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| 1 | Living Bacteria-Mediated Aerobic Photoinduced Radical Polymerization for in Situ Bacterial Encapsulation and Differentiation显示文摘Conventional polymerizations mediated by living cells typically require synthetic transition-metal complexes or photoredox catalysts.Herein,we report an alternative photoinduced polymerization strategy for preparing functional polymer hydrogels through bacteria-initiated radical polymerization of acrylamides in ordinary culture media.Upon light irradiation under ambient conditions,polyacrylamides were obtained with molecular weights of over 150 kDa using various bacteria. | Huan Lu Yiming Huang Fengting Lv Libing Liu Yuguo Ma Shu Wang | 2021 | CCS Chemistry2021，3，7： | 2 |
| 2 | Conjugated Polymer Nanomaterials for Phototherapy of Cancer显示文摘Due to the excellent properties including high specificity,low side-effect and good biocompatibility,conjugated polymer nanomaterials have been served as efficient anticancer reagents in die past decades.According to the developed anticancer systems based on conjugated polymer nanomaterials,it could be summarized into three main cancer therapy strategies:photodynamic therapy(PDT),photothermal therapy(PTT)and combination therapy.In this mini review,we provide a brief introduction to three different cancer therapy modes,their mechanisms and potential biological applications.Furthermore,some perspectives on the further development of conjugated polymer nanomaterials are proposed in the territory of anticancer precision medicine. | FU Xuancheng BAI Haotian LYU Fengting LIU Libing WANG Shu | 2020 | Chemical Research in Chinese Universities2020，36，2： | 2 |
| 3 | Oligo(p-phenylenevinylene)-rhodium complex as intracellular catalyst for enhancing biosynthesis of polyhydroxybutyrate biomaterials显示文摘Microbial synthesis utilizes sustainable resources to produce valuable chemicals,as a potential alternative to petroleum-based chemical industry.Although metabolic engineering is an efficient method to enhance the biosynthesis efficacy of microorganisms,it requires complicated biological procedures.Herein,we report a facile intracellular catalysis system for augmenting the production of bio-based material in microorganism.Covalent linking of oligo(p-phenylenevinylene)(OPV)and cyclopentadienyl rhodium(Ⅲ)bipyridine offers intracellular metal catalyst(OPV-Rh).The OPV-Rh complex displayed certain resistance to toxic biomolecules,which guaranteed its catalytic activity in complicated biological systems.With uptake by Gramnegative bacterium Ralstonia eutropha H16(R.eutropha H16),the OPV-Rh complex promotes the transformation of intracellular NADP+to NADPH,which further enhances the biosynthesis of polyhydroxybutyrate(PHB)by this microorganism.This work demonstrates that synthetic metal catalyst can be employed for regulating microbial biosynthesis intracellularly. | Nan Dai Hao Zhao Wen Yu Fengting Lv Libing Liu Shu Wang | 2021 | Science China Chemistry2021，64，1： | 2 |
| 4 | Cationic conjugated polymers for detection and inactivation of pathogens显示文摘Conjugated polymers(CPs) are referred to a kind of fluorescent polymer materials with delocalized π-conjugated backbones.For the last decades, cationic CPs(CCPs) have been widely used in biosensor, imaging and biomedical fields due to their good photophysical properties and solubility in water medium resulting from side chain modification with ionized moieties. In this mini-review, we mainly introduced the applications of CCPs in detection and inactivation of pathogen with typical examples, and also briefly discussed the relevant mechanisms. We hold the expectation that this mini-review can offer researchers a general reference and inspire them to construct new systems with high performances of pathogen detection and antimicrobial activity. | Ping He Fengting Lv Libing Liu Shu Wang | 2017 | Science China Chemistry2017，60，12： | 1 |
| 5 | Removal of Cu(II) from aqueous solution by adsorption onto functionalized SBA-16 mesoporous silica 显示文摘 | Xiaoming Xue Fengting Li Liu Y | 2008 | Microporous and Mesoporous Materials2008，116，13： | 1 |
