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| 1 | Emergence and prevalence of naturally occurring lower virulent African swine fever viruses in domestic pigs in China in 2020显示文摘African swine fever virus(ASFV)has been circulating in China for more than two years,and it is not clear whether the biological properties of the virus have changed.Here,we report on our surveillance of ASFVs in seven provinces of China,from June to December,2020.A total of 22 viruses were isolated and characterized as genotype II ASFVs,with mutations,deletions,insertions,or short-fragment replacement occurring in all isolates compared with Pig/HLJ/2018(HLJ/18),the earliest isolate in China.Eleven isolates had four different types of natural mutations or deletion in the EP402R gene and displayed a nonhemadsorbing(non-HAD)phenotype.Four isolates were tested for virulence in pigs;two were found to be as highly lethal as HLJ/18.However,two non-HAD isolates showed lower virulence but were highly transmissible;infection with 106 TCID50 dose was partially lethal and caused acute or sub-acute disease,whereas 103 TCID50 dose caused non-lethal,sub-acute or chronic disease,and persistent infection.The emergence of lower virulent natural mutants brings greater difficulty to the early diagnosis of ASF and creates new challenges for ASFV control. | Encheng Sun Zhenjiang Zhang Zilong Wang Xijun He Xianfeng Zhang Lulu Wang Wenqing Wang Lianyu Huang Fei Xi Haoyue Huangfu Ghebremedhin Tsegay Hong Huo Jianhong Sun Zhijun Tian Wei Xia Xuewu Yu Fang Li Renqiang Liu Yuntao Guan Dongming Zhao Zhigao Bu | 2021 | Science China(Life Sciences)2021，64，5： | 46 |
| 2 | Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters显示文摘Since metabolic process differs between humans and mice, studies were performed in hamsters, which are generally considered to be a more appropriate animal model for studies of obesityrelated metabolic disorders. The modulation of gut microbiota, bile acids and the farnesoid X receptor(FXR) axis is correlated with obesity-induced insulin resistance and hepatic steatosis in mice. However,the interactions among the gut microbiota, bile acids and FXR in metabolic disorders remained largely unexplored in hamsters. In the current study, hamsters fed a 60% high-fat diet(HFD) were administeredvehicle or an antibiotic cocktail by gavage twice a week for four weeks. Antibiotic treatment alleviated HFD-induced glucose intolerance, hepatic steatosis and inflammation accompanied with decreased hepatic lipogenesis and elevated thermogenesis in subcutaneous white adipose tissue(sWAT). In the livers of antibiotic-treated hamsters, cytochrome P450 family 7 subfamily B member 1(CYP7 B1) in the alternative bile acid synthesis pathway was upregulated, contributing to a more hydrophilic bile acid profile with increased tauro-β-muricholic acid(TβMCA). The intestinal FXR signaling was suppressed but remained unchanged in the liver. This study is of potential translational significance in determining the role of gut microbiota-mediated bile acid metabolism in modulating diet-induced glucose intolerance and hepatic steatosis in the hamster. | Lulu Sun Yuanyuan Pang Xuemei Wang Qing Wu Huiying Liu Bo Liu George Liu Min Ye Wei Kong Changtao Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 29 |
| 3 | Machine learning for pore-water pressure time-series prediction:Application of recurrent neural networks显示文摘Knowledge of pore-water pressure(PWP)variation is fundamental for slope stability.A precise prediction of PWP is difficult due to complex physical mechanisms and in situ natural variability.To explore the applicability and advantages of recurrent neural networks(RNNs)on PWP prediction,three variants of RNNs,i.e.,standard RNN,long short-term memory(LSTM)and gated recurrent unit(GRU)are adopted and compared with a traditional static artificial neural network(ANN),i.e.,multi-layer perceptron(MLP).Measurements of rainfall and PWP of representative piezometers from a fully instrumented natural