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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Synergistic therapy of magnetism-responsive hydrogel for soft tissue injuries显示文摘Soft tissue injury is very common and associated with pain,tissue swelling and even malformation if not treated on time.Treating methods include cryotherapy,electrical therapy,ultrasound therapy and anti-inflammatory drug,but none of them is completely satisfying.In this work,for a better therapeutic effect,drug therapy and pulsed electromagnetic field(PEMF)therapy were combined.We constructed a drug delivery system using the tetra-PEG/agar hydrogel(PA).By incorporating Fe3O4 NPs into the hydrogel network,a magnetism-responsive property was achieved in the system.The cytotoxicity and in vivo study showed a good biocompatibility of the PA/Fe3O4 hydrogel.A magnetism-controlled release was attained by the incorporation of Fe3O4.Finally,in vivo study showed a better performance of the DS-loaded PA/Fe3O4 compared with the commercially available DS ointment regarding the recovery of the injured soft tissue.Therefore,this magnetism-responsive hydrogel may represent a promising alternative to treat soft tissue injury. | Lining Zhang Xiuqin Zuo Shengjie Li Mi Sun Huimin Xie Kai Zhang Jikun Zhou Liyun Che Junxuan Ma Zishan Jia Fei Yang | 2019 | Bioactive Materials2019，4，1： | 7 |
| 3 | The Role of HBx Gene Mutations in PLA2R Positive Hepatitis-B-associated Membranous Nephropathy显示文摘China is a higher-intermediate hepatitis B virus(HBV)endemicity country,and HBV is among the most important infectious diseases[1,2].Hepatitis-Bassociated glomerulonephritis(HBV-GN)is also one of the main forms of secondary kidney diseases seen in China[3].The main pathological type is hepatitis-Bassociated membranous nephropathy(HBV-MN).In the recent years,it has been found that human renal podocyte membrane M-type phospholipase 2 receptor(PLA2R)is the main autoantigen in idiopathic membranous nephropathy(IMN)[4].At present,it is found that PLA2 R and its antibodies are. | DONG Hui XU Yan XU Ting SUN Jing Yi BU Quan Dong WANG Yan Fei CHE Lin ZHAO Long JIANG Wei | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 4 | Microbial Diversity in Rhizosphere Soil of Cotinus coggygria Based on High Throughput Sequencing显示文摘In order to reveal the influence of different plant configurations on the microbial community structure and diversity in rhizosphere soil of Cotinus coggygria in Fragrant Hills park,the ITS+5.8S rDNA gene and 16S rDNA gene V3-V4 region sequencing analysis for fungi and bacteria,respectively,were conducted by high throughput sequencing(Illumina MiSeq).The results showed that the fungal diversity in the rhizosphere soil samples of C.coggygria in Fragrant Hills park in 2018 was significantly higher than that in 2016,and it was higher in the rhizosphere soil of healthy C.coggygria in Xunlupo than that in diseased ones in 2018.Verticillium dahliae,which is the causal agent of C.coggygria wilt,was detected in five soil samples.In 2018,the bacterial diversity in the rhizosphere soil of diseased C.coggygria in Xunlupo was the lowest,while it was the highest in the rhizosphere soil of healthy C.coggygria under Platycladus orientalis in Langfengting. | Zhou Jianghong Xia Fei Che Shaochen Ge Yuxuan Zhou Xiaohong | 2019 | Plant Diseases and Pests2019，10，5： | 3 |
| 5 | Effects of boundary conditions on vibrating mode of acoustic logging dipole transducer显示文摘Acoustic transducer is an important part of acoustic well logging tool. In this paper,ANSYS software package is used to design acoustic dipole transducer and simulate vibrating mode of the dipole transducer in different mechanical boundary conditions. The results show that boundary conditions influence the number of vibrating mode in the same frequency band and the frequency value of the same vibrating mode. Several acoustic dipole transducers are designed according to the results of numerical simulation and laboratory measurements. The basic frequency of vibrating mode of experi-ment has good agreement with that of simulation. The numerical simulation plays a good guidance role in designing,producing and correctly installing the acoustic dipole transducer. | QIAO WenXiao,CHE XiaoHua & ZHANG Fei State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing 102249,China | 2008 | Science China Earth Sciences2008，51，S2： | 3 |
