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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 3 | Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients显示文摘Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.a.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts. | Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 4 | Mutation Analysis in the BRCA1 Gene in Chinese Breast Cancer Families显示文摘Objective: To study the mutation of BRCA1 gene in Chinese breast cancer families. Methods:Fifteen families were selected, involving 41 members, consisting of 23 breast cancer patients. Using poly-merase chain reaction and single stranded conformation polymorphism (PCR-SSCP), and subsequent DNA sequencing, the mutation of BRCA1 genes were analyzed. Results: Four mutations were found in all fam-ilies, and the proportion of mutation was 26.7% (4/15) in breast cancer families. One of the 4 mutations was 2228 insC, resulting in chain termination at codon 711. The remaining 3 mutations were 1884A→T and 3232A→G, resulting in single amino acid change respectively. Conclusion: BRCA1 is a breast cancer susceptibility gene. The relatively low proportion and frequency of BRCA1 mutations in our study hints additional BRCA genes existed. | WUZhengyan ZHENLinlin FANPing | 2003 | The Chinese-German Journal of Clinical Oncology2003，2，3： | 5 |
| 5 | Ternary NiCoFe-layered double hydroxide hollow polyhedrons as highly efficient electrocatalysts for oxygen evolution reaction显示文摘With exhaustion of fossil fuels and the deterioration of global environment,widespread and intensive researches have been concentrated on clean and sustainable alternative energy sources,such as metal-air batteries[1],fuel cells[2]and water splitting devices[3].Electrocatalytic oxidation of water to O2(oxygen evolution reaction,OER)is a vital chemical process involved in energy storage and conversion from renewable sources in form of molecular fuels such as H2 via water electrolysis,which has attracted a great amount of research efforts in the past few years[4,5].Nowadays,RuO2 and IrO2 are widely used as typical excellent OER electrocatalysts.However,their high-cost and scarce nature restricts the broadly commercial application of those materials[6,7].Hence,there is an urgent demand to develop low cost,highly efficient,and superb stable OER catalysts. | Yongji Qin Fanping Wang Jing Shang Muzaffar Iqbal Aijuan Han Xiaoming Sun Haijun Xu Junfeng Liu | 2020 | Journal of Energy Chemistry2020，29，4： | 4 |
| 6 | Kneading Sequences for Unimodal Expanding Maps of the Interval | Zeng Fanping, Institute of Mathematics, Guangxi University, Nanning 530004, China | 1998 | Acta Mathematica Sinica,English Series1998，14，4： | 4 |
| 7 | PRE-IMAGE ENTROPY OF NONAUTONOMOUS DYNAMICAL SYSTEMS显示文摘作者定义并且学习拓扑预先想象为一个紧缩的拓扑的空格的连续自我地图的一个序列给的非自治的分离动态系统的熵。基本性质并且关于 equiconjugacy 不变预先想象为非自治的分离动态系统的熵被获得。 | Xianjiu HUANG Xi WEN Fanping ZENG | 2008 | Journal of Systems Science & Complexity2008，21，3： | 3 |
| 8 | Deep learning for non-parameterized MEMS structural design显示文摘The geometric designs of MEMS devices can profoundly impact their physical properties and eventual performances.However,it is challenging for researchers to rationally consider a large number of possible designs,as it would be very time-and resource-consuming to study all these cases using numerical simulation.In this paper,we report the use of deep learning techniques to accelerate the MEMS design cycle by quickly and accurately predicting the physical properties of numerous design candidates with vastly different geometric features.Design candidates are represented in a nonparameterized,topologically unconstrained form using pixelated black-and-white images.After sufficient training,a deep neural network can quickly calculate the physical properties of interest with good accuracy without using conventional numerical tools such as finite element analysis.As an example,we apply our deep learning approach in the prediction of the modal frequency and quality factor of disk-shaped microscale resonators.With reasonable training,our deep learning neural network becomes a high-speed,high-accuracy calculator:it can identify the flexural mode frequency and the quality factor 4.6×10^(3)times and 2.6×10^(4)times faster,respectively,than conventional numerical simulation packages,with good accuracies of 98.8±1.6%and 96.8±3.1%,respectively.When simultaneously predicting the frequency and the quality factor,up to~96.0%of the total computation time can be saved during the design process.The proposed technique can rapidly screen over thousands of design candidates and promotes experience-free and data-driven MEMS structural designs. | Ruiqi Guo Fanping Sui Wei Yue Zekai Wang Sedat Pala Kunying Li Renxiao Xu Liwei Lin | 2022 | Microsystems & Nanoengineering2022，8，4： | 2 |
