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| 1 | Production of Two Elite Glutinous Rice Varieties by Editing Wx Gene显示文摘The waxy gene(Wx) in rice, which encodes the granule bound starch synthase enzyme, is responsible for amylose synthesis. Glutinous(sticky) rice has little or no amylose that can be used in various applications, such as brewing. In this study, knockout of the Wx gene with CRISPR/Cas9 technology was conducted in two elite japonica rice lines, Huaidao 5(HD5) and Suken 118(SK118), aiming to develop elite sticky rice varieties. We achieved six homozygous T_0 plants with more than 200 bp deletion in the Wx gene, as well as 36 wx-HD5 and 18 wx-SK118 homozygous transgene-free plants in the T_1 generation. The seeds of all the mutants were white and opaque, similar to those of sticky rice, and contained only 2.6%–3.2% amylose. Results of scanning electron microscopy showed that the quality of rice did not change. In conclusion, we successfully developed two elite sticky rice varieties. | FEI Yunyan YANG Jie WANG Fangquan FAN Fangjun LI Wenqi WANG Jun XU Yang ZHU Jinyan ZHONG Weigong | 2019 | Rice science2019，26，2： | 6 |
| 2 | Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-β peptide(1–42)-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway显示文摘Tongluojiunao(TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. However, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with Aβ1–42(10 μmol/L) significantly increased the release of lactate dehydrogenase, which was markedly reduced by TLJN(2 μL/mL), specifically by the component geniposide(26 μmol/L), but not ginsenoside Rg1(2.5 μmol/L). The estrogen receptor inhibitor, ICI182780(1 μmol/L), did not block TLJN- or geniposide-mediated decrease of lactate dehydrogenase under Aβ1–42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002(50 μmol/L) or U0126(10 μmol/L), respectively blo cked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. Therefore, these results suggest that the non-classical estrogen pathway(i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, specifically its component, geniposide, against Aβ1–42-mediated cell death in primary cultured hippocampal neurons. | Jiao Li Feng Wang Haimin Ding Chunyan Jin Jinyan Chen Yanan Zhao Xiaojing Li Wenju Chen Ping Sun Yan Tan Qi Zhang Xu Wang Angran Fan Qian Hua | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 3 | A note on the Levenberg–Marquardt parameter显示文摘 | Jinyan Fan Jianyu Pan | 2008 | Applied Mathematics and Computation2008，，2： | 1 |
| 4 | On the quadratic convergence of the Levenberg-Marquardt method without nonsingulari- ty assumption显示文摘 | Fan Jinyan Yuan Yaxiang | 2005 | Computing2005，74，1： | 1 |
| 5 | Interaction of arterial proteoglycans with low density lipoproteins(LDLs):From theory to promising therapeutic approaches显示文摘Although atherosclerosis is a multifactorial process,proteoglycans mediated lipoprotein(LDL)retention at the subendothelial space is a necessary and sufficient event in provoking lesion initiation.Proteoglycans(PGs)are usually composed of one core protein backbone with one or more glycosaminoglycan chains(GAGs)covalently linked,mainly include perlecan,biglycan,versican,and decorin.The interaction between LDL and proteoglycans is apparently mediated by the basic amino acids in apoB-100,the moiety of LDL,electrostatic interacting with the negatively charged GAGs(sulfate or carbohydrate groups)of proteoglycans or though some bridge molecules like sphingomyelinase(SMase)or lipoprotein lipase(LpL).In the later section,we collate the promising therapeutic approaches that have been proposed up to now,targeting LDL-PGs interaction.It should be concluded that previous studies on interaction between LDL and PGs mainly focused on perlecan,biglycan,decorin,and versican that all located in the extracellular matrix(ECM),future studies should pay more attention to the endothelial surface glycocalyx and its interaction with LDLs,seeking promising therapeutic targets more specifically. | Hongyan Kang Jinyan Lu Jiali Yang Yubo Fan Xiaoyan Deng | 2019 | Medicine in Novel Technology and Devices2019，，3： | 1 |
| 6 | A note on the Levenberg Marquardt parameter显示文摘 | FAN Jinyan PAN Jianyu | 2009 | Applied Mathematics and Computation2009，207，： | 1 |
| 7 | The solvability of the multidimensional TLS problem显示文摘 | Xu Lingling Fan Jinyan Huang Kaibin | 1998 | Numer Math J of Chin Uni1998，7，2： | 1 |
| 8 | The modified Levenberg-Marquardt method for nonlinear equations with cubic convergence显示文摘 | Jinyan Fan | 2011 | 2011 (277)2011，，277： | 1 |
| 9 | Polymorphisms in the 5 '-flanking region of CYP2E1 gene and genetic susceptibility to sporadic ALS显示文摘 | Fan Dongsheng Zhang Huagang Cui Jinyan | 2005 | J Neurol Neurosurg Psychiatry2005，76，4： | 1 |
