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| 1 | Health-related quality of life among rural residents aged 45-69 years in Hua County, Henan Province, China: Results of ESECC Trial for esophageal cancer screening with endoscopy显示文摘Objective: There have been few population-based studies evaluating health related quality of life(HRQOL) in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in China.Methods: From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China(ESECC) trial(Clinical Trials.gov:NCT01688908) randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk factors.Results: Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort(25.52%) was the most frequently reported problem followed by anxiety/depression(7.97%), mobility(5.82%), usual activities(2.61%) and self-care(1%). These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic diseases.Conclusions: Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial. | Hui Wang Yaqi Pan Chuanhai Guo Fenglei Li Ruiping Xu Mengfei Liu Zhen Liu Fangfang Liu Hong Cai Yang Ke Zhonghu He | 2018 | Chinese Journal of Cancer Research2018，30，2： | 3 |
| 2 | Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study显示文摘Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.Methods:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China.The oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy controls.DESeq analysis was performed to identify taxa of differential abundance.Differential oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression models.Results:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P<0.05&false discovery rate-adjusted Q<0.10).A multivariate logistic model including 11 SDA lesion-related species and family history of esophageal cancer provided an area under the receiver operating characteristic curve(AUC)of 0.89(95%CI,0.84-0.93).Cross-validation and sensitivity analysis,excluding cases diagnosed within 1 year of collection of the baseline specimen and their matched controls,or restriction to screenendoscopic-detected or clinically diagnosed case-control triads,or using only bacterial data measured at the baseline,yielded AUCs>0.84.Conclusions:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs. | Fangfang Liu Mengfei Liu Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu Zhen Liu Qiuju Deng Xiang Li Chaoting Zhang Yaqi Pan Tao Ning Xiao Dong Zhe Hu Huanyu Bao Hong Cai Isabel Dos Santos Silva Zhonghu He Yang Ke | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 3 | Identification of cancer patients using claims data from health insurance systems: A real-world comparative study显示文摘Objective: To evaluate the accuracy of identifying cancer patients by use of medical claims data in a health insurance system in China, and provide the basis for establishing the claims-based cancer surveillance system in China.Methods: We chose Hua County, Henan Province as the study site, and randomly selected 300 and 1,200 qualified inpatient electronic medical records(EMRs) as well as the New Rural Cooperative Medical Scheme(NCMS) claims records for cancer patients in Hua County People’s Hospital(HCPH) and Anyang Cancer Hospital(ACH) in 2017. Diagnostic information for NCMS claims was evaluated on an individual level, and sensitivity and positive predictive value(PPV) were calculated taking the EMRs as the gold standard.Results: The sensitivity of NCMS was 95.2%(93.8%-96.3%) and 92.0%(88.3%-94.8%) in ACH and HCPH,respectively. The PPV of the NCMS was 97.8%(96.7%-98.5%) in ACH and 89.0%(84.9%-92.3%) in HCPH.Overall, the weighted and combined sensitivity and PPV of NCMS in Hua County was 93.1% and 92.1%,respectively. Significantly higher sensitivity and PPV in identifying patients with common cancers than noncommon cancers were detected in HCPH and ACH separately(P<0.01).Conclusions: Identification of cancer patients by use of the NCMS is accurate on individual level, and it is therefore feasible to conduct claims-based cancer surveillance in areas not covered by cancer registries in China. | Hongrui Tian Ruiping Xu Fenglei Li Chuanhai Guo Lixin Zhang Zhen Liu Mengfei Liu Yaqi Pan Zhonghu He Yang Ke | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 4 | High-efficiency acetaldehyde removal during solid-state polycondensation of poly(ethylene terephthalate) assisted by supercritical carbon dioxide显示文摘The concentration of acetaldehyde(AA) is the main quality index of poly(ethylene