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| 1 | Developing the Science Product Algorithm Testbed for Chinese Next-Generation Geostationary Meteorological Satellites:Fengyun-4 Series显示文摘Fengyun-4A(FY-4A), the first of the Chinese next-generation geostationary meteorological satellites, launched in2016, offers several advances over the FY-2: more spectral bands, faster imaging, and infrared hyperspectral measurements. To support the major objective of developing the prototypes of FY-4 science algorithms, two science product algorithm testbeds for imagers and sounders have been developed by the scientists in the FY-4 Algorithm Working Group(AWG). Both testbeds, written in FORTRAN and C programming languages for Linux or UNIX systems, have been tested successfully by using Intel/g compilers. Some important FY-4 science products, including cloud mask, cloud properties, and temperature profiles, have been retrieved successfully through using a proxy imager, Himawari-8/Advanced Himawari Imager(AHI), and sounder data, obtained from the Atmospheric Infra Red Sounder, thus demonstrating their robustness. In addition, in early 2016, the FY-4 AWG was developed based on the imager testbed—a near real-time processing system for Himawari-8/AHI data for use by Chinese weather forecasters.Consequently, robust and flexible science product algorithm testbeds have provided essential and productive tools for popularizing FY-4 data and developing substantial improvements in FY-4 products. | Min MIN Chunqiang WU Chuan LI Hui LIU Na XU Xiao WU Lin CHEN Fu WANG Fenglin SUN Danyu QIN Xi WANG Bo LI Zhaojun ZHENG Guangzhen CAO Lixin DONG | 2017 | Journal of Meteorological Research2017，31，4： | 35 |
| 2 | The Impact of the Linked Factors of Provenance,Tectonics and Climate on Potash Formation:An Example from the Potash Deposits of Lop Nur Depression in Tarim Basin,Xinjiang,Western China显示文摘Potash deposits commonly accumulate in highly restricted settings at the final stage of brine evaporation. This does not mean that potash deposits are formed simply as a result of the evaporation concentration of seawater or lake water, but rather as a coupling result of particular provenance, tectonics and climate activities. In this paper, we focus on the formative mechanism of the potash deposits of Lop Nur depression in Tarim Basin to interpret the detailed coupling mechanism among provenance, tectonics and climate. In terms of the provenance of Lop Nur Lake, the water of the Tarim River which displays 'potassium-rich' characteristics play an important role. In addition, the Pliocene and Lower-Middle Pleistocene clastic beds surrounding Lop Nur Lake host a certain amount of soluble potassium and thus serves as 'source beds' for potash formation. During the late Pliocene, the Lop Nur region has declined and evolved into a great lake from the previous piedmont and diluvial fan area. Since the mid Pleistocene, the great-united Lop Nur Lake has been separated and has generated a chain system consisting of Taitema Lake, Big Ear Lake and Luobei Lake which has turned into the deepest sag in Lop Nur Lake. Dry climate in Lop Nur region has increased since the Pliocene, and became extreme at the late Pleistocene. The study implies that potash formation in Lop Nur Lake depends on the optimal combination of extreme components of provenance, tectonics and climate during a shorter-term period. The optimal patterns of three factors are generally characterized by the long-term accumulation and preliminary enrichment of potassium, the occurrence of the deepest sub-depression and the appearance of an extremely arid climate in Lop Nur region. These factors have been interacting synergistically since the forming of the saline lake and in the later stages strong 'vapor extraction' caused by extremely arid climate is needed to trigger large scale mineralization of potash deposits. | LIU Chenglin JIAO Pengcheng Lü Fenglin WANG Yongzhi SUN Xiaohong ZHANG Hua WANG Licheng YAO Fojun | 2015 | Acta Geologica Sinica(English Edition)2015，89，6： | 18 |
