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| 1 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 2 | Determination of carnosine in Black-Bone Silky Fowl (Gallus gallus domesticus Brisson) and common chicken by HPLC显示文摘 | Yinggang Tian Mingyong Xie Weiya Wang Hongjing Wu Zhihong Fu Lin Lin | 2007 | European Food Research and Technology (-)2007，，1： | 1 |
| 3 | Polar stationary phases for capillary electrochromatography显示文摘 | XIE Chuanhui FU Hongjing HU Jiwei | 2004 | Electrophoresis2004，25，23： | 1 |
| 4 | Physical characteristic study of LiCoO2 prepared by molten salt synthesis method in 550 - 800C 显示文摘 | Juan Fu Ying Bai Caiyun Liu Hongjing Yu Yujun Mo | 2009 | Materials Chemistry and Physics2009，115，： | 1 |
| 5 | Experiment Research on Grinding of Optical Glass with Indige- nously Developed Monolayer Brazed Diamond Grinding Wheel显示文摘 | Zhang Bei Xu Hongj un Fu Yucan | 2010 | Advanced Materials Research2010，136，： | 1 |
| 6 | The separa- tion of biomolecules using capillary electroehromatography 显示文摘 | Hongjing Fu Xiaodong Huang Wenhai Jin | 2003 | Current Opinion in Biotechnology2003，14，1： | 1 |
| 7 | Identification of two novel BCKDHA mutations in a Chinese patient with maple syrup urine disease显示文摘 | Jian Wang Hongjing Liu Guoqiang Chen Sian Hsiang-Te Tsuei Tingting Yu Qihua Fu | 2011 | Journal of Pediatric Endocrinology and Metabolism (-)2011，，9： | 1 |
| 8 | Mod- el parameter identification of tire dynamic balance de- tection system 显示文摘 | Yang Jingfang Feng Xianying Fu Hongj un | 2012 | Applied Mechanics and Materials2012，157，1： | 1 |
| 9 | Naphthenic acids speciation and removal during petroleumcoke adsorption and ozonation of oil sands processaffected water显示文摘 | El-Din M G Fu Hongjing Wang Nan | 2011 | SciTotal Environ2011，409，23： | 1 |
| 10 | A self-adaptive differential evolution algprithm for binary CSPs 显示文摘 | Fu Hongj ie Ouyang Dantong Xu Jiaming | 2011 | Computers and Mathematics with Applications2011，62，7： | 1 |
| 11 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping ZhuZhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
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