terephthalate)(PET) used in food and drink packaging.A new method for AA removal has been developed by using supercritical carbon dioxide(sc CO2) during the solid-state polycondensation of PET.The influence factors of AA removal including the temperature,pressure,reaction time and the size of pre-polymer particles are systematically studied in this work.The results indicate that it is a highly efficient way to obtain high molecular weight PET with relative low concentration of AA.Correspondingly,the polymerization degree of PET could increase from 27.9 to 85.6 while the concentration of AA reduces from 0.229 × 10^(-6) to 0.055 × 10^(-6) under the optimal operation conditions of 230 °C,8 MPa and size of 0.30–0.45 mm.Thermodynamic performance tests show the increasing extent of PET crystallinity due to the fact that the plasticization of sc CO_2 is not obvious with extended reaction time,therefore the increasing crystallinity has no significant influence on AA removal.SEM observations reveal that the effects of sc CO_(2-) induced plasticization and swelling on PET increase significantly with the decrease of prepolymer size,and the surface of PET becomes more loose and porous in favor of the AA removal. | Zhenhao Xi Tian Liu Wei Si Fenglei Bi Zhimei Xu Ling Zhao | 2018 | Chinese Journal of Chemical Engineering2018，26，6： | 2 |
| 5 | PLASTIC BEHAVIOR AND CONSTITUTIVE MODELING OF ARMOR STEEL OVER WIDE TEMPERATURE AND STRAIN RATE RANGES显示文摘Plastic behavior of 603 armor steel is studied at strain rates ranging from 0.001 s-1 to 4500 s-1 , and temperature from 288 K to 873 K. Emphasis is placed on the effects of temperature, strain rate, and plastic strain on flow stress. Based on experimental results, the JC and the KHL models are used to simulate flow stress of this material. By comparing the model prediction and the experimental results of strain rate jump tests, the KHL model is shown to have a better prediction of plastic behavior under complex loading conditions for this material, especially in the dynamic region. | Zejian Xu Fenglei Huang | 2012 | Acta Mechanica Solida Sinica2012，25，6： | 2 |
| 6 | Simulation-based optimization of control policy on multi-echelon inventory system for fresh agricultural products显示文摘As fresh agricultural products are perishable and vulnerable,reducing inventory cost is a strategic target for supply chain enterprises.How to design a reliable multi-echelon inventory control policy is still a great challenge.Therefore,the inventory cost of a three-level fresh agricultural products inventory system was firstly mathematically analyzed.Then,the simulation-based optimization model of the multi-echelon inventory system for fresh agricultural products was proposed by using the Flexsim simulation software and the improved particle swarm optimization algorithm.Finally,the multi-echelon inventory system is simulated based on a large number of survey data.Simulation results demonstrate that the proposed simulation-based optimization model of multi-echelon inventory system for fresh agricultural products can provide decision-making and technical support for the formulation of inventory control policy,and also it shows that the modeling of system simulation is an effective method to solve the problem of complex system. | Guangyin Xu Jihao Feng Fenglei Chen Heng Wang Zhenfeng Wang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 2 |
| 7 | Complexes with a tridentate aroylhydrazone ligand: microwave solid-state synthesis, crystalline architectures through supramolecular interactions and electrochemical properties 显示文摘 | Xu Suoping Yang Fenglei Zhu Guangzhou | 2014 | Polyhed-ron2014，68，1： | 1 |
| 8 | Surfactants with aromatic-group tail and single quaternary ammonium head for directing single-crystalline mesostructured zeolite nanosheets 显示文摘 | Xu Dongdong Jing Zhifeng Cao Fenglei | 2014 | Chem Mater2014，26，15： | 1 |
| 9 | Dual amine-and brnsted acid-catalyzed α-allylic alkylation of aldehydes显示文摘 | Xu Liwen Gao Guang Gu Fenglei | 2010 | Advanced Synthesis & Catalysis2010，352，9： | 1 |
| 10 | Blocking the Natural Killer (NK) Cell Inhibitory Receptor NKG2A Increases Activity of Human NK Cells and Clears HBV Infection in Mice显示文摘 | Fenglei Li Hairong Wei Haiming Wei Yufeng Gao Long Xu Wenwei Yin Rui Sun Zhigang Tian | 2012 | Gastroenterology2012，，： | 1 |
