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| 1 | Production of Two Elite Glutinous Rice Varieties by Editing Wx Gene显示文摘The waxy gene(Wx) in rice, which encodes the granule bound starch synthase enzyme, is responsible for amylose synthesis. Glutinous(sticky) rice has little or no amylose that can be used in various applications, such as brewing. In this study, knockout of the Wx gene with CRISPR/Cas9 technology was conducted in two elite japonica rice lines, Huaidao 5(HD5) and Suken 118(SK118), aiming to develop elite sticky rice varieties. We achieved six homozygous T_0 plants with more than 200 bp deletion in the Wx gene, as well as 36 wx-HD5 and 18 wx-SK118 homozygous transgene-free plants in the T_1 generation. The seeds of all the mutants were white and opaque, similar to those of sticky rice, and contained only 2.6%–3.2% amylose. Results of scanning electron microscopy showed that the quality of rice did not change. In conclusion, we successfully developed two elite sticky rice varieties. | FEI Yunyan YANG Jie WANG Fangquan FAN Fangjun LI Wenqi WANG Jun XU Yang ZHU Jinyan ZHONG Weigong | 2019 | Rice science2019，26，2： | 6 |
| 2 | Genetic analysis and gene fine mapping of a rolling leaf mutant (rl_(11(t))) in rice (Oryza sativa L.)显示文摘The exploration of new genes controlling rice leaf shape is an important foundation for rice functional genomics and plant architecture improvement. In the present study, we identified a rolling leaf mutant from indica variety Yuefeng B, named rl11(t), which exhibited reduced plant height, rolling and narrow leaves. Leaves in rl11(t) mutant showed abnormal number and morphology of veins compared with those in wild type plants. In addition, rl11(t) mutant was less sensitive to the inhibitory effect of auxin than the wild type. Genetic analysis suggested that the mutant was controlled by a single recessive gene. Gene Rl11(t) was initially mapped between SSR markers RM6089 and RM124 on chromosome 4. Thirty-two new STS markers around the Rl11(t) region were developed for fine mapping. A physical map encompassing the Rl11(t) locus was constructed and the target gene was finally delimited to a 31.6 kb window between STS4-25 and STS4-26 on BAC AL606645. This provides useful information for cloning of Rl11(t) gene. | ZHOU Yong FANG YunXia ZHU JinYan LI ShengQiang GU Fei GU MingHong LIANG GuoHua | 2010 | Chinese Science Bulletin2010，55，17： | 5 |
| 3 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 4 | Synergistic impact of cocatalysts and hole scavenger for promoted photocatalytic H2 evolution in mesoporous TiO2–NiSx hybrid显示文摘Photocatalytic solar energy conversion to hydrogen is sustainable and attractive for addressing the global energy and environmental issue. Herein, a novel photocatalytic system (NiS/Ni3S4 cocatalysts modified mesoporous TiO2) with superior photocatalytic hydrogen evolution capability through the synergistic impact of NiS/Ni3S4 (NiSx) cocatalyst and efficient hole scavenger has been demonstrated. The photocatalytic hydrogen evolution of TiO2-NiSx hybrids with the different content of NiSx and upon different organic hole scavengers was both investigated. The hybrid of TiO2 decorated with 3%(mole ratio of Ni^2+) NiSx cocatalyst in methanol solution showed the optimal photocatalytic hydrogen evolution rate of 981.59 μmol h^-1 g^-1 which was about 20 times higher than that of bare mesoporous TiO2. Our results suggested that the boosted hydrogen production performance is attributed to both the improved photoinduced electrons migration between NiS and Ni3S4 in cocatalyst and the high hole captured efficiency by hole scavengers of methanol. | Yi Wei Gang Cheng Jinyan Xiong Jiaxin Zhu Yixin Gan Mengmeng Zhang Zhen Li Shixue Dou | 2019 | Journal of Energy Chemistry2019，28，5： | 3 |