| 6 | Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability显示文摘Increasing multidrug-resistant(MDR) superbugs emerge worldwide causing a public health crisis. Consequently, it is urgent to find new antibiotics with efficient broad-spectrum antimicrobial activity. By virtue of versatility in molecular design, a new peptide-like cell membrane-broken molecule, oligo-(7,7′-bifluoren-benzo[c][1,2,5]thiadiazole)(OFBT) possessing a conjugated backbone and eight pendant guanidyl moieties was designed and synthesized. OFBT exhibits favorable broad-spectrum of antimicrobial activity to pathogens including Gram-negative and Gram-positive bacteria, and fungi with the minimum inhibitory concentration(MIC)below 3.0 μM. Moreover, OFBT exhibits high selectivity for pathogens over human cells to make it a promising broad spectrum antimicrobial agent. | Hui Chen Meng Li Zhang Liu Rong Hu Shengliang Li Yuan Guo Fengting Lv Libing Liu Yilin Wang Yuanping Yi Shu Wang | 2018 | Science China Chemistry2018，61，1： | 1 |
| 7 | Multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers显示文摘The mutation detections of KRAS and BRAF genes are of significant importance to predict the responses to anti-cancer therapy and develop new drugs. In this paper, we developed a multi-step fluorescence resonance energy transfer (FRET) assay for multiplex detection of KRAS and BRAF mutations using cationic conjugated polymers (CCP). The newly established detection system could detect as low as 2% mutant DNAs in DNA admixtures. By triggering the emission intensity change of CCP and the dyes labeled in the DNA, four possible statuses (three mutations and one wildtype) can be differentiated in one extension reaction. The detection efficiency of this new method in clinical molecular diagnosis was validated by determining KRAS and BRAF mutations of 51 formalin-fixed paraffin-embedded (FFPE) ovary tissue samples. Furthermore, the result of the CCP-based multi-step FRET assay can be directly visualized under UV light so that no expensive instruments and technical expertise are needed. Thus, the assay provides a sensitive, reliable, cost-effective and simple method for the detection of disease-related gene mutations. | XING BaoLing SONG JinZhao GE SuMei TANG ZhengHua LIU MengLu YANG Qiong Lü FengTing LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，8： | 1 |
| 8 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
| 9 | In Situ-Induced Multivalent Anticancer Drug Clusters in Cancer Cells for Enhancing Drug Efficacy显示文摘Increasing intracellular drug concentration is an effec-tive way for cancer chemotherapeutics to enhance efficacy and combat drug resistance.In this work,a series of anticancer drug conjugates were prepared by linking thiol-modified oligo(p-phenylene viny-lene)with paclitaxel,vincristine,teniposide,tamoxi-fen,doxorubicin,or podophyllotoxin(OPV-S-Drugs)through a Michael addition reaction. | Lingyun Zhou Fengting Lv Libing Liu Shu Wang | 2019 | CCS Chemistry2019，1，1： | 1 |
| 10 | Comparative performance of polyepoxysuccinic acid and polyaspartic acid on scaling inhibition by static and rapid controlled precipitation methods显示文摘 | Dan Liu Wenbo Dong Fengting Li | 2012 | Desalination2012，，304： | 1 |
| 11 | Comparative performance of polyepoxysuccinic acid and polyaspartic acid on scaling inhibi- tion by static and rapid controlled precipitation methods 显示文摘 | Liu Dan Dong Wenbo Li Fengting | 2012 | Desal- ination2012，，304： | 1 |
| 12 | Comparative performance of polyepoxysuccinic acid and polyaspartic acid on scaling inhibition by static and rapid controlled precipitation methods显示文摘 | Dan Liu Wenbo Dong Fengting Li Franck Hui Jean Lédion | 2012 | Desalination2012，，： | 1 |
| 13 | Well-defined PMMA brush on silica particles fabricated by surface-initiated photopolymerization (SIPP) 显示文摘 | Chen Fengting Jiang Xuesong Liu Rui | 2010 | ACS Applied Materials & Interfaces2010，2，4： | 1 |