| 11 | Preparationof Mn2 O3 / SBA-15 catalyst with high loading and catalyt-ic peroxidation for degradation of organic pollutants显示文摘 | CAO Fenglei LI Hu XU Zhenmin | 2012 | Journal of Molecular Catalysis A: Chemical2012，，： | 1 |
| 12 | Complexes with a tridentate aroylhydrazone ligand: microwave solid- state synthesis,crystalline architectures through supramolecular interactions and electrochemical properties显示文摘 | Xu Suoping Yang Fenglei Zhu Guangzhou | 2014 | Polyhed- ron2014，68，1： | 1 |
| 13 | Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment显示文摘Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation,which may be a potential strategy for cancer therapy.Here we demonstrated for the first time that Resveratrol(RSV),a traditional Chinese medicine(TCM)chemical monomer,could effectually inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis pathway.Mechanistically,RSV evoked the increase of reactive oxygen species and lipid peroxidation in colorectal cancer cells,and eventually lead to ferroptosis.Furthermore,RSV could promote ferroptosis by downregulating the expression of the channel protein solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).To improve the delivery efficiency of RSV,a biomimetic nanocarrier was developed by coating RSV-loaded poly(ε-caprolactone)-poly(ethylene glycol)(PCL-PEG)nanoparticles with erythrocyte membrane(RSV-NPs@RBCm).The RSV-NPs@RBCm provide the possibility to escape macrophage phagocytosis and have a long circulation effect.In addition,when coupled with a tumor-penetrating peptide iRGD,which could trigger enhanced tissue penetration tumor-specifically,the delivery of RSV-NPs@RBCm into tumors would be significantly improved results from the in vivo study demonstrated an excellent treatment efficacy for CRC.Altogether,our study highlighted the therapeutic potential of RSV as a ferroptosis-inducing anticancer agent and when loaded into a biomimetic nanoplatform,it might pave the way for the application of RSV loaded nanosystems for colorectal cancer treatment. | Ziting Zhang You Ji Nan Hu Qinqi Yu Xinrui Zhang Jie Li Fenglei Wu Huae Xu Qiyun Tang Xiaolin Li | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
| 14 | High-speed penetration of ogive-nose projectiles into thick concrete targets:Tests and a projectile nose evolution model显示文摘The majority of the projectiles used in the hypersonic penetration study are solid flat-nosed cylindrical projectiles with a diameter of less than 20 mm.This study aims to fill the gap in the experimental and analytical study of the evolution of the nose shape of larger hollow projectiles under hypersonic penetration.In the hypersonic penetration test,eight ogive-nose AerMet100 steel projectiles with a diameter of 40 mm were launched to hit concrete targets with impact velocities that ranged from 1351 to 1877 m/s.Severe erosion of the projectiles was observed during high-speed penetration of heterogeneous targets,and apparent localized mushrooming occurred in the front nose of recovered projectiles.By examining the damage to projectiles,a linear relationship was found between the relative length reduction rate and the initial kinetic energy of projectiles in different penetration tests.Furthermore,microscopic analysis revealed the forming mechanism of the localized mushrooming phenomenon for eroding penetration,i.e.,material spall erosion abrasion mechanism,material flow and redistribution abrasion mechanism and localized radial upsetting deformation mechanism.Finally,a model of highspeed penetration that included erosion was established on the basis of a model of the evolution of the projectile nose that considers radial upsetting;the model was validated by test data from the literature and the present study.Depending upon the impact velocity,v0,the projectile nose may behave as undistorted,radially distorted or hemispherical.Due to the effects of abrasion of the projectile and enhancement of radial upsetting on the duration and amplitude of the secondary rising segment in the pulse shape of projectile deceleration,the predicted DOP had an upper limit. | Xu Li Yan Liu Junbo Yan Zhenqing Shi Hongfu Wang Yingliang Xu Fenglei Huang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 15 | Research on the quasi-isentropic driving model of aluminized explosives in the detonation wave propagation direction显示文摘Taking CL-20(Hexanitrohexaazaisowurtzitane)-based aluminized explosives with high gurney energy as the research object, this research experimentally investigates the