| 10 | Convergence properties of a self-adaptive levenberg-marquardt algorithm under local error bound condition 显示文摘 | Fan Jinyan Pan Jianyu | 2006 | Computational Optimization and Applications2006，34，： | 1 |
| 11 | Convergence rate of the trust region method for nonlinear equations under error bound condition显示文摘 | Fan Jinyan | 2005 | Computational Optimization and Applications2005，34，： | 1 |
| 12 | Completely positive tensors in the complex field显示文摘In this paper, we introduce the complex completely positive tensor, which has a symmetric complex decomposition with all real and imaginary parts of the decomposition vectors being non-negative. Some properties of the complex completely positive tensor are given. A semidefinite algorithm is also proposed for checking whether a complex tensor is complex completely positive or not. If a tensor is not complex completely positive, a certificate for it can be obtained;if it is complex completely positive, a complex completely positive decomposition can be obtained. | Anwa Zhou Jinyan Fan Qingwen Wang | 2020 | Science China Mathematics2020，63，6： | 0 |
| 13 | A RETROSPECTIVE TRUST REGION ALGORITHM WITH TRUST REGION CONVERGING TO ZERO显示文摘我们建议一个回顾的信任区域算法,信任区域为非强迫的优化问题收敛到零。不同于传统的信任区域算法,算法根据回顾的比率更新信任区域半径,它使用最近的模型信息。我们证明算法保存传统的信任区域算法的全球集中。superlinear 集中也在一些合适的条件下面被证明。[从作者抽象] | Jinyan Fan Jianyu Pan Hongyan Song | 2016 | Journal of Computational Mathematics2016，34，4： | 0 |
| 14 | Analysis of Products Related to Vegetation Blanket显示文摘Roof greening has gradually become an important component of urban greening. Because of the advantages of low building load and low price,vegetation blanket roof greening has gradually become a widely spread technology of roof greening. In this paper,the characteristics of vegetation blanket roof greening technology are analyzed and summarized,and reasonable suggestions are provided for construction. | Shengxu CAO Jinyan YIN Dan QIAN Xiaoqing HUANG Ming GUO Duping FAN Xinjie HE | 2018 | Asian Agricultural Research2018，10，6： | 0 |
| 15 | Partially positive matrices显示文摘A real n × n symmetric matrix P is partially positive(PP) for a given index set I ? {1,..., n} if there exists a matrix V such that V(I, :) 0 and P = V VT. We give a characterization of PP-matrices. A semidefinite algorithm is presented for checking whether a matrix is partially positive or not. Its properties are studied. A PP-decomposition of a matrix can also be obtained if it is partially positive. | ZHOU AnWa FAN JinYan | 2015 | Science China Mathematics2015，58，10： | 0 |
| 16 | Subspace choices for the Celis-Dennis-Tapia problem显示文摘Grapiglia et al.(2013) proved subspace properties for the Celis-Dennis-Tapia(CDT) problem. If a subspace with lower dimension is appropriately chosen to satisfy subspace properties, then one can solve the CDT problem in that subspace so that the computational cost can be reduced. We show how to find subspaces that satisfy subspace properties for the CDT problem, by using the eigendecomposition of the Hessian matrix of the objection function. The dimensions of the subspaces are investigated. We also apply the subspace technologies to the trust region subproblem and the quadratic optimization with two quadratic constraints. | ZHAO Xin FAN JinYan | 2017 | Science China Mathematics2017，60，9： | 0 |
| 17 | Insights into varicella-zoster virus assembly from the B-and C-capsid at near-atomic resolution structures显示文摘Varicella-zoster is a highly communicable virus that can be transmitted through the airborne route.About one quarter of people are infected with this virus.Previous studies have described the structure of A-capsid and a blurred reconstruction of the C-capsid with icosahedral symmetry.In this study,we have determined the more precise detailed structures of the varicella-zoster virus(VZV)B-and C-capsid in icosahedral symmetry using a combination of block-based reconstruction and symmetry relaxation strategies.In addition,we are reporting structural details of the portal vertex reconstructions in five-fold symmetry and portal reconstructions in twelve-fold symmetry.The structures unveil the basis for the high thermal stability of the VZV capsid.The conformational flexibility of structural elements of the capsid plays a role in the assembly of the capsid and drives processes critical for the viral life cycle.The results of the study open up new avenues for the development of drugs against a highly prevalent and contagious pathogen. | Lei Cao Nan Wang Zhe Lv Wenyuan Chen Zhonghao Chen Lifei Song Xueyan Sha Guiqiang Wang Yaling Hu Xiaojun Lian Guoliang Cui Jinyan Fan Yaru Quan Hongrong Liu Hai Hou Xiangxi Wang | 2024 | hLife2024，2，2： | 0 |
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