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| 1 | Sex disparity of lung cancer risk in non-smokers:a multicenter population-based prospective study based on China National Lung Cancer Screening Program显示文摘Background: Non-smokers account for a large proportion of lung cancer patients, especially in Asia, but the attention paid to them is limited compared with smokers. In non-smokers, males display a risk for lung cancer incidence distinct from the females-even after excluding the influence of smoking;but the knowledge regarding the factors causing the difference is sparse. Based on a large multicenter prospective cancer screening cohort in China, we aimed to elucidate the interpretable sex differences caused by known factors and provide clues for primary and secondary prevention.Methods: Risk factors including demographic characteristics, lifestyle factors, family history of cancer, and baseline comorbidity were obtained from 796,283 Chinese non-smoking participants by the baseline risk assessment completed in 2013 to 2018. Cox regression analysis was performed to assess the sex difference in the risk of lung cancer, and the hazard ratios (HRs) that were adjusted for different known factors were calculated and compared to determine the proportion of excess risk and to explain the existing risk factors.Results: With a median follow-up of 4.80 years, 3351 subjects who were diagnosed with lung cancer were selected in the analysis. The lung cancer risk of males was significantly higher than that of females;the HRs in all male non-smokers were 1.29 (95% confidence interval [CI]: 1.20-1.38) after adjusting for the age and 1.38 (95% CI: 1.28-1.50) after adjusting for all factors, which suggested that known factors could not explain the sex difference in the risk of lung cancer in non-smokers. Known factors were 7% (|1.29-1.38|/1.29) more harmful in women than in men. For adenocarcinoma, women showed excess risk higher than men, contrary to squamous cell carcinoma;after adjusting for all factors, 47% ([1.30-1.16]/[1.30-1]) and 4% ([7.02-6.75]/[7.02-1])) of the excess risk was explainable in adenocarcinoma and squamous cell carcinoma. The main causes of gender differences in lung cancer risk were lifestyle factors, baseline comorbidity, and family history.Conclusions: Significant gender differences in the risk of lung cancer were discovered in China non-smokers. Existing risk factors did not explain the excess lung cancer risk of all non-smoking men, and the internal causes for the excess risk still need to be explored;most known risk factors were more harmful to non-smoking women;further exploring the causes of the sex difference would help to improve the prevention and screening programs and protect the non-smoking males from lung cancers. | Zheng Wu Fengwei Tan Zhuoyu Yang Fei Wang Wei Cao Chao Qin Xuesi Dong Yadi Zheng Zilin Luo Liang Zhao Yiwen Yu Yongjie Xu Jiansong Ren Jufang Shi Hongda Chen Jiang Li Wei Tang Sipeng Shen Ning Wu Wanqing Chen Ni Li Jie He | 2022 | Chinese Medical Journal2022，，11： | 3 |
| 2 | Seroprevalence of influenza viruses in Shandong,Northern China during the COVID-19 pandemic显示文摘Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China. | Chuansong Quan Zhenjie Zhang Guoyong Ding Fengwei Sun Hengxia Zhao Qinghua Liu Chuanmin Ma Jing Wang Liang Wang Wenbo Zhao Jinjie He Yu Wang Qian He Michael J.Carr Dayan Wang Qiang Xiao Weifeng Shi | 2022 | Frontiers of Medicine2022，16，6： | 1 |
| 3 | The e / a values of ideal metallic glasses in relation to cluster formulae显示文摘 | Guang Han Jianbing Qiang Fengwei Li Liang Yuan Shiguan Quan Qing Wang Yingmin Wang Chuang Dong Peter H?ussler | 2011 | Acta Materialia2011，，15： | 1 |
| 4 | A Top-Down Approach towards Cu(I)Alkynyl Clusters with Unusual Geometry显示文摘Main observation and conclusion To search for novel Cu(I)complexes,traditional approaches focus on designing and screening ligands,metal precursors and reaction parameters.In this report,we propose a top-down approach,in which Cu precursor is first reduced to nanoparticles in the presence of alkynyl and phosphine ligands. | Huan Li Ting Li Shuimiao Liu Mei Qu Linfeng Liang Fengwei Zhang Xian-Ming Zhang | 2021 | Chinese Journal of Chemistry2021，39，4： | 1 |
