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| 1 | Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937). | Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan | 2020 | Neural Regeneration Research2020，15，7： | 54 |
| 2 | Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan,China:a retrospective study显示文摘Background:The 2019 novel coronavirus has caused the outbreak of the acute respiratory disease in Wuhan,Hubei Province of China since December 2019.This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease(COVID-19).Methods:Clinical data were collected from two tertiary hospitals in Wuhan.A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19(death group)and we compare them with recovered patients(recovered group).Continuous variables were analyzed using the Mann-WhitneyU test.Categorical variables were analyzed byχ2 test or Fisher exact test as appropriate.Results:Our study enrolled 109 COVID-19 patients who died during hospitalization and 116 recovered patients.The median age of the death group was older than the recovered group(69[62,74]vs.40[33,57]years,Z=9.738,P<0.001).More patients in the death group had underlying diseases(72.5%vs.41.4%,χ2=22.105,P<0.001).Patients in the death group had a significantly longer time of illness onset to hospitalization(10.0[6.5,12.0]vs.7.0[5.0,10.0]days,Z=3.216,P=0.001).On admission,the proportions of patients with symptoms of dyspnea(70.6%vs.19.0%,χ2=60.905,P<0.001)and expectoration(32.1%vs.12.1%,χ2=13.250,P<0.001)were significantly higher in the death group.The blood oxygen saturation was significantly lower in the death group(85[77,91]%vs.97[95,98]%,Z=10.625,P<0.001).The white blood cell(WBC)in death group was significantly higher on admission(7.23[4.87,11.17]vs.4.52[3.62,5.88]×109/L,Z=7.618,P<0.001).Patients in the death group exhibited significantly lower lymphocyte count(0.63[0.40,0.79]vs.1.00[0.72,1.27]×109/L,Z=8.037,P<0.001)and lymphocyte percentage(7.10[4.45,12.73]%vs.23.50[15.27,31.25]%,Z=10.315,P<0.001)on admission,and the lymphocyte percentage continued to decrease during hospitalization(7.10[4.45,12.73]%vs.2.91[1.79,6.13]%,Z=5.242,P<0.001).Alanine transaminase(22.00[15.00,34.00]vs.18.70[13.00,30.38]U/L,Z=2.592,P=0.010),aspartate transaminase(34.00[27.00,47.00]vs.22.00[17.65,31.75]U/L,Z=7.308,P<0.001),and creatinine levels(89.00[72.00,133.50]vs.65.00[54.60,78.75]μmol/L,Z=6.478,P<0.001)were significantly higher in the death group than those in the recovered group.C-reactive protein(CRP)levels were also significantly higher in the death group on admission(109.25[35.00,170.28]vs.3.22[1.04,21.80]mg/L,Z=10.206,P<0.001)and showed no significant improvement after treatment(109.25[35.00,170.28]vs.81.60[27.23,179.08]mg/L,Z=1.219,P=0.233).The patients in the death group had more complications such as acute respiratory distress syndrome(ARDS)(89.9%vs.8.6%,χ2=148.105,P<0.001),acute cardiac injury(59.6%vs.0.9%,χ2=93.222,P<0.001),acute kidney injury(18.3%vs.0%,χ2=23.257,P<0.001),shock(11.9%vs.0%,χ2=14.618,P<0.001),and disseminated intravascular coagulation(DIC)(6.4%vs.0%,χ2=7.655,P=0.006).Conclusions:Compared to the recovered group,more patients in the death group exhibited characteristics of advanced age,pre-existing comorbidities,dyspnea,oxygen saturation decrease,increased WBC count,decreased lymphocytes,and elevated CRP levels.More patients in the death group had complications such as ARDS,acute cardiac injury,acute kidney injury,shock,and DIC. | Yan Deng Wei Liu Kui Liu Yuan-Yuan Fang Jin Shang Ling Zhou Ke Wang Fan Leng Shuang Wei Lei Chen Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，11： | 29 |
