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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Edaravone injection reverses learning and memory deficits in a rat model of vascular dementia显示文摘Edaravone 是由禁止 endothelial 损害并且由改善施加 neuroprotective 效果的新奇免费激进的 scavenger 在大脑局部缺血的 neuronal 损坏。最近, edaravone 能减轻病理和 Alzheimers 疾病病人的认知赤字,这被报导。然而,它到脉管的痴呆(VaD ) 的关联不是清楚的。在这研究,我们部分堵塞了老鼠的双边的颈动脉动脉通过手术导致长期的服的 hypoperfusion (CCH ) , VaD 的一个著名老鼠模型。水迷宫和电压降低的禁止的测试被用来评估记忆赤字。superoxide dismutase 的活动 ?( 草皮) 并且喂奶脱氢酶(LDH ) , malondialdehyde 的内容 ?(MDA ) 并且全部的反应的氧种类被测量评估氧化压力水平。西方的污点分析被用来计算 synaptic 蛋白质表达式。有为一个 5 星期的时期的 edaravone 的治疗在有 CCH 的老鼠对空间的颠倒和害怕记忆赤字有能力,这被发现。Edaravone 显著地由增加草皮活动并且减少与 CCH 在老鼠的大脑减少了氧化应力的水平 MDA, LDH,和全部的反应的氧种类的内容。而且, edaravone 处理也与 CCH 在老鼠的海马恢复了多重 synaptic 蛋白质的层次。我们的数据提供在 VaD 支持 edaravone 的 neuroprotective 效果的直接证据。我们建议氧化应力的缓和和 synaptic 蛋白质的恢复在 neuroprotection 起重要作用。 | Xu Li Fen Lu Wei Li Lingzhi Qin Yong Yao Xuerong Ge Qingkai Yu Xinliang Liang Dongmei Zhao Xiaohong Li Jiewen Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，1： | 14 |
| 3 | Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias显示文摘In early life, the immune system plays an essential role in brain development. In our study, the immunopotentiator thymosin alpha-1(Ta1) was peripherally administered to neonatal mice to explore whether the peripheral immunopotentiator affects neurodevelopment and cognition, and to further investigate the relevant mechanism. Compared with the control group, the Ta1 mice displayed better cognitive abilities in early life. The numbers of 5-bromodeoxyuridine(Brd U)+, nestin+,T-box transcription factor 2(Tbr2)+, Brd U+/doublecortin(DCX)+, Brd U+/ionized calcium-binding adaptor molecule 1(Iba1)+, and Brd U+/neuronal nuclei(Neu N)+ cells in the hippocampus were increased in the Ta1 group,accompanied by increased interleukin-4(IL-4), interferon-gamma, brain-derived neurotrophic factor, nerve growth factor, and insulin-like growth factor-1 as well as decreased IL-6 and tumor necrosis factor-a. Furthermore, the Ta1-group showed a Th1-polarized immune response, and the neurotrophic factors were positively associated with the Th1/Th2 ratio. More importantly, administration of Ta1 blocked lipopolysaccharide-induced impairment of hippocampal neurogenesis in early life. These findings suggest that peripheral Ta1 contributes to neurogenesis and cognition probably through a systemic Th1 bias, as well as neuroprotection against LPS infection by Ta1. | Ge Wang Fen He Yunlong Xu Yuwei Zhang Xiao Wang Chunhua Zhou Yihong Huang Juntao Zou | 2017 | Neuroscience Bulletin2017，33，6： | 8 |
| 4 | Genetic Algorithm Based Mapping and Routing Approach for Network on Chip Architectures显示文摘 | GE Fen WU Ning | 2010 | Chinese Journal of Electronics2010，19，1： | 5 |
| 5 | Clinical correlation of B7-H3 and B3GALT4 with the prognosis of colorectal cancer显示文摘AIM To investigate the expression and clinical significance of B7 homolog 3(B7-H3) and β-1,3-galactosyltransferase-4(B3 GALT4) in colorectal cancer(CRC) patients.METHODS Using tissue microarray, we identified the expression of B7-H3 and B3 GALT4 in 223 CRC patient samples by immunohistochemistry and evaluated the possible correlation between B7-H3 and B3 GALT4 and clinicaloutcomes. Further, the m RNA and protein expression were identified to establish the regulatory relationship of B7-H3 with B3 GALT4 in vitro.RESULTS A significant positive correlation between B7-H3 and B3 GALT4 was observed in CRC specimens(r = 0.219, P = 0.001). High expression of B7-H3 was identified as a significant independent predictor of poor overall survival(OS) [hazard ratio(HR) = 1.781; 95%CI: 1.027-3.089; P = 0.040]. Moreover, high expression of B3 GALT4 was also recognized as an independent predictor of inferior OS(HR = 1.597; 95%CI: 1.007-2.533; P = 0.047). Additionally, CRC patients expressing both high B7-H3 and high B3 GALT4 contributed to a significant decrease in OS(HR = 2.283; 95%CI: 1.289-4.042; P = 0.005). In CRC cell lines with stable expression of high B7-H3, the m RNA and protein expressions of B3 GALT4 were significantly upregulated. Similarly, the expression of B3 GALT4 was significantly reduced when expression of B7-H3 was knocked down.CONCLUSION The expression of B3 GALT4 in CRC is positively correlated with B7-H3 expression in vitro. B7-H3/B3 GLAT4 may be used as dual prognostic biomarkers for CRC. | Ting Zhang Fang Wang Jing-Yi Wu Zhi-Chao Qiu Yan Wang Fen Liu Xiao-Song Ge Xiao-Wei Qi Yong Mao Dong Hua | 2018 | World Journal of Gastroenterology2018，24，31： | 4 |