| 6 | Research Progress on Estimation of the Atmospheric Boundary Layer Height显示文摘Atmospheric boundary layer height(ABLH)is an important parameter used to depict characteristics of the planetary boundary layer(PBL)in the lower troposphere.The ABLH is strongly associated with the vertical distributions of heat,mass,and energy in the PBL,and it is a key quantity in numerical simulation of the PBL and plays an essential role in atmospheric environmental assessment.In this paper,various definitions and methods for deriving and estimating the ABLH are summarized,from the perspectives of turbulent motion,PBL dynamics and thermodynamics,and distributions of various substances in the PBL.Different methods for determining the ABLH by means of direct observation and remote sensing retrieval are reviewed,and comparisons of the advantages and disadvantages of these methods are presented.The paper also summarizes the ABLH parameterization schemes,discusses current problems in the estimation of ABLH,and finally points out the directions for possible future breakthroughs in the ABLHrelated research and application. | Hongsheng ZHANG Xiaoye ZHANG Qianhui LI Xuhui CAI Shaojia FAN Yu SONG Fei HU Huizheng CHE Jiannong QUAN Ling KANG Tong ZHU | 2020 | Journal of Meteorological Research2020，34，3： | 3 |
| 7 | A novel derivative of valepotriate inhibits the PI3K/AKT pathway and causes Noxa-dependent apoptosis in human pancreatic cancer cells显示文摘Natural compound valepotriate exhibits inhibitory activity against a number of cancers,but the effect of valepotdriate against pancreatic cancer is unclear,and the structure-activity relationship of valepotriate has not been characterized:In this study,we performed a structure-based similarity search and found 16 hit compounds.Among the 16 hits,(1S,6S,7R)-6-(acetyloxy)-1-[(3-methylbutanoyl)oxy]-4a,5,6,7a-tetrahydro-1H-spiro[cyclopenta[c]pyran-7,2'-oxiran]-4-ylmethyl 3-methylbutanoate(denoted as Amcp)exhibited superior anticancer activity against human pancreatic cancer BxPC-3 and SW1990 cells.The anti-proliferation activity of Amcp was validated in human pancreatic cancer BxPC-3 and SW1990 cells in vitro.Amcp more effectively induced apoptosis in BxPC-3 and SW1990 cells than gemcitabine.At a concentration of 15μM,Amcp Significantly suppressed the PI3K/AKT pathway and disrupted the mitochondrial membrane equilibrium through modulation of Noxa and Mcl-1 balance in both cell lines.Meanwhile,knockdown of Noxa substantially attenuated Amcp-induced reduction of cell viability and anti-apoptotic protein Mcl-1 level in BxPC-3 cells.In addition,Amcp showed synergistic anticancer effects when combined with gemcitabine in BxPC-3 cells.To conclude,this work not only suggests that Amcp possesses a dual-inhibitory activity towards PI3K/AKT pathway and Mcl-1,but also enlightens further development of bioactive valepotriate derivatives. | You-you Yan Ke-yu Shi Fei Teng Jing Chen Jin-xin Che Xiao-wu Dong Neng-ming Lin Bo Zhang | 2020 | Acta Pharmacologica Sinica2020，41，6： | 2 |
| 8 | A New High-throughput Real-time PCR Assay for the Screening of Multiple Antimicrobial Resistance Genes in Broiler Fecal Samples from China显示文摘Objective Antimicrobial resistance(AMR)has become a global concern and is especially severe in China.To effectively and reliably provide AMR data,we developed a new high-throughput real-time PCR assay based on microfluidic dynamic technology,and screened multiple AMR genes in broiler fecal samples.Methods A high-throughput real-time PCR system with an new designed integrated fluidic circuit assay were performed AMR gene detection.A total of 273 broiler fecal samples collected from two geographically separated farms were screened AMR genes.Results