slope in Hong Kong are used to establish the prediction models.The coefficient of determination(R^2)and root mean square error(RMSE)are used for model evaluations.The influence of input time series length on the model performance is investigated.The results reveal that MLP can provide acceptable performance but is not robust.The uncertainty bounds of RMSE of the MLP model range from 0.24 kPa to 1.12 k Pa for the selected two piezometers.The standard RNN can perform better but the robustness is slightly affected when there are significant time lags between PWP changes and rainfall.The GRU and LSTM models can provide more precise and robust predictions than the standard RNN.The effects of the hidden layer structure and the dropout technique are investigated.The single-layer GRU is accurate enough for PWP prediction,whereas a double-layer GRU brings extra time cost with little accuracy improvement.The dropout technique is essential to overfitting prevention and improvement of accuracy. | Xin Wei Lulu Zhang Hao-Qing Yang Limin Zhang Yang-Ping Yao | 2021 | Geoscience Frontiers2021，12，1： | 12 |
| 4 | Synthesis, mechanical investigation, and application of nitrogen and phosphorus co-doped carbon dots with a high photoluminescent quantum yield显示文摘有高 photoluminescent 量收益(PLQY ) 的做 Heteroatom 的碳点(CD ) 最近在化学传感器,光催化, bioimaging,和药交货中由于他们的应用吸引了注意。氮和磷在到在周期表的碳的靠近的最近并且是关键的在生物医学的成像的地里追踪元素。这二个元素改变 CD 的光、电子的性质并且帮助改进他们的 PLQY 的基本理解。这能也在 photoimaging 和 photothermal 治疗导致多功能的用法。然而,源于做 P 的 CD 的合成的大多数 PLQY 当前低于 50% 。这些 CD 在 bioimaging 和药交货的地里限制了实用性。在这研究,一个单个步的、高效率的热水的方法被使用综合氮和磷药的碳点((N, P ) 有有独立排放的多达 53.8% 的 PLQY 的 -CDs) 行为。而且, CD 在一个大 pH 范围上介绍了高 monodispersity,柔韧的刺激无关的光,和稳定性。分光镜的调查显示 PLQY (N, P ) CD 主要由于 P 的增加和氧化表面的钝化效果。优秀荧光性质(N, P ) CD 能被 Hg 2+ 离子有效地并且有选择地熄灭。如此的系统与一短反应时间在 0-900 nM 集中范围显示出线性回答,显示他们为化学和生物学的领域里的应用程序的潜力。 | Quan Xu Bofan Li Yingchun Ye Wei Cai Weijun Li Chuanyao Yang Yusheng Chen Meng Xu Neng Li Xusheng Zheng Jason Street Yan Luo Lulu Cai | 2018 | Nano Research2018，11，7： | 7 |
| 5 | Influence of pre-tension on ballistic impact performance of multi-layer Kevlar 49 woven fabrics for gas turbine engine containment systems显示文摘In this paper, ballistic impact tests on wrapped multi-layer Kevlar 49 woven fabric systems were carried out with a flat blade projectile to investigate the impact response during a fan blade out event. The influences of the number of Kevlar layers and pre-tension were discussed particularly. Test results were used to analyze failure modes and energy absorption characteristics of multi-ply Kevlar fabrics. Results show that there are two kinds of impact damage for fabrics: global deformation mainly involving stretching of yarns in the impact region and fabric wrinkle from both sides to the impact zone, and local damage characterized by yarn fracture, yarn pull-out, and yarn unraveling. The energy absorption capability of Kevlar 49 woven fabrics improves with the number of fabric layers. The energy absorbed by multi-layer fabrics increases slightly at the beginning and then decreases substantially with pre-tension. The work in this paper can provide guidance for designing light-weight multi-layer fabrics containment systems. | Lulu LIU Zhenhua ZHAO Wei CHEN Gang LUO | 2018 | Chinese Journal of Aeronautics2018，31，6： | 7 |
| 6 | Red/orange dual-emissive carbon dots for pH sensing and cell imaging显示文摘The dual-emissive N,S co-doped carbon dots (N,S-CDs) with a long emission wavelength were synthesized via solvothermal method.The N,S-CDs possess relatively high photoluminescence (PL) quantum yield (QY) (35.7%) towards near-infrared fluorescent peak up to 648 nm.With the advanced characterization techniques including X-ray photoelectron spectroscopy (XPS),Fourier transform infrared spectroscopy (FTIR),etc.It is found that the doped N,S elements play an important role in the formation of high QY CDs.The N,S-CDs exist distinct pH-sensitive feature with reversible fluorescence in a good linear relationship with pH values in the range of 1.0-13.0.What is more,N,S-CDs can be used as an ultrasensitive Ag+ probe sensor with the resolution up to 0.4 μM.This finding will expand the application of as prepared N,S-CDs in sensing and environmental fields. | Miaoran Zhang Rigu Su Jian Zhong Ling Fei Wei Cai Qingwen Guan Weijun Li Neng Li Yusheng Chen Lulu Cai Quan Xu | 2019 | Nano Research2019，12，4： | 6 |