| 6 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 7 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 8 | A Compact Implementation of AES S-Box Using Evolutionary Algorithm显示文摘S-Box based on Composite field arithmetic(CFA) technology is optimized by Genetic algorithm(GA)and Cartesian genetic programming(CGP) model for reducing the hardware complexity. After using the CFA technique to map Multiplicative inverse(MI) over GF(2~8)into composite field GF((2~4)~2), the compact MI circuit over GF(2~4) is selected from 100 evolved circuits, and same design method is applied to the compact multiplication circuit over GF(2~2). Compared with the direct implementations, the areas of optimized circuits of MI over GF(2~4) and multiplication over GF((2~2)2) are reduced by66% and 57.69%, respectively. The area reductions for MI over GF(2~8) and the whole of S-Box are up to 59.23%and 56.14%, separately. In 180 nm 1.8V COMS technology,compared to previous works, the S-Box proposed in this paper has the minimum area and minimum power, which are 11.27% and 6.65% smaller than that of the smallest area S-Box, respectively. | LIU Yaoping WU Ning ZHANG Xiaoqiang ZHOU Fang GE Fen | 2017 | Chinese Journal of Electronics2017，26，4： | 2 |
| 9 | Activation and Clinical Significance of p38 MAPK Signaling Pathway in Patients With Severe Trauma显示文摘 | Yi Xin Wang Xin Yun Xu Wen Li Su Qiang Wang Wen Xian Zhu Fen Chen Ge Jin Yu Jian Liu Yi Dong Li Yan Ping Sun Wen Chao Gao Can Ping Ruan | 2010 | Journal of Surgical Research2010，，1： | 1 |
| 10 | Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: An open-label, controlled, prospective study显示文摘 | Xiang-Yang Li Fen Gao Zhan-Quan Li Wei Guan Wei-Li Feng Ri-Li Ge | 2009 | Clinical Therapeutics2009，，11： | 1 |
| 11 | Power and thermal aware mapping for 3D network-on-chip 显示文摘 | Ge Fen Feng Gui Yu Shuang | 2013 | Information Technology Journal2013，12，23： | 1 |
| 12 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 13 | Amphiphobic fluorinated polyurethane composite microfibrous membranes with robust waterproof and breathable performances显示文摘 | GE Jianfeng SI Yang FU Fen | 2013 | RSC Advances2013，3，7： | 1 |
| 14 | Two 2D uranyl coordination complexes showing effective photocatalytic degradation of Rhodamine B and mechanism study显示文摘Two new hydrostable two-dimensional(2 D) uranyl coordination complexes [(UO_(2))_(5)(μ_(3)-O)_(2)(nbca)_(2)].7 H_(2)O(1) and [(UO_(2))_(3)(nbca)_(2)(H_(2)O)_(3)]·2 H_(2)O(2)(H_(3) nbca=5-nitro-1,2,3-benzenetricarboxylic acid) were hydrothermal synthesized.Single-crystal structural refinements reveal that both of the two complexes were formed by the packing of 2D uranyl coordination sheets via the hydrogen bonds.The nbca ligand coordinating to the uranyl polyhedron centers constructed the 2D sheets.There are UO8 hexagonal bipyramids and UO7 pentagonal bipyramids in 1 while only U07 pentagonal bipyramids in 2.Photocatalytic degradation of rhodamine B(RhB) in aqueous solution was studied.Complex 2 possesses better performance than 1 with 96.2 % of the RhB was degraded in only 60 min.Mechanism studies reveal that the dissolved oxygens are essential to the RhB degradation.The photocurrent density of 2 is more stable than that of 1,which indicating the stronger ability to separate photoexcited electrons and hole pairs of 2. | Xiaolan Tong Shan Wang Jun Zuo Yingchong Ge Qiang Gao Suijun Liu Jianhua Ding Fen Liu Jianqiang Luo Jianbo Xiong | 2021 | Chinese Chemical Letters2021，32，2： | 0 |
| 15 | Total or subtotal glossectomy and reconstruction of defect without splitting lip and mandible显示文摘 | Rui Wu Li Chang Fu Sun Xue Xin Tan Shu Fen Ge Shao Hui Huang De Hao Shang | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 16 | Ultrasensitive determination of mercury by solution anode glow discharge atomic emission spectrometry coupled with hydride generation显示文摘An innovative method for the ultrasensitive detection of mercury by solution anode glow discharge atomic emission spectroscopy(SAGD-AES) coupled with hydride generation(HG) was first investigated.In this method,the mercury vapor generated by the HG was transmitted to the SAGD through the miniature hollow tungsten tube for excitation and detected by a miniaturized spectrograph.A thorough parametric evaluation of the HG and SAGD system was performed,including the type and concentration of ca rrier acid,He flow rate,concentrations of NaBH4,discha rge current and discharge gap.Under optimal operating conditions,the detection limit for Hg^(2+) achieved 0.03 μg/L,with a relative standard deviation of 1.1% at the Hg^(2+) concentration of 5 μg/L.Moreover,the correlation coefficient of the calibration curve was 0.9996 in the range between 0.1 and 10 μg/L.The accuracy and practicability of HG-SAGD-AES were verified by measuring GBW09101 b(human hair),GBW10029(fish),soil and rice samples.The results showed good agreement with the certified values and values from direct mercury analyzer(DMA). | Mingli Yuan Xiaoxu Peng Fen Ge Mingyue Zhao Qing Li Zheng Wang | 2020 | Chinese Chemical Letters2020，31，10： | 0 |