The new assay with limits of detection ranging from 40.9 to 8,000 copies/reaction.The sensitivity rate,specificity rate,positive predictive value,negative predictive value and correct indices were 99.30%,98.08%,95.31%,99.79%,and 0.9755,respectively.Utilizing this assay,we demonstrate that AMR genes are widely spread,with positive detection rates ranging from 0 to 97.07%in 273 broiler fecal samples.bla CTX-M,bla TEM,mcr-1,fex A,cfr,optr A,and int I1 showed over 80%prevalence.The dissemination of AMR genes was distinct between the two farms.Conclusions We successfully established a new high-throughput real-time PCR assay applicable to AMR gene surveillance from fecal samples.The widespread existence of AMR genes detected in broiler farms highlights the current and severe problem of AMR. | CHE Jie LU Jin Xing LI Wen Ge ZHANG Yun Fei ZHAO Xiao Fei YUAN Min BAI Xue Mei CHEN Xia LI Juan | 2019 | Biomedical and Environmental Sciences2019，32，12： | 2 |
| 9 | Melatonin alleviates alcoholic liver disease via EGFR-BRG1-TERT axis regulation显示文摘Chronic alcohol consumption causes liver steatosis,cell death,and inflammation.Melatonin(MLT)is reported to alleviate alcoholic liver disease(ALD)-induced injury.However,its direct regulating targets in hepatocytes are not fully understood.In the current study,a cell-based screening model and a chronic ethanol-fed mice ALD model were used to test the protective mechanisms of MLT.MLT ameliorated ethanol-induced hepatocyte injury in both cell and animal models(optimal doses of 10μmol/L and 5 mg/kg,respectively),including lowered liver steatosis,cell death,and inflammation.RNA-seq analysis and loss-of-function studies in AML-12 cells revealed that telomerase reverse transcriptase(TERT)was a key downstream effector of MLT.Biophysical assay found that epidermal growth factor receptor(EGFR)on the hepatocyte surface was a direct binding and regulating target of MLT.Liver specific knock-down of Tert or Egfr in the ALD mice model impaired MLT-mediated liver protection,partly through the regulation of nuclear brahma-related gene-1(BRG1).Long-term administration(90 days)of MLT in healthy mice did not cause evident adverse effect.In conclusion,MLT is an efficacious and safe agent for ALD alleviation.Its direct regulating target in hepatocytes is EGFR and downstream BRG1-TERT axis.MLT might be used as a complimentary agent for alcoholics. | Zhaodi Che Yali Song Chengfang Xu Wei Li Zhiyong Dong Cunchuan Wang Yixing Ren Kwok-Fai So George L.Tipoe Fei Wang Jia Xiao | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 2 |
| 10 | Realization of warm white light emitting in single phase Gd(P_(x)V_(1−x))O_(4):y at% Sm^(3+),1 at% Bi^(3+) phosphor显示文摘A series of single phase,warm white light emitting phosphors,Gd(P_(x)V_(1−x))O_(4):y at%Sm^(3+),with 1 at%Bi^(3+) doping concentration were synthesized by high temperature solid state method in this work.The experimental results indicate broadband cyan emission of Bi^(3+)and characteristic orange-red emission of Sm^(3+)can be effectively tuned by changing the ratios of PO^(3−)_(4)/VO^(3−)_(4) in Gd(P_(x)V_(1−x))O_(4):1 at%Sm^(3+),1 at%Bi^(3+),and the energy transfer process among VO^(3−)_(4),Sm^(3+),Bi^(3+) also can be adjusted.Based on this,warm white light emitting can be realized by further optimizing the doping concentration of Sm^(3+) in the phosphors.At 423 K,the PL intensity of Gd(P_(0.7)V_(0.3))O_(4):2 at%Sm^(3+),1 at%Bi^(3+) remains~84.3%of the initial value at 293 K,while the measured quantum efficiency is 67.8%.EL spectrum analysis results of the fabricated white light emitting diode(wLED)based on a 310 nm UV-chip and Gd(P_(0.7)V_(0.3))O4:2 at%Sm^(3+),1 at%Bi^(3+)phosphors imply low correlated color temperature(3132 K)and appropriate color-rending index(R_(a)=82.7).These results demonstrate that Gd(P_(0.7)V_(0.3))O4:2 at%Sm^(3+),1 at%Bi^(3+)is a good candidate for manufacturing UV-activated warm white light emitting diodes. | Chao Dou Yanzhen Yin Fei Zheng Zhen Wang Shijia Sun Chen Hu Yang Che Bing Teng Degao Zhong | 2022 | Journal of Rare Earths2022，40，4： | 2 |