| 7 | Ridge subduction, magmatism, and metallogenesis显示文摘Modern oceans contain large bathymetric highs(spreading oceanic ridges,aseismic ridges or oceanic plateaus and inactive arc ridges)that,in total,constitute more than 20–30%of the total area of the world’s ocean floor.These bathymetric highs may be subducted,and such processes are commonly referred to as ridge subduction.Such ridge subduction events are not only very common and important geodynamic processes in modern oceanic plate tectonics,they also play an important role in the generation of arc magmatism,material recycling,the growth and evolution of continental crust,the deformation and modification of the overlying plates,and metallogenesis at convergent plate boundaries.Therefore,these events have attracted widespread attention.The perpendicular or high-angle subduction of mid-ocean spreading ridges is commonly characterized by the occurrence of a slab window,and the formation of a distinctive adakite–high-Mg andesite–Nb-enriched basalt-oceanic island basalt(OIB)or a mid-oceanic ridge basalt(MORB)-type rock suite,and is closely associated with Au mineralization.Aseismic ridges or oceanic plateaus are traditionally considered to be difficult to subduct,to typically collide with arcs or continents or to induce flat subduction(low angle of less than 10°)due to the thickness of their underlying normal oceanic crust(>6–7 km)and high topography.However,the subduction of aseismic ridges and oceanic plateaus occurred on both the western and eastern sides of the Pacific Ocean during the Cenozoic.On the eastern side of the Pacific Ocean,aseismic ridges or oceanic plateaus are being subducted flatly or at low angles beneath South and Central American continents,which may cause a magmatic gap.But slab melting can occur and adakites,or an adakite–high-Mg andesite–adakitic andesite–Nb-enriched basalt suite may be formed during the slab rollback or tearing.Cu-Au mineralization is commonly associated with such flat subduction events.On the western side of the Pacific Ocean,however,aseismic ridges and oceanic plateaus are subducted at relatively high angles(>30°).These subduction processes can generate large scale eruptions of basalts,basaltic andesites and andesites,which may be derived from fractional crystallization of magmas originating from the subduction zone fluid-metasomatized mantle wedge.In addition,some inactive arc ridges are subducted beneath Southwest Japan,and these subduction processes are commonly associated with the production of basalts,high-Mg andesites and adakites and Au mineralization.Besides magmatism and Cu-Au mineralization,ridge subduction may also trigger subduction erosion in subduction zones.Future frontiers of research will include characterizing the spatial and temporal patterns of ridge subduction events,clarifying the associated geodynamic mechanisms,quantifying subduction zone material recycling,establishing the associated deep crustal and mantle events that generate or influence magmatism and Cu-Au mineralization,establishing criteria to recognize pre-Cenozoic ridge subduction,the onset of modernstyle plate tectonics and the growth mechanisms for Archean continental crust. | Qiang WANG Gongjian TANG Lulu HAO Derek WYMAN Lin MA Wei DAN Xiuzheng ZHANG Jinheng LIU Tongyu HUANG Chuanbing XU | 2020 | Science China Earth Sciences2020，63，10： | 3 |
