|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer显示文摘Triple negative breast cancer(TNBC) is an aggressive subtype of breast cancer that currently lacks effective biomarkers and therapeutic targets required to investigate the diagnosis and treatment of TNBC. Here we performed a comprehensive differential analysis of 165 TNBC samples by integrating RNA-seq data of breast tumor tissues and adjacent normal tissues from both our cohort and The Cancer Genome Atlas(TCGA). Pathway enrichment analysis was conducted to evaluate the biological function of TNBC-specific expressed genes. Further multivariate Cox proportional hazard regression was performed to evaluate the effect of these genes on TNBC prognosis. In this report, we identified a total of 148 TNBC-specific expressed genes that were primarily enriched in mammary gland morphogenesis and hormone levels related pathways, suggesting that mammary gland morphogenesis might play a unique role in TNBC patients differing from other breast cancer types. Further survival analysis revealed that nine genes(FSIP1, ADCY5, FSD1, HMSD, CMTM5, AFF3, CYP2 A7, ATP1 A2,and C11 orf86) were significantly associated with the prognosis of TNBC patients, while three of them(ADCY5,CYP2 A7, and ATP1 A2) were involved in the hormone-related pathways. These findings indicated the vital role of the hormone-related genes in TNBC tumorigenesis and may provide some independent prognostic markers as well as novel therapeutic targets for TNBC. | Fei Chen Yuancheng Li Na Qin Fengliang Wang Jiangbo Du Cheng Wang Fangzhi Du Tao Jiang Yue Jiang Juncheng Dai Zhibin Hu Cheng Lu Hongbing Shen | 2020 | The Journal of Biomedical Research2020，34，2： | 4 |
| 2 | FTIR spectroscopic characterization of soy proteins obtained through AOT reverse micelles显示文摘 | Xiangyan Chen Yi Ru Fengliang Chen Xianchang Wang Xiaoyan Zhao Qiang Ao | 2013 | Food Hydrocolloids2013，，2： | 2 |
| 3 | Method of calculation of a methane concentration field in gob areas with a known velocity field based on the model of stream tubes显示文摘在有已知的速度域的嘴区域的煤气的集中地的控制方程是有可变系数的部分微分方程,谁的传统的数学计算方法是很复杂的。一个数字模拟方法能被用来计算煤气的集中地,但是它也需要计算机资源的可观的数量,在嘴区域的不同的点的煤气的集中的关系是未定义的。基于流试管的模型,在流试管以内的集体、煤气的部件的保存方程被用来与已知的速度域在一个嘴区域推出煤气的集中域的方程。一块煤气的集中地的计算的这个方法在一个嘴区域被使用, U 类型通风工作面对,它建议这个新方法有准确计算的优点简单操作并且有清楚的物理解释。 | Wang Honggang Wu Fengliang | 2011 | Mining Science and Technology2011，21，2： | 2 |
| 4 | Research on droplet transfer of MIG welding with alternating longitudinal magnetic field显示文摘 | Zhu Sheng Wang Qiwei Yin Fengliang | | 0，，09： | 1 |
| 5 | Expression of recombinant hybrid peptide cecropinA(1–8)–magainin2(1–12) in Pichia pastoris : Purification and characterization显示文摘 | Fengliang Jin Xiaoxia Xu Liexi Wang Wenqing Zhang Dexiang Gu | 2006 | Protein Expression and Purification2006，，2： | 1 |
| 6 | Treatments for primary aneurysmal bone cysts of the cervical spine: experience of 14 cases显示文摘 | Wang Chao Liu Xiaoguang Jiang Liang Yang Shaomin Wei Feng Wu Fengliang Liu Zhongjun | 2014 | Chinese Medical Journal2014，，23： | 1 |
| 7 | A systematic review of hypermethylation of p16 gene in esophagealcancer显示文摘 | Ruobing Xu Fengliang Wang Liang Wu Jianming Wang Cheng Lu | 2013 | Cancer Biomarkers2013，，4： | 1 |
| 8 | Expression of recombinant hybrid peptide cecropinA (1-8)-magainin2 (1-2)in Pichia pastoris显示文摘 | JIN Fengliang XU Xiaoxia WANG Liexi | 2006 | Protein Expression and Purification2006，50，2： | 1 |
| 9 | BmMD-2A responds to 20-hydroxyecdysone and regulates Bombyx mori silkworm innate immunity in larva-to-pupa metamorphosis显示文摘20E-hydroxyecdysone(20E)plays important roles in larval molting and metamorphosis in insects and is also involved in the insect innate immune response.Insect metamorphosis is a highly successful strategy for environmental adaptation and is the most vulnerable stage during which the insect is susceptible to various pathogens.20E regulates a series of antimicrobial peptides(AMPs)through the immunodeficiency(IMD)pathway activation in Drosophila;nevertheless,whether other immune pathways are involved in 20E-regulated insect immunity is unknown.Our previous studies showed that BmMD-2A is a member of the MD-2-related lipid recognition(ML)family of proteins that are involved in the Bombyx mori innate immunity Toll signaling pathway.In this study,we further demonstrate that BmMD-2A is also positively regulated by 20E,and the BmMD-2A neutralization experiment suggested that 20E activates some downstream immune effect factors,the AMP genes against Escherichia coli and Staphylococcus aureus,through the regulation of BmMD-2A in larval metamorphosis,implying that B.mori may use the Toll-ML signaling pathway to maintain innate immune balance in the larval-pupal metamorphosis stage,which is a different innate immunity pathway regulated by 20E compared to the IMD pathway in Drosophila. | Ruonan Zhang Xue Chen Yuan Wang Xu Bai Qiong Yang Yangjin Zhong Xiao-Qiang Yu Fengliang Jin Wanying Yang | 2023 | Insect Science2023，30，2： | 0 |