| 3 | Simultaneous removal of COD and nitrogen using a novel carbon-membrane aerated biofilm reactor显示文摘膜给简历电影反应堆充气了是为废水处理的一种有希望的技术。在这研究,碳膜给简历电影反应堆(CMABR ) 充气了被开发了,到同时把碳 organics 和氮从一个反应堆移开。当它与 20 h 的一水力的保留时间(HRT ) 被操作,结果证明 CMABR 有一个高化学的氧要求(货到付款) 和氮移动效率,并且它也显示出完美的表演,就算 HRT 被弄短到 12 h。在这个时期,货到付款,氨氮(NH4+-N ) ,和总氮(TN ) 的移动效率分别地到达了 86% , 94% ,和 84% 。然而,当 HRT 被弄短到 8 h, NH4+-N 和 TN 的移动效率很快衰退了。这因为非编织的纤维和很高器官的装载率上的生物资源的过多的生长。荧光原位杂交(鱼) 分析显示氧化的氨细菌(AOB ) 主要在简历电影的内部层被散布。在一部简历电影的 AOB 和 eubacteria 的共存能提高货到付款和氮的同时的移动。 | HU Shaowei YANG Fenglin SUN Cui ZHANG Jianye WANG Tonghua | 2008 | Journal of Environmental Sciences2008，20，2： | 12 |
| 4 | Expanded endoscopic therapy criteria should be cautiously used in intramucosal gastric cancer显示文摘Objective: Accurate estimation of lymph node metastasis(LNM) in intramucosal gastric cancer is essential to select less invasive treatment options and even avoid surgery. The aim of this study was to evaluate combined clinicopathological features to predict the presence of LNM.Methods: A retrospective review of data from 386 intramucosal gastric cancer patients who underwent gastrectomy with extended lymphadenectomy from 2003 to 2010 was conducted. The mutual relation between clinicopathological characteristics and LNM was analyzed.Results: LNM was detected in 40(10.4%) of the 386 patients. Histological type and vascular or lymphatic invasion presence showed a positive correlation with LNM occurrence by univariate analysis. Multivariate analysis revealed that histological type was the only factor associated with LNM. Combined clinicopathologic characteristics would be more predictable for LNM. We found no LNM when we used combined clinicopathological characteristics conforming to Japanese absolute indications for endoscopic therapy. The LNM rate was as high as 8.7% when Japanese expanded criteria were used. Univariate analysis in cancer conformity to expand endoscopic submucosal dissection(ESD) indication also revealed that the undifferential type was the only significant factor for LNM.Conclusions: It was possible to predict intramucosal gastric cancer cases without LNM using combined clinicopathological characteristic analysis. Extended indication for ESD should be cautiously used for intramucosal gastric cancer patients. | Hongshan Wang Heng Zhang Cong Wang Yong Fang Xuefei Wang Weidong Chen Fenglin Liu Kuntang Shen Xinyu Qin Zhenbin Shen Yihong Sun | 2016 | Chinese Journal of Cancer Research2016，28，3： | 8 |
| 5 | Pattern of No.12a lymph node metastasis in gastric cancer显示文摘Objective:The current standard D2 lymphadenectomy for gastric cancer(GC)includes dissection of lymph nodes(LNs)along the proper hepatic artery(No.12 a),however,the survival benefit remains controversial.The purpose of this study was to evaluate the pattern of No.12 a LN metastasis(LNM)in GC and explore the indications for No.12 a LN dissection.Methods:Medical records of 413 consecutive GC patients who underwent curative surgery in Zhongshan Hospital,Fudan University between January 2015 and December 2018 were enrolled and reviewed retrospectively.The correlation between No.12 a LNM and clinicopathologic characteristics of patients was analyzed.Results:The overall incidence of No.12 a LNM was 2.67%(11/413).Tumor location(P=0.012),depth of tumor infiltration(P<0.01)and N stage(P=0.018)were significant factors associated with No.12 a LNM.All the tumors with No.12 a LNM involved the lower third of the stomach and were in T3-4 stages.Patients with No.12 a LNM had extensive LNM than those without(20.91±4.25 vs.5.0±0.54,P<0.001).For advanced GC patients(stage III/IV)with tumors involving the lower third of the stomach,the incidence of No.12 a LNM increased to 10.7%(11/103).Patients with No.12 a LNM had a significantly poorer recurrence-free survival(RFS)(P=0.005)and overall survival(OS)(P=0.017).According to the result of multivariable Cox regression,No.12 a LNM was not an independent impact factor on RFS and OS.Conclusions:The overall incidence of No.12 a LNM was low but it was much higher in GC patients who had very advanced tumors involving the lower third of the stomach.No.12 a LN dissection should be considered for these patients to improve the survival outcomes. | Ping Shu Xiangfei Sun Fenglin Liu Yong Fang Kuntang Shen Yihong Sun Jing Qin Xinyu Qin | 2021 | Chinese Journal of Cancer Research2021，33，1： | 3 |