work capability of different aluminized explosive formulations when driving metal flyer plates in the denotation wave propagation direction.The research results showed that the formulations with 43 μm aluminum(Al) powder particles(The particle sizes of Al powder were in the range of 2~43 μm) exhibited the optimal performance in driving flyer plates along the denotation wave propagation direction. Compared to the formulations with Al powder 13 μm, the formulations with Al powder 2 μm delivered better performance in accelerating metal flyer plates in the early stage, which, however, turned to be poor in the later stage. The CL-20-based explosives containing 25% Al far under-performed those containing 15% Al. Based on the proposed quasi-isentropic hypothesis, relevant isentropy theories, and the functional relationship between detonation parameters and entropy as well as Al reaction degree, the characteristic lines of aluminized explosives in accelerating flyer plates were theoretically studied, a quasi-isentropic theoretical model for the aluminized explosive driving the flyer plate was built and the calculation methods for the variations of flyer plate velocity, Al reaction degree, and detonation product parameters with time and axial positions were developed. The theoretical model built is verified by the experimental results of the CL-20-based aluminized explosive driving flyer plate. It was found that the model built could accurately calculate the variations of flyer plate velocity and Al reaction degree over time. In addition, how physical parameters including detonation product pressure and temperature varied with time and axial positions was identified. The action time of the positive pressure after the detonation of aluminized explosives was found prolonged and the downtrend of the temperature was slowed down and even reversed to a slight rise due to the aftereffect reaction between the Al powder and the detonation products. | Hongfu Wang Yan Liu Fan Bai Chao He Yingliang Xu Qiang Zhou Chuan Xiao Fenglei Huang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 16 | Experimental and numerical analyses of the effect of fibre content on the close-in blast performance of a UHPFRC beam显示文摘Limited research has been conducted on the influences of fiber content on close-in blasting characteristics for ultrahigh-performance fiber-reinforced concrete(UHPFRC)beams.This paper aims to address this knowledge gap through experimental and mesoscale numerical methods.Experiments were conducted on ten UHPFRC beams built with varying steel fiber volumetric fractions subjected to close-in explosive conditions.Additionally,this study considered other parameters,such as the longitudinal reinforcement type and ratio.In the case of UHPFRC beams featuring normal-strength longitudinal reinforcement of diametersΦ12,Φ16,andΦ20,a reduction in maximum displacement by magnitudes of19.6%,19.5%,and 17.4%was observed,respectively,as the volumetric fractions of fiber increased from1.0%to 2.5%.In addition,increasing the longitudinal reinforcement ratio and using high-strength steel longitudinal reinforcement both significantly reduced the deformation characteristics and increase the blasting resistances of UHPFRC beams.However,the effects on the local crushing and spalling damage were not significant.A mesoscale finite element model,which considers the impacts of fiber parameters on UHPFRC beam behaviors,was also established and well correlated with the test findings.Nevertheless,parametric analyses were further conducted to examine the impacts of the steel fiber content and length and the hybrid effects of various types of microfibers and steel fibers on the blasting performance of UHPFRC beams. | Junbo Yan Qiyue Zhang Yan Liu Yingliang Xu Zhenqing Shi Fan Bai Fenglei Huang | 2024 | Defence Technology(防务技术)2024，31，1： | 0 |