| 8 | Adakitic rocks at convergent plate boundaries:Compositions and petrogenesis显示文摘Adakitic rocks are intermediate-acid magmatic rocks characterized by enrichment in light rare-earth elements,depletion in heavy rare-earth elements,positive to negligible Eu and Sr anomalies,and high La/Yb and Sr/Y ratios.Cenozoic adakitic rocks generated by partial melting of subducted oceanic crust(slab)under eclogite-facies conditions(i.e.,the original definition of“adakite”)occur mainly in Pacific Rim volcanic arcs(intra-oceanic,continental,and continental-margin island arcs),whereas those generated by partial melting of thickened lower crust occur mainly in Tethyan Tibetan collisional orogens.In volcanic arcs,adakitic melts derived from the melting of subducted oceanic crust metasomatize the mantle wedge to form a unique rock suite comprising adakite-adakite-type high-Mg andesite-Piip-type high-Mg andesite-Nb-rich basalt-boninite.This suite differs from the basalt-andesite-dacite-rhyolite suite formed from mantle wedge metasomatized by fluids derived from subducted oceanic crust.Previously published data indicate that partial melting of mafic rocks can generate adakitic magmas under pressure,temperature,and hydrous conditions of 1.2-3.0 GPa,800-1000℃,and 1.5-6.0 wt.%H_(2)O,respectively,leaving residual minerals of garnet and rutile with little or no plagioclase.Cenozoic Au and Cu deposits occur proximally to adakitic rocks,with host rocks of some deposits actually being adakitic rocks.Adakitic rocks thus have important implications for both deep-Earth dynamics and Cu-Au mineralization/exploration.Although studies of Cenozoic adakitic rocks have made many important advances,there remain weaknesses in some important areas such as their tectonic settings,petrogenesis,magma sources,melt-mantle interactions of pre-Cenozoic adakitic rocks,and their relationship with the onset of plate tectonics and crustal growth.Future research directions are likely to involve(1)the generation of adakitic magmas by experimental simulations of partial melting of different types of rock(including intermediate-acid rocks)and magma fractional crystallization at different temperatures and pressures,(2)the relationship between magma reservoir evolution and the formation of adakitic rocks,(3)the tectonic setting and petrogenesis of pre-Cenozoic adakitic rocks and related geodynamic processes,(4)interactions between slab melts and the mantle wedge,(5)the formation of Archean adakitic tonalite-trondhjemite-granodiorite and its link to the onset of plate tectonics and crustal growth,and(6)the relationship between the formation of adakitic rocks and metal mineralization in different tectonic settings. | Qiang Wang Lulu Hao Xiuzheng Zhang Jinsheng Zhou Jun Wang Qiwei Li Lin Ma Long Zhang Yue Qi Gongjian Tang Wei Dan Jingjing Fan | 2020 | Science China Earth Sciences2020，63，12： | 3 |
| 9 | Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events显示文摘The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants.Ongoing concerns of emergent variants include possible recombinants,as genome recombination is an important evolutionary mechanism for the emergence and re-emergence of human viral pathogens.In this study,we identified diverse recombination events between two Omicron major subvariants(BA.1 and BA.2)and other variants of concern(VOCs)and variants of interest(VOIs),suggesting that co-infection and subsequent genome recombination play important roles in the ongoing evolution of SARS-CoV-2.Through scanning high-quality completed Omicron spike gene sequences. | Junxian Ou Wendong Lan Xiaowei Wu Tie Zhao Biyan Duan Peipei Yang Yi Ren Lulu Quan Wei Zhao Donald Seto James Chodosh Zhen Luo Jianguo Wu Qiwei Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 3 |
