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| 1 | ATF4 regulates lipid metabolism and thermogenesis显示文摘(ATF4 ) 激活抄写因素 4 被显示了在许多生理的过程起关键作用。然而,没有报告表明在 ATF4 和类脂化合物新陈代谢之间的一个直接连接。我们注意到 Atf4 缺乏的老鼠是瘦的,建议为在调整类脂化合物新陈代谢的 ATF4 的一个可能的角色。我们的当前的学习的目标是在类脂化合物新陈代谢调查 ATF4 的参与并且阐明内在的机制。用 Atf4 缺乏的老鼠的研究揭示了增加的精力开销,由氧消费测量了。这些鼠标也显示出增加在分解,解开的表示蛋白质 2 (UCP2 ) 并且在在白脂肪质的织物(WAT ) 的 lipogenic 基因的表示的尾 - 氧化基因和减少,建议增加的利用和丰满的酸的减少的合成分别地。UCP1 的表示, 2 和 3 也在棕色的脂肪质的织物(蝙蝠) 被增加,建议增加了生热作用。在蝙蝠的 UCP 的表示上的 ATF4 删除的效果建议增加的生热作用可以位于增加的精力开销下面。因此,我们的学习在调整类脂化合物新陈代谢和生热作用为 ATF4 识别可能的新功能。 | Chunxia Wang Zhiying Huang Ying Du Ying Cheng Shanghai Chen Feifan Guo | 2010 | Cell Research2010，20，2： | 16 |
| 2 | Determination of 20(S)-protopanaxadiol in human plasma by HPLC–MS/MS:application to a pharmacokinetic study显示文摘A rapid,specific and sensitive HPLC-MS/MS method was developed and validated for the determination of 20(S)-protopanaxadiol(PPD)in human plasma.PPD and the internal standard PD were extracted from plasma by liquid-liquid extraction with cyclohexane-methylene dichloride(2:1,v/v).The separation was performed on a HyPURIYTY C18 column using methanol-5 mM ammonium formate(90:10,v/v)as mobile phase at a flow rate of 0.35 mL/min.Mass spectrometric detection was carried out by electrospray ionization(ESI)in the positive ion mode using multiple reaction monitoring(MRM).The monitored transitions were m/z 425.4-217.2 for PPD and at m/z 461.4-425.5 for PD.The method was linear over the range 0.512-100 ng/mL with a lower limit of quantification(LLOQ)of 0.512 ng/mL.The mean extraction recovery of PPD was greater than 78.2%and no significant matrix effect was detected.The intra-and inter-day precisions were less than 10%and the biases below 4%for PPD.The validated method was applied to a three-level single-dose clinical pharmacokinetics study of 12 healthy Chinese volunteers and the main pharmacokinetic parameters of PPD were obtained. | Feifan Xie Sanwang Li Zeneng Cheng Xingling Liu Hong Zhang Peijiong Li Zhi Liu Xin Guo Peng Yu | 2013 | Acta Pharmaceutica Sinica B2013，3，6： | 3 |
| 3 | BnVIR:bridging the genotype-phenotype gap to accelerate mining of candidate variations underlying agronomic traits in Brassica napus显示文摘Dear Editor,Genetic variations,which range from single nucleotide polymor-phisms(SNPs)and short insertion/deletions(InDels)to large-scale structural variations(SVs),are the basis of phenotypic diversity.Understanding the effect of genetic variations on traits is critical for uncovering the genetic architecture of various phe-notypes. | Zhiquan Yang Congyuan Liang LuLu Wei Shengbo Wang Feifan Yin Dongxu Liu Liang Guo Yongming Zhou Qing-Yong Yang | 2022 | Molecular Plant2022，15，5： | 2 |
| 4 | Branched chain amino acids and metabolic regulation显示文摘Amino acids are fundamental nutrients required for protein synthesis. The branched chain amino acids (BCAAs) leucine, isoleucine, and valine are the most abundant of the essential amino acids. BCAAs have recently been recognized as having functions in processes other than simple nutrition. For example, metabolic diseases are characterized by higher levels of circulating BCAAs. Moreover, supplementation with or deficiency in BCAAs is closely related to the regulation of metabolic homeostasis. Indeed, leucine deprivation induces increased lipolysis and thermogenesis, which result in fat loss, as well as suppressed lipogenesis and enhanced insulin sensitivity in the liver. Accumulating evidence has indicated that several amino acid sensors, including GCN2, ATF4, mTOR, and AMPK, play pivotal roles in the regulation of lipid metabolism, glucose metabolism, and energy homeostasis. Furthermore, the hypothalamus is critical for sensing amino acid levels and mediates the metabolic adaptation of the body upon limitation of essential amino acids (EAAs) through regulating expression of the S6K1, MC4R, and CRH. In this review, we highlight recent studies investigating the cellular mechanisms linking amino acids, amino acid sensors, metabolic regulation, and metabolic diseases. Amino acid sensing and metabolic regulation have become research hotspots in the metabolic field. | WANG ChunXia GUO FeiFan | 2013 | Chinese Science Bulletin2013，58，11： | 2 |