| 11 | A novel capacitive acce- lerometer with an eight-beam-mass structure by self-stop aniso- tropic etching of( 100 ) silicon 显示文摘 | Xiao Fei Che Lufeng Xiong Bin | 2008 | J Micromechanics and Micro- engineering2008，18，75： | 1 |
| 12 | Co-Expression of XIAP and Cyclin D1 Complex Correlates with a Poor Prognosis in Patients with Hepatocellular Carcinoma显示文摘 | Yufang Che Fei Ye Ruliang Xu Haitao Qing Xinying Wang Fei Yin Miao Cui David Burstein Bo Jiang David Y. Zhang | 2012 | The American Journal of Pathology2012，，5： | 1 |
| 13 | Water quality improvemeat and phytoplankton response in the drinking water source in M filiang Bay of Lake Taihu, China显示文摘 | Fei Z Che N Song X L | 2009 | Ecological Engineering2009，，35： | 1 |
| 14 | Dust aerosol drives upward trend of surface so- lar radiation during 1980 -2009 in the Taklimakan Desert 显示文摘 | Fei Y Xia X Che H | 2014 | At- mospheric Science Letters2014，15，4： | 1 |
| 15 | Design of optical system for flattop beam shaper based on the measurement of laser induced damage threshold of thin films显示文摘 | LI Yu-yao WANG Fei CHE Ying | 2014 | Optik2014，125，： | 1 |
| 16 | Multi - parameter Hopf bifurcation in Hodgkin-Huxley model exposed to ELF external electric field 显示文摘 | Wang J Che Y Q Fei X Y | 2005 | Chaos Solitons & Fractals2005，26，4： | 1 |
| 17 | Experimental simulation of the relative contribution of volatile-N and char-N to NO_X formation from a low-capacity bituminous coal-fired industrial boiler显示文摘The conversion of fuel-N to NOx is the main contribution of NOx from coal-fired industrial boilers and is the least-studied modelling problem arising from coal combustion. This paper summarises the current understanding of the mechanisms that account for the formation of NOx from fuel-N during coal combustion. Further experimentation on NOx emissions during bituminous coal combustion was simulated with attention focused on the contribution of char-N and volatile-N to fuel-NOx through the Coal/Char combustion method. The critical analysis of this issue allowed for the identification of uncertainties and produced well-founded conclusions. The results indicated that fuel-NOx formation was a very complex physical-chemical process involving many competing mechanisms. These mechanisms included chemical reactions, convective mass transfer, heat transfer, adsorption and desorption. The contribution of char-N in this experiment varied between 30% and 70%. There may be a slight question as to the exact identity of the main contributor to fuel-NOx , and no definitive conclusion can be made as of yet. This uncertainty is because the contribution of char-N to fuel-NO x was heavily affected by the combustion conditions and the contribution of char-N increased monotonically as temperature increased. There was a critical point in the relationship between particle size, air flow, O2 concentration and the contribution of char-N. The contribution of char-N increased with the increase of particle size and air flow initially when less than the critical value, and decreased when more than thecritical value. The contribution of char-N initially decreased when the O2 concentration was increased from 10% to 15% and increased more with the further increase in O2 concentration. | WU XueFang WANG Sheng WANG ZongShuang CHE Fei WANG ZhanShan XU Shu LI Qin TAN YuFei | 2013 | Science China Chemistry2013，56，4： | 1 |
| 18 | Aerosol Optical Properties and Radiative Impacts in the Pearl River Delta Region of China during the Dry Season显示文摘Aerosol optical properties and direct radiative effects on surface irradiance were examined using seven years(2006–2012)of Cimel sunphotometer data collected at Panyu—the main atmospheric composition monitoring station in the Pearl River Delta(PRD) region of China. During the dry season(October to February), mean values of the aerosol optical depth(AOD)at 550 nm, the ?ngstr?m exponent, and the single scattering albedo at 440 nm(SSA) were 0.54, 1.33 and 0.87, respectively.About 90% of aerosols were dominated by fine-mode