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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Zircon SHRIMP geochronology of the Xinkailing-Kele complex in the northwestern Lesser Xing'an Range, and its geological implications显示文摘Located in the eastern portion of the Xing'an-Mongolian Orogenic Belt (XMOB), the Xinkailing-Kele complex has previously been considered to be Precambrian metamorphic rocks, mainly according to its relatively high metamorphic grade. Our filed observation, however, revealed that the complex is composed mainly of metamorphic rocks (Kele complex), tectono-schists (“Xinkailing Group”),and granitoids (Xinkailing granitic complex). Dating on these rocks using advanced SHRIMP zircon U-Pb technique indicates that: (1) Biotite-plagioclase gneiss from the Kele complex has a protolith age of 337±7Ma (2σ) and a metamorphic age of 216±3Ma (2σ); (2) the tectono-schist of the “Xinkailing Group” gave a magmatic age of 292±6Ma (2σ), indicative of felsic volcanic protolith of the schist formed in Late Paleozoic time; and (3) the Menluhedingzi and Lengchuan granites of the Xinkailing granitic complex were emplaced at167±4 (20σ) and 164±4Ma (2σ), respectively. These results suggest that the Xinkailing-Kele complex is not Precambrian metamorphic rocks and the so-called Precambrian “Nenji-ang Block” does essentially not exist. In combination with regional geological data, we propose that the Kele metamorphic complex is likely related to a collisional tectonism that took place in Triassic lime, as indicted by its metamorphic age of 216±3Ma. The Xinkailing granitic complex was emplaced along the collisional zone during Mid-Jurassic time,likely in a post-orogenic or anorogenic setting. | MIAOLaicheng FAN,Weiming ZHANGFuqing LIUDunyi JIANPing SHIGuanghai TAOHua SHIYuruo | 2004 | Chinese Science Bulletin2004，49，2： | 58 |
| 3 | MR-DBSCAN: a scalable MapReduce-based DBSCAN algorithm for heavily skewed data显示文摘 | Yaobin HE Haoyu TAN Wuman LUO Shengzhong FENG Jianping FAN | 2014 | Frontiers of Computer Science2014，8，1： | 18 |
| 4 | Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。 | Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao | 2015 | Nano Research2015，8，8： | 11 |
| 5 | TAOK1 negatively regulates IL-17-mediated signaling and inflammation显示文摘Interleukin 17(IL-17)is an important cytokine that can induce tissue inflammation and is involved in the pathogenesis of numerous autoimmune diseases.However,the regulation of its signaling transduction has not been well described.In this study,we report that thousand and one kinase 1(TAOK1)functions as a negative regulator of IL-17-mediated signal transduction and inflammation.TAOK1 knockdown promotes IL-17-induced cytokine and chemokine expression and the activation of mitogen-activated protein kinases and nuclear factor-κB.We further demonstrate that TAOK1 interacts with IL-17 receptor A(IL-17RA)independent of its kinase activity,and TAOK1 dose-dependently prevents the formation of the IL-17R-Act1(nuclear factor activator 1,also known as tumor necrosis factor receptor-associated factor 3 interacting protein 2)complex.Consistent with this,TAOK1 deficiency exacerbates colitis in the 2,4,6-trinitrobenzenesulfonic acid-induced experimental model of inflammatory bowel disease,likely by its promotion of the IL-17-mediated signaling pathway.TAOK1 expression is decreased in the colons of ulcerative colitis patients.In conclusion,these findings suggest that TAOK1 is involved in the development of IL-17-related autoimmune disorders. | Zhaoru Zhang Zhen Tang Xianwei Ma Kai Sun Liping Fan Jie Fang Jianping Pan Xiaojian Wang Huazhang An Jun Zhou | 2018 | Cellular & Molecular Immunology2018，15，8： | 10 |
| 6 | AN INTEGRATED COUPLING ELEMENT FOR VEHICLE-RAIL-BRIDGE INTERACTION SYSTEM WITH A NON-UNIFORM CONTINUOUS BRIDGE显示文摘An integrated coupling element considering wheel-rail interface for analyzing the dynamic responses of vehicle-rail-bridge interaction system with a non-uniform continuous bridge is presented. The governing equations of the interaction system are established first, and the solution procedure and assembly method of the coupling element are demonstrated. Finally, the accuracy, efficiency and function of the integrated coupling element are tested using two numerical examples. The influences of different combinations of rail and bridge element length in the coupling element on the solution are investigated, and the effects of different rail irregularities on the dynamic responses are discussed. | Hongyin Yang Zhijun Chen Shaofan Li Hailong Zhang Jianping Fan | 2015 | Acta Mechanica Solida Sinica2015，28，3： | 9 |