| 5 | Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice显示文摘 | Fei Xiao Junjie Yu Yajie Guo Jiali Deng Kai Li Ying Du Shanghai Chen Jianmin Zhu Hongguang Sheng Feifan Guo | 2014 | Metabolism2014，，： | 1 |
| 6 | Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo 显示文摘 | Feifan Guo Keren Bakal | 2004 | Endocrine Society2004，145，5： | 1 |
| 7 | Amygdala, an important regulator for food intake显示文摘Amygdala plays a critical role in the regulation of emotional behavior and food intake.Neuropeptides are short chains of amino acids secreted by neurons as intercellular messengers,which regulate different functions such as emotion,food intake,learning and memory.In this review,we summarize the recent progress on the regulation of food intake by amygadala,which is mediated by those neuropeptides known to be critical in the regulation of this process. | Qian ZHANG Houkai LI Feifan GUO | 2011 | Frontiers in Biology2011，6，1： | 0 |
| 8 | An ERA5 tropospheric parameters-augmented approach for improving GNSS precise point positioning显示文摘Precise Point Positioning(PPP) technology has developed into a potent instrument for geodetic positioning, ionospheric modeling, tropospheric atmospheric parameter detection, and seismic monitoring.As atmospheric reanalysis data products’ accuracy and spatiotemporal resolution have improved recently, it has become important to apply these products to obtain high-accuracy tropospheric delay parameters, like zenith tropospheric delay(ZTD) and tropospheric horizontal gradient. These tropospheric delay parameters can be applied to PPP to reduce the convergence time and to increase the accuracy in the vertical direction of the position. The European Centre for Medium-Range Weather Forecasts Reanalysis 5(ERA5) atmospheric reanalysis data is the latest product with a high spatiotemporal resolution released by the European Center for Medium-Range Weather Forecasts(ECMWF). Only a few researches have evaluated the application of ERA5 data to Global Navigation Satellite System(GNSS)PPP. Therefore, this study compared and validated the ZTD products derived from ERA5 data using ZTD values provided by 290 global International GNSS Service(IGS) stations for 2016-2017. The results indicated a stable performance for ZTD, with annual average bias and RMS values of 0.23 cm and 1.09 cm,respectively. Further, GNSS observations for one week in each of the four seasons(spring: DOY 92-98;summer: DOY 199-205;autumn: DOY 275-281;and winter: DOY 22-28) from 34 multi-GNSS experiments(MGEX) stations distributed globally in 2016 were considered to evaluate the performance of ERA5-derived tropospheric delay products in GNSS PPP. The performance of ERA5-enhanced PPP was compared with that of the two standard GNSS PPP schemes(without estimated tropospheric horizontal gradient and with estimated tropospheric horizontal gradient). The results demonstrated that ERA5-enhanced GNSS PPP showed no significant improvement in the convergence times in both the Eastern(E) and Northern(N) directions, while the average convergence time over four weeks in the vertical(U)direction improved by 53.3% and 52.7%, respectively(in the case of pngm station). The average convergence times for each week in the U direction of the northern and southern hemisphere stations indicated a decrease of 16.3%, 12.6%, 9.6%, and 9.1%, and 16.9%, 9.6%, 8.9%, and 14.5%, respectively.Regarding positioning accuracy, ERA5-enhanced PPP showed an improvement of 13.3% and 16.2% over the two standard PPP schemes in the U direction, respectively. No significant improvement in the positioning performance was observed in both the E and N directions. Thus, this study demonstrated the potential application of the ERA5 tropospheric parameters-augmented approach to Beidou navigation and positioning. | Liangke Huang Feifan Liu Lijie Guo Guiwen Lan Lv Zhou Cheng Wang Lilong Liu | 2023 | Geodesy and Geodynamics2023，14，5： | 0 |