| 6 | A novel vector of topological and structural information for amino acids and its QSAR applications for peptides and analogues显示文摘A new descriptor, called vector of topological and structural information for coded and noncoded amino acids (VTSA), was derived by principal component analysis (PCA) from a matrix of 66 topological and structural variables of 134 amino acids. The VTSA vector was then applied into two sets of peptide quantitative structure-activity relationships or quantitative sequence-activity modelings (QSARs/ QSAMs). Molded by genetic partial least squares (GPLS), support vector machine (SVM), and immune neural network (INN), good results were obtained. For the datasets of 58 angiotensin converting en-zyme inhibitors (ACEI) and 89 elastase substrate catalyzed kinetics (ESCK) , the R2, cross-validation R2, and root mean square error of estimation (RMSEE) were as follows: ACEI, R2cu≥0.82, Q2cu≥0.77, Ermse≤0.44 (GPLS+SVM); ESCK, R2cu≥0.84, Q2cu≥0.82, Ermse≤0.20 (GPLS+INN), respectively. | LI ZhiLiang LI GenRong SHU Mao SUN JiaYing YANG ShanBin MEI Hu ZHANG MengJun ZHOU Ping WU ShiRong CHEN GuoHua LU FengLin LU TingTing | 2008 | Science China Chemistry2008，51，10： | 2 |
| 7 | PREPARATION OF HETEROBIMETALLIC COMPLEXES BRIDGING WITH π,π-BOUND PHENYLCYCLOPENTADIENYL LIGAND AND X-RAY CRYSTAL STRUCTURE OF (TRICARBONYL-π-CHROMIUM)PHENYLCYCLOPENTADIENYLCOBALT DICARBONYL显示文摘PREPARATIONOFHETEROBIMETALLICCOMPLEXESBRIDGINGWITHπ,π-BOUNDPHENYLCYCLOPENTADIENYLLIGANDANDX-RAYCRYSTALSTRUCTUREOF(TRICARBONYL... | Chang Tao QIAN Jian Hua GVO and Jie SUN(Laboratory of Organometallic Chemistry. Shanghai Institute of Organic Chemistry. 354 Fenglin Lu. Shanghai. 200032) | 1996 | Chinese Chemical Letters1996，7，2： | 2 |
| 8 | Applica- tion of seawater to enhance SO2 removal from simulated flue gas through hollow fiber membrane contactor显示文摘 | Sun Xueyan Meng Fangang Yang Fenglin | 2008 | J Membr Sci2008，312，12： | 1 |
| 9 | A Research on the Causes of Chinese College Students’ Overall Physique Decline and Physique Promotion Strategies显示文摘At present,Chinese colleges and universities are facing the reality of the overall physical decline of college students,and the quality of college physical education has been questioned by all parties.In order to improve the quality of college physical education and strengthen the physique of college students,this paper first studies the causes of the decline of College Students'overall physique.The study found that,in addition to historical and social factors,many practical factors of college physical education,including teaching content,teaching organization form,teachers’quality,teaching evaluation mechanism and hardware facilities construction,have great influences on the improvement of college students’overall physique.Based on the causes of the decline of college students’overall physique,this paper puts forward feasible promotion strategies from the aspects of physical education curriculum,extracurricular sports activities,and physique monitoring. | Fenglin Sun | 2021 | 教育研究前沿(中英文版)2021，11，1： | 1 |
| 10 | Application of seawater to enhance SO 2 removal from simulated flue gas through hollow fiber membrane contactor显示文摘 | Xueyan Sun Fangang Meng Fenglin Yang | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 11 | Tertiary lymphoid structure patterns predicted anti-PD1 therapeutic responses in gastric cancer显示文摘Objective:Recent studies have highlighted the distinct value of tertiary lymphoid structure(TLS)for immunotherapeutic response prediction.However,it remains unclear whether TLS could play such roles in gastric cancer(GC).Methods:In this study,tumor tissue slices from 292 GC patients from Zhongshan Hospital were firstly reviewed to explore the correlation between TLS and clinical characteristics.Subsequently,we curated 38 reported genes that may function as triggers of TLS and performed consensus molecular