| 5 | Fine mapping and cloning of MT1,a novel allele of D10显示文摘瑞斯是为谷物生产的一个重要决定因素到 ering 为止。调查机制到 ering 为止,我们描绘了一到从装饰用的梨树变化识别的 ering 异种(mt1 ) 为止多重, Zhonghua 11,与他们对待。展览推进了到 ering 开发为止并且与野类型的植物相比相形见绌的这异种。印射的基因分析和好基因显示 mt1 异种被后退的基因控制,住在染色体 1 的 AP003376 上的一扇 29-kb 窗户上。在这个区域的一通常认为的基因,编码类胡萝卜素劈开 dioxygenase 8 (CCD8 ) ,对 D10 突变而产生之遗传。mt1 异种显型被野类型的 MT1 的介绍补充,并且在模仿的野类型的米饭的 MT1 击倒变异的显型。实时 PCR 分析显示 MT1 基因在腋的芽,圆锥花序,叶子,和根在茎并且在底层高度被表示。另外, MT1 表示清楚地在反馈规定下面。 | Yong Zhou Jinyan Zhu Zhengyi Li Fei Gu Honggen Zhang Shuzhu Tang Minghong Gu Guohua Liang | 2009 | Progress in Natural Science:Materials International2009，19，12： | 3 |
| 6 | Weakness Ranking Method for Subsystems of Heavy-Duty Machine Tools Based on FMECA Information显示文摘Heavy-duty machine tools are composed of many subsystems with different functions,and their reliability is governed by the reliabilities of these subsystems.It is important to rank the weaknesses of subsystems and identify the weakest subsystem to optimize products and improve their reliabilities.However,traditional ranking methods based on failure mode effect and critical analysis(FMECA)does not consider the complex maintenance of products.Herein,a weakness ranking method for the subsystems of heavy-duty machine tools is proposed based on generalized FMECA information.In this method,eight reliability indexes,including maintainability and maintenance cost,are considered in the generalized FMECA information.Subsequently,the cognition best worst method is used to calculate the weight of each screened index,and the weaknesses of the subsystems are ranked using a technique for order preference by similarity to an ideal solution.Finally,based on the failure data collected from certain domestic heavy-duty horizontal lathes,the weakness ranking result of the subsystems is obtained to verify the effectiveness of the proposed method.An improved weakness ranking method that can comprehensively analyze and identify weak subsystems is proposed herein for designing and improving the reliability of complex electromechanical products. | Zhaojun Yang Jinyan Guo Hailong Tian Chuanhai Chen Yongfu Zhu Jia Liu | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 2 |
| 7 | Tumor Microenvironment Cascade‑Responsive Nanodrug with Self‑Targeting Activation and ROS Regeneration for Synergistic Oxidation‑Chemotherapy显示文摘Carrier-free nanodrug with exceptionally high drug payload has attracted increasing attentions.Herein,we construct a pH/ROS cascade-responsive nanodrug which could achieve tumor acidity-triggered targeting activation followed by circularly amplified ROS-triggered drug release via positive-feedback loop.The di-selenide-bridged prodrug synthesized from vitamin E succinate and methotrexate(MTX)self-assembles into nanoparticles(VSeM);decorating acidity-cleavable PEG onto VSeM surface temporarily shields the targeting ability of MTX to evade immune clearance and consequently elongate circulation time.Upon reaching tumor sites,acidity-triggered detachment of PEG results in targeting recovery to enhance tumor cell uptake.Afterward,the VSeM could be dissociated in response to intracellular ROS to trigger VES/MTX release;then the released VES could produce extra ROS to accelerate the collapse of VSeM.Finally,the excessive ROS produced from VES could synergize with the released MTX to efficiently suppress tumor growth via orchestrated oxidation-chemotherapy.Our study provides a novel strategy to engineer cascade-responsive nanodrug for synergistic cancer treatment. | Yang Li Jinyan Lin Peiyuan Wang Qiang Luo Fukai Zhu Yun Zhang Zhenqing Hou Xiaolong Liu Jingfeng Liu | 2020 | Nano-Micro Letters2020，12，12： | 2 |