| 10 | Benzo[a]pyrene stimulates miR-650 expression to promote the pathogenesis of fatty liver disease and hepatocellular carcinoma via SOCS3/JAK/STAT3 cascades显示文摘Modern diets,which often feature high levels of fat and charcoal-grilled meat,contribute to the pathogenesis of obesity and non-alcoholic fatty liver disease(NAFLD),resulting in liver cancer progression.Benzo(a)pyrene(B[a]P)is a common environ-mental and foodborne pollutant found in smoke and fire-grilled foods,which can have an adverse effect on human health.Hepatocellular carcinoma(HCC)is the fifth leading cause of cancer and the second leading cause of cancer-related deaths worldwide.The epidemiological studies suggest that both environmental risk factors and chronic liver injury including NAFL are important for HCC development,but the precise mechanisms linking eating habits to hepato-carcinogenesis remain unclear.In the present study,we demonstrated that various miRNAs in B[a]P-exposed tumor cells contribute to tumor metastasis,among which miR-650 could be the most potent inducer.Furthermore,we found that the suppressor of cytokine signaling 3(SOCS3)is directly regulated by miR-650 and its suppression regulates the activation of the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3)cascade.Our findings reveal a possible adverse outcome pathway of SOCS3/JAK/STAT3 regulation in B[a]P-induced HCC progress.These results provide a better understanding of the adverse effects of chronic exposure to B[a]P on human health. | Yang Ge Pengfei Gu Wenbo Wang Liyuan Cao Lulu Zhang Jingquan Li Wei Mu Hui Wang | 2021 | Journal of Molecular Cell Biology2021，13，8： | 3 |
| 11 | Effects of Aqueous Extract of Plumbago zeylanica L. in the Reversal of DMN-induced Hepatic Fibrosis in Rat显示文摘[Objectives] This study was conducted to evaluate the action of the aqueous extract of a medicinal plant Plumbago zeylanica L. in the reversal of dimethylnitrosamine( DMN)-induced hepatic fibrosis in rats,and to provide a scientific basis for the utilization of P. zeylanica in treatment of hepatic fibrosis. [Methods] Hepatic fibrosis in rats was induced by intraperitoneal injection of DMN. The rats were then given the aqueous extract of P. zeylanica at high,medium or low concentration by gavage for five weeks. Serum level of alanine aminotransferase( ALT) was determined by lactate dehydrogenase( LDH)-release assay,and serum level of aspartate transaminase( AST) was measured by UV-malate dehydrogenase( MDH) assay. Serum levels of total bilirubin( TBIL),direct bilirubin( DBIL)and indirect bilirubin( IBIL) were measured by vanadate oxidation assay. Four indices of hepatic fibrosis( hyaluronic acid,laminin,procollagen type Ⅲ and collagen type IV) were determined by radioimmunoassay( RIA) assay. Morphological damage of liver tissue was observed by hematoxylin-eosin staining( H&E staining). Immunohistochemical staining was performed to determine the location and area of deposited collagen type I,collagen type Ⅲ and α-smooth muscle actin( α-SMA) in liver tissue. [Results]Compared with the negative control( rats with diseased liver and untreated with P. zeylanica aqueous extract),the serum levels of ALT,AST,TBIL,DBIL and IBIL were significantly decreased by P. zeylanica aqueous extract; the levels of the four serum indices of hepatic fibrosis were also obviously reduced. H&E staining showed that hepatic fibrosis in rats was obviously inhibited or even reversed by P. zeylanica aqueous extract. Immunohistochemical staining proved that the aqueous extract of P. zeylanica significantly reduced the area and coloration of collagen type I,collagen type Ⅲ and α-SMA in rat liver. [Conclusions] The aqueous extract of P. zeylanica has a definite effect in reversal of DMN-induced hepatic fibrosis in rat by promoting the recovery of liver function,reversal of histopathological changes and reducing fibrotic collagen. | Yue PENG Xuelin DUAN Tiejian ZHAO Yanfei WEI Guiyu LI Lulu LIU | 2017 | Agricultural Biotechnology2017，6，3： | 3 |
| 12 | The 2-axis stress component decoupling of {100} c-Si by using oblique backscattering micro-Raman spectroscopy显示文摘With the application of strain engineering in microelectronics,complex stress states are introduced into advanced semiconductor devices.However,there is still a lack of effective metrology for the decoupling analysis of the complex stress states in semiconductor materials.This paper presents an investigation on the 2-axis stress component decoupling of{100}monocrystalline silicon(c-Si)by using oblique backscattering micro-Raman spectroscopy.A spectral-mechanical model was established,and two practicable methods for actual stress decoupling analyses were proposed.The verification experiments demonstrated the correctness and applicability of the methods proposed in this paper. | DongHui Fu XiaoYong He LuLu Ma HuaDan Xing Tian Meng Ying Chang Wei Qiu | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，9： | 2 |