| 3 | Risk factors for intracranial aneurysm in a Chinese ethnic population显示文摘背景 Intracranial 动脉瘤( IAN )在一根大脑动脉上是一个耸出的水泡或囊汽球外面随着时间的过去,它可以导致自发的 subarachnoid 出血( SAH ),最终,残疾和 mortality.Current 研究显示疾病由于多重原因,包括环境因素和血容器的各种各样的先天的畸形。除了先天的倾向,象性别,年龄,高血压,和动脉粥样硬化那样的各种各样的高风险的因素涉及 intracranial 动脉瘤的形成。这研究的目的是调查在中国汉种族 patients.Methods 与分散的 intracranial 动脉瘤的形成联系的风险因素有 intracranial 动脉瘤的 251 个病人和有另外的服的疾病(控制组) 的 338 个病人的一个总数在这研究被注册。单个因素和逻辑回归模型被用来与年龄分析 intracranial 动脉瘤的协会;性别;香烟吸烟;酒精或可卡因消费;高血压,冠的动脉疾病,糖尿病 mellitus 和继承结缔组织疾病的历史;并且 fasting 血的层次葡萄糖和血脂肪。数据表示了同样吝啬的敤摡攠摮吗? | GU Yu-xiang CHEN Xian-cheng SONG Dong-lei LENG Bing ZHAO Fan | 2006 | Chinese Medical Journal2006，，16： | 28 |
| 4 | Graphene-based Li-ion hybrid supercapacitors with ultrahigh performance显示文摘有一个成长要求让混合 supercapacitor 系统克服存在产生的精力密度限制电的双层电容器(EDLC ) ,在力量与最小的牺牲导致下 generation-II supercapacitors 密度和周期生活。这里,一个先进基于 graphene 的混合系统,由插入 graphene 的 Li4Ti5O12 (LTO ) 组成合成阳极(G-LTO ) 和三维的多孔的 graphene 蔗糖阴极,为两个都联合 Li 离子电池(精力来源) 和 supercapacitors (力量来源) 的好处的目的被制作了。基于 Graphene 的材料关于混合 supercapacitor 的高效在两个电极起一个重要作用。例如,与 175 | Kai Leng Fan Zhang Long Zhang Tengfei Zhang Yingpeng Wu Yanhong Lu Yi Huang Yongsheng Chen | 2013 | Nano Research2013，6，8： | 15 |
| 5 | Credit Risk Transfer in SME Loan Guarantee Networks显示文摘Joint loan guarantee contracts and mutual guarantee contracts among SMEs form the basis of SME guarantee networks. The expansion of these networks increases the fragility of a financial system as a result of the regional and industrial risk contagion embedded within them. By providing a theoretical framework of a loan guarantee network, a method is proposed for calculating the amount of risk spillover caused by loan guarantees taking the perspective of the entire network. In addition,the route of risk contagion in guarantee networks is analyzed, revealing that when default risk shocks occur, risk contagion travels along the nodes not once but for several rounds and that the risk control of one firm cannot prevent these systemic risks. Therefore, a risk control scheme is designed based on the location and importance of firms in the network. Using data from a real guarantee network,we demonstrate that identifying the node locations of firms' in the guarantee network(including the coritivity and closeness of the firm) can help in understanding risk contagion mechanisms and preventing systemic credit risk before a crisis occurs. | LENG Aolin XING Guangyuan FAN Weiguo | 2017 | Journal of Systems Science & Complexity2017，30，5： | 10 |
| 6 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 7 | World’s first spaceflight on-orbit demonstration of a flexible solar array system based on shape memory polymer composites显示文摘With a 10%reversible compressive strain in more than 10 deformation cycles,the shape memory polymer composites(SMPCs)could be used for deployable structure and releasing mechanism.In this paper,without traditional electro-explosive devices or motors/controllers,the deployable SMPC flexible solar array system(SMPC-FSAS)is studied,developed,ground-based tested,and finally on-orbit validated.The epoxy-based SMPC is used for the rolling-out variable-stiffness beams as a structural frame as well as an actuator for the flexible blanket solar array.The releasing mechanism is primarily made of the cyanate-based SMPC,which has a high locking stiffness to withstand 50 g gravitational acceleration and a large unlocking displacement of 10 mm.The systematical mechanical and thermal qualification tests of the SMPC-FSAS flight hardware were performed,including sinusoidal sweeping vibration,shocking,acceleration,thermal equilibrium,thermal vacuum cycling,and thermal cycling test.The locking function of the SMPC releasing mechanisms was in normal when launching aboard the SJ20 Geostationary Satellite on 27 Dec.,2019.The SMPC-FSAS flight hardware successfully unlocked and deployed on 5 Jan.,2020 on geostationary orbit.The triggering signal of limit switches returned to ground at the 139 s upon heating,which indicated the successful unlocking function of SMPC releasing mechanisms.A pair of epoxy-based SMPC rolled variable-stiffness tubes,which clapped the flexible blanket solar array,slowly deployed and finally approached an approximate 100%shape recovery