| 8 | Embryonic array configuration optimization method based on reliability and hardware consumption显示文摘Embryonic Array(EA) with different configuration methods will directly affect its reliability and hardware consumption. At present, EA configuration design is lack of quantitative analysis method. In order to reasonably optimize EA configuration design, an EA configuration optimization design method is proposed, which is based on the constraints of EA hardware consumption and reliability. Through the analysis of EA working process and composition, quantitative analysis of EA reliability and hardware consumption are completed. Based on the constraints of EA hardware consumption and reliability, the mathematical model of EA configuration optimization design is established, which transfers EA configuration optimization design into an integer nonlinear programming model problem. According to the difference of the fitness value of individual waiting for mutation in population, adaptive mutation operator and crossover operator are selected, and a novel Modified Adaptive Differential Evolution(MADE) algorithm is proposed,which is used to solve EA configuration optimization design problem. Simulation experiments and analysis indicate that the MADE is able to effectively improve the speed, accuracy and stability of algorithm. Moreover, the proposed EA configuration optimization design method can select the most reasonable EA configuration design, and play an important guiding role in EA optimization design. | Tao WANG Jinyan CAI Yafeng MENG Sai ZHU | 2019 | Chinese Journal of Aeronautics2019，32，3： | 1 |
| 9 | MOVPE Growth and Fabrication of 1.3μm High Power InGaAsP-InP Polarization-Insensitive Superluminescent Diodes with Complex Strained Quantum Wells显示文摘 | Hong Ma Sihai Chen Xinjian Yi Guangxi Zhu Jinyan Jin | 2004 | Optical and Quantum Electronics2004，，6： | 1 |
| 10 | A reliability evaluation method for embryonic cellular array based on Markov status graph model显示文摘Due to the limitations of the existing fault detection methods in the embryonic cellular array(ECA), the fault detection coverage cannot reach 100%. In order to evaluate the reliability of the ECA more accurately, embryonic cell and its input and output(I/O) resources are considered as a whole, named functional unit(FU). The FU fault detection coverage parameter is introduced to ECA reliability analysis, and a new ECA reliability evaluation method based on the Markov status graph model is proposed.Simulation experiment results indicate that the proposed ECA reliability evaluation method can evaluate the ECA reliability more effectively and accurately. Based on the proposed reliability evaluation method, the influence of parameters change on the ECA reliability is studied, and simulation experiment results show that ECA reliability can be improved by increasing the FU fault detection coverage and reducing the FU failure rate. In addition, by increasing the scale of the ECA, the reliability increases to the maximum first, and then it will decrease continuously. ECA reliability variation rules can not only provide theoretical guidance for the ECA optimization design, but also point out the direction for further research. | WANG Tao CAI Jinyan MENG Yafeng ZHU Sai | 2020 | Journal of Systems Engineering and Electronics2020，31，2： | 1 |
| 11 | Tailoring the adsorption behavior of superoxide intermediates on nickel carbide enables high-rate Li-O_(2) batteries显示文摘Probing the relationship between the adsorption of superoxide species and the kinetics of Li-O_(2) chemistry is critical for designing superior oxygen electrodes for the Li-O_(2) battery,yet the modulation essence,especially at the atomic level,remains little understood.Herein,we reveal that the adsorption behaviors of superoxide species can be effectively regulated via a core-induced interfacial charge interaction,and we find that moderate adsorption strength can enable superior rate capability in a Li-O_(2) battery.More importantly,operando X-ray absorption near-edge structure and surface-enhanced Raman spectroscopy provide tools to monitor in situ the evolution of the superoxide intermediates and the electronic states of the catalyst's metal sites during the discharge and charge processes,and correlate these with the surface adsorption states.The concept of tuning adsorption behavior through interfacial charge engineering could open up new opportunities to further advance the development of the Li-O_(2) battery and beyond. | Yun Liu Jinyan Cai Jianbin Zhou Yipeng Zang Xusheng Zheng Zixuan Zhu Bo Liu Gongming Wang Yitai Qian | 2022 | eScience2022，2，4： | 1 |