| 5 | A third dose of inactivated SARS-CoV-2 vaccine induces robust antibody responses in people with inadequate response to two-dose vaccination显示文摘Mass application of SARS-CoV-2 vaccines is a major approach to reduce SARS-CoV-2 transmission and COVID19 symptoms worldwide.The inactivated SARS-CoV-2 vaccine is one of the most widely administered vaccine types in many countries,with over 2 billion doses administered as of 31 August 2021.However,clinical trials estimate 65%–85%protection from detectable symptoms for inactivated SARS-CoV-2 vaccines[1–4],with 15%–35%of people remaining insufficiently protected after two-dose immunization.Immune protectionforthese‘non-responders’is critical for population immunity as established by mass vaccination.A third dose of inactivated(CoronaVac)vaccine has been shown to boost antibody response by between 3–5 folds in the general population[5].Whether a third dose can induce an adequate antibody response in‘non-responders’remains unclear.Here we report a trial of a third dose in a cohort of 105 vaccinated participants(Supplementary Fig.S1)with suboptimal antibody responses(non-responders)aftertwo doses(43.8%were men;average age 43±11 years[±SD];average BMI 23.5±3.4[±SD],Supplementary Table S1). | Taicheng Zhou Tianpei Shi Ao Li Lingzhi Zhu Xinshuai Zhao Naiyin Mao Wanting Qin Hanfang Bi Mei Yang Muxian Dai Fengwei Liu Rong Wang Wei Su Liang Zhang Wenbo Xu Jia Wei Zijie Zhang | 2022 | National Science Review2022，9，7： | 0 |
| 6 | Disparities in the global burden of tracheal,bronchus,and lung cancer from 1990 to 2019显示文摘Background:Tracheal,bronchus,and lung(TBL)cancer imposes a high disease burden globally,and its pattern varies greatly across regions and countries.This study aimed to explore the global burden and temporal trends of TBL cancer from 1990 to 2019.Methods:Data on incidence,mortality,and disability-adjusted life years(DALYs)metrics(number,crude rate,and age-standardized rates),and the attributable risk fraction of DALY of TBL cancer from 1990 to 2019 in 21 Global Burden of Disease(GBD)regions,four World Bank income regions,204 countries and territories,and the globe were obtained from the up-to-date GBD 2019 study.We applied estimated annual percentage changes(EAPCs)to the age-standardized incidence rate(ASIR),age-standardized mortality rate(ASMR),and age-standardized DALY rate(ASDR)to quantify the temporal trends of the TBL cancer burden from 1990-2019.Associations of EAPC of age-standardized rates with universal health coverage(UHC)index at the national level were evaluated with Pearson correlation analysis.Results:Globally,approximately 2,260,000 new TBL cancer cases,2,042,600 deaths,and 45,858,000 DALYs were reported in 2019.Combination of all modifiable risk factors,behavioral,environmental,and metabolic risk factors accounted for 79.1%,66.4%,33.3%,and 7.9%of global lung cancer DALYs,respectively.The overall ASIR(EAPC:-0.1[95%confidence interval[CI]:-0.2,-0.1]),ASMR(EAPC:-0.3[95%CI:-0.4,-0.3]),and ASDR(EAPC:-0.7[95%CI:-0.7,-0.6])decreased from 1990 to 2019.The highest mortality rate of TBL cancer occurred in the>85-year-old age group for both sexes among high-income countries(HICs)and upper-middle-income countries(UMCs),and in males aged 80-84 years and females aged>85 years in lower middle-income countries(LMCs).HICs experienced the largest declines in ASIR(-12.6%),ASMR(-20.3%),and ASDR(-27.8%)of TBL cancer between 1990 and 2019,while UMCs had the highest increases in ASIR(16.7%)and ASMR(8.0%)over the period.Eleven(52.4%),14(66.7%),and 15(71.4%)regions of the 21 GBD regions experienced descending trends in ASIR,ASMR,and ASDR of TBL cancer between 1990 and 2019,respectively,with the greatest mean decrease per year(EAPC:-1.7[95%CI:-2.0,-1.5]for ASIR,-1.9[95%CI:-2.2,-1.7]for ASMR,and-2.2[95%CI:-2.5,-2.0]for ASDR)being observed in eastern Europe.The ASIR,ASMR,and ASDR of TBL cancer were deemed to be in decreasing trends in 85,91,and 104 countries and territories,with the largest decrease in Bahrain(EAPC:-3.0[95%CI:-3.3,-2.7]for ASIR,-3.0[95%CI:-3.3,-2.6]for ASMR,and-3.4[95%CI:-3.8,-3.1]for ASDR).ASIR(r=0.524),ASMR(r=0.411),and ASDR(r=0.353)of TBL cancer were positively associated with UHC index at the national level in 2019.Conclusions:The TBL cancer burden shows a downward trend at the global level but varies greatly across regions and countries.A decreasing trend in the TBL cancer burden was observed in the most of the 21 GBD regions and 204 countries from 1990 to 2019.UMCs had the highest burden of TBL cancer and showed the largest increases in ASIR and ASMR. | Chenran Wang Zheng Wu Yongjie Xu Yadi Zheng Zilin Luo Wei Cao Fei Wang Xuesi Dong Chao Qin Liang Zhao Changfa Xia Fengwei Tan Wanqing Chen Ni Li Jie He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，1： | 0 |