ratio within 60 s upon heating.The study and on-orbit successful validation of the SMPC-FSAS flight hardware could accelerate the related study and associated productions to be used for the next-generation releasing mechanisms as well as space deployable structures,such as new releasing mechanisms with low-shocking,testability and reusability,and ultra-large space deployable solar arrays. | LAN Xin LIU LiWu ZHANG FengHua LIU ZhengXian WANG LinLin LI QiFeng PENG Fan HAO SiDa DAI WenXu WAN Xue TANG Yong WANG Mian HAO YanYan YANG Yang YANG Cheng LIU YanJu LENG JinSong | 2020 | Science China(Technological Sciences)2020，63，8： | 7 |
| 8 | Fabric Defect Detection Using Independent Component Analysis and Phase Congruency显示文摘A novel method based on independent component analysis and phase congruency is proposed for detecting defects in textile fabric images. By independent component, we can obtain textile structural features of fabric-free images. By phase congruency, structure information is reduced, which can distinguish the defect region from the defect-free regions. Finally, we have the detecting result from binary image which is obtained by a threshold step. Compared with other algorithms, the proposed method not only has robustness with high detection rate, but also detects various types of defects quite well. | LENG Qiujun ZHANG Hu FAN Cien DENG Dexiang | 2014 | Wuhan University Journal of Natural Sciences2014，19，4： | 7 |
| 9 | Evaluation and optimization of blasting approaches to reducing oversize boulders and toes in open-pit mine显示文摘A new blasting approach of combined blastholes with different diameters is proposed to solve the problems of oversize boulders and rock toes in open-pit mine. A non-ideal detonation model and a statistical damage constitutive model are implemented in dynamic finite element analysis to investigate the formation mechanism of oversize boulders and toes. The damage distribution and evolution process of rock blasting fragmentation is simulated, and the scheme is further optimized. Numerical analysis results showed that pocket charges and satellite blastholes can only improve bench top fragmentation, but they cannot reduce the oversize in the middle and bottom of bench as well as the toe problem. The new blasting approach of combined blastholes with different diameters can effectively reduce the oversize boulders and toes as well as the production costs. | Zhendong Leng Yong Fan Qidong Gao Yingguo Hu | 2020 | International Journal of Mining Science and Technology2020，30，3： | 6 |
| 10 | The effects of air temperature and precipitation on the net primary productivity in China during the early 21st century显示文摘Research on how terrestrial ecosystems respond to climate change can reveal the complex interactions between vegetation and climate,net primary productivity (NPP),an important vegetation parameter and ecological indicator,fluctuates within any given ecological environment or regional carbon budget.In this study, spatial interpolation was used to generate a spatial dataset, with 1-km spatial resolution,with meteorological data from 736 observation stations across China.An improved CASA model was used to simulate NPP over the period of 2001-2013 by taking into account land-cover change in every year during the same period.We propose the grid- based spatial patterns and dynamics of annual NPP,annual average temperature,and annual total precipitation based on the model.We also used the model to demonstrate the spatial correlation between NPP,temperature,and pre- cipitation in the study area with special focus on the impact of climate change in the early 21st century.Results showed that the spatial pattern of NPP over all of China is characterized by higher values in the southeast and lower values in the northwest.The spatial pattern of temperature indicates substantial latitudinal differences across the country,and the spatial pattem of precipitation