| 10 | Topological Landau–Zener nanophotonic circuits显示文摘Topological edge states(TESs),arising from topologically nontrivial phases,provide a powerful toolkit for the architecture design of photonic integrated circuits,since they are highly robust and strongly localized at the boundaries of topological insulators.It is highly desirable to be able to control TES transport in photonic implementations.Enhancing the coupling between the TESs in a finite-size optical lattice is capable of exchanging light energy between the boundaries of a topological lattice,hence facilitating the flexible control of TES transport.However,existing strategies have paid little attention to enhancing the coupling effects between the TESs through the finite-size effect.Here,we establish a bridge linking the interaction between the TESs in a finite-size optical lattice using the Landau–Zener model so as to provide an alternative way to modulate/control the transport of topological modes.We experimentally demonstrate an edge-to-edge topological transport with high efficiency at telecommunication wavelengths in silicon waveguide lattices.Our results may power up various potential applications for integrated topological photonics. | Bing-Cong Xu Bi-Ye Xie Li-Hua Xu Ming Deng Weijin Chen Heng Wei Fengliang Dong Jian Wang Cheng-Wei Qiu Shuang Zhang Lin Chen | 2023 | Advanced Photonics2023，5，3： | 0 |
| 11 | An RNA-RNA crosstalk network involving HMGB1 and RICTOR facilitates hepatocellular carcinoma tumorigenesis by promoting glutamine metabolism and impedes immunotherapy by PD-L1+ exosomes activity显示文摘Hepatocellular carcinoma(HCC)is the global leading cause of cancer-related deaths due to the deficiency of targets for precision therapy.A new modality of epigenetic regulation has emerged involving RNA-RNA crosstalk networks where two or more competing endogenous RNAs(ceRNAs)bind to the same microRNAs.However,the contribution of such mechanisms in HCC has not been well studied.Herein,potential HMGB1-driven RNA-RNA crosstalk networks were evaluated at different HCC stages,identifying the mT0RC2 component RICTOR as a potential HMGB1 ceRNA in HBV^(+)early stage HCC.Indeed,elevated HMGB1 mRNA was found to promote the expressio n of RICTOR mRNA through competitively bin ding with the miR-200 family,especially miR-429.Functio nal assays emplo ying overexpressi on or in terference strategies dem on strated that the HMGB1 and RICTOR 3zuntra nslated regions(UTR)epigenetically promoted the malignant proliferation,self-renewal,and tumorigenesis in HCC cells.Intriguingly,in terference agai nst HMGB1 and RICTOR in HCC cells promoted a stron ger an ti-PD-L1 immuno therapy resp on se,which appeared to associate with the production of PD-L1^(+)exosomes.Mechanistically,the HMGB1-driven RNA-RNA crosstalk network facilitated HCC cell glutamine metabolism via dual mechanisms,activating a positive feedback loop involving mT0RC2-AKT-C-MYC to upregulate glutamine synthetase(GS)expression,and inducing mTORCI signaling to derepress SIRT4 on glutamate dehydrogenase(GDH).Meanwhile,this crosstalk network could impede the efficacy of immunotherapy through mTORCI-P70S6K dependent PD-L1 production and PD-L1^(+)exosomes activity.In conclusion,our study highlights the non-coding regulatory role of HMGB1 with implicatio ns for RNA-based therapeutic targeting together with a predictio n of an ti-PD-L1 immuno therapy in HCC. | Yanping Wei Xuewu Tang Yibin Ren Yun Yang Fengliang Song Jingbo Fu Shuowu Liu Miao Yu Jing Chen Suyang Wang Kecheng Zhang Yexiong Tan Zhipeng Han Lixjn Wei Baohua Zhang Zhangjun Cheng Liang Li Hongyang Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 12 | Rebels Lead to the Doctrine of the Mean: A Heterogeneous DeGroot Model显示文摘The DeGroot model is one of the most classical models in the field of opinion dynamics. The standard DeGroot model assumes that agents are homogeneous and update their opinions in the direction of a weighted average of their neighbors'opinions.One natural question is whether a second type of agents could significantly change the main properties of the model.The authors address this question by introducing rebels,who update their opinions toward the opposite of their neighbors' weighted average.The authors find that the existence of rebels remarkably affects the opinion dynamics. Under certain mild conditions,the existence of a few rebels will lead the group opinion to the golden mean,regardless of the initial opinions of the agents and the structure of the learning network.This result is completely different from that of the standard DeGroot model,where the final consensus opinion is determined by both the initial opinions and the learning topology.The study then provides new insights into understanding how heterogeneous individuals in a group reach consensus and why the golden mean is so common in human society. | CAO Zhigang JIAO Fengliang QU Xinglong WANG Wen-Xu YANG Mingmin YANG Xiaoguang ZHANG Boyu | 2018 | Journal of Systems Science & Complexity2018，31，6： | 0 |