| 17 | Bio-inspired surface manipulation of halloysite nanotubes for highperformance flame retardant polylactic acid nanocomposites显示文摘High-performance flame-retardant polylactic acid(PLA)bio-composites based on biobased fillers to meet usage requirements represents a promising direction for creating a sustainable world.Although flame retardant PLA composites have been reported extensively,it still remains a huge challenge to develop mechanically robust.The flame retardant PLA composites due to plastication effect of organic flame retardants and poor compatibility of organic fillers with the matrix lead to the severe deterioration in mechanical properties.In this work,a bio-inspired surface manipulation strategy for halloysite nanotubes(HNTs)was proposed via a facile and green self-assembly process.The structure and morphology of bio-inspired HNTs(b-HNTs)proved that biomass nanofillers(PA-NA-Fe)grew well both within the lumen and on the surface of HNTs.The growth of biomass on the inner and outer surfaces of HNTs was inspired from wooden towards enhancing the interface compatibility and imparting multi-properties to PLA biopolymer.Excellent mechanical properties(tensile,thermomechanical and anti-impact mechanical),great fire safety(heat release and smoke emission),thermostability and improved electromagnetic interference shielding effectiveness of this well-designed PLA nanocomposite were realized.The mechanisms of the enhanced performances of the PLA bio-composites by loading b-HNTs were proposed.This work presents a facile and environmentally-friendly bio-inspired modification strategy for HNTs to fabricate high-performance,multi-functional polymer composites,which is also suitable for surface modification of many other nanomaterials,including nanofibers,nanotubes,nanowires,and nanosheets. | Yaru Sun Bin Yu Yan Liu Junbo Yan Zixi Xu Bo Cheng Fenglei Huang Jun Wang | 2024 | Nano Research2024，17，3： | 0 |
| 18 | ARoad Segmentation Model Based on Mixture of the Convolutional Neural Network and the Transformer Network显示文摘Convolutional neural networks(CNN)based on U-shaped structures and skip connections play a pivotal role in various image segmentation tasks.Recently,Transformer starts to lead new trends in the image segmentation task.Transformer layer can construct the relationship between all pixels,and the two parties can complement each other well.On the basis of these characteristics,we try to combine Transformer pipeline and convolutional neural network pipeline to gain the advantages of both.The image is put into the U-shaped encoder-decoder architecture based on empirical combination of self-attention and convolution,in which skip connections are utilized for localglobal semantic feature learning.At the same time,the image is also put into the convolutional neural network architecture.The final segmentation result will be formed by Mix block which combines both.The mixture model of the convolutional neural network and the Transformer network for road segmentation(MCTNet)can achieve effective segmentation results on KITTI dataset and Unstructured Road Scene(URS)dataset built by ourselves.Codes,self-built datasets and trainable models will be available on http://gffzz188fe103f8f1460asonu6nkp96cpp6vqb.ffgz.tsg.suse.edu.cn/xflxfl1992/MCTNet. | Fenglei Xu Haokai Zhao Fuyuan Hu Mingfei Shen Yifei Wu | 2023 | Computer Modeling in Engineering & Sciences2023，，5： | 0 |
| 19 | Study on Sulfide-melt Inclusions in Mantle Xenoliths of Xinchang, Zhejiang显示文摘In minerals of mantle xenoliths captured within Tertiary alkali-basalt from Xinchang, Zhejiang province, China, many sulfidemelt inclusions were found by the observation of polished thin section. Electron microprobe analysis has been applied to detect the components of sulfide-melt inclusions. The result shows that the sulfide phases of inclusions are mainly pentlandite, and secondarily pyrrho- tite, The molar ratio of Ni to Fe, rNi,/rFe, of mineral phases in sulfide inclusions is related to olivine contents in host mantle xenoliths. The rNi/rNi, of sulfides from Xinchang samples has a possitive correlation to rFe+Ni,/rS. The rFe+Ni,/rS, becomes higher with the increasing of rNi/rFe In single sulfide-melt inclusions, rNi,/rFe, rFe+Ni,/r, and Ni contents increase from the center to edge, reflecting a result of different cooling speed in an inclusion. A comparison between the data from Hannuoba, West Eifel of Germany and Nograd-Gomor of east Europe suggests that the composition of the inclusions is different for each area, which indicated that a regional differentiation of sulfide in mantle fluids. | Jiuhua Xu Xuelei Chu YulingXie Fenglei Bie Dayi Qian University of Science and Technology Beijing, Beijing 100083, China China University of Geosciences, Beijing 100083, China The Research Center of Mineral Resources Exploration, Chinese Academy | 2000 | International Journal of Minerals,Metallurgy and Materials2000，14，1： | 0 |
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