shows a ribbon of decline from the southeast coast to the northwest inland.Most areas show an upward trend in NPP. Temperatures appear to decrease across the country during the global warming hiatus (1998-2008),and are accom- panied by an increase in precipitation over most regions.The correlation between NPP and annual average temperature is weak.Alternatively,NPP and annual total precipitation are positively correlated in northern and central China at a coefficient above 0.64(p <0.01)yet negatively correlated in the eastem parts of the Qinghai- Tibet Plateau and Sichuan Basin.Results can provide useful information for improving parameters for calibra- tion of the terrestrial ecosystem process model. | Qianfeng WANG Jingyu ZENG Song LENG Bingxiong FAN Jia TANG Cong JIANGs Yi HUANG Qing ZHANG Yanping QU Wnlin WANG Wei SHUI | 2018 | Frontiers of Earth Science2018，12，4： | 6 |
| 11 | Functionalized graphene oxide based on p-phenylenediamine as spacers and nitrogen dopants for high performance supercapacitors显示文摘p-Phenylenediamine(PPD)functionalized graphene oxide(GO)materials(PPDG)were prepared through a one-step solvothermal process and their application as supercapacitors(SCs)were studied.The PPD is not only as the spacers to prevent aggregating and restacking of the graphene sheets in the preparing process but also as nitrogen sources to obtain the nitrogen-doped graphene.The structures of PPDG were characterized by Fourier transformed infrared spectroscopy(FT-IR),X-ray diffraction spectroscopy(XRD),Raman spectroscopy and X-ray photoelectron spectroscopy(XPS)and the results show that the nitrogen-doped graphene was achieved with nitrogen content as high as 10.85 at.%.The field emission scanning electron microscopy(FE-SEM)and high resolution transmission electron microscopy(HR-TEM)have confirmed that the morphologies of PPDG were loose layered with less aggregation,indicating that PPD molecules,as spacers,effectively prevent the graphene sheets from restacking during the solvothermal reaction.The special loose textures make PPDG materials exhibit excellent electrochemical performance for symmetric SCs with superior specific capacitance(313 F/g at 0.1 A/g),rate capability and cycling stability.The present synthesis method is convenient and may have potential applications as ultrahigh performance SCs. | Yanhong Lu Yi Huang Fan Zhang Long Zhang Xi Yang Tengfei Zhang Kai Leng Mingjie Zhang Yongsheng Chen | 2014 | Chinese Science Bulletin2014，59，16： | 5 |
| 12 | Hepatic perivascular epithelioid cell tumor in three patients显示文摘Perivascular epithelioid cell tumor(PEComa) is a rare, soft tissue tumor that can occur in various locations. The present report included three patients(one male and two females; age range, 25-51 years) with hepatic PEComas. The collected data included the clinical manifestations, diagnosis, management, treatment, and prognosis. Since it is difficult to diagnose hepatic PEComas by imaging, the patients were diagnosed by tumor tissue examination such as immunohistochemistry, which was positive for HMB-45, Melan-A, and SMA on all slides. The tumor was composed of diverse tissues including smooth muscle, adipose tissue, and thick-walled blood vessels. During the follow-up period, one of the tumors was malignant(double-positive for CD34 and Ki-67) and recurred 3 months after surgery. In addition, malignant hepatic PEComas were reviewed in the literature, indicating that the majority of hepatic PEComas are benign, but few hepatic PEComas exhibit malignant behaviors in older female patients(>50 years of age) with abdominal discomfort and pain, larger tumor size(>10 cm), or positive staining for CD34 and Ki-67. In conclusion, there is no effective method to diagnose PEComas. Currently, the diagnosis of PEComas depends on immunohistochemical staining. Tumor resection and close follow-up are the principal methods for the management of PEComas. | Bao-Bin Hao Jian-Hua Rao Ye Fan Chuang-Yong Zhang Xin-Zheng Dai Xiao Li Yan Leng Feng Zhang | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 4 |