| 12 | Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer?显示文摘Objective Previous studies have proven that cumulative smoking dose predicts the prevalence of epidermal growth factor receptor(EGFR) mutations. The aim of this study was to investigate the relationship between smoking-related factors and EGFR mutation status. Methods Samples were collected from 195 smokers with non-small cell lung cancer(NSCLC) who underwent surgical resection and the presence of EGFR mutations(exons 19 and 21) were determined by real-time polymerase chain reaction(RT-PCR).Results EGFR gene mutations were present in 33(16.9%) patients who were smokers; the patients were divided into three groups according to the smoking index(SI). The incidence of EGFR mutations decreased from 38.9% in mild smokers to 8.1% in severe smokers(P = 0.001). Compared to daily smoking dose(P = 0.547), initial smoking age(P = 0.085) and duration of smoking history had a larger effect on EGFR mutation status(P = 0.002).Conclusion Although there is a decrease in the incidence of mutations with increasing SI, there were still around 17% of smokers with NSCLC that harbored EGFR mutations, so it is necessary to test for EGFR mutation status in smokers with NSCLC. | Jianfei Zhu Jinyan Yuan Yawei Dou Wei Tian Shudong Li Hongtao Wang Zhe Li | 2017 | Oncology and Translational Medicine2017，3，4： | 1 |
| 13 | Orbital-regulated interfacial electronic coupling endows Ni3N with superior catalytic surface for hydrogen evolution reaction显示文摘The interstitial structure and weak Ni-N interaction of Ni3N lead to high unoccupied d orbital energy and unsuitable orbital orientation,which consequently results in weak orbital coupling with H2O and slow water dissociation kinetics for alkaline hydrogen evolution catalysis.Herein,we successfully lower the unoccupied d orbital energy of Ni3N to strengthen the interfacial electronic coupling by employing the strong electron pulling capability of oxygen dopants.The prepared O-Ni3N catalyst delivers an overpotential of 55 mV at 10 mA cm−2,very close to the commercial Pt/C.Refined structural characterization indicates the oxygen incorporation can decrease the electron densities around the Ni sites.Moreover,density functional theory calculation further proves the oxygen incorporation can create more unoccupied orbitals with lower energy and superior orientation for water adsorption and dissociation.The concept of orbital-regulated interfacial electronic coupling could offer a unique approach for the rational design of hydrogen evolution catalysts and beyond. | Yanyan Fang Da Sun Shuwen Niu Jinyan Cai Yipeng Zang Yishang Wu Linqin Zhu Yufang Xie Yun Liu Zixuan Zhu Amirabbas Mosallanezhad Di Niu Zheng Lu Junjie Shi Xiaojing Liu Dewei Rao Gongming Wang Yitai Qian | 2020 | Science China Chemistry2020，63，11： | 1 |
| 14 | Efficient large fragment deletion in plants:double pairs of sgRNAs are better than dual sgRNAs显示文摘Dear Editor,Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)is a powerful and versatile gene editing system that has been extensively utilized in various animals and plants,which holds enormous potential and value for scientific research and breeding.However,single-targeted CRISPR can only induce a few base deletions,insertions,or substitution.Ideally,thesemutations result in premature termination of the protein encoded by the target gene,leading to a loss of function[1]. | Guoning Zhu Lingling Zhang Liqun Ma Qing Liu Kejian Wang Jinyan Li Guiqin Qu Benzhong Zhu Daqi Fu Yunbo Luo Hongliang Zhu | 2023 | Horticulture Research2023，10，10： | 1 |
| 15 | Select the Optimal Ecological Bank-Protection Technique for Plain-Area Channel Using AHP显示文摘 | Liu Dedong Zhu Lei Zhang Juan Liang Jinyan | | 0，，01： | 1 |