| 9 | Leucine deprivation results in antidepressant effects via GCN2 in AgRP neurons显示文摘Essential amino acids(EAAs)are crucial nutrients,whose levels change in rodents and patients with depression.However,how the levels of a single EAA affects depressive behaviors remains elusive.Here,we demonstrate that although deprivation of the EAA leucine has no effect in unstressed mice,it remarkably reverses the depression-like behaviors induced by chronic restraint stress(CRS).This beneficial effect is independent of feeding and is applicable to the dietary deficiency of other EAAs.Furthermore,the effect of leucine deprivation is suppressed by central injection of leucine or mimicked by central injection of leucinol.Moreover,hypothalamic agouti-related peptide(AgRP)neural activity changes during CRS and leucine deprivation,and chemogenetically inhibiting AgRP neurons eliminates the antidepressant effects of leucine deprivation.Finally,the leucine deprivation-regulated behavioral effects are mediated by amino acid sensor general control non-derepressible 2(GCN2)in AgRP neurons.Taken together,our results suggest a new drug target and/or dietary intervention for the reduction of depressive symptoms. | Feixiang Yuan Shangming Wu Ziheng Zhou Fuxin Jiao Hanrui Yin Yuguo Niu Haizhou Jiang Shanghai Chen Feifan Guo | 2023 | Life Metabolism2023，2，1： | 0 |
| 10 | Oocyte TET3: an epigenetic modifier responsible for maternal inheritance of glucose intolerance显示文摘In a recent paper published in Nature,Chen et al.provide a new perspective on how glucose tolerance of the offspring is affected by pregestational hyperglycaemia.1 They showed that oocytes isolated from hyperglycemic mice transmit the impaired glucose homeostasis to the offspring via epigenetic modifications,and insufficiency of oocyte TET3 dioxygenase is indispensable for this process. | Xiaoxue Jiang Fei Xiao Feifan Guo | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
| 11 | Functional Autapses Form in Striatal Parvalbumin Interneurons but not Medium Spiny Projection Neurons显示文摘Autapses selectively form in specific cell types in many brain regions.Previous studies have also found putative autapses in principal spiny projection neurons(SPNs)in the striatum.However,it remains unclear whether these neurons indeed form physiologically functional autapses.We applied whole-cell recording in striatal slices and identified autaptic cells by the occurrence of prolonged asynchronous release(AR)of neurotransmitters after bursts of high-frequency action potentials(APs).Surprisingly,we found no autaptic AR in SPNs,even in the presence of Sr^(2+).However,robust autaptic AR was recorded in parvalbumin(PV)-expressing neurons.The autaptic responses were mediated by GABA_(A) receptors and their strength was dependent on AP frequency and number.Further computer simulations suggest that autapses regulate spiking activity in PV cells by providing self-inhibition and thus shape network oscillations.Together,our results indicate that PV neurons,but not SPNs,form functional autapses,which may play important roles in striatal functions. | Xuan Wang Zhenfeng Shu Quansheng He Xiaowen Zhang Luozheng Li Xiaoxue Zhang Liang Li Yujie Xiao Bo Peng Feifan Guo Da-Hui Wang Yousheng Shu | 2023 | Neuroscience Bulletin2023，39，4： | 0 |
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