strongly absorbing particles. The size distribution was bimodal, with fine-mode particles dominating. The fine mode showed a peak at a radius of 0.12 μm in February and October(~0.10μm^3μm^(-2)). The mean diurnal shortwave direct radiative forcing at the surface, inside the atmosphere(FATM), and at the top of the atmosphere, was-33.4 ± 7.0, 26.1 ± 5.6 and-7.3 ± 2.7 W m^(-2), respectively. The corresponding mean values of aerosol direct shortwave radiative forcing per AOD were-60.0 ± 7.8, 47.3 ± 8.3 and-12.8 ± 3.1 W m^(-2), respectively. Moreover,during the study period, FATMshowed a significant decreasing trend(p < 0.01) and SSA increased from 0.87 in 2006 to 0.91 in 2012, suggesting a decreasing trend of absorbing particles being released into the atmosphere. Optical properties and radiative impacts of the absorbing particles can be used to improve the accuracy of inversion algorithms for satellite-based aerosol retrievals in the PRD region and to better constrain the climate effect of aerosols in climate models. | Boru MAI Xuejiao DENG Zhanqing LI Jianjun LIU Xiang'ao XIA Huizheng CHE Xia LIU Fei LI Yu ZOU Maureen CRIBB | 2018 | Advances in Atmospheric Sciences2018，35，2： | 1 |
| 19 | Evaluating the performance and influencing factors of three portable black carbon monitors for field measurement显示文摘Black carbon(BC)is associated with adverse human health and climate change.Mapping BC spatial distribution imperatively requires low-cost and portable devices.Several portable BC monitors are commercially available,but their accuracy and reliability are not always satisfactory during continuous field observation.This study evaluated three models of portable black carbon monitors,C12,MA350 and DST,and investigates the factors that affect their performance.The monitors were tested in urban Beijing,where portable devices running for one month alongside a regular-size reference aethalometer AE33.The study considers several factors that could influence the monitors'performance,including ambient weather,aerosol composition,loading artifacts,and built-in algorithms.The results show that MA350and DST present considerable discrepancies to the reference instrument,mainly occurring at lower concentrations(0-500 ng/m^(3))and higher concentrations(2500-8000 ng/m^(3)),respectively.These discrepancies were likely caused by the anomalous noise of MA350 and the loading artifacts of DST.The study also suggests that the ambient environment has limited influence on the monitors'performance,but loading artifacts and accompanying compensation algorithms can result in unrealistic data.Based on the evaluation,the study suggests that C12 is the best choice for unsupervised field measurement,DST should be used in scenarios where frequent maintenance is available,and MA350 is suitable for research purposes with post-processing applicable.The study highlights the importance of assigning portable BC monitors to appropriate applications and the need for optimized real-time compensation algorithms. | Liqing Wu Yicheng Shen Fei Che Yuzhe Zhang Jian Gao Chong Wang | 2024 | Journal of Environmental Sciences2024，，5： | 0 |
| 20 | Molecular phylogeny found the distribution of Bungarus candidus in China(Squamata: Elapidae)显示文摘Based on molecular phylogeny of the Chinese white cross-band krait, Bungarus multicinctus, several individuals from southwestern and southern China were found to be nested within putative species B. candidus(Linnaeus, 1758) with high support values. Morphological examination also indicated these specimens were identical to B. candidus. We concluded that the Chinese white cross-band krait, previously identified as B. multicinctus in southwest and south China, should be recognized as B. candidus, a new record in China, and B. m. wanghaoti should be invalid. B. multicinctus is recurrently limited to southern China within China. | Yulin Xie Ping Wang Guanghui Zhong Fei Zhu Qin Liu Jing Che Lei Shi Robert W. Murphy Peng Guo | 2018 | Zoological Systematics2018，43，1： | 0 |
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