| 13 | 同时性原发直肠癌和肺癌一例报告(英文)显示文摘Multiple primary cancers refer to the condition where more than two cancers occur independently in an individual. The incidence of lung cancer in cases of colorectal cancer is rare and synchronous rectal cancer and lung cancer is even rare. A 61-year-old man was referred to our hospital with a 2-month history of blood in his stool, tenesmus, and mucous discharge in July 2010. Colonoscopy showed an irregular ulcerated rectal mass and histological examination of biopsy material showed a poorly differentiated adenocarcinoma. Computed tomography (CT) scan of the chest and abdomen showed a mass in the posterior segment of the right upper lobe of the lung and a mass in the right rectal wall of upper rectum. The rectal tumor was diagnosed as primary cancer based on the findings of immunohistochemical stain. An anterior resection (AR) and video assisted thoracoscopic (VAT) wedge resection were performed and histological findings of resected rectal and lung tumor specimen showed synchronous primary rectal cancer and lung cancer. A combination chemotherapy regimen with docetaxel and lobaplatin was used and the patient was successfully discharged from hospital in August 2010. Although the incidence of synchronous multiple primary cancers is very low, we need to remain suspicious, when faced with two or even multiple organ lesions, and employ the necessary examination methods to confirm the diagnosis. For synchronous multiple primary cancers, if conditions allow, surgical resection for all the cancers can be performed in a single operation. | Wentao Zhao Fengliang Hu Jiyong Wang Xin Jin Xiong Zhang Hongjie Li Yuying Li Mingneng Ren | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，1： | 0 |
| 14 | Adaptive Reference Power Based Voltage Droop Control for VSC-MTDC Systems显示文摘Featuring low communication requirements and high reliability,the voltage droop control method is widely adopted in the voltage source converter based multi-terminal direct current(VSC-MTDC)system for autonomous DC voltage regulation and power-sharing.However,the traditional voltage droop control method with fixed droop gain is criticized for over-limit DC voltage deviation in case of large power disturbances,which can threaten stable operation of the entire VSCMTDC system.To tackle this problem,this paper proposes an adaptive reference power based voltage droop control method,which changes the reference power to compensate the power deviation for droop-controlled voltage source converters(VSCs).Besides retaining the merits of the traditional voltage droop control method,both DC voltage deviation reduction and power distribution improvement can be achieved by utilizing local information and a specific control factor in the proposed method.Basic principles and key features of the proposed method are described.Detailed analyses on the effects of the control factor on DC voltage deviation and imbalanced power-sharing are discussed,and the selection principle of the control factor is proposed.Finally,the effectiveness of the proposed method is validated by the simulations on a five-terminal VSC based high-voltage direct current(VSC-HVDC)system. | Yizhen Wang Fengliang Qiu Guowei Liu Ming Lei Chao Yang Chengshan Wang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，1： | 0 |
| 15 | Recent advances in charge mechanism of noble metal-based cathodes for Li-O_(2) batteries显示文摘Lithium-oxygen(Li-O_(2)) batteries are considered as the next generation for energy storages systems due to the higher theoretical energy density than that of Li-ion batteries. However, the high charge overpotential caused by the insulated Li_(2)O_(2)results in low energy efficiency, side reaction from electrolyte and cathode, and therefore poor battery performance. Designing noble metal-based catalysts can be an effective strategy to develop high-performance Li-O_(2)batteries with low charge overpotentials and outstanding cycle stability. However, the charge mechanism for noble metal-based catalysts is not clear and even contradictory. Herein, several charge mechanisms of Li_(2)O_(2)are first discussed. Subsequently, the possible charge processes of Li-O_(2)batteries with noble metal-based catalysts are illustrated. In addition, the future development for noble metal-based catalysts is outlined. | Yong Zhao Wei Cheng Jiahan Wu Zhengguang Hu Fengliang Liu Li Wang Honggen Peng | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员