| 7 | ARTICLE OPEN Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer显示文摘Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate multiple biological functions of colorectal cancer(CRC).Here,we demonstrate a cell-extrinsic role of KRAS,where KRAS engages with the tumor microenvironment by functional reprogramming of tumor-associated macrophages(TAMs).In human CRC specimens,mutant KRAS positively correlates with the presence of TAMs.Mutationally activated KRAS in tumor cells reprograms macrophages to a TAM-like phenotype via a combination effect of tumor-derived CSF2 and lactate.In turn,KRAS-reprogrammed macrophages were shown to not only promote tumor progression but also induce the resistance of tumor cells to cetuximab therapy.Mechanistically,KRAS drives the production of CSF2 and lactate in tumor cells by stabilizing hypoxia-inducible factor-la(HIF-1a),a transcription factor that controls the expression of CSF2 and glycolytic genes.Mutant KRAS increased the production of reactive oxygen species,an inhibitor of prolyl hydroxylase activity which decreases HIF-1a hydroxylation,leading to enhanced HIF-1a stabilization.This cell-extrinsic mechanism awards KRAS a critical role in engineering a permissive microenvironment to promote tumor malignancy,and may present new insights on potential therapeutic defense strategies against mutant KRAS tumors. | Huashan Liu Zhenxing Liang Chi Zhou Ziwei Zeng Fengwei Wang Tuo Hu Xiaowen He Xiaojian Wu Xianrui Wu Ping Lan | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 8 | PSO-LSSVM-based Online SOC Estimation for Simulation Substation Battery显示文摘As the emergency power supply for a simulation substation,lead-acid batteries have a work pattern featuring noncontinuous operation,which leads to capacity regeneration.However,the accurate estimation of battery state of charge(SOC),a measurement of the amount of energy available in a battery,remains a hard nut to crack because of the non-stationarity and randomness of battery capacity change.This paper has proposed a comprehensive method for lead-acid battery SOC estimation,which may aid in maintaining a reasonable charging schedule in a simulation substation and improving battery’s durability.Based on the battery work pattern,an improved Ampere-hour method is used to calculate the SOC during constant current and constant voltage(CC/CV)charging and discharging.In addition,the combined Particle Swarm Optimization(PSO)and Least Squares Support Vector Machine(LSSVM)model is used to estimate the SOC during non-CC discharging.Experimental results show that this method is workable in online SOC estimation of working batteries in a simulation substaion,with the maximum relative error standing at only 2.1%during the non-training period,indicating a high precision and wide applicability. | Qiang Zhang Xianguang Zha Jun Wu Liang Zhang Wei Dai Gang Ren Shiqian Li Ning Ji Xiangjun Zhu Fengwei Tian | 2022 | Structural Durability & Health Monitoring2022，16，1： | 0 |
| 9 | Research progress,trends and prospects of big data technology for new energy power and energy storage system显示文摘The development of new energy industry is an essential guarantee for the sustainable development of society,and big data technology can enable new energy industrialization.Firstly,this paper presents an in-depth analysis and discussion of big data technology in new energy power and energy storage systems.Furthermore,the current status of big data technology application is discussed based on power generation,grid and user side,while future development trends are proposed based on the characteristics of big data technology.Finally,a comprehensive cloud-platform-based new energy power and energy storage system is proposed,which efficiently combines new energy power generation,consumption,and transmission sides to optimize energy allocation and improve energy utilization efficiency.This paper aims to provide certain guidance significance for new energy research and application. | Jichao Hong Fengwei Liang Haixu Yang | 2023 | Energy Reviews2023，2，3： | 0 |
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