| 14 | Functional Hyperbranched Polythioamides Synthesized from Catalyst-free Multicomponent Polymerization of Elemental Sulfur显示文摘Hyperbranched polymers with unique topological structures,large number of branching sites and terminal groups have attracted much attention,and are expected to possess advanced functionalities compared with their linear polymer counterparts.The devel-opment of hyperbranched polymers is hence highly desired but challenging,especially for sulfur-containing polymers which are at-tractive metal absorbents,optical materials,dielectric materials,and self-healing materials.In this work,six hyperbranched polythi-oamides with various topological structures,well-defined repeating units,satisfying yields(up to 99%),and high molecular weights(up to 101400 g/mol)were successfully designed and synthesized from the catalyst-free multicomponent polymerization of ele-mental sulfur,aromatic alkynes and aliphatic amines,through different monomer combination strategies based on the designed three-or four-functional alkyne and amine monomers.The hyperbranched polythioamides possess unique luminescence property,and strong affinity toward Hg^(2+),which can be utilized in the fluorescence detection of Hg^(2+),as well as mercury removal from aque-ous solutions with high efficiency of 99.99%and low mercury residue of 0.1 ppb.Hyperbranched polythioamides with unique struc-tures may be developed to a group of fascinating materials and find their potential applications as metal absorbents and optoelec-tronic materials. | Shangrun Liu Fengting Li Wenxia Cao Rongrong Hu Ben Zhong Tang | 2022 | Chinese Journal of Chemistry2022，40，6： | 1 |
| 15 | Comparative performance of polyepoxysuccinic acid and polyaspartic acid on scaling inhibition by static and rapid controlled precipitation method 显示文摘 | Dan Liu Wenbo Dong Fengting Li | 2012 | Desalination2012，304，15： | 1 |
| 16 | Self-synthesized second mitochondria-derived activator of caspase(SMAC)mimetic TP-WY-1345 enhances the radiosensitivity of NSCLC cells H1299 by targeting anti-apoptotic protein cIAP1显示文摘Objective:To explore the toxicity and cellular uptake of the self-synthesized second mitochondria-derived activator of caspase(SMAC)mimetic TP-WY-1345 polypeptide and its radiosensitizing effect on non-small cell lung cancer(NSCLC).Methods:A fluorescence microscope was used to observe the uptake efficiency of TP-WY-1345 by human NSCLC cells H1299.Toxicity of the TP-WY-1345 peptide in normal cells was examined in human embryonic lung fibroblasts MRC5.CCK-8 and clone formation experiments were performed to detect the radiosensitizing effect of TP-WY-1345 in the H1299 cells.The AutoDock Vina simulation software was employed to predict the binding efficiency of TP-WY-1345 to the inhibitor of apoptosis proteins(IAPs).Moreover,Western blot and qPCR experiments were carried out to determine the protein and gene expressions,and the flow cytometry(FCM)technique was used to detect the apoptosis level under different conditions.Results:TP-WY-1345 can be self-synthesized,and significant green fluorescence was observed in H12992 h and 6 h after incubation with TP-WY-1345.The cell counting and CCK-8 results showed that 10μmol/L and 20μmol/L TP-WY-1345 did not produce a significant toxic effect on the MRC5 cells(P>0.05).Compared with the single ionizing radiation group,the cell viability and clone formation of H1299 cells were significantly inhibited after treatment with TP-WY-1345 at a concentration of 50μmol/L(P<0.05).The sensitivity enhancement ratio(SER)was calculated to be 1.14.Moreover,the binding efficiency of TP-WY-1345 to cIAP1 protein was predicted to be7.3,and this strong binding force was demonstrated by Western blot.TP-WY-1345 inhibited the protein and mRNA expressions of cIAP1 and further increased the apoptosis level of the H1299 cells at 24 h(P<0.01)and 48 h after radiation(P<0.05).Conclusion:SMAC mimetic TP-WY-1345 can enter the H1299 cells and produce a radiosensitizing effect by increasing the level of radiation-induced apoptosis of the cells.There,TP-WY-1345 is expected to become a new generation of radiosensitizing drugs. | Hao Sun Fengting Liu Hezheng Zhai Jiang Wu Shasha Nie Hui Cai Kaixue Wen Li Feng Qiang Liu Kaihua Ji Yan Wang | 2023 | Radiation Medicine and Protection2023，4，1： | 0 |