| 13 | CSN6 promotes tumorigenesis of gastric cancer by ubiquitin-independent proteasomal degradation of p16INK4a显示文摘Objective: CSN6 is a vital subunit of the constitutive photomorphogenesis 9(COP9) signalosome(CSN), which is responsible for development disorders and promotes ubiquitin-26 S proteasome-dependent degradation in vitro and vivo.Its role in the tumor development of gastric cancer remains unclear.In this study, we investigated the role of CSN6 in gastric cancer progression.Methods: Human gastric cancer samples were collected and immunohistochemistry was performed to identify the role of CSN6 in gastric cancer.The cell proliferation was measured by CCK-8 and the EdU incorporation method.Immunofluorescence localization and a co-immunoprecipitation study were used to show the interaction between the protein CSN6 and p16.Ubiquitination assay was performed to validate whether ubiquitination is involved in CSN6-mediated p16 degradation.BALB/c nude mice were used to produce a tumor model in order to test the effect of CSN6 on cancer growth in vivo.Results: CSN6 expression was dramatically increased in gastric cancer tissues compared with paired adjacent non-tumor tissues and CSN6 was correlated with worse overall and disease-specific survival.Additionally, we also found that CSN6 downregulated p16 protein expression, thereby promoting gastric cancer cell growth and proliferation.Moreover, CSN6 interacted with p16 and a proteasome activator REGγ(PA28γ), thereby facilitating ubiquitin-independent degradation of p16.Conclusions: CSN6 promoted the loss of p16-mediated tumor progression and played an important role in regulating ubiquitin-independent proteasomal degradation of p16. | Wenqi Du Zongxiang Liu Wentao Zhu Tongtong Li Zhiman Zhu Lulu Wei Jun Song Dongsheng Pei | 2019 | Cancer Biology & Medicine2019，16，3： | 2 |
| 14 | Synthesis of Magnetically Modified Fe-Al Pillared Bentonite and Heterogeneous Fenton-like Degradation of Orange II显示文摘Magnetically modified Fe-Al pillared bentonite(Fe3O4/ Fe-Al-Bent) was prepared via chemical co-precipitation method and characterized by powder X-ray diffraction(XRD), Brunauer-EmmettTeller(BET), Fourier transform infrared spectroscopy(FTIR) and scanning electron microscopy(SEM). A series of experiments were carried out to investigate the degradation of Orange II by the obtained heterogeneous catalysts in the presence of H2O2. The experimental result indicated that the synthetic materials had a high catalytic activity and good reusability. | 陈坤 WANG Guanghua 李文兵 WAN Dong HU Qin LU Lulu WEI Xiaobi CHENG Zhengzai | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，2： | 2 |
| 15 | Enhancing low-temperature NH_(3)-SCR performance of Fe-Mn/CeO_(2)catalyst by Al_(2)O_(3)modification显示文摘In the work,supported catalysts of FeO_(x) and MnO_(x) co-supported on aluminum-modified CeO_(2)was synthesized for low-temperature NH_(3)-selective catalytic reduction(NH_(3)-SCR)of NO.Impressively,the SCR activity of the obtained catalyst is markedly influenced by the adding amount of Al and the appropriate Ce/Al molar ratio is 1/2.The activity tests demonstrate that Fe-Mn/Ce1 Al2 catalyst shows over 90%NO conversion at 75-250℃and exhibits better SO_(2)resistance compared to Fe-Mn/CeO_(2).Fe-Mn/Ce1 Al2 shows the expected physicochemical characters of the ideal catalyst including the larger surface and increased active reaction active sites by controlling the amount of Al doping.Also,the better catalytic activity is well correlated with the present advantaged surface adsorption oxygen species,Mn^(4+)species,Ce^(3+)species and the enhanced reducibility of Fe-Mn/Ce1 Al2,which is superior to the Fe-Mn/CeO_(2)catalyst.More importantly,we further demonstrate that the amount and strength of surface acid sites are improved by Al-doping and more active intermediates(monodentate nitrate)is generated during NH_(3)-SCR reaction.This work provides certain insight into the rational creation of simple and practical denitration catalyst environmental purification. | Lulu Li Jiawei Ji Wei Tan Wang Song Xin Wang Xiaoqian Wei Kai Guo Wanyu Zhang Changjin Tang Lin Dong | 2022 | Journal of Rare Earths2022，40，9： | 2 |
