivariate analysis demonstrated that LPCAT1 expression was independently associated with OS,with an HR of 1.04(CI:1.01–1.06,P=0.003).The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell cycle.Finally,we identified a hub gene,CDK1,which has been reported to act on the cell cycle,consistent with the result of KEGG enrichment analysis.Collectively,these data confirmed LPCAT1 was upregulated in HCC,and was an independent predictor of the prognosis. | Hongbin Zhang Ke Xu Qin Xiang Lijuan Zhao Benxu Tan Ping Ju Xiufu Lan Yi Liu Jian Zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu Zhang Tingxiu Xiang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 7 | Green Hydrothermal Synthesis and Applications of Sorbus pohuashanensis/Aronia melanocarpa Extracts Functionalized-Au/Ag/AuAg Nanoparticles显示文摘Nanoparticles(NPs)have already been widely used in catalysis,antibacterial and coating fields.Compared with the traditional toxic and harmful reducing reagents,green synthesis of NPs by using plant extracts is not only environmental-friendly and cost-effective but also conducive to the multi-level and efficient utilization of wild plant resources.In this study,the aqueous extracts from Sorbus pohuashanensis(SP)and Aronia melanocarpa(AM)fruits were used as the reducing and protective reagents for synthesizing Au/AgNPs,with the characteristics of originality operation and high repeatability.The SP/AM fruit extracts functionalized Au/AgNPs were characterized by UV-vis spectroscopy(UV-vis),transmission electron microscopy(TEM),energy dispersive spectroscopy(EDS),scanning electron microscope(SEM),X-ray diffraction(XRD)and Fourier transform infrared spectroscopy(FTIR).UV-vis spectrums showed the NPs peaks verified by the presence between 400–550 nm;TEM and SEM demonstrated NPs displayed approximately spherical structures;EDS confirmed the existence of Au/Ag elements;XRD measurements confirmed that the obtained NPs showed highly crystalline structures;FTIR demonstrated the fruits extracts were adsorbed on the surface of NPs.Primary experiments indicated that SP/AM fruit extracts functionalized-NPs could be used as the reagents for removing the organic dyes efficiently;Zone of inhibition tests(ZOI)explained that NPs have slow-release antibacterial activity. | Jin Huang Jixiang Sun Kai Shao Yamei Lin Zhiguo Liu Yujie Fu Liqiang Mu | 2023 | Journal of Renewable Materials2023，11，4： | 0 |
| 8 | Scalar curvatures in almost Hermitian geometry and some applications显示文摘On an almost Hermitian manifold, there are two Hermitian scalar curvatures associated with a canonical Hermitian connection. In this paper, two explicit formulas on these two scalar curvatures are obtained in terms of the Riemannian scalar curvature, norms of the components of the covariant derivative of the fundamental 2-form with respect to the Levi-Civita connection, and the codifferential of the Lee form. Then we use them to get characterization results of the K?hler metric, the balanced metric, the locally conformal K?hler metric or the k-Gauduchon metric. As corollaries, we show partial results related to a problem given by Lejmi and Upmeier(2020) and a conjecture by Angella et al.(2018). | Jixiang Fu Xianchao Zhou | 2022 | Science China Mathematics2022，65，12： | 0 |
| 9 | THE MODULI SPACE OF COMPLEX LAGRANGIAN SUBMANIFOLDS IN THE HYPER-KAEHLER MANIFOLD显示文摘The deformation of a compact complex Lagrangian submanifold in a hyper-Kaehler manifold and the moduli space are studied. It is proved that the moduli space Mc1 is a special Kaehler manifold, where special means that there is a real flat torsionfree symplectic connection satisfying dI = 0 (I is a complex structure of Mcl). Thus, following [4], one knows thatT*Mcl is a hyper-Kaehler manifold and then that Mcl is a complex Lagrangian submanifold in T* Mcl. | FU JIXIANG(Institute of Mathematics, Fudan University, Shanghai 200433, China) | 1999 | Chinese Annals of Mathematics,Series B1999，20，4： | 0 |
| 10 | A Hermitian Curvature Flow显示文摘A Hermitian curvature flow on a compact Calabi-Yau manifold is proposed and a regularity result is obtained.The solution of the flow,if exists,is a balanced HermitianEinstein metric. | Jixiang FU Jieming YANG | 2022 | Chinese Annals of Mathematics,Series B2022，43，5： | 0 |
| 11 | An example of special Lagrangian fibration显示文摘On the total space of the line bundle π: π*1T*P1(◎)π2*T*P1 → P1× P1, acomplete Ricci-flat Kaehler metric and a smooth special Lagrangian fibration are given.This special Lagrangian fibration is smoothly built up of 4 Harvey-Lawson's models in 4directions. | FU Jixiang | 2005 | Science China Mathematics2005，48，8： | 0 |
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