| 17 | Protein-assisted conjugated polymer microarray: Fabrication and sensing applications显示文摘A new strategy is performed to fabricate conjugated polymer microarray with the assistance of protein in this work.The water-soluble cationic conjugated polymer employed in the present work is capable of absorbing light at 510 nm,which makes it compatible with a variety of commercial microarray scanners.It is demonstrated that the protein-assisted conjugated polymer microarray exhibits higher fluorescence signal and better stability in comparison with the case without protein.The conjugated polymer microarray can be used for sensitive detection of picric acid(PA).A major advantage of our approach is its simplicity and chemical linking is not required between the conjugated polymer and microarray substrate.Considering the simplicity of the preparation of the conjugated polymer microarray,it is anticipated that novel sensing platforms will be constructed by employing this versatile method. | Lü FengTing FENG XuLi LIU LiBing WANG Shu | 2013 | Chinese Science Bulletin2013，58，33： | 0 |
| 18 | Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity. | Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang Xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 19 | Conjugated polymer nanoparticles as fluorescence switch for selective cell imaging显示文摘Fluorescence switch plays a vital role in bioelectronics and bioimaging.Herein,we presented a new kind of facile electrostatic complex nanoparticles(ECNs)for fluorescence switching in cells and marking of individual cell.The ECNs were prepared by mixing positively charged poly(6-(2-(thiophen-3-yl)ethoxy)hexyl trimethylammonium bromide)(PT)and negatively charged diarylethene sodium salt(DAECOONa).DAE-COONa is a photoswitchable molecule which can be transformed between the ring-closed fo rm and ring-open form under the irradiation of UV or visible light.The closed-form of DAE-COONa can efficie ntly quench the fluorescence of PT through intermolecular energy transfer,while the open form of DAE-COONa does not influence the emission of PT.Thus,the fluorescence of ECNs can be modulated by light irradiation,and the ECNs with good fluorescence switching performance have been employed for fluorescence imaging and individual cell lighting up process successfully.We demonstrate that the electrostatic complex strategy provides a facile method to construct fluorescence switch fo r selective cell marking and imaging applications. | Ke Peng Fengting Lv Huan Lu Jianwu Wang Hao Zhao Libing Liu Shu Wang | 2020 | Chinese Chemical Letters2020，31，3： | 0 |
| 20 | Electrochemical Regulation of Antibacterial Activity Using Ferrocene-Containing Antibiotics显示文摘The widespread use of antibiotics causes the accumulation of a large amount of antibiotics in the environment.Excessively active antibiotics in the environment results in the emergence of bacterial resistance.Building smart antibiotics capable of reversible regulation between active and inactive states on demand is a promising approach to address this issue.Herein,a ferrocene-containing quaternary ammonium compound has been developed for electrochemical redox-controlled bacterial inhibition.The reversible switch of the reduced and oxidized ferrocene groups between hydrophobic and hydrophilic states triggers the assembly and disassembly of the micelles while modulating the interactions of antibiotic molecules with the bacteria membrane,providing a new way to regulate antibacterial activity.In addition,the alternate use of reduced and oxidized antibiotics exhibits a favorable effect in preventing bacterial resistance.Thus,an unconventional strategy is offered to prevent the build-up of active bactericide in the environment and decrease bacterial resistance. | Song Shen Yiming Huang Anran Yuan Fengting Lv Libing Liu Shu Wang | 2021 | CCS Chemistry2021，3，11： | 0 |
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