| 9 | Multi-cellCooperativeTransmissionBased on Unitary Space-time Modulation显示文摘 | LIU H FANP HAO L | 2012 | EURASIPJournalon WirelessCommunicationsandNetworking2012，2012，1： | 1 |
| 10 | Adaptive Ro- bust Motion Control of Single-rod Hydraulic Actua- tors: Theory and Experiments显示文摘 | Yao Bin Bu Fanping Reedy J | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，1： | 1 |
| 11 | Nonlinear model based coordination adaptive robust control of electro-hydraulic robotic manipulators: Prastical issue and comparative studies显示文摘 | BU Fanping YAO Bin | 2001 | ASME International Mechanical Engineers Congress and Exposition(IMECE)2001，3，1： | 1 |
| 12 | Interfacial studies of a thin-film Li2Mn4O9 electrode显示文摘 | Robert Kosteeki Fanping Kong Yoshiaki Matsuo | 1999 | Electrochimica Acta1999，45，： | 1 |
| 13 | Fractal Image Compression Based on Spatial Correlation and Hybrid Genetic Algorithm显示文摘 | Wang Xingyuan Li Fanping Wang Shuguo | 2009 | Journal of Visual Communication and Image Represenlation2009，20，8： | 1 |
| 14 | Adaptive Robust Motion Control of Single-rod Hydraulic Actuators: Theory and Experiments显示文摘 | Yao Bin Bu Fanping Reedy J | 2000 | Transactions on Mechatronics2000，5，1： | 1 |
| 15 | Sequence analysis of a mouse mAb against AchR显示文摘 | Yang kangjuan Y Graus | 1995 | Jourmal of Yanbian Medical College1995，18，2： | 1 |
| 16 | A Class of Nonlinear Iterated Function System Attractors显示文摘 | Wang Xingyuan Li Fanping | 2009 | Nonlinear Analysis2009，70，： | 1 |
| 17 | Microalgal Cultivation in Secondary Effluents:Enhancement of Algal Biomass,Nutrient Removal,and Lipid Productivity显示文摘The growth performance,nutrient removal,lipid accumulation and morphological changes of Cyanobacterium aponinum OUC1 and Scenedesmus obliquus which were cultured in secondary effluents from two wastewater treatment plants:Tuandao Wastewater Treatment Plant(ETD)and Licun River Wastewater Treatment Plant(ELR)were investigated.The results showed that both C.aponinum OUC1 and S.obliquus have superior growth performances in both undiluted effluents,while the better of them was that in ETD effluent,with cell densities of C.aponinum OUC1 and S.obliquus increased by 159%and 66%over that of BG11(control),respectively.Regarding nutrient removal,S.obliquus could completely remove inorganic phosphorus,and decrease ammonia nitrogen in ETD effluent by 81%.In addition,both C.aponinum OUC1 and S.obliquus cultivated in ETD exhibited extraordinary potential for biofuel production,increasing lipid productivities by 133%and 89%of that cultivated in ELR,respectively.As to ultrastructural changes,the differences in the lipoidal globules and glycogen granules of S.obliquus and C.aponinum OUC1 among the ETD and ELR treatments were mostly related to phosphorus limitations.The findings from this research reveal the probability using the secondary effluents as cultivation media to enhance algal biomass,nutrient removal and lipid productivity. | ZHANG Bo MENG Fanping CUI Hongwu DOU Xiang DU Shuhao PENG Xiaoling | 2020 | Journal of Ocean University of China2020，19，6： | 1 |
| 18 | Non-linear adaptive robust control of electro-hydraulic systems driven by double-rod actuators显示文摘 | Yao Bin Bu Fanping Chiu George T C | 2001 | International Journal of Control2001，74，8： | 1 |
| 19 | Electro -me- chanical impedance modeling of active material systems 显示文摘 | Liang Chen Sun Fanping Rogers Craig A | 1996 | Smart Materials and Structures1996，5，2： | 1 |
| 20 | Adaptive Ro- bust Motion Control of Single- rod Hydraulic Actu- ators: Theory and Experiments显示文摘 | Yao Bin Bu Fanping Reedy ] et aI | 2000 | IEEE/ASME Transactions on Mechatronics2000，5，1： | 1 |
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