| 17 | Design of an adaptive precoding/STBC baseband transceiver on a reconfigurable architecture显示文摘Precoding and space-time block coding (STBC)techniques using the uniform channel decomposition (UCD)are proposed to improve the bit error rate (BER) of themultiple-antenna communication system, but at a cost of areduced data rate. In order to achieve a higher overall systemperformance, a novel adaptive transceiver architecture whichflexibly combines both UCD and UCD + STBC technologies isproposed. The channel state information (CSI) feedback pathwas added to the precoder to select which coding method wasto be used, i.e. UCD alone or UCD + STBC. With thesmaller constellation sizes, Matlab simulation results showthat, the adaptive transceiver architecture will select the UCD-only mode under the higher SNR conditions in order to achievea higher bit rate. The UCD + STBC mode will be selectedunder the lower SNR conditions (e. g., SNR 〈 10 dB) inorder to maintain good BER performance at the cost of areduced data rate. This architecture was implemented andverified using both UMC 0.18 ASIC process technology and aXilinx xc4vlx Virtex-4 FPGA at 150 MHz. The simulationresults demonstrate that the required number of reconfigurablearithmetic unit slices grows linearly with the channel matrixsize, while the number of adder array unit and reconfigurablelogic unit slices increases slightly with the constellation size. | Ye Yunfei Wu Ning Ge Fen Zhou Fang | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 0 |
| 18 | Studies on a New Usage of Hypophosphorous Acid-iodine System in N-C Bond Cleavage显示文摘A mixture of hypophosphorous acid (H3PO2) and iodine in acetic acid can cleave the N-alkyl bond in a variety of N-1 substituted pyrimidine derivative in relatively high yields, without any damage to the amido bond in the non-nucleosides pyrimidine base skeleton. | Ge MENG, Ling ZHAO, You Fu LUO, Fen Er CHEN* Department of Chemistry, Fudan University, Shanghai 200433 | 2003 | Chinese Chemical Letters2003，14，4： | 0 |
| 19 | Cervicofacial and cervicothoracic rotation flaps in oromaxillofacial head & neck reconstruction显示文摘 | Rui Wu Li Shu Fen Ge | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 20 | Potassium alleviated high nitrogen-induced apple growth inhibition by regulating photosynthetic nitrogen allocation and enhancing nitrogen utilization capacity显示文摘There is a close relationship between potassium(K)and nitrogen(N).However,the roles of K under high N conditions remain unclear.Using a hydroponics approach,we monitored the morphological,physiological,and molecular changes in M9T337 apple(Malus domestica)rootstocks under different nitrate(10 and 30 mmol·L^(-1)NO_(3)^(-))and K supply(0.5,6,10,and 20 mmol·L_(-1)K^(+))conditions.Results revealed that high nitrate inhibited the root growth of M9T337 rootstocks,downregulated the expressions of K transporter genes(MdPT5,MdHKT1,and MdATK1),and reduced the net NO3-and K+influx at the surface of roots,thereby resulting in an N/K imbalance in rootstocks.Further investigation showed that 10 mmol·L^(-1)K increased the activity of N metabolic enzymes(NR,GS,NiR,and GOGAT),upregulated the expressions of genes related to nitrate uptake and transport(MdNRT1.1,MdNRT1.2,MdNRT1.5,and MdNRT2.4),promoted15N transport from the roots to the shoots,optimized leaf N distribution,and improved photosynthetic N utilization efficiency under high nitrate conditions.These results suggest that the negative effects of high nitrate may be related to the N/K imbalance and that reducing N/K in plants by increasing K supply level can effectively alleviate the inhibition of N assimilation by high nitrate stress. | Xinxiang Xu Guangyuan Liu Jingquan Liu Mengxue Lyu Fen Wang Yue Xing Hao Meng Min Li Yu Jiang Ge Tian Zhanling Zhu Yuanmao Jiang Shunfeng Ge | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
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