| 7 | Lentinan administration alleviates diarrhea of rotavirus-infected weaned pigs via regulating intestinal immunity显示文摘Background:Lentinan(LNT)may regulate many important physiological functions of human and animals.This study aimed to verify whether LNT administration could relieve diarrhea via improving gut immunity in rotavirus(RV)-challenged weaned pigs.Methods:Twenty-eight weaned pigs were randomly fed 2 diets containing 0 or 84 mg/kg LNT product for 19 d(n=14).RV infection was executed on d 15.After extracting polysaccharides from LNT product,its major monosaccharides were analyzed.Then,LNT polysaccharide was used to administrate RV-infected IPEC-J2 cells.Results:Dietary LNT supplementation supported normal function of piglets even when infected with RV,as reflected by reduced growth performance loss and diarrhea prevalence,and maintained gut immunity(P<0.05).The polysaccharide was isolated from LNT product,which molecular weight was 5303 Da,and major monosaccharides included glucose,arabinose and galactose.In RV-infected IPEC-J2 cells,this polysaccharide significantly increased cell viability(P<0.05),and significantly increased anti-virus immunity via regulating pattern recognition receptors and host defense peptides(P<0.05).Conclusion:Those results suggest that LNT administration increases the piglets’resistance to RV-induced stress,likely by supporting intestinal immunity. | Xiangqi Fan Haiyan Hu Daiwen Chen Bing Yu Jun He Jie Yu Junqiu Luo Erik Eckhardt Yuheng Luo Jianping Wang Hui Yan Xiangbing Mao | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 8 |
| 8 | Combination Patterns and Depositional Characteristics of Ordovician Carbonate Banks in the Western Tarim Basin,China显示文摘碳酸盐银行的联合模式和 depositional 特征在西方的 Tarim 盆基于奥陶纪的露头节,薄节,和碳同位素被调查,中国。四个碳酸盐银行联合模式在奥陶纪被扔,西方的 Tarim 盆,包括:礁石银行建筑群(RBC ) , Algae-Reef-Bank Interbed (ARBI ) ,厚层的蛋糕沉积银行(TLCAB ) ,和薄层的蛋糕逆行银行(TLCRB ) 。所有联合模式垂直地显示出清楚的时期。RBC 主要由礁石和 bioclastic 银行组成,并且 RBC 的尺寸取决于礁石的规模。Bioclastic 银行存款包围礁石。ARBI 的范围被水藻礁石,水藻 peloid 白云石 microfacies 和垂直地轮流出现的海藻的白云石 microfacies 沉积物的规模决定。当在周期叠并且与生气床上用品广泛地延长的层蛋糕发展了, TLCAB 和 TLCRB 被扔。TLCAB 和 TLCRB 的谷物是多样的并且多来源。与影响相对的海水平变化,生物发展和地形学, ARBI, TLCAB 或 TLCRB, RBC 连续地从更低的奥陶纪 Penglaiba 形成被开发到中间的奥陶纪 Yijianfang 形成。奥陶纪的 depositional 环境分析显示 RBC 和 ARBI 能形成有效的油和煤气的水库,并且 TLCAB 和 TLCRB 有潜力形成巨大的规模油和煤气的水库并且以后是为奥陶纪碳酸盐银行的探索的关键目标。 | HU Xiaolan FAN Tailiang GAO Zhiqian YU Bingsong CHEN Xiaozhi WANG Hongyu WANG Jianping LI Rangbin DING Meng LI Yifan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 7 |
| 9 | Aerosol characteristics and impacts on weather and climate over the Tibetan Plateau显示文摘With themostmassive snow and ice globally between 60°S and 60°S ,the Tibetan Plateau(TP),also called the third pole of the world,plays significant roles in the weather,climate and lives in South Asia and East Asia and even the world[1–3].Investigating the variation of weather and the climate system over the TP has long been carried out,which is significant for fresh water supplies for over 1.4 billion people in Asia.Actually,the‘Third Pole Environment’program was initiated to call international efforts to understand both climate and environment changes on the plateau[1],which has already shown rapid warming and intensified cryospheric melt and water cycle. | Chuanfeng Zhao Yikun Yang Hao Fan Jianping Huang Yunfei Fu Xiaoye Zhang Shichang Kang Zhiyuan Cong Husi Letu Massimo Menenti | 2020 | National Science Review2020，7，3： | 7 |