| 16 | Recent advances in synthesis strategies and solar-to-hydrogen evolution of 1T phase MS_(2)(M=W,Mo)co-catalysts显示文摘Photocatalytic water splitting is a promising strategy to produce hydrogen as a sustainable and clean energy carrier,based on abundant solar energy and semiconductor photocatalysts,and it has received extensive research and discussion over the past several decades.It is challenging,however,to achieve an efficient solar-to-hydrogen evolution process with a single particulate photocatalyst due to the weak solar spectrum harvest and the rapid recombination of photogenerated electron-hole pairs during the photocatalysis reaction.Combining semiconductors to create different co-catalysts presents a viable solution to the above issues.Recently,semiconductor photocatalysts modified by different transition metal sulfidebased co-catalysts with designed functions,especially in light absorption enhancement and chargecarrier-separation efficiency promotion,have attracted much attention.As continued breakthroughs have been made in the preparation,modification,and solar-to-hydrogen evolution application of the 1T phase MS_(2)(M=W,Mo)co-catalyst-based photocatalysis system in recent years,we believe that a comprehensive review of this kind of co-catalyst would further promote its research and development to address the energy and environmental challenges that we are currently facing.Herein,recent studies and progress are summarized on the fabrication of 1T phase MS_(2)(M=W,Mo)-based co-catalyst materials,as well as their roles and functional mechanisms for photocatalytic H;evolution.Finally,concluding perspectives on the opportunities in and challenges for the further exploration of the 1T-MS_(2)(M=W,Mo)-based solar-tohydrogen evolution system are presented. | Shuo Li Jinyan Xiong Xueteng Zhu Weijie Li Rong Chen Gang Cheng | 2022 | Journal of Materials Science & Technology2022，，6： | 1 |
| 17 | A Simplified Road Network Model Considering Delay Time at Intersection and Its Application on Automobile Navigation显示文摘 | Zhu Zhengyu Wang Lina Li Jinyan | 2011 | Communications in Computer and Information Science2011，158，1： | 1 |
| 18 | A Simplified Time- division Based on Road Network Model Considering Inter- section Delay for Vehicle Navigation显示文摘 | Zhu Zhengyu Li Jinyan Liu Lin | 2011 | Applied Mechanics and Materials2011，5254，： | 1 |
| 19 | Selenium Suppresses Lipopolysaccharide-Induced Fibrosis in Peritoneal Mesothelial Cells Through Inhibition of Epithelial-to-Mesenchymal Transition显示文摘 | Jinyan Liu Lingling Zeng Yuliang Zhao Bin Zhu Wanjun Ren Chunling Wu | 2014 | Biological Trace Element Research2014，，2： | 1 |
| 20 | Facilely anchoring Cu_(2)O nanoparticles on mesoporous TiO_(2)nanorods for enhanced photocatalytic CO_(2)reduction through efficient charge transfer显示文摘Semiconductor-employed photocatalytic CO_(2) reduction has been regarded as a promising approach for environmental-friendly conversion of CO_(2) into solar fuels.Herein,TiO_(2)/Cu_(2)O composite nanorods have been successfully fabricated by a facile chemical reduction method and applied for photocatalytic CO_(2) reduction.The composition and structure characterization indicates that the Cu_(2)O nanoparticles are coupled with TiO_(2) nanorods with an intimate contact.Under light illumination,all the TiO_(2)/Cu_(2)O composite nanorods enhance the photocatalytic CO_(2)reduction.In particular,the TiO_(2)/Cu_(2)O-15%sample exhibits the highest CH_(4)yield(1.35μmol g^(-1)h^(-1)) within 4 h irradiation,and it is 3.07 and 15 times higher than that of pristine TiO_(2)nanorods and Cu_(2)O nanoparticles,respectively.The enhanced photoreduction capability of the TiO_(2)/Cu_(2)O-15%is attributed to the intimate construction of Cu_(2)O nanoparticles on TiO_(2) nanorods with formed p-n junction to accelerate the separation of photogenerated electron-hole pairs.This work provides a reference for rational design of a p-n heterojunction photocatalyst for CO_(2) photoreduction. | Ge Yang Pei Qiu Jinyan Xiong Xueteng Zhu Gang Cheng | 2022 | Chinese Chemical Letters2022，33，8： | 0 |
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