| 13 | Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over显示文摘 | Zheng-Xing He Ting-Ting Sun Shu Wang Hong-Hui Shi Qing-Bo Fan Lan Zhu Jin-Hua Leng Da-Wei Sun Jian Sun Jing-He Lang | 2018 | Chinese Medical Journal2018，，11： | 4 |
| 14 | The ethyl acetate extraction of Pileostegia tomentella(ZLTE) exerts anti-cancer effects on H1299 cells via ROS-induced canonical apoptosis显示文摘Lung cancer is the leading cause of cancer death and the most common malignant tumor, the long-term survival of which has stagnated in the past several decades.Pileostegia tomentella Hand.Mazz is a traditional Chinese medicine called 'Zhongliuteng'(ZLT) in the pharmacopeia, which has been proved to possess a potent anti-tumor effect on various cancers.In this study, the effects of ZLT N-butanol extraction(ZLTN) and ZLT ethyl acetate extraction(ZLTE) on the viability of non-small cell lung cancer cell(NSCLC) lines H1299 and A549 were evaluated.Here, we firstly reported that ZLTE significantly inhibited H1299 cells growth without affecting the release of lactate dehydrogenase(LDH).In addition, ZLTE induced caspase-dependent apoptosis in a concentration-dependent manner and increased the expression cleaved-PARP and decreased pro-caspase-3, pro-caspase-7, pro-caspase-8, and pro-caspase-9.Moreover, ZLTE increased the level of cellular reactive oxygen species(ROS) in H1299 cells to lead to apoptosis,which was reversed by N-acetyl-cysteine(NAC).Taken together, our results revealed that ZLTE induced caspase-dependent apoptosis via ROS generation, suggesting that ZLTE is a promising herbal medicine for the treatment of NSCLC. | FAN Qiu-Mei ZHAO Wen-Tong YUAN Renyikun WANG Qin-Qin ZHANG Li-Feng GAO Hong-Wei LENG Jing YANG Shi-Lin | 2020 | Chinese Journal of Natural Medicines2020，18，7： | 4 |
| 15 | Catalytic methanation of syngas over Ni-based catalysts with different supports显示文摘Co-precipitation method was selected for the preparation of Ni/Al_2O_3, Ni/ZrO_2 and Ni/CeO_2 catalysts, and their performances in methanation were investigated in this study. The structure and surface properties of these catalysts were characterized by BET, XRD, H_2-TPD, TEM and H_2-TPR. The results showed that the catalytic activity at low temperature followed the order: Ni/Al_2O_3>Ni/ZrO_2>Ni/CeO_2. Ni/Al_2O_3 catalyst presented the best catalytic performance with the highest CH_4 selectivity of 94.5%. The characterization results indicated that the dispersion of the active component Ni was the main factor affecting the catalytic activity and the one with higher dispersion gave better performance. | Yincong Liu Lingjun Zhu Xiaoliu Wang Shi Yin Furong Leng Fan Zhang Haizhou Lin Shurong Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，5： | 3 |
| 16 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 17 | Changes of chymase,angiotensin converting enzyme and angiotensin Ⅱ type 1 receptor expressions in the hamster heart during the development of heart failure显示文摘Background Little is known about the role of dual angiotensin Ⅱ forming pathways during heart failure. In the present study, the changes of chymase and angiotensin converting enzyme (ACE) expressions in the failing hearts of hamsters were analysed.Methods Heart failure was induced by ligation of left anterior descending branch of the coronary artery. Chymase, ACE and angiotensin Ⅱ type 1 receptor (AT1R) mRNA levels were analysed by reverse transcription polymerase chain reaction (RT-PCR). The activities of chymase and ACE were determined by radioimmunoassay (RIA). Myocardial collagen fibre analysis was performed under optical microscope.Results Left ventricular systolic pressure (LVSP) and maximum left ventricular developed pressure increase rate (dp/dtmax , mmHg/s) gradually moved lower at 2, 3, 4 and 8 weeks after operation. On the