| 16 | Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis显示文摘Dear Editor Cardiovascular disease(CVD)is the leading cause of death around the world(Truelsen,et al.,2015).Atherosclerosis,the dominant underlying cause of CVD,is a chronic inflam-matory disease characterized by lipid accumulation and immune cell infiltration in plaques and vessels(Weber,et al.,1950).The immune microenvironment is critical for the development of atherosclerosis.Homocysteine(Hcy)is an intermediate product of methionine metabolism,and its ele-vation in plasma(>15μmol/L),known as hyperhomocys-teinemia(HHcy),is an independent risk factor for atherosclerosis.HHcy is more common in Asia because of genetic factors and dietary habits(Huo,et al.,2015).folic acid supplement is one of the most important way to treat HHcy in clinic.Although HHcy potentiates atherosclerosis mainly through endothelial injury and inflammatory activa-tion(Luo,et al.,2016),a comprehensive understanding of the immune microenvironment and potential mechanisms in HHcy-accelerated atherosclerotic aortas(HHcy-AA)is still lacking. | Xiaolong Ma Jiacheng Deng Lulu Han Yuwei Song Yutong Miao Xing Du Guohui Dang Dongmin Yang Bitao Zhong Changtao Jiang Wei Kong Qingbo Xu Juan Feng Xian Wang | 2022 | Protein & Cell2022，13，7： | 2 |
| 17 | Core clock component MtLUX controls shoot architecture through repression of MtTB1/MtTCP1A in Medicago truncatula显示文摘Plants are capable of regulating their shoot architecture in response to diverse internal and external environments.The circadian clock is an adaptive mechanism that integrates information from internal and ambient conditions to help plants cope with recurring environmental fluctuations.Despite the current understanding of plant circadian clock and genetic framework underlying plant shoot architecture,the intricate connection between these two adaptive mechanisms remains largely unclear.In this study,we elucidated how the core clock gene LUX ARRHYTHMO(LUX)regulates shoot architecture in the model legume plant Medicago truncatula.We show that mtlux mutant displays increased main stem height,reduced lateral shoot length,and decreased the number of lateral branches and biomass yield.Gene expression analysis revealed that Mt LUX regulated shoot architecture by repressing the expression of strigolactone receptor MtD14 and MtTB1/MtTCP1A,a TCP gene that functions centrally in modulating shoot architecture.In vivo and in vitro experiments showed that Mt LUX directly binds to a cis-element in the promoter of MtTB1/MtTCP1A,suggesting that Mt LUX regulates branching by rhythmically suppressing MtTB1/MtTCP1A.This work demonstrates the regulatory effect of the circadian clock on shoot architecture,offering a new understanding underlying the genetic basis towards the flexibility of plant shoot architecture. | Liping Wang Anqi Zhou Lulu Wang Jing Li Mingkang Yang Tingting Duan Jian Jin Liang Chen Liangfa Ge Wei Huang | 2023 | The Crop Journal2023，11，3： | 2 |
