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| 1 | Chemopreventive and Growth Inhibitory Effects of Selenium显示文摘There is very convincing evidence that a high dietary level of selenium substantially reduces the incidence of a wide variety of animal cancers. The human epidemiological evidence is less clear cut, but overall suggests that selenium may be protective: the evidence is strongest in men in relation to gastro-intestinal cancers. There is evidence that dietary selenium compounds reduce the formation of DNA adducts by carcinogens. Selenium compounds also inhibit growth in vitro and induce apoptosis. In general, there is a good correlation between the effectiveness of selenium compounds in chemoprevention and growth inhibition, implying that the mechanisms of growth inhibition and chemoprevention may be similar and that a major factor in the chemopreventive effects of selenium compounds in vivo is their ability to retard outgrowth of pre-malignant cells. Various hypotheses have been advanced as to how selenium compounds might prevent tumour cellgrowth. One is that they cause apoptosis by inducing oxidative stress. However, we have shown that the most potent selenium compound, selenodiglutathione (SDG), a natural metabolite of selenite, does not induce oxidative stress, at least not in the sarne way as other oxidants such as H2O2 and diamide. Firstly, a partially selenium-resistant variant cell line does not show increased resistance to H2O2. Moreover, SDG does not induce widespread tyrosine phosphorylation, including MAP and SAN kinases, like other oxidants such as H2O2 and diamide and its effects are not reversed by pretreatment with the tyrosine kinase inhibitor, herbimycin. Our experiments with the selenium-resistant variant suggest that a novel selenium-binding protein may be involved in growth inhibition by | P. R. HARRISON J. LANFEAR L. WU J. FLEMING L. MCGARRY, AND L. BLOWER (The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road,Bearsden, Glasgow, G61 1BD, Scotland, UK) | 1997 | Biomedical and Environmental Sciences1997，10，2： | 5 |
| 2 | Impact of biochar amendments on the quality of a typical Midwestern agricultural soil显示文摘 | David A. Laird Pierce Fleming Dedrick D. Davis Robert Horton Baiqun Wang Douglas L. Karlen | 2010 | Geoderma2010，，3： | 5 |
| 3 | Impact of biochar amendments on the quality of a typical Midwestern agricultural soil显示文摘 | David A. Laird Pierce Fleming Dedrick D. Davis Robert Horton Baiqun Wang Douglas L. Karlen | 2010 | Geoderma2010，，3： | 2 |
| 4 | 医疗卫生保健系统对乳腺癌和宫颈癌妇女的作用 | Kirsner R.S. Fleming L. 高雪莲 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，9： | 2 |
| 5 | Outcomes of Endoscopic and Percutaneous Drainage of Pancreatic Fluid Collections Arising after Pancreatic Tail Resection显示文摘 | Nabeel Azeem Todd H. Baron Mark D. Topazian Ning Zhong Chad J. Fleming Michael L. Kendrick | 2012 | Journal of the American College of Surgeons2012，，2： | 1 |
| 6 | Effect of muscle loads and torque applied to the tibia on the strain behavior of the anterior cruciate ligament: An in vitro investigation显示文摘 | Hiroto Fujiya Petteri Kousa Braden C. Fleming David L. Churchill Bruce D. Beynnon | 2011 | Clinical Biomechanics2011，，10： | 1 |
| 7 | Vegetative Forage Quality and Moist-soil Management on Wetlands Reserve Program Lands in Mississippi显示文摘 | K. Sarah Fleming Richard M. Kaminski Todd E. Tietjen Michael L. Schummer Gary N. Ervin Kevin D. Nelms | 2012 | Wetlands2012，，5： | 1 |
| 8 | Valuing scenic amenity using life satisfaction data显示文摘 | Christopher L. Ambrey Christopher M. Fleming | 2011 | Ecological Economics2011，，： | 1 |