other hand, left ventricular end-diastolic pressure (LVEDP) increased gradually after operation. Compared with the control group (3.55±0.06, 4.79±0.70), the heart weight/body weight ratio in operation group had increased significantly at 4 weeks and 8 weeks (4.28±0.43, 6.17±0.73) (P<0.01). Collagen staining showed that the quantity of myocardial collagen fibre increased significantly in the operation group. RT-PCR showed that the chymase mRNA level in the operation group was consistently greater than that in the control group. AT1R mRNA level was also increased significantly at 3 weeks and 4 weeks, both being 1.3 times that of the control group (P<0.01), whereas ACE mRNA level was not changed. Higher activity of chymase was detected in operation group, being 4, 8, 13 and 19 times that of the control group at 2, 3, 4 and 8 weeks (P<0.01), respectively. ACE activity was also significantly higher at the same time, being 7, 10, 10 and 3.5 times that of the control (P<0.01). Angiotensin Ⅱ (Ang Ⅱ) level in operation group increased significantly, being 2.5, 2.7, 3.5 and 2 times that of the control group at 2, 3, 4 and 8 weeks, respectively (P<0.01).Conclusions A dual Ang Ⅱ forming pathway from both ACE and chymase in the hamster hearts plays an important role during the development of heart failure. At the decompensatory stage, the reduction of AngII level may be associated with the decrease of ACE activity. | CHEN Peng-min LENG Xi-gang FAN Li-li MA Jun WANG Ya-fang CHEN Lan-ying | 2005 | Chinese Medical Journal2005，，22： | 3 |
| 18 | De-oncogenic HPV E6/E7 vaccine gets enhanced antigenicity and promotes tumoricidal synergy with cisplatin显示文摘以便与高风险的人的乳头状瘤病毒(HPV ) 对癌症开发更有效的治疗学的疫苗感染,它对关键提高 immunogenicity,消除 oncoproteins 的 oncogenicity,并且拿包含 E7 和包含 E6 疫苗的联合。它最近被看了那 PE ( III ) -E7-KDEL3 ( E7 ),包含 HPV16 oncoprotein E7 的熔化蛋白质和 Pseudomonas aeruginosa 外毒素 A 的 translocation 域,对因此,在鼠标接种的 TC-1 肿瘤房间是有效的我们设计了 PE ( III ) -E6-CRL-KDEL3 ( E6 ), E7 和 E6 熔化蛋白质的 de-oncogenic 版本[即 PE ( III )-E7(d)-KDEL3, E7 (d),和 PE ( III )-E6(d)-CRL-KDEL3, E6 (d)]并且作为单音测试了这些熔化蛋白质的 immunoefficacies --并且二原子价的疫苗。结果比它的野类型和 E6 熔化蛋白质扩充他们的 E7 对应物的 immunogenicity 和 antitumor 效果的显示 E7 (d) 得到更高的 immunogenicity。而且,面对 cisplatin,加 E6 (d) 的二原子价的疫苗的系统 E7 (d) 在 vivo 对确定的肿瘤显示出最好的 tumoristatic 和 tumoricidal 效果。因此,在进一步的优化之上,这个新奇治疗学的疫苗的系统可以在 HPV 相关的癌的临床的管理上打开新灯,这能被结束。 | Shaochun Chen Chaowei Liao Yiukay Lai Yan Fan Gang Lu Hua Wang Xiaoai Zhang Marie C.M. Lin Shuilong Leng Hsiang-Fu Kung | 2014 | Acta Biochimica et Biophysica Sinica2014，46，1： | 3 |
| 19 | Serum CA125 changes in one case with malignant transformation from benign endometriosis to Müllerian adenosarcoma显示文摘To the editor:We here present a rare case of müllerian adenosarcoma arising in pelvic endometriosis and the changes of serum CA125 level during the course of malignant changes.Serum CA125 was found being persistently abnormal during the course of endometriosis progression;and the fluctuation of CA125 seemed be relative to disease condition and could reflect the response to treatment. | WANG Shu LANG Jing-he LENG Jin-hua ZHU lan FAN Qing-bo LI Xiao-chuan | 2013 | Chinese Medical Journal2013，，17： | 3 |
| 20 | Pathogenetic gene changes of eutopic endometrium in patients with ovarian endometriosis显示文摘To the Editor:Endometriosis refers to the endometrial tissue (interstitial substance and gland) with growth function occurring in the uterine lining of uterine cavity and the places outside myometrium.It often leads to pain,infertility,nodules or masses and other symptoms and signs,and thus,brings a heavy burden on individuals and society.Traditional blood reflux theory,immune theory,inflammatory theory,hormone theory,etc.,cannot fully elucidate the pathogenesis of endometriosis. | Ling Li Qian Chen Qing-Bo Fan Shu Wang Hong-Hui Shi Lan Zhu Da-Wei Sun Jin-Hua Leng Jing-He Lang | 2019 | Chinese Medical Journal2019，，9： | 2 |
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