subtyping in public RNA-seq datasets to determine TLS patterns in GC.Based on the differentially expressed genes acquired from two TLS patterns,we quantified TLS-related genes on the principal component analysis(PCA)algorithm to develop TLS score.A Zhongshan immunotherapy cohort including 13 patients who received programmed cell death 1(PD1)blockade therapy was established to conduct RNA sequencing analysis and multiplex immunohistochemistry(mIHC)tests using formalin-fixed and paraffin-embedded(FFPE)tissues.The corresponding TLS score and immune cell counts were further compared based on therapeutic response variations.Results:Mature TLS was revealed as an independent prognostic factor in 292 GC patients.Patients with higher TLS score was characterized by prolonged survival time and superior response to immunotherapy.TLS score was correlated with immunotherapy-related characters,such as microsatellite instability(MSI)and tumor mutation burden(TMB).In addition,RNA-seq data analysis in the Zhongshan immunotherapy cohort indicated that a higher TLS score was correlated with a superior response to PD1 blockade therapy.mIHC tests also revealed that PD1+CD8+T cell counts were significantly increased in the high-TLS score group.Conclusions:This study highlighted that TLS was significantly associated with immune landscape diversity and complexity.Quantitatively evaluating TLS patterns of individual tumor will strengthen our understanding of TME characteristics and promote more effective immunotherapy strategies. | Quan Jiang Chenyu Tian Hao Wu Lingqiang Min Hao Chen Lingli Chen Fenglin Liu Yihong Sun | 2022 | Chinese Journal of Cancer Research2022，34，4： | 1 |
| 12 | Application of seawater to enhance SO 2 removal from simulated flue gas through hollow fiber membrane contactor显示文摘 | Xueyan Sun Fangang Meng Fenglin Yang | 2008 | Journal of Membrane Science2008，，1： | 1 |
| 13 | A comprehensive multi‐hazard risk assessment model for an urban agglomeration with multiple factors显示文摘To assist the Department of Emergency Management in understanding the overall risk characteristics and situation of an urban agglomeration for a reasonable risk prevention and control strategy,this study developed a comprehensive multi-hazard risk assessment model for an urban agglomeration with multiple factors.The proposed model includes disaster probability and disaster loss sub-models.The model evaluated four types of disaster risk in urban agglomerations:natural disasters,accidental disasters,public health incidents,and social security incidents.In addition,a variety of factors were integrated into the model,including the socioeconomic foundation of urban agglomerations,the oligopoly effect of core cities,historical disaster losses,the effect of disaster chains,the ability of disaster prevention and mitigation,and intercity coordinated rescue capabilities.Finally,the risk assessment model was applied to the Beijing-Tianjin-Hebei urban agglomeration.The assessment results were compared to the distribution of the new coronavirus pneumonia epidemic in the target urban agglomeration.The results showed that after analyzing the risk characteristics and evaluating the risk levels,the model not only showed the comprehensive risk levels and distribution of urban agglomerations but also revealed the high-risk areas and the key points of risk prevention and control.More importantly,the results obtained through the model can facilitate the strategic planning of disaster prevention and mitigation for urban agglomerations. | Changkun Chen Dongyue Zhao Fan He Fenglin Sun | 2023 | Journal of Safety Science and Resilience2023，4，1： | 1 |