| 9 | Randomized controlled trial of recombinant alpha-2a-interferon for chronic hepatitis C显示文摘 | David D. Douglas MD Dr. Jorge Rakela MD Hsiang Ju Lin DSc F. Blaine Hollinger MD Howard F. Taswell MD Albert J. Czaja MD John B. Gross MD Monte L. Anderson MD Kevin Parent MD C. Richard Fleming MD John R. Cangemi MD Peter C. O’Brien PhD Pauline E. Powis R | 1993 | Digestive Diseases and Sciences1993，，4： | 1 |
| 10 | Association of Tumor Size, Location, R.E.N.A.L., PADUA and Centrality Index Score with Perioperative Outcomes and Postoperative Renal Function显示文摘 | Jason R. Bylund Dustin Gayheart Tyler Fleming Ramakrishna Venkatesh David M. Preston Stephen E. Strup Paul L. Crispen | 2012 | The Journal of Urology2012，，： | 1 |
| 11 | Long-Term Survival After Multidisciplinary Management of Resected Pancreatic Adenocarcinoma显示文摘 | Matthew H. G. Katz MD Huamin Wang MD PhD Jason B. Fleming MD Charlotte C. Sun DrPH MPH Rosa F. Hwang MD Robert A. Wolff MD Gauri Varadhachary MD James L. Abbruzzese MD Christopher H. Crane MD Sunil Krishnan MD Jean-Nicolas Vauthey MD Eddie K. Abdalla MD | 2009 | Annals of Surgical Oncology2009，，4： | 1 |
| 12 | The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma显示文摘 | Nikki L. Neubauer Laura J. Havrilesky Brian Calingaert Anuradha Bulusu Marcus Q. Bernardini Nicole D. Fleming Amy E. Bland Angeles Alvarez Secord | 2008 | Gynecologic Oncology2008，，3： | 1 |
| 13 | UV absorption cross sections of nitrous oxide (N2O) and carbon tetrachloride (CCl4) between 210 and 350 K and the atmospheric implications显示文摘 | Rontu Carlon N. Papanastasiou D. K. Fleming E. L. Jackman C. H. Newman P. A. Burkholder J. B | 2010 | 2010 (201)2010，，201： | 1 |
| 14 | Infiltration of fibrous preforms by a pure metal: Part I. Theory显示文摘 | A. Mortensen L. J. Masur J. A. Cornie M. C. Flemings | 1989 | Metallurgical Transactions A1989，，11： | 1 |
| 15 | Development of an Integrated Biospecimen Bank and Multidisciplinary Clinical Database For Pancreatic Cancer显示文摘 | Rosa F. Hwang MD Huamin Wang MD PhD Axbal Lara MBA Henry Gomez MD Tracy Chang BS Nicole Sieffert BA Younghee Moon BS Sabina Ram MS Stuart Zimmerman PhD Jeffrey H. Lee MD Peter W. T. Pisters MD Eric P. Tamm MD Jason B. Fleming MD James L. Abbruzzese MD Do | 2008 | Annals of Surgical Oncology2008，，5： | 1 |
| 16 | Perineural and Intraneural Invasion in Posttherapy Pancreaticoduodenectomy Specimens Predicts Poor Prognosis in Patients With Pancreatic Ductal Adenocarcinoma显示文摘 | Deyali Chatterjee Matthew H. Katz Asif Rashid Hua Wang Alina C. Iuga Gauri R. Varadhachary Robert A. Wolff Jeffrey E. Lee Peter W. Pisters Christopher H. Crane Henry F. Gomez James L. Abbruzzese Jason B. Fleming Huamin Wang | 2012 | The American Journal of Surgical Pathology2012，，3： | 1 |
| 17 | Bone structure and breaking strength in laying hens housed in different husbandry systems显示文摘 | R. H. Fleming C. C. Whitehead D. Alvey N. G. Gregory L. J. Wilkins | 1994 | British Poultry Science1994，，5： | 1 |
| 18 | Multimodality Therapy Offers a Chance for Cure in Patients with Pancreatic Adenocarcinoma Deemed Unresectable at First Operative Exploration显示文摘 | Mark J. Truty Ryan M. Thomas Matthew H. Katz Jean-Nicolas Vauthey Christopher Crane Gaury R. Varadhachary Robert A. Wolff James L. Abbruzzese Jeffrey E. Lee Jason B. Fleming | 2012 | Journal of the American College of Surgeons2012，，1： | 1 |
| 19 | Granulocyte-Colony Stimulating Factor Reactivates Human Cytomegalovirus in a Latently Infected Humanized Mouse Model显示文摘 | M. Shane Smith Devorah C. Goldman Alexis S. Bailey Dana L. Pfaffle Craig N. Kreklywich Doran B. Spencer Florence A. Othieno Daniel N. Streblow J. Victor Garcia William H. Fleming Jay A. Nelson | 2010 | Cell Host & Microbe2010，，： | 1 |
| 20 | Infiltration of fibrous preforms by a pure metal: Part I. Theory显示文摘 | A. Mortensen L. J. Masur J. A. Cornie M. C. Flemings | 1989 | Metallurgical Transactions A1989，，11： | 1 |
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