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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design显示文摘 | Rachel P Dreyer Xi Li Xue Du Nicholas S Downing Li Li Hai-Bo Zhang Fang Feng Wen-Chi Guan Xiao Xu Shu-Xia Li Zhen-Qiu Lin Frederick A Masoudi John A Spertus Harlan M Krumholz Li-Xin Jiang | 2016 | Chinese Medical Journal2016，，1： | 13 |
| 3 | K48-1inked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites显示文摘 | Frederick A Mallette | 2012 | Cell Research2012，22，8： | 7 |
| 4 | Bilateral vs unilateral placement of metal stents for inoperable highgrade hilar biliary strictures: A systemic review and meta-analysis显示文摘BACKGROUND Bilateral vs unilateral biliary stenting is used for palliation in malignant biliary obstruction.No clear data is available to compare the efficacy and safety of bilateral biliary stenting over unilateral stenting.AIM To assess the efficacy and safety of bilateral vs unilateral biliary drainage in inoperable malignant hilar obstruction.METHODS PubMed,Embase,Scopus,and Cochrane databases,as well as secondary sources(bibliographic review of selected articles and major GI proceedings),were searched through January 2019.The primary outcome was the re-intervention rate.Secondary outcomes were a technical success,early and late complications,and stent malfunction rate.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated for each outcome.RESULTS A total of 9 studies were included(2 prospective Randomized Controlled Study,5 retrospective studies,and 2 abstracts),involving 782 patients with malignant hilar obstruction.Bilateral stenting had significantly lower re-intervention rate compared with unilateral drainage(OR=0.59,95%CI:0.40-0.87,P=0.009).There was no difference in the technical success rate(OR=0.7,CI:0.42-1.17,P=0.17),early complication rate(OR=1.56,CI:0.31-7.75,P=0.59),late complication rate(OR=0.91,CI:0.58-1.41,P=0.56)and stent malfunction(OR=0.69,CI:0.42-1.12,P=0.14)between bilateral and unilateral stenting for malignant hilar biliary strictures.CONCLUSION Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures,with no significant difference in technical success,and early or late complication rates. | Munish Ashat Sumant Arora Jagpal S Klair Christopher A Childs Arvind R Murali Frederick C Johlin | 2019 | World Journal of Gastroenterology2019，25，34： | 5 |
| 5 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 6 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 7 | Interleukin- 6 in theinjured patient 显示文摘 | Emest E Frederick A | 1996 | AnnSurg1996，224，： | 1 |
| 8 | Structura1 comparison of anticancer drug- DNA complexes:adriamycin and daunomycin显示文摘 | Wi11iams L D Ughetto G | 1990 | Biochemistry1990，29，10： | 1 |
| 9 | TEN versus TPN following majox abdominal trauma 2 Reduced septic morbidity 显示文摘 | Frederick A Moore Evcnest E et at | 2004 | J Trauma2004，29，11： | 1 |
| 10 | Standards for nutrition support: home care patients 显示文摘 | Kovacevich DS Frederick A Kelly D | 2005 | Nutr Clin Pract2005，20，5： | 1 |
| 11 | Risk Factors for hepatic morbidity following nonoperative management显示文摘 | Rosemary A K Frederick A M Clay C | 2006 | Archives of Surgery2006，141，5： | 1 |
| 12 | Eddy current offers a powerful tool for investigating residual stress and other metallurgical properties显示文摘 | Hong Chang Frederick C Schoenig Jr Jack A Soules | 1999 | Materials Evaluation1999，57，12： | 1 |
| 13 | Growing more ductile epoxies: an essential work of fracture study 显示文摘 | FREDERICK A PFAFF | 2007 | J Coat Technol Res2007，4，2： | 1 |
| 14 | Beyond employment interview validity: a comprehensive narrative review of recent research and trends over time 显示文摘 | RICHARD A P FREDERICK P M MICHAEL A C | 2002 | Personnel Psychology2002，，55： | 1 |
| 15 | Entrepreneurial risk allocation in publicprivate infrastructure provision in South Africa 显示文摘 | Frederick A | 2002 | South African Journal of Business Management2002，33，4： | 1 |
| 16 | Combustion effects of C6osoot in ammonium nitrate propellants显示文摘 | Greiner B E Frederick R A Maser M D | | 0，，4： | 1 |
| 17 | 自发性高血压大鼠发育过程中D_1多巴胺受体对钠-氢交换体3的调节显示文摘目的 探讨是否原发性高血压继发于多巴胺受体、G蛋白和Na+ H+ 交换体 3(NHE3)的相互作用障碍。方法 为避免第二信使的影响 ,我们采用无细胞质成分的肾小管细胞膜刷状缘进行实验 ,实验对象为高血压产生前 (2~ 3周龄 )和高血压产生后 (12周龄 )的自发性高血压大鼠 (SHR) ,研究多巴胺受体激活剂对SHR肾小管细胞膜刷状缘的NHE活性的抑制作用和对G蛋白亚基与NHE3结合的影响。结果 正常对照鼠 (WKY鼠 )NHE3活性随年龄增长而增强 ,但SHR肾NHE3活性未随年龄变化而改变。SHR与WKY鼠的D1多巴胺受体表达不受年龄影响。多巴胺D1受体激活剂对WKY肾NHE3活性的抑制能力随年龄增长而增强 ,但对SHR的抑制未随年龄变化。多巴胺D1受体激活剂 (Fenoldopam)增加WKY幼鼠Gsα/NHE3结合量与成年鼠相同 ,但使SHR幼鼠Gsα/NHE3结合量减少。结论 多巴胺D1受体激活剂对SHR中NHE3活性的抑制减少早于高血压的形成 。 | 李晓曦 Frederick E Albrecht 徐镜 Jean E Robillard Gilbert M Eisner Pedro A Jose | 2001 | 中华医学杂志2001，81，9： | 1 |
| 18 | An orthogonal approach to chiral method development screening 显示文摘 | ANNE A FREDERICK JA JENNY LA | 2007 | Curr Pharm Anal2007，3，1： | 1 |
| 19 | The effects of global climate change on seagrasses 显示文摘 | Frederick T S Hilary A N | 1999 | Aquatic Botany1999，63，： | 1 |
| 20 | TEN versus TPN following major abdominal trauma 2 Reduced septic morbidity显示文摘 | Frederick A Moore Evenest E | 2004 | J Trauma2004，29，： | 1 |
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