| 14 | Predictors of mortality in patients with acute smallbowel perforation transferred to ICU after emergency surgery:a single-centre retrospective cohort study显示文摘Background Although small-bowel perforation is a life-threatening emergency even after immediate surgical intervention,studies have rarely investigated surgical outcomes due to its relatively low incidence.This study aimed to investigate the outcomes of emergency surgery for patients with small-bowel perforation transferred to the intensive care unit(ICU)and the risk factors for mortality.Methods Consecutive patients with small-bowel perforation who were confirmed via emergency surgery and transferred to the ICU in Zhongshan Hospital,Fudan University(Shanghai,China)between February 2011 and May 2020 were retrospectively analysed.Medical records were reviewed to determine clinical features,laboratory indicators,surgical findings,and pathology.Results A total of 104 patients were included in this study,among whom 18(17.3%),59(56.7%),and 27(26.0%)underwent perforation repair,segmental resection with primary anastomosis,and small-bowel ostomy,respectively.Malignant tumours were the leading cause of perforation in these patients(40.4%,42/104).The overall post-operative complication rate and mortality rates were 74.0%(77/104)and 19.2%(20/104),respectively.Malignant tumour-related perforation(odds ratio[OR],4.659;95%confidence interval[CI],1.269–17.105;P=0.020)and high post-operative arterial blood-lactate level(OR,1.479;95%CI,1.027–2.131;P=0.036)were identified as independent risk factors for post-operative mortality in patients with small-bowel perforation transferred to the ICU.Conclusions Patients with small-bowel perforation who are transferred to the ICU after emergency surgery face a high risk of post-operative complications and mortality.Moreover,those patients with malignant tumour-related perforation and higher post-operative blood-lactate levels have poor prognosis. | Jianzhang Wu Ping Shu Hongyong He Haojie Li Zhaoqing Tang Yihong Sun Fenglin Liu | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 15 | ACSL5,a prognostic factor in acute myeloid leukemia,modulates the activity of Wnt/β-catenin signaling by palmitoylation modification显示文摘Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.The dysregulation of ACSL5 has been reported in some cancers,such as glioma and colon cancers.However,little is known about the role of ACSL5 in acute myeloid leukemia(AML).We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy donors.ACSL5 level could serve as an independent prognostic predictor of the overall survival of AML patients.In AML cells,the ACSL5 knockdown inhibited cell growth both in vitro and in vivo.Mechanistically,the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of Wnt3a.Additionally,triacsin c,a pan-ACS family inhibitor,inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199,the FDA approved BCL-2 inhibitor for AML therapy.Our results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML. | Wenle Ye Jinghan Wang Jiansong Huang Xiao He Zhixin Ma Xia Li Xin Huang Fenglin Li Shujuan Huang Jiajia Pan Jingrui Jin Qing Ling Yungui Wang Yongping Yu Jie Sun Jie Jin | 2023 | Frontiers of Medicine2023，17，4： | 0 |
| 16 | Temperature effect on the ease of aggregation显示文摘The effect of temperature on the critical aggregate concentration (CAgC) has been investigated for the first time, by measurement of the hydrolytic rate constants of p-nitrophenyl dodecanoate (C12) and hexadecanoate (C16) at different temperatures in the 30:70 V/V (Φ=0.30) and 40:60 V/V (Φ= 0.40) dioxane (DX)-H2O systems. The CAgC values of C12 and C16 increase with the increase of the temperature, i.e., high temperatures disfavor aggregation. Activation energies for the hydrolysis of C12 in the monomeric and aggregated concentration domains have also been discussed. | ZHANG, Jin-Tao NIE, Jin SUN, Si-Xun JI, Guo-Zhen JIANG, Xi-KuiShanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China | 1994 | Chinese Journal of Chemistry1994，12，2： | 0 |
| 17 | TELOMERIZATION OF TETRAFLUOROETHYLENE AND CHLOROTRIFLUOROETHYLENE WITH TRICHLOROMETHANESULFONYL BROMIDE AS A TELOGEN显示文摘TELOMERIZATION OF TETRAFLUOROETHYLENE AND CHLOROTRIFLUOROETHYLENE WITH TRICHLOROMETHANESULFONYL BROMIDE AS A TELOGENTELOMERIZ... | Wei Min FU Yu ZBU Si Xun SUN Yu Huang ZHANG Guo Zben JI and Xi Kui JLANG(Shanghal Institute of Organic Chemistry Chinese Academy of Sciences.354 Fenglin Lu.Shanghai 200032) | 1996 | Chinese Chemical Letters1996，7，8： | 0 |
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