| 18 | B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis显示文摘Hyperhomocysteinemia(HHcy)is a risk factor for chronic kidney diseases(CKDs)that affects about 85%CKD patients.HHcy stimulates B cells to secrete pathological antibodies,although it is unknown whether this pathway mediates kidney injury.In HHcytreated 2-kidney,1-clip(2K1C)hypertensive murine model,HHcy-activated B cells secreted anti-beta 2 glycoprotein I(β2GPI)antibodies that deposited in glomerular endothelial cells(GECs),exacerbating glomerulosclerosis and reducing renal function.Mechanistically,HHcy 2K1C mice increased phosphatidylethanolamine(PE)(18:0/20:4,18:0/22:6,16:0/20:4)in kidney tissue,as determined by lipidomics.GECs oxidative lipidomics validated the increase of oxidized phospholipids upon Hcy-activated B cells culture medium(Hcy-B CM)treatment,including PE(18:0/20:4+3[O],PE(18:0a/22:4+1[O],PE(18:0/22:4+2[O]and PE(18:0/22:4+3[O]).PE synthases ethanolamine kinase 2(etnk2)and ethanolamine-phosphate cytidylyltransferase 2(pcyt2)were increased in the kidney GECs of HHcy 2K1C mice and facilitated polyunsaturated PE synthesis to act as lipid peroxidation substrates.In HHcy 2K1C mice and Hcy-B CM-treated GECs,the oxidative environment induced by iron accumulation and the insufficient clearance of lipid peroxides caused by transferrin receptor(TFR)elevation and down-regulation of SLC7A11/glutathione peroxidase 4(GPX4)contributed to GECs ferroptosis of the kidneys.In vivo,pharmacological depletion of B cells or inhibition of ferroptosis mitigated the HHcy-aggravated hypertensive renal injury.Consequently,our findings uncovered a novel mechanism by which B cell-derived pathogenic anti-β2GPI IgG generated by HHcy exacerbated hypertensive kidney damage by inducing GECs ferroptosis.Targeting B cells or ferroptosis may be viable therapeutic strategies for ameliorating lipid peroxidative renal injury in HHcy patients with hypertensive nephropathy. | Xing Du Xiaolong Ma Ying Tan Fangyu Shao Chun Li Yang Zhao Yutong Miao Lulu Han Guohui Dang Yuwei Song Dongmin Yang Zhenling Deng Yue Wang Changtao Jiang Wei Kong Juan Feng Xian Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 19 | BnVIR:bridging the genotype-phenotype gap to accelerate mining of candidate variations underlying agronomic traits in Brassica napus显示文摘Dear Editor,Genetic variations,which range from single nucleotide polymor-phisms(SNPs)and short insertion/deletions(InDels)to large-scale structural variations(SVs),are the basis of phenotypic diversity.Understanding the effect of genetic variations on traits is critical for uncovering the genetic architecture of various phe-notypes. | Zhiquan Yang Congyuan Liang LuLu Wei Shengbo Wang Feifan Yin Dongxu Liu Liang Guo Yongming Zhou Qing-Yong Yang | 2022 | Molecular Plant2022，15，5： | 2 |
| 20 | Printable Zinc‑Ion Hybrid Micro‑Capacitors for Flexible Self‑Powered Integrated Units显示文摘Wearable self-powered systems integrated with energy conversion and storage devices such as solar-charging power units arouse widespread concerns in scientific and industrial realms.However,their applications are hampered by the restrictions of unbefitting size matching between integrated modules,limited tolerance to the variation of input current,reliability,and safety issues.Herein,flexible solar-charging self-powered units based on printed Zn-ion hybrid micro-capacitor as the energy storage module is developed.Unique 3D micro-/nano-architecture of the biomass kelp-carbon combined with multivalent ion(Zn2+)storage endows the aqueous Zn-ion hybrid capacitor with high specific capacity(196.7 mAh g^−1 at 0.1 A g^−1).By employing an in-plane asymmetric printing technique,the fabricated quasi-solid-state Zn-ion hybrid microcapacitors exhibit high rate,long life and energy density up to 8.2μWh cm^−2.After integrating the micro-capacitor with organic solar cells,the derived self-powered system presents outstanding energy conversion/storage efficiency(ηoverall=17.8%),solar-charging cyclic stability(95%after 100 cycles),wide current tolerance,and good mechanical flexibility.Such portable,wearable,and green integrated units offer new insights into design of advanced self-powered systems toward the goal of developing highly safe,economic,stable,and long-life smart wearable electronics. | Juan Zeng Liubing Dong Lulu Sun Wen Wang Yinhua Zhou Lu Wei Xin Guo | 2021 | Nano-Micro Letters2021，13，1： | 2 |
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