| 10 | Combination of heterogeneous Fenton-like reaction and photocatalysis using Co–TiO_2 nanocatalyst for activation of KHSO_5 with visible light irradiation at ambient conditions显示文摘A novel coupled system using Co–Ti O2was successfully designed which combined two different heterogeneous advanced oxidation processes,sulfate radical based Fenton-like reaction(SR-Fenton)and visible light photocatalysis(Vis-Photo),for degradation of organic contaminants.The synergistic effect of SR-Fenton and Vis-Photo was observed through comparative tests of 50 mg/L Rhodamine B(Rh B)degradation and TOC removal.The Rhodamine B degradation rate and TOC removal were 100%and 68.1%using the SR-Fenton/Vis-Photo combined process under ambient conditions,respectively.Moreover,based on XRD,XPS and UV-DRS characterization,it can be deduced that tricobalt tetroxide located on the surface of the catalyst is the SR-Fenton active site,and cobalt ion implanted in the Ti O2lattice is the reason for the visible light photocatalytic activity of Co–Ti O2.Finally,the effects of the calcination temperature and cobalt concentration on the synergistic performance were also investigated and a possible mechanism for the synergistic system was proposed.This coupled system exhibited excellent catalytic stability and reusability,and almost no dissolution of Co2+was found. | Qingkong Chen Fangying Ji Qian Guo Jianping Fan Xuan Xu | 2014 | Journal of Environmental Sciences2014，26，12： | 5 |
| 11 | 新辅助放化疗加直肠癌切除术后外科切缘的放射性损伤:吻合口漏的预判线索显示文摘背景:对于直肠癌切除术后吻合口状态及其对吻合口漏的影响,目前鲜有研究报道。本研究旨在分析新辅助放化疗+直肠前切除术后外科切缘可能受到的放射性损伤,以及其与吻合口漏发生的关系。方法:回顾性纳入2014-2015年间连续收治的161例直肠前切除手术患者,包括行新辅助放化疗、单纯新辅助化疗或未行术前新辅助治疗者。采用一种专门的组织病理学评分和黏膜下层微血管密度,来对手术切缘标本进行评估。采用倾向评分匹配方法来平衡基线资料。分析吻合口漏与组织病理学特征的相关性。结果:54例新辅助放化疗患者中13例术后发生吻合口漏,48例新辅助化疗患者中5例术后发生吻合口漏,而59例未行新辅助治疗的患者中有7例出现术后吻合口漏。倾向评分匹配后,新辅助放化疗、新辅助化疗和未行新辅助治疗三组患者近切缘组织病理评分中位数(范围)分别为3(0-8)、0(0-3)和0(0-2)(P<0.001),远切缘组织病理评分分别为4(2-9)、0(0-4)和0(0-3)(P<0.001);近切缘微血管密度平均数(标准差)分别为21.7(7.9)、27.2(8.6)和27.3(9.4)(P=0.003),远切缘微血管密度分别为18.1(9.3)、25.2(12.9)和24.9(7.4)(P<0.001)。在新辅助放化疗患者中,吻合口漏的发生与组织病理学评分增高(P=0.003)及微血管密度减少(P=0.004)密切相关。结论:新辅助放化疗后,直肠癌切除术的外科切缘存在一定程度的放射性损伤。近切缘放射性损伤越严重,吻合口漏发生概率越高。 | Qiyuan Qin Yaxi Zhu Peihuang Wu Xinjuan Fan Yan Huang Binjie Huang Jianping Wang Lei Wang | 2019 | Gastroenterology Report2019，7，2： | 5 |
| 12 | MODIFIED SCHEME BASED ON SEMI-ANALYTIC APPROACH FOR COMPUTING NON-PROBABILISTIC RELIABILITY INDEX显示文摘A new computation scheme proposed to tackle commensurate problems is developed by modifying the semi-analytic approach for minimizing computational complexity. Using the proposed scheme, the limit state equations, usually referred to as the failure surface, are obtained from transformation of an interval variable to a normalized one. In order to minimize the computational cost, two algorithms for optimizing the calculation steps have been proposed. The monotonicity of the objective function can be determined from narrowing the scope of interval variables in normalized infinite space by incorporating the algorithms into the computational scheme. Two examples are used to illustrate the operation and computational efficiency of the approach. The results of these examples show that the proposed algorithms can greatly reduce the computation complexity without sacrificing the computational accuracy. The advantage of the proposed scheme can be even more efficient for analyzing sophistic structures. | Xuyong Chen Chak-yin Tang Chi-pong Tsui Jianping Fan | 2010 | Acta Mechanica Solida Sinica2010，23，2： | 5 |
| 13 | Influence of Blade Thickness on Transient Flow Characteristics of Centrifugal Slurry Pump with Semi-open Impeller显示文摘As the critical component, the impellers of the slurry pumps usually have blades of a large thickness. The increasing excretion coefficient of the blades affects the flow in the impeller resulting in a relatively higher hydraulic loss, which is rarely reported.In order to investigate the influence of blade thickness on the transient flow characteristics of a centrifugal slurry pump with a semi-open impeller, transient numerical simulations were carried out on six impellers, of which the meridional blade thickness from the leading edge to trailing edge varied from 5?10 mm, 5?15 mm, 5?20 mm, 10?10 mm, 10?15 mm, and 10?20 mm, respectively. Then,two of the six impellers, namely cases 4 and 6, were manufactured and experimentally tested for hydraulic performance to verify the simulation results. Results of these tests agreed reasonably well with those of the numerical simulation. The results demonstrate that when blade thickness increases, pressure fluctuations at the outlet of the impeller become severe. Moreover, the standard deviation of the relative velocity in the middle portion of the suction sides of the blades decreases and that at the outlet of the impeller increases.Thus, the amplitude of the impeller head pulsation for each case increases. Meanwhile, the distribution of the time-averaged relative flow angle becomes less uniform and decreases at the outlet of the impeller. Hence, as the impeller blade thickness increases, the pump head drops rapidly and the maximum efficiency point is offset to a lower flow rate condition. As the thickness of blade trailing edge increases by 10 mm, the head of the pump drops by approximately 5 m, which is approximately 10 % of the original pump head.Futhermore, it is for the first time that the time-averaged relative flow angle is being considered for the analysis of transient flow in centrifugal pump. The presented work could be a useful guideline in engineering practice when designing a centrifugal slurry pump with thick impeller blades. | TAO Yi YUAN Shouqi LIU Jianrui ZHANG Fan TAO Jianping | 2016 | Chinese Journal of Mechanical Engineering2016，29，6： | 4 |
| 14 | Heat rate variability and dyssomnia and their correlations to neurological defects in cerebral infarction patients complicated by insomnia A concurrent non-randomized case-control study显示文摘BACKGROUND: Heart rate variability refers to the beat-to-beat alteration in heart rate. It is usually a slight periodic variation of R-R intervals. Much information of autonomic nerve system balance can be obtained by measuring the heart rate variability of patients. It remains to be shown whether heart rate variability can be used as an index for determining the severity of insomnia and cerebral infarction. OBJECTIVE: This study aimed to analyze the correlation for each frequency spectrum parameter of heart rate variability with an insomnia index, as well as the degree of neurological defects in patients with simple cerebral infarction and cerebral infarction complicated by insomnia. The goal was to verify the feasibility of frequency spectrum parameters for heart rate variability as a marker for insomnia and cerebral infarction. DESIGN: A case-control observation. SETTING: Department of Neurology, First Hospital Affiliated to China Medical University. PARTICIPANTS: Sixty inpatients, and/or outpatients, with cerebral infarction were admitted to the 202 Hospital of Chinese PLA between December 2005 and October 2006, confirmed by CT, and recruited to the study. According to the insomnia condition (insomnia is defined by a Pittsburgh Sleep Quality Index score > 7), the patients were assigned to a simple cerebral infarction group and a cerebral infarction complicated by insomnia group, with 30 subjects in each group. Thirty additional subjects, who concurrently received ex- aminations and were confirmed to not suffer from cerebral infarction and insomnia, were recruited into the control group. Written informed consent was obtained from each subject for laboratory specimens. The pro- tocol was approved by the Hospital's Ethics Committee. METHODS: Following admission, each subject's neurological impairment was assessed with the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index. Heart rate variability of each subject was measured with an autonomic nerve analyzer (Weijin Science and Technology Co., Ltd., Taiwan). Each frequency spectrum parameter of heart rate variability was obtained, including very low frequency, low fre- quency, high frequency, total power, R-R interval, and its mean square. In addition, percentage of low fre- quency, high frequency, and ratio of low frequency to high frequency were calculated. For each heart rate frequency spectrum parameter, the difference between groups was analyzed. Moreover, correlations of each frequency spectrum parameter with insomnia and disease condition were analyzed. Data from each index, which were not normally distributed, were processed by logarithmic transformation. The t-test was used for the comparison of intergroup differences. Single-factor linear regression analysis and t-test were used for the analysis of factor-factor correlation and coefficient of correlation, respectively. MAIN OUTCOME MEASURES: ① Differences of scores in the National Institutes of Health Stroke Scale and Pittsburgh Sleep Quality Index between the simple cerebral infarction group and the cerebral in- farction complicated by insomnia group. ② Differences of heart rate variability parameters between the simple cerebral infarction group and the control group. ③ Correlation of heart rate variability parameters, the Pittsburgh Sleep Quality Index score, and the neurological impairment score. RESULTS: Sixty patients and thirty healthy controls were included in the final analysis. ① The scores of the Pittsburgh Sleep Quality Index and the neurological impairment were significantly higher in the cerebral infarction complicated by insomnia group compared to the simple cerebral infarction group (P < 0.05-0.01). ② R-R interval was significantly longer in the simple cerebral infarction group than in the control group, while R-R interval variance and high-frequency band were significantly lower in the simple cerebral infarc- tion group compared to the control group (P < 0.05). ③ For cerebral infarction patients with insomnia, the Pittsburgh Sleep Quality Index score was significantly positively correlated with neurological impairment (r = 0.54, P < 0.01). The low-frequency band, very low-frequency band, high-frequency band, R-R interval variance, total power, R-R interval, and the percentage of high-frequency were significantly negativelycorrelated with the National Institutes of Health Stroke Scale score (r =-0.45 to -0.90, P < 0.05-0.01) and with the Pittsburgh Sleep Quality Index scores (r = -0.56 to -0.36, P < 0.05-0.01). CONCLUSION: Each heart rate variability parameter can be used as an index for assessing dyssomnia and neurologic impairment (r =-0.56 to -0.36, P < 0.05-0.01). | Jianping Chu Xueli Shen Jun Fan Changhai Chen Shuyang Lin | 2008 | Neural Regeneration Research2008，3，1： | 4 |
| 15 | Repeated febrile convulsions impair hippocampal neurons and cause synaptic damage in immature rats: neuroprotective effect of fructose-1,6-diphosphate显示文摘Fructose-1,6-diphosphate is a metabolic intermediate that promotes cell metabolism. We hypothesize that fructose-1,6-diphosphate can protect against neuronal damage induced by febrile convulsions. Hot-water bathing was used to establish a repetitive febrile convulsion model in rats aged 21 days, equivalent to 3–5 years in humans. Ninety minutes before each seizure induction, rats received an intraperitoneal injection of low- or high-dose fructose-1,6-diphosphate(500 or 1,000 mg/kg, respectively). Low- and high-dose fructose-1,6-diphosphate prolonged the latency and shortened the duration of seizures. Furthermore, high-dose fructose-1,6-diphosphate effectively reduced seizure severity. Transmission electron microscopy revealed that 24 hours after the last seizure, high-dose fructose-1,6-diphosphate reduced mitochondrial swelling, rough endoplasmic reticulum degranulation, Golgi dilation and synaptic cleft size, and increased synaptic active zone length, postsynaptic density thickness, and synaptic interface curvature in the hippocampal CA1 area. The present findings suggest that fructose-1,6-diphosphate is a neuroprotectant against hippocampal neuron and synapse damage induced by repeated febrile convulsion in immature rats. | Jianping Zhou Fan Wang Jun Zhang Hui Gao Yufeng Yang Rongguo Fu | 2014 | Neural Regeneration Research2014，9，9： | 4 |
| 16 | A digitally generated ultrafine optical frequency comb for spectral measurements with 0.01-pm resolution and 0.7-μs response time显示文摘Optical spectral measurements are crucial for optical sensors and many other applications,but the prevailing methods,such as optical spectrum analysis and tunable laser spectroscopy,often have to make compromises among resolution,speed,and accuracy.Optical frequency combs are widely used for metrology of discrete atomic and molecular spectral lines.However,they are usually generated by optical methods and have large comb spacing,which limits the resolution for direct sampling of continuous spectra.To overcome these problems,this paper presents an original method to digitally generate an ultrafine optical frequency comb(UFOFC)as the frequency ruler for spectral measurements.Each comb line provides one sampling point,and the full spectrum can be captured at the same time using coherent detection.For an experimental demonstration,we adopted the inverse fast Fourier transform to generate a UFOFC with a comb spacing of 1.46 MHz over a 10-GHz range and demonstrated its functions using a Mach–Zehnder refractive index sensor.The UFOFC obtains a spectral resolution of 0.01 pm and response time of 0.7 μs;both represent 100-fold improvements over the state of the art and could be further enhanced by several orders of magnitude.The UFOFC presented here could facilitate new label-free sensor applications that require both high resolution and fast speed,such as measuring binding kinetics and single-molecule dynamics. | Yuan Bao Xingwen Yi Zhaohui Li Qingming Chen Jianping Li Xudong Fan Xuming Zhang | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 17 | Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial显示文摘Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP. | Dapeng Mo Baixue Jia Huaizhang Shi Yaxuan Sun Qingan Liu Chengzhe Fan Jianping Deng Jinglin Yuan Wei Wu Changchun Jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 18 | Numerical analysis of rainfall infiltration in the slope with a fracture显示文摘With the finite volume method, a 2D numerical model for seepage in unsaturated soil has been established to study the rainfall infiltration in the fractured slope. The result shows that more rain may infiltrate into the slope due to existing fracture and then the pore pressure rises correspondingly. Very probably, it is one of the crucial factors accounting for slope failure. Furthermore a preliminary study has been conducted to investigate the influence of various fracture and rainfall factors such as the depth, width and location of a crack, surface condition, rainfall intensity and duration. Pore pressure and water volumetric content during the transient seepage are carefully examined to reveal the intrinsic mechanism. | FAN Ping LIU Qingquan LI Jiachun SUN Jianping | 2005 | Science China(Technological Sciences)2005，48，z1： | 3 |
| 19 | Fast assignment reduction in inconsistent incomplete decision systems显示文摘This paper focuses on fast algorithm for computing the assignment reduct in inconsistent incomplete decision systems. It is quite inconvenient to judge the assignment reduct directly according to its definition. We propose the judgment theorem for the assignment reduct in the inconsistent incomplete decision system, which greatly simplifies judging this type reduct. On such basis, we derive a novel attribute significance measure and construct the fast assignment reduction algorithm(FARA), intended for computing the assignment reduct in inconsistent incomplete decision systems. Finally, we make a comparison between FARA and the discernibility matrixbased method by experiments on 13 University of California at Irvine(UCI) datasets, and the experimental results prove that FARA is efficient and feasible. | Min Li Shaobo Deng Shengzhong Feng Jianping Fan | 2014 | Journal of Systems Engineering and Electronics2014，25，1： | 3 |
| 20 | Refinement of the crystal structure for a new mineral──antimonselite显示文摘The crystal structure of a new mineral of the stibnite group, Sb-2Se-3, has been determined. The cell constants, obtained by least-squares calculation from direct θ -value’s measurements on the diffractometer are: a =1.158 8(5), b =1.174 4(4), c =0.395 5(2) nm; orthorhombic; V =0.538 23 nm+3; Z =4. The space group is Pbnm. X-ray single crystal data, using Mo K α radiation, were measured on a RIGAKU RASA-5RP automated diffractometer and refined to a final R index of 0.048 1. Sb-2Se-3 is isostructural with Sb-2S-3 and Bi-2S-3. Each Sb(1) atom is six-coordinated by 3 Se(1), 1 Se(2) and 2 Se(3) atoms at distances 0.266 0-0.323 6 nm. Each Sb(2) atom is seven-coordinated by 2 Se(1), 2 Se(2) and 3 Se(3) atoms at distances of 0.258 1- 0.346 7 nm. The crystal structure consists of chains parallel to c or needle axis. The strongest bonds (shortest separations) are within the chains. Many important physical properties of antimonselite (optical, ferroelectric, etc.) are related to its crystal structure. | MIN Maozhong 1, ZHAI Jianping 1, WANG Xiangyun 1,SHEN Baopei 2, WEN Guangdou 2 and FAN Tao 21. Department of Earth Sciences, Nanjing University, Nanjing 210093, China 2. Uranium Geology Bureau of Central-South China, Changsha 410000, China | 1998 | Chinese